• 제목/요약/키워드: Laboratory safety & health

검색결과 463건 처리시간 0.027초

Effects of early commercial milk supplement on the mucosal morphology, bacterial community and bacterial metabolites in jejunum of the pre- and post-weaning piglets

  • Hu, Ping;Niu, Qingyan;Zhu, Yizhi;Shi, Chao;Wang, Jing;Zhu, Weiyun
    • Asian-Australasian Journal of Animal Sciences
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    • 제33권3호
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    • pp.480-489
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    • 2020
  • Objective: Sow milk (SM) may not be able to meet the piglet's nutritional needs in late lactation. Hence, this study was conducted to investigate the effects of early commercial milk (CM) supplement on the mucosal morphology, bacterial community and bacterial metabolites in jejunum of piglets. Methods: Ten litters of newborn piglets ([Yorkshire×Landrace]×Duroc) were randomly divided into 2 groups of 5 litters. The piglets in the control group were suckled by the sow (SM), while the piglets in the treatment group (CM supplement) were supplemented with a CM supplement along with suckling from d 4 to d 28 of age. Results: No significant differences were observed about jejunal mucosal morphology on d 28 and d 35 between two groups. On d 28, the activity of lactase in the jejunum was significantly decreased in the CM group, while the activity of sucrase and the ratio of maltase to lactase were significantly increased (p<0.05). On d 35, the activity of maltase in the jejunum was significantly increased in the CM group (p<0.05), and maltase to lactase ratio tended to increase in the CM group (p = 0.065). In addition, piglets in the CM group had a higher abundance of Clostridium XI, Tuicibater, and Moraxella in the jejunum on d 28, while the abundance of Lactobacillus was significantly increased on d 35 (p<0.05). Conclusion: The early CM supplement improved the maturation of the jejunum to some extent by enhancing the maltase and sucrase activities. Moreover, the early CM supplement could help maintain the homeostasis of internal environment in jejunum by increasing the microbial-derived metabolites.

Comparisons of Fit Factors Between Two Quantitative Fit Testers (PortaCount vs. MT)

  • Don-Hee Han;Hyekyung Seo;Byoung-kab Kang;Hoyeong Jang;HuiJu Kim;SuA Shim
    • Safety and Health at Work
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    • 제13권4호
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    • pp.500-506
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    • 2022
  • This study evaluated the consistency between two quantitative fit test devices with different methods of ambient aerosol counting. Three types of respirators (N95, half mask, and full facepiece) were worn by 50 participants (male, n = 25; female, n = 25), PortaCount (Pro+ 8038) and MT (05U) were connected to one probe to one mask, and fit factors (FFs) were measured simultaneously with the original and modified protocols. As a result of comparing MT FFs with PortaCount FFs as references and by applying for the pass/fail criteria (FF = 100), the consistency between the two devices for half masks and full facepieces was very high. N95 was somewhat weaker than the two type of respirators in the consistency; however, the correlation between the two devices was very strong (p < 0.0001). The results showed that an FF of 100 as measured by PortaCount was likely to be measured as 75 by the MT. Therefore, when performing the fit test for N95 using the MT and pass level of FF 100, a certain level of adjustment is necessary, whether end-user or putting a scaling factor by manufacturer.

Analysis of Variation in Total Airborne Bacteria Concentration to Assess the Performance of Biological Safety Cabinets in Microbial Laboratories

  • Hwang, Sung Ho;Park, Hyun Hee;Yoon, Chung Sik
    • Safety and Health at Work
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    • 제5권1호
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    • pp.23-26
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    • 2014
  • Background: The purpose of this study was to compare the concentration of total airborne bacteria (TAB) in biosafety cabinets (BSCs) at universities and hospital microbial laboratories to assess the performance of BSCs. Methods: TAB was determined by using the single-stage Anderson sampler (BioStage Viable Cascade Impactor). The samples were obtained three times (with the BSC turned off and the shield open; with the BSC turned off and the shield closed; and with the BSC tuned on and operating) from the areas in front of 11 BSCs. Results: TAB concentrations of accredited and nonaccredited BSCs were determined. No significant differences were observed in the TAB concentrations of the accredited BSCs and the nonaccredited BSCs for the areas outside the BSCs in the laboratories (p > 0.05). TAB concentrations for the BSCs sampled with the shield open and the instrument turned off showed differences based on the sampling site outside the BSC in each laboratory. Conclusion: These results imply that TAB concentration is not altered by the performance of the BSCs or TAB itself and/or concentration of TAB outside the BSC is not a good index of BSC performance.

The effects of work environment monitoring organization's analysts' equipment and chemical substance incident response to the safety management awareness

  • Park, Hyun-A;Choi, Seo-Yeon;Rie, Dong-Ho
    • 한국컴퓨터정보학회논문지
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    • 제22권5호
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    • pp.97-103
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    • 2017
  • In this paper, we propose a method to investigate the safety consciousness of a analyst incident response. This study conducted a statistical survey on 154 analysts who hired as expert in environment monitoring organizations in South Korea. The results of the analyses showed that respondents had good awareness on the equipment incident response and complied with laboratory safety regulations very well. Secondly, respondents were aware of the importance in the order of equipment incident response, an analytical laboratory incident response, and the cause of a chemical substance associated incident in an analytical laboratory in regarding the regulation compliance for creating a safe laboratory environment and the securement of laboratory safety. Therefore, (it was identified that) it would be necessary to create a safe environment and integrate a safety management system.

특수 건강진단기관의 유기용제 분석 외부정도관리 실태 (The Status of Analytical External Quality Assurance Program of Organic Solvents for the Special Health Examination Laboratories)

  • 박관식;이미영;김종호
    • 대한임상검사과학회지
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    • 제42권1호
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    • pp.16-21
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    • 2010
  • It has been well known that organic industrial solvents such as toluene, xylene and styrene are environmental health hazards causing occupational diseases to workers. The detection of biological metabolites of toluene, xylene and styrene in blood, urine, breast milk, saliva, and hair of workers exposed to these organic industrial solvents is a useful tool for assessing the amount of organic industrial solvents. Therefor, the external analytical quality assurance program is extremely important work for increasing reliability of the data analyzed in the special health examination laboratory. We evaluated the results of analysis by Korean analytical quality assurance program from the second half 2007 to the first half 2009. The number of participants for analytical quality assurance program for both mandatory item and one of optional items, hippuric acid and methylhippuric acid were 116-122, 116-122 and 105-115 laboratories, respectively. The proficient rate of the special health examination laboratories analyzed both mandatory item and optional item, hippuric acid and methylhippuric acid were 92-98%, 92-98% and 96-98%, respectively. We can conclude from our data that the analytical quality assurance program is a essential tool for improvement of reliability on the data analyzed in the special health examination laboratories.

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앙상블 인공지능 모델을 활용한 안전 관리 자율운영 플랫폼 설계 (Safety Autonomous Platform Design with Ensemble AI Models)

  • Dongyeop Lee;Daesik Lim;Soojeong Woo;Youngho Moon;Minjeong Kim;Joonwon Lee
    • 한국항행학회논문지
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    • 제28권1호
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    • pp.159-162
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    • 2024
  • This paper proposes a novel safety autonomous platform (SAP) architecture that can automatically and precisely manage on-site safety through ensemble artificial intelligence models generated from video information, worker's biometric information, and the safety rule to estimate the risk index. We practically designed the proposed SAP architecture by the Hadoop ecosystem with Kafka/NiFi, Spark/Hive, Hue, ELK (Elasticsearch, Logstash, Kibana), Ansible, etc., and confirmed that it worked well with safety mobility gateways for providing various safety applications.

일부 석면취급사업장의 석면폭로 농도 및 작업환경관리 기준에 관한 연구 (A Study on Worker Exposure Level and Variation to Asbestos in some Asbestos Industries)

  • 오세민;신용철;박두용;박동욱;정규철
    • 한국산업보건학회지
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    • 제3권1호
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    • pp.100-109
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    • 1993
  • This study was performed to evaluate the asbestos exposure levels and variations in textile, brake lining manufacturing and slate manufacturing industries. For this study, fifteen plants of brake lining manufacturing industry, 7 plants of textile industry, and 2 plants of slate manufacturing industry were selected and surveyed. Geometric means (GMs) of airborne asbestos concentrations in textile, brake lining manufacturing, and slate manufacturing industries were 1.42 f/cc(0.07-6.1O f/cc), 0.19 f/cc(<0.01-2.67 f/cc) and 0.08 f/cc(0.02-0.67 f/cc), respectively. In textile industry overall GMs of airborne asbestos concentrations in plants with less than 50 workers and in plants with more than 50 workers were 1.60 f/cc and 0.3 f/cc, respectively. Therefore, the size of plant showed some difference in the airborne asbestos concentrations. Three out of 7(42.9%) exceed the Korean standard, 2 f/cc, and every plant exceed the USA standard, 0.2 f/cc of the OSHA-Permissible Exposure Level(OSHA-PEL). Especially, one plant showed the highest average concentration of 2.87 f/cc. In brake lining manufacturing industry, the plants with less than 50 workers showed 0.22 f/cc. The plants with more than 50 workers showed 0.18 f/cc. All plants showed the exposure level below the Korean standard. Five of 15 (33.3%) were above the OSHA-PEL. One plant showed the highest average concentraton of 0.84 f/cc. In slate manufacturing industry, the average exposure level was 0.08 f/cc, and all of the plants were below the Korean standard and the OSHA-PEL.

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Associations of Depressive Symptoms and Brachial Artery Reactivity among Police Officers

  • Violanti, John M.;Charles, Luenda E.;Gu, Ja K.;Burchfiel, Cecil M.;Andrew, Michael E.;Joseph, Parveen N.;Dorn, Joan M.
    • Safety and Health at Work
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    • 제4권1호
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    • pp.27-36
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    • 2013
  • Objectives: Mental health has been shown to be linked with certain underlying physiological mechanisms. The objective of this cross sectional study was to investigate the relationship between depressive symptoms and brachial artery reactivity (BAR) in an understudied population: police officers. Methods: Participants were 351 police officers who were clinically examined in the Buffalo Cardio-Metabolic Police Stress (BCOPS) study. BAR was performed using standard B-Mode ultrasound procedures. Depressive symptoms were measured using the Center for Epidemiological Studies Depression (CES-D) scale. Mean values of the difference between the baseline and maximum diameters of the brachial artery were determined across three categories of CES-D score using the analysis of variance and the analysis of covariance. p-values for linear trends were obtained from linear regression models. Results: The mean age (${\pm}$ standard deviation) of all officers was $40.9{\pm}7.2$ years. Women had a slightly higher mean CES-D score than men ($8.9{\pm}8.9$ vs. $7.4{\pm}6.4$) and a slightly higher percentage increase of BAR than men (6.90 vs. 5.26%). Smoking status significantly modified the associations between depressive symptoms and BAR. Among current smokers, mean absolute values of BAR significantly decreased as depressive symptoms increased after adjustment for age, gender, race/ethnicity, hypertension, and diabetes; the multivariate-adjusted p-values were 0.033 (absolute) and 0.040 (%). Associations between depressive symptoms and BAR were not statistically significant among former smokers or never smokers. Conclusion: Depressive symptoms were inversely associated with BAR among police officers who were current smokers and together may be considered a risk factor for cardiovascular disease among police officers. Further prospective research is warranted.

산재보험 수준의 연구실안전보험 보장성강화 방안 - 장해보험금 연금형태 지급을 중심으로 - (A Study on the Improvement of the Safety Insurance for the Laboratory at the Korean Worker's Compensation Insurance - Focusing on Disability Benefit Pension Type Payment -)

  • 송혜숙;이난희;최재규;천성현;김재중;이병현
    • 한국안전학회지
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    • 제34권1호
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    • pp.115-121
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    • 2019
  • Background: Due to the diversification and advancement of research, researchers have become to deal with a variety of chemical and biological harmful materials in the laboratories of universities and research institutes and the risk has increased as well. Therefore, it is necessary to strengthen the social safety net for laboratory accidents by strengthening the compensation to the level comparable to that of Korean Workers' Compensation & Welfare Service, when the researchers become physically disabled by laboratory accidents. The purpose of this study is to secure researchers' health rights and to create a research environment where researchers can work with confidence by strengthening the compensation to the level comparable to that of Korean Workers' Compensation & Welfare Service. Method: We analyzed the laboratory accidents by year, injury type, severity of accident and disability grade with the 6 year data from 2011 to 2016, provided by Laboratory Safety Insurance. Based on the analysis result, we predicted the financial impact on Laboratory Safety Insurance if we introduce a compensation annuity by disability grade which is similar to Injury-Disease Compensation Annuity of Korean Workers' Compensation & Welfare Service. Result :As of 2011, the insured number of Laboratory Safety Insurance was approximately 700,000. The Average premium per insured was KRW 3,339 and there were 158 claims. Total claim amount was KRW 130 million, whereas the premium was about KRW 2.3 billion. The loss ratio was very low at 5.75%. If we introduce a compensation annuity by disability grade similar to Injury-Disease Compensation Annuity of Korean Workers' Compensation & Welfare Service, the expected benefit amount for 1 case of disability grade 1 would be KRW 1.6 billion, assuming 2% of interest rate. Given current premium, the loss ratio, the ratio of premium income to claim payment, is expected 41.4% in 2017 and 151.6% in 2026. The increased loss ratio due to the introduce of the compensation annuity by disability grade is estimated to be 11.0% in 2017 and 40.4% in 2026. Conclusion: Currently, laboratories can purchase insurance companies' laboratory safety insurance that meets the standards prescribed by Act on the Establishment of Safe Laboratory Environment. However, if a compensation annuity is introduced, it would be difficult for insurance companies to operate the laboratory safety insurance due to financial losses from a large-scale accident. Therefore, it is desirable that one or designated entities operate laboratory safety insurance. We think that it is more desirable for laboratory safety insurance to be operated by a public entity rather than private entities.

Oxidative DNA Damage from Nanoparticle Exposure and Its Application to Workers' Health: A Literature Review

  • Rim, Kyung-Taek;Song, Se-Wook;Kim, Hyeon-Yeong
    • Safety and Health at Work
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    • 제4권4호
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    • pp.177-186
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    • 2013
  • The use of nanoparticles (NPs) in industry is increasing, bringing with it a number of adverse health effects on workers. Like other chemical carcinogens, NPs can cause cancer via oxidative DNA damage. Of all the molecules vulnerable to oxidative modification by NPs, DNA has received the greatest attention, and biomarkers of exposure and effect are nearing validation. This review concentrates on studies published between 2000 and 2012 that attempted to detect oxidative DNA damage in humans, laboratory animals, and cell lines. It is important to review these studies to improve the current understanding of the oxidative DNA damage caused by NP exposure in the workplace. In addition to examining studies on oxidative damage, this review briefly describes NPs, giving some examples of their adverse effects, and reviews occupational exposure assessments and approaches to minimizing exposure (e.g., personal protective equipment and engineering controls such as fume hoods). Current recommendations to minimize exposure are largely based on common sense, analogy to ultrafine material toxicity, and general health and safety recommendations.