• 약학회지
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• 제54권4호
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• pp.295-299
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• 2010

The aim of this study was to develop and validate for determination of alibendol in human plasma by HPLC method. After precipitation of 500 ${\mu}l$ plasma samples by 50% methanol 50 ${\mu}l$ and 60% perchloric acid 30 ${\mu}l$ and the supernatant 50 ${\mu}l$ was injected into HPLC. The assay was performed isocratically using 10 mM potassium phosphate (pH 3.0) and acetonitrile (80 : 20, v/v) as mobile phase. The $C_{18}$ column (particle size $3.5{\mu}m$, $4.6{\times}50$ mm, Zorbax Eclipse) was used as a solid phase. The mobile phase was delivered at a flow-rate of 1.7 ml/min, detection was by ultraviolet absorption at 232 nm and concentrations were calculated on the basis of peak areas. In these conditions, alibendol can be separated from ethylparaben, the internal standard, and endogenous substances. The retention times of alibendol and ethylparaben were just about 2.6 and 3.5 minutes, respectively. This rapid HPLC method was validated by examining the precision and accuracy for inter- and intra-day analysis. The standard curve was linear ($R^2$=1.0000) over the concentration range of 0.05~20 ${\mu}g$/ml. The inter-day relative standard deviation (R.S.D.) and accuracy were 0.2~12.2% and 94.4~101.2% (82.7% at the lower limit of quatitation). The intra-day R.S.D. and accuracy were 0.1~11.8% and 98.8~102.5%, respectively. The method was successfully applied to the determination of alibendol in plasma for a pharmacokinetic study.

• 한국도로학회논문집
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• 제8권3호
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• pp.21-28
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• 2006

Field or laboratory wheel tracking tests have been employed for the evaluation of the rutting potential of asphalt paving mixtures. Compared to field tests, laboratory wheel tracking tests are much less expensive and more manageable for most road projects. However, most test laboratories are not equipped to perform such tests because there does not exist any standard test procedure, and the required equipment is rather expensive. Futhermore, the size of test specimens and the relatively large quantity of test mixture required present difficulties for laboratory specimen mixing and compaction. This paper describes a project conducted to study the feasibility of replacing wheel tracking testsby a repeated-load creep test for rutting potential evaluation. Comparisons were made between the results of the two tests for different test temperatures, loading speeds and applied pressures. Three types of asphalt mixtures were studied in the test program. Favorable conclusions concerning the use of the repeated-load test for rutting potential evaluation were drawn based on the findings of the experimental test results. The correlation between the two types of tests was found to be good for all threeasphalt mixtures. Adopting the repeated-load creep test would lead to cost savings since it employs standard test equipment already available in most laboratories. It would also result in substantial time savings due to the much smaller quantity of mix needed, and the ease in specimen preparation.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2007년도 7th International Meeting on Information Display 제7권1호
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• pp.698-701
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• 2007

A top emission organic light emitting diode comprising of a triple anode on polycarbonate $film/TNATA/NPB/Alq_3:C545T/cathodes$ has been fabricated. The triple layer structure of Cr/Al/Cr allowed for fabrication of a crack-free anode and provided better higher work function than ITO anode.The anode showed compatibility with flexible plastic substrate and no crack was formed during bending test while ITO anode showed crack.

• 대한임상검사과학회지
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• 제52권3호
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• pp.271-277
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• 2020

"건강검진"이란 건강상태 확인과 질병의 예방 및 조기발견을 목적으로 건강검진기관을 통하여 진찰 및 상담, 신체계측, 진단검사, 병리검사, 영상의학 검사 등 의학적 검진을 시행하는 것을 말한다. 건강검진의 종류에는 일반건강검진, 종합건강검진, 특수건강검진, 기타건강검진이 있다. 건강검진센터에서 근무하고 있는 임상병리사들의 일반건강검진 업무의 비중은 전체 업무에서 50% 이상 기여를 하고 있는 것으로 추정할 수 있다. 질환의심 비용적인 측면은 25% 이상 기여하는 것으로 추정할 수 있다. 진단검사 비용은 약 5%로 추정되며 의학진단 사용 비율은 70%를 차지하고 있다. 본 연구 결과에서 임상병리사들이 건강검진 업무에서 사회적, 경제적, 정책적인 타당한 처우를 받고 있는가를 검토되어져야 할 것이다. 임상병리사의 미래는 향후 업무적으로 정밀의료와 원격의료에서 진단검사 및 질 관리에서 전문성이 더욱 확대될 것으로 예측된다. 따라서 임상병리사들은 국가건강검진 관련 정부정책결정에 적극적으로 참여하고 더불어 처우개선의 노력이 필요할 것이다.

• Wind and Structures
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• 제20권5호
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• pp.643-660
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• 2015

The wind tunnel test of large-scale sectional model and computational fluid dynamics (CFD) are employed for the purpose of studying the aerodynamic appendices and mechanism on suppression for the vortex-induced vibration (VIV). This paper takes the HongKong-Zhuhai-Macao Bridge as an example to conduct the wind tunnel test of large-scale sectional model. The results of wind tunnel test show that it is the crash barrier that induces the vertical VIV. CFD numerical simulation results show that the distance between the curb and crash barrier is not long enough to accelerate the flow velocity between them, resulting in an approximate stagnation region forming behind those two, where the continuous vortex-shedding occurs, giving rise to the vertical VIV in the end. According to the above, 3 types of wind fairing (trapezoidal, airfoil and smaller airfoil) are proposed to accelerate the flow velocity between the crash barrier and curb in order to avoid the continuous vortex-shedding. Both of the CFD numerical simulation and the velocity field measurement show that the flow velocity of all the measuring points in case of the section with airfoil wind fairing, can be increased greatly compared to the results of original section, and the energy is reduced considerably at the natural frequency, indicating that the wind fairing do accelerate the flow velocity behind the crash barrier. Wind tunnel tests in case of the sections with three different countermeasures mentioned above are conducted and the results compared with the original section show that all the three different countermeasures can be used to control VIV to varying degrees.

• 대한임상검사과학회지
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• 제41권1호
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• pp.42-46
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• 2009

Unlike most bacteria, Treponema pallidum subspecies cannot be readily isolated or sustained in cell culture for numerous generations. In korea, two non treponemal tests are currently considered as standard; the VDRL slide test and RPR card test. These tests are based on an antigen composed of an alcoholic solution containing measured amount of cardiolipin, cholesterol, and sufficient purified lecithin to produce reactivity. The nontreponemal reagin tests measure immunoglobulin M (IgM) and IgG to lipoidal material released from damaged host cells as well as to lipoprotein-like material and possibly by cardiolipin released from the treponemes. The object of the evaluation was to evaluate the performance of the Mediace RPR kit on the automated biochemistry analyzer system as a method for screen method of syphilis as well as to identify BFP possibility. For evaluation of routine screening test, a total 2,380 specimens tested by Mediace RPR from 28th Oct, 2007 to 22th Feb, 2008. For evaluation of BFP possiblility, we measured samples which have potential BFP reaction in Syphilis test such as ANA (anti-nuclear antibody) positive (135 samples), CRP (C-reactive protein) positive (100 samples), RF (Rheumatoid factor) positive (26 samples), and other potential BFP cases (17 samples) including total 278 samples. These samples were tested quantitative test Mediace RPR with Hitachi 7600 P module. For comparison with current manual test, VDRL slide test were performed. Of these 2380 specimens, 2350 were negative, 30 were positive, and one were positive with TPHA. Both methods agreed for 2356 (98.9%) samples. Of the 30 samples showed positive results over 1.0 R.U, 6 samples showed positive results with VDRL test. Of these 6 samples, 1 samples showed positive with TPHA test. The combination of the Automated Biochemistry analyzer and VDRL test for retest can be increase efficiency of syphilis screening test.

• 대한의생명과학회지
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• 제17권4호
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• pp.355-361
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• 2011

We evaluated the performance of the NOW $Streptococcus$ $pneumoniae$ urinary antigen test, standard culture and polymerase chain reaction for detecting $S.$ $pneumoniae$. The urinary antigen test of pneumonia patients represented sensitivity at 72% and specificity at 79%. The results of PCR were targeting for autolysin ($lyt$A), pneumolysin ($ply$), and spn9828. The $lyt$A sensitivity and specificity stood at 56% and 87% respectively while $ply$ sensitivity reported 83% and specificity was 47%, sensitivity and specificity of spn9828 stood at 83% and 73% respectively. The results of urinary antigen test and three genes were all statistically meaningful within $P$ <0.05. When the urinary antigen test of $S.$ $pneumoniae$ was positive, the three kinds of genes were also likely to be positive. According to the result of urinary antigen test, the results of PCR presented a meaningful difference ($P$ <0.05). Especially, the urinary antigen test of $S.$ $pneumoniae$ was likely to be positive ($P$ <0.05) when more than two genes were positive in PCR results.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 하계학술대회 논문집 C
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• pp.1969-1971
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• 2004

For evaluation of partial discharge performances of electrical power appratus such as Insulator, circuit breaker and transformer and so on, Partial discharge measuring system(ERA) consisted of PD detector including amplifier, coupling capacitor, PD calibrator and voltage divider are used PD measuring system is very important factor which affect the test result and show reliability of test result in test laboratory, In this paper, we describe tracebility and uncertainty of PD measuring system in test laboratory based on IEC 60270.

• ETRI Journal
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• 제34권4호
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• pp.621-624
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• 2012

A new miniaturized 4-port waveguide generating a transverse electromagnetic wave is proposed. The waveguide presents enhanced performance of higher field uniformity in extended test volume up to an increased test frequency limit compared to that of the conventional 2-port waveguide. The advantageous features of the proposed waveguide have been obtained through a new design scheme based on effective miniaturization maintaining good impedance matching. Consequently, we can provide a more accurate electromagnetic compatibility test method, covering larger devices operating in higher frequencies, which is a marked improvement upon the conventional approaches.

• International Journal of Aeronautical and Space Sciences
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• 제16권4호
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• pp.602-613
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• 2015

As one of the mission payloads to be verified through the cube satellite mission of Cube Laboratory for Space Technology Experimental Project (STEP Cube Lab), we developed a hinge driving separation nut-type holding and releasing mechanism. The mechanism offers advantages, such as a large holding capacity and negligible induced shock, although its activation principle is based on a nylon cable cutting mechanism triggered by a nichrome burn wire generally used for cube satellite applications for the purpose of holding and releasing onboard appendages owing to its simplicity and low cost. The basic characteristics of the mechanism have been measured through a release function test, static load test under qualification temperature limits, and shock measurement test. In addition, the structural safety and operational functionality of the mechanism module under launch and on-orbit environments have been successfully demonstrated through a vibration test and thermal vacuum test.