• Title/Summary/Keyword: LIN

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Clustered LAG-1 binding sites in lag-1/CSL are involved in regulating lag-1 expression during lin-12/Notch-dependent cell-fate specification

  • Choi, Vit Na;Park, Seong Kyun;Hwang, Byung Joon
    • BMB Reports
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    • v.46 no.4
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    • pp.219-224
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    • 2013
  • The cell-fate specification of the anchor cell (AC) and a ventral uterine precursor cell (VU) in Caenorhabditis elegans is initiated by a stochastic interaction between LIN-12/Notch receptor and LAG-2/Delta ligand in two neighboring Z1.ppp and Z4.aaa cells. Both cells express lin-12 and lag-2 before specification, and a small difference in LIN-12 activity leads to the exclusive expressions of lin-12 in VU and lag-2 in the AC, through a feedback mechanism of unknown nature. Here we show that the expression pattern of lag-1/CSL, a transcriptional repressor itself that turns into an activator upon binding of the intracellular domain of Notch, overlaps with that of lin-12. Site-directed mutagenesis of LAG-1 binding sites in lag-1 maintains its expression in the AC, and eliminates it in the VU. Thus, AC/VU cell-fate specification appears to involve direct regulation of lag-1 expression by the LAG-1 protein, activating its transcription in VU cells, but repressing it in the AC.

Security Improvement of Remote User Authentication Scheme based on Smart Cards (스마트 카드 기반 사용자 인증 스킴의 보안 개선)

  • Joo, Young-Do;An, Young-Hwa
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.11 no.5
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    • pp.131-137
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    • 2011
  • Recently Lin et al. proposed a simple remote user authentication scheme using smart cards. But the proposed scheme has not satisfied security requirements which should be considered in the user authentication scheme using the password based smart card. In this paper, we show that Lin et al.'s scheme is insecure against off-line password guessing attack. In their scheme, any legal user's password may be derived from the password guessing when his/her smart card is stolen and the secret information is leaked from the smart card by an attacker. Accordingly, we demonstrate the vulnerability of their scheme and present an enhancement to resolve such security weakness. Our proposed scheme can withstand various possible attacks including password guessing attack. Furthermore, this improved scheme can provide mutual authentication to improve the security robustness. Performance evaluation shows that the proposed scheme is relatively more effective than Lin et al.'s scheme.

Prophylactic Intraoperative Nasolacrimal Duct Intubation in Surgical Treatment of Facial Fractures-Is There a Role?

  • Teoh, Ryan Liang Wei;Fong, Pei Yuan;Cai, Elijah Zhengyang;Yap, Yan Lin;Hing, Eileen Chor Hoong;Lee, Han Jing;Nallathamby, Vigneswaran;Ong, Wei Chen;Lim, Jane;Sundar, Gangadhara;Lim, Thiam Chye
    • Archives of Plastic Surgery
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    • v.49 no.2
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    • pp.195-199
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    • 2022
  • Nasolacrimal duct (NLD) damage is associated in the majority of type II and III naso-orbito-ethmoid (NOE) fractures. Our study aims to investigate the efficacy and safety of prophylactic NLD intubation in the setting of facial fractures, by comparing incidence of postoperative epiphora and wound infection. A retrospective matched control study was conducted on all patients with surgically treated facial fractures from 2008 to 2013 (n=280) (IRB ref number: DSRB 2013/01198). Patients with the following fracture types were included: NOE (n=16), frontal sinus (n=2), Le Fort II/III (n=8), and > 1 type (n=48). All patients in this study were included with the intention to treat. The study group comprised patients who were intubated, while the control group patients were not intubated. Each group had 37 patients matched for age, gender, fracture type, and injury type. A single oculoplastic surgeon skilled in lacrimal surgery performed the procedure for all intubated patients. Patients with more severe and complex facial fractures were intubated with bicanalicular Crawford stents. Postoperative epiphora and infective complications (both facial wound and dacryocystitis) were assessed at 1, 3, 6, and 12 months. There was no significant difference in incidence of either postoperative epiphora (p=0.152) or wound infection (p=0.556) comparing both groups. Reduced incidence of postoperative epiphora in the study group is statistically not significant and does not support the need for prophylactic intubation. If radiographic evidence of NLD disruption or regurgitation seen on syringing on the NLD intraoperatively is present, intubation is safe and efficacious only if performed by an expert.

A field survey on the noise environment of apartment according to site location (주거단지 입지특성에 따른 소음환경 실태조사 - 도로변 아파트단지를 대상으로 -)

  • 박수빈
    • Proceeding of Spring/Autumn Annual Conference of KHA
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    • 1994.05a
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    • pp.11-17
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    • 1994
  • The increase of road traffic niose in residential area has been considered to be a serious environmental problem to deteriorate a living condition. The understanding of noise environment in multiple family housing is needed for noise reduction. This study attempts to find out the characteristics of noise environment. For this purpose, the field survey has been carried out to investigate the noise environment(sound level, quality of sound) and the residents' responses(noiseness, annoyance) for noise environment based on 173 households living in 3 apartment compounds built in Pusan according to site location. The major findings are as follows : 1. The sound levels by road traffic noise were measured by dB(A) and dB(Lin). The sound levels were : 77.0dB(A), 86.6dB(Lin) in D-Apt, 73.3dB(A), 82.6dB(Lin) in K-Apt, and 59.1dB(A), 74.6dB(Lin) in M-Apt. Especially, the difference between dB(A) and dB(Lin) was very big in the cae of M-Apt with a barriers for traffic noise reduction. 2. The internal sound levels were shown the soudn attenuation by horizontal distance and by opening or shuting condition of windows.

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Multi-Axis-Adjusted System for Color Reproduction

  • Hsieh, Pei-Lin;Li, Yu-Hung;Lin, Shih-Chieh;Lin, Hsiang-Tan
    • 한국정보디스플레이학회:학술대회논문집
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    • 2009.10a
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    • pp.1554-1556
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    • 2009
  • In this paper, we propose a system to adjust specific color of image. The HSV of R/Y/G/C/B/M regions can be modified individually. The color reproduction can be preferred color, true color, or stander color for customer requirement.

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The application of fuzzy mathemation method in antiseismic structures

  • Xiang, Gu-Wen;Yun, Li-Su
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 1993.06a
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    • pp.915-916
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    • 1993
  • In this paper, the fuzzy ISODATA algorithm is applied to forecasting liquefaction of sand in the antiseismic structures. According to the data of the earthquake taken place in Tang Shan in 1976, we construct a model of mathematics, on which we forecast 32 samples in the earthquake of Tang Shan. The correct rate of forecast is 90.7 %.

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An efficient LIN MCU design for In-Vehicle Networks

  • Yeon, Kyu-Bong;Chong, Jong-Wha
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.13 no.5
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    • pp.451-458
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    • 2013
  • This paper describes a design of LIN MCU using efficient memory accessing architecture which provides concurrent data and address fetch for faster communication. By using slew rate control it can reduce EMI emission while satisfying required communication specifications. To verify the efficiency of the LIN MCU, we developed a SoC and tested for several data packets. Measurements show that this LIN MCU improves network efficiency up to 17.19 % and response time up to 31.26 % for nominal cases. EMI radiation also can be reduced up to 10 dB.

Path finding for vehicular telematics based on the Lin-Kernighan heuristic (Lin-Kernighan 휴리스틱에 기반한 차량 텔레매틱스 운행 경로의 결정)

  • Lee, Jung-Hoon;Hong, Young-Shin;Park, Gyung-Leen
    • Proceedings of the Korea Information Processing Society Conference
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    • 2008.05a
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    • pp.1011-1012
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    • 2008
  • 본 논문은 차량 텔레매틱스 시스템에서 중요한 응용중의 하나인 다중 목적지 방문을 위한 경로 결정방식을 구현하기 위하여 Lin-Kernighan 휴리스틱을 텔레매틱스 시스템에 결합하는 방법에 대해 기술하고 다중 목적지 결정 서버를 구현한다. 서버는 클라이언트는 로드 네트워크에 대한 자료구조를 공유하고 있으며 클라이언트가 목적지 리스트를 요청하면 1) 서버가 $A^*$ 기법에 의해 각 목적지간의 비용을 계산하고 2) Lin-Kernighan 프로그램의 인자로 변환하여 3) 경로 결정 모듈을 수행시킨다. 이 경로의 순서는 클라이언트에게 정해진 메시지 포맷에 의해 전달되며 클라이언트는 각 인접한 목적지간에 $A^*$ 기법에 의해 실제 도로 네트워크 상에서의 경로를 결정하여 사용자에게 제공한다. 성능측정 결과 방문지 수가 많더라도 수초 이내에 경로를 결정할 수 있으며 그 정확성도 거의 100%에 근접한다.