• Title/Summary/Keyword: Laboratory audit

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BSL2 Audit and Certification Program: An Effort to Harmonize and to Raise Standards in Both Laboratory Infrastructure and Biosafety Practices in Singapore

  • Tin, Tun;Lee, Kien Wah
    • Biomedical Science Letters
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    • v.22 no.3
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    • pp.65-74
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    • 2016
  • The critical aspects of biosafety and bio-containment have been increasingly important in recent years. Biological agents involved in biological research projects at the Nanyang Technological University (NTU) Singapore are usually those with low risks. Biosafety level 2 or BSL 2 laboratories are widely used. However, biosafety measures which refer to the implementation of laboratory practices and procedures, specific construction features of laboratory facilities and safety equipment must be in place to reduce the exposure of laboratory personnel, the public or the environment to potentially infectious agents or other biological hazards. It is also required to pay more attention to laboratory-acquired infections (LAIs) which may occur in research laboratories, clinical laboratories or animal facilities. BSL 2 audit and certification program is implemented as an internal exercise covering laboratories in the university where biological agents are handled or biological research works are carried out. We have put some efforts to raise biosafety standards university-wide in both laboratory infrastructure and laboratory practices to a higher level. Common audit findings are briefly discussed in this presentation.

The audit method of cooling energy performance in office building using the Simple Linear Regression Analysis Model

  • Park, Jin-Young;Kim, Seo-Hoon;Jang, Cheol-Young;Kim, Jong-Hun;Lee, Seung-Bok
    • KIEAE Journal
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    • v.15 no.5
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    • pp.13-20
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    • 2015
  • Purpose: In order to upgrade the energy performance of existing building, energy audit stage should be implemented first because it is useful method to find where the problems occur and know how much time and cost consumption for retrofit. In overseas researches, three levels of audit is proposed whereas there are no standards for audit in Korea. Besides, most studies use dynamic simulation in detail like audit level 3 even though the level 2 can save time and cost than level 3. Thus, this paper focused on audit level 2 and proposed the audit method with the simple linear regression analysis model. Method: Two parameters were considered for the simple regression analysis, which were the monthly electric use and the mean outdoor temperature data. The former is a dependent variable and the latter is a independent variable, and the building's energy performance profile was estimated from the regression analysis method. In this analysis, we found the abnormal point in cooling season and the more detailed analysis were conducted about the three heat source equipments. Result: Comparing with real and predicted models, the total consumption of predicted model was higher than real value as 23,608 kWh but it was the results that was reflected the compulsory control in 2013. Consequently, it was analyzed that the revised model could save the cooling energy as well as reduce peak electric use than before.

Efficient Public Verification on the Integrity of Multi-Owner Data in the Cloud

  • Wang, Boyang;Li, Hui;Liu, Xuefeng;Li, Fenghua;Li, Xiaoqing
    • Journal of Communications and Networks
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    • v.16 no.6
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    • pp.592-599
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    • 2014
  • Cloud computing enables users to easily store their data and simply share data with others. Due to the security threats in an untrusted cloud, users are recommended to compute verification metadata, such as signatures, on their data to protect the integrity. Many mechanisms have been proposed to allow a public verifier to efficiently audit cloud data integrity without receiving the entire data from the cloud. However, to the best of our knowledge, none of them has considered about the efficiency of public verification on multi-owner data, where each block in data is signed by multiple owners. In this paper, we propose a novel public verification mechanism to audit the integrity of multi-owner data in an untrusted cloud by taking the advantage of multisignatures. With our mechanism, the verification time and storage overhead of signatures on multi-owner data in the cloud are independent with the number of owners. In addition, we demonstrate the security of our scheme with rigorous proofs. Compared to the straightforward extension of previous mechanisms, our mechanism shows a better performance in experiments.

Various underwriting methods through case audit (증례점검 사례를 통한 다양한 언더라이팅 접근 방향 모색)

  • Choi, So-Yung
    • The Journal of the Korean life insurance medical association
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    • v.27 no.1
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    • pp.18-20
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    • 2008
  • I have taught various case audit underwriting methods to underwriters for many years. Underwriting requires specialized medical knowledge and experience of comprehensive individual risk analysis. Decisions in individualized underwriting depend on the insurance company's management philosophy and vision, marketing strategies, culture, product line etc. They also depend on the information acquired through proposal forms, inspection reports, laboratory results and disclosures. Underwriters match this acquired information to each insurance product, search appropriate medical resources, assess the probabilities of future claims, and decide what, if any, further medical information should be gathered. Sources include doctors' reports, medical records, biopsies, blood and urine tests, CT, MRI, Holter monitoring, sonography etc. Insurance medical directors help and teach underwriters to analyze individual medical risks and make effective.

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Action-Based Audit with Relational Rules to Avatar Interactions for Metaverse Ethics

  • Bang, Junseong;Ahn, Sunghee
    • Smart Media Journal
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    • v.11 no.6
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    • pp.51-63
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    • 2022
  • Metaverse provides a simulated environment where a large number of users can participate in various activities. In order for Metaverse to be sustainable, it is necessary to study ethics that can be applied to a Metaverse service platform. In this paper, Metaverse ethics and the rules for applying to the platform are explored. And, in order to judge the ethicality of avatar actions in social Metaverse, the identity, interaction, and relationship of an avatar are investigated. Then, an action-based audit approach to avatar interactions (e.g., dialogues, gestures, facial expressions) is introduced in two cases that an avatar enters a digital world and that an avatar requests the auditing to subjects, e.g., avatars controlled by human users, artificial intelligence (AI) avatars (e.g., as conversational bots), and virtual objects. Pseudocodes for performing the two cases in a system are presented and they are examined based on the description of the avatars' actions.

Audit of Appropriateness of Fresh Frozen Plasma Transfusion (신선동결혈장의 적정수혈 분석)

  • Seo, Youkyung;Kim, Moon Jung;Kim, Sinyoung;Kim, Hyun Ok
    • The Korean Journal of Blood Transfusion
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    • v.23 no.2
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    • pp.136-144
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    • 2012
  • Background: Fresh frozen plasma (FFP) transfusion is administered primarily for management of acquired bleeding disorders. However, in practice, FFP transfusion is increasing without a solid rationale. Methods: We conducted an audit to evaluate the appropriateness of the indications for FFP transfusion during the period from July 2010 through June 2011. Assessment of the appropriateness of the indications was based on the national transfusion guidelines and the transfusion criteria promulgated by the Severance Hospital. Results: In total, 17,733 units of plasma were transfused to 1,949 patients over 4,982 events. We found that administration of FFP was not in compliance with the recommended guidelines in 1,990 events. The number of total FFP transfusions was higher in medical departments (Gastroenterology) than in surgical departments (Thoracic and cardiovascular surgery, General surgery). However, the proportion of cases of inappropriate transfusion was higher in surgical departments than in medical departments. Both the total number of FFP transfusion and the proportion of inappropriate transfusion were high in patient with neoplasm, disease of the digestive system, and diseases of the circulatory system. Conclusion: Continuous monitoring on appropriateness for FFP transfusion and feedback to the physician are critical in securing the transfusion safety as well as maintaining the quality of FFP transfusion. New-found indication for FFP transfusion should be investigated and applied in timely manner.

AN ANOMALY DETECTION METHOD BY ASSOCIATIVE CLASSIFICATION

  • Lee, Bum-Ju;Lee, Heon-Gyu;Ryu, Keun-Ho
    • Proceedings of the KSRS Conference
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    • 2005.10a
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    • pp.301-304
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    • 2005
  • For detecting an intrusion based on the anomaly of a user's activities, previous works are concentrated on statistical techniques or frequent episode mining in order to analyze an audit data. But, since they mainly analyze the average behaviour of user's activities, some anomalies can be detected inaccurately. Therefore, we propose an anomaly detection method that utilizes an associative classification for modelling intrusion detection. Finally, we proof that a prediction model built from associative classification method yields better accuracy than a prediction model built from a traditional methods by experimental results.

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Relationship between Negative Sexual Experience and Psychiatric Symptoms in Patients with Depression or Anxiety Disorders by Gender and Type of Negative Sexual Experience (우울 및 불안장애 환자에서 성별 및 성경험 유형에 따른 부정적 성경험과 정신과적 증상 사이의 연관성)

  • Ji, Min-A;Jeong, Bo-Ram;Chae, Jeong-Ho
    • Anxiety and mood
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    • v.15 no.2
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    • pp.77-83
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    • 2019
  • Objective : This study aims to investigate the relationship between negative sexual experience and psychiatric symptoms by gender and compare the effects of sexual assault and unwanted sexual experiences on psychiatric symptoms in patients with depression or anxiety disorders. Methods : A total of 204 respondents who have had negative sexual experiences of outpatients diagnosed with depression or anxiety disorders were evaluated with AUDIT, PSS, STAI, BDI, and SSI. Independent samples t-test was performed to compare the psychiatric symptom scale scores between male and female and identify the difference of the psychiatric symptom scale scores between those who have had sexual assault and those who have had only unwanted sexual experience. Results : There was no difference in psychiatric symptom scale scores except for AUDIT between male and female in 204 patients with negative sexual experience. There was also no significant difference in AUDIT, PSS, and STAI scores between those who experienced sexual assault and those who experienced only unwanted sexual experiences. BDI and SSI scores are significant higher in those who experienced sexual assault than those who experienced only unwanted sexual experiences. Conclusion : This suggests that male and female may have similar levels of psychiatric symptoms after experiencing negative sexual experiences. Psychiatric symptoms caused by sexual assault may have differences from the psychiatric symptoms caused by unwanted sexual experience. Understanding the differences in psychiatric symptoms according to the type of negative sexual experience may helpful to direct the therapeutic plans.

Uncertified Facility (BSL 2 plus): Its Journey through Life for Preparations and Setting up, Compliance with Biosafety Regulations, Implementation, and Registration of the Facility with the Ministry of Health, Singapore

  • Tun, Tin;Sim, Xander
    • Korean Journal of Clinical Laboratory Science
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    • v.53 no.1
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    • pp.68-80
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    • 2021
  • An uncertified facility is a facility not certified, as defined in the Biological Agents and Toxins Act (BATA) in Singapore, but has met the requirements of the Ministry of Health to possess First and Fifth Schedule biological agents and toxins. This type of facility is also known as a Biosafety Level 2 Plus (BSL 2+) facility. Registration as an uncertified facility or a BSL 2+ facility requires a certain process and procedure to be sought with the Biosafety Branch of the ministry. This review, shares first-hand knowledge on the journey to achieving registration of the authors' facility. The procedure involved considerable preparation, setting up facility requirements, biosafety precautions, procedures and practices, and training and competence of laboratory users. The ministry conducted a thorough onsite facility audit to ensure that the facility requirements and biosafety procedures and practices were in place. It then issued an approval letter of possession for the first-time use of biological agents and registered the laboratory as an uncertified facility. The expectation is that the comprehensive information shared may be of great benefit to other facilities with similar interests.