• The Journal of Internal Korean Medicine
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• v.39 no.4
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• pp.699-707
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• 2018

Objectives: This study was designed to investigate characteristics of digital infrared thermal imaging (DITI) and quantitative evaluations in patients with burning mouth syndrome (BMS). Methods: We reviewed the clinical records of 38 patients with BMS who visited the Oral Diseases Clinic of Kyung Hee University Korean Medicine Hospital from March 1st, 2018 to June 30th, 2018. The subjects were evaluated with digital infrared thermal imaging (DITI) and for heart rate variability (HRV), unstimulated salivary flow rate (USFR), and the proportion of coated tongue. Results: Most patients showed higher temperatures on the central part of the tongue (T2) than on the middle of the forehead (T1). The patients tended to have a high Low frequency/High frequency (LF/HF) ratio. Statistically significant negative correlations were noted between the age of patients and the temperature of T1 and T2. Statistically significant negative correlations were also observed between the LF/HF ratio and 'T1-T2' values. Conclusions: This study suggests that DITI and HRV are useful for the validation of patients with BMS. Correlations between the result values suggest that sympathetic function acceleration is related to temperature distribution and, ultimately, to symptoms.

• The Journal of Korean Obstetrics and Gynecology
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• v.23 no.4
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• pp.155-163
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• 2010

Purpose: The aim of the study was to compare the characteristics of the autonomic innervation of the heart in polycystic ovary syndrome(PCOS) patients with regulary cycling controls. Methods: We studied 21 patients visiting $\bigcirc\bigcirc$hospital from 25th June 2009 to 25th June 2010. The subjects were categorized in two groups, 11 PCOS patients and 10 healthy regularly cycling controls. We studied the difference of Heart rate variability (HRV) between two groups by Independent samples T-test using SPSS for windows(version 17.0). Results: The Standard deviation of all normal R-R intervals (SDNN), The spuare root of the sum of the spuare of difference between adjacent normal R-R intervals (RMS-SD) of PCOS group was non-significantly lower than non-PCOS group. High frequency power (HF) and Normalized high frequency power (HF norm) of PCOS group was significantly higher than non-PCOS group. Normalized low frequency power (LF norm) of PCOS was signficantly lower than non-PCOS group. The results means increased sympathetic and decreased vagal modulation. Total power (TP), Very low frequency power (VLF) of PCOS group was non-significantly lower than non-PCOS group. Low frequency power (LF), LF/HF ratio of PCOS group was non-significantly higher than non-PCOS group. Conclusion: The results suggest that PCOS can be related to decreased activity of parasympathetic nervous system.

• Journal of Biomedical Engineering Research
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• v.33 no.4
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• pp.194-201
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• 2012

This study was designed to investigate the effect of a combined stimulus which was composed of chiropractic massage and thermotherapy on the relief of mental and physical stress. Fifteen healthy male subjects were treated with three type of stimuli; control (without any stimulus), a single stimulus (only chiropractic) and a combined stimulus. To evaluate the effects of stimuli, visual analogue scale (VAS), trunk extension, electromyogram (EMG) on erector spinae muscle and electrocardiogram (ECG) were measured and analyzed before and after stimuli. In the control group, there were no significant changes in EMG root mean square (RMS) value and low Frequency/high Frequency (LF/HF) ratio (p > 0.05, p > 0.05). However, both stimulus groups showed significant increases in trunk extension and EMG RMS values (p < 0.05, p < 0.05), but significant decreases in LF/HF ratios (p < 0.05). Particularly the decrement rate in LF/HF ratio was significantly higher in the combined stimulus group than that in the single stimulus group (p < 0.05). Also, a significantly lower VAS was recorded after combined stimulus. Our findings indicate that the combined stimulus might not only improve flexibility and strength of muscle, but also active parasympathetic nerve activity. The combined stimulus may thus contribute to relieve the stress and to enhance the muscle function.

• Journal of Biomedical Engineering Research
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• v.33 no.3
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• pp.141-147
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• 2012

In this paper, we have investigated effects of two specific meditations (Chinese qigong meditation and Kundalini yoga meditation) on the heart rate variability (HRV), which is a well-known quantitative measure of autonomic balance, of skilled students. To analyze the effects, the MIT/BIH physionet database was utilized. The database includes RR intervals of eight skilled Chinese qigong meditators (5 women and 3 men; age range 26-35) and four skilled Kundalini yoga meditators (2 women and 2 men; age range 20-52). RR intervals of each subject were measured before and during the meditations. For HRV analysis, we have used typical four HRV parameters - the low frequency to high frequency power ratio (LF/HF ratio), SD2/SD1 ratio, sample entropy, and fractal dimension. The LF/HF ratio was calculated by the autoregressive spectrum and the SD2/SD1 ratio was derived from the Poincar$\grave{e}$ plot. The sample entropy was computed from the phase space plot and the fractal dimension was estimated by the Higuchi's algorithm. In the experiments, the Wilcoxon signed rank test was employed because we used small datasets and compared HRV parameters before and during the meditations. As a result, we have found increment of the LF/HF and SD2/SD1 ratios in both meditations; whereas the sample entropy is decreased during the meditations. In addition, the fractal dimension is increased during the Chinese qigong meditation; whereas it is decreased during the Kundalini yoga meditation. The results show that the sympathetic nervous system is generally more activated in skilled Chinese qigong and Kundalini yoga meditators, but the activation of the parasympathetic nervous tone is suppressed.

• Journal of Korean Traditional Oncology
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• v.16 no.1
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• pp.15-31
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• 2011

Objective : The study aims to investigate the effect of moxibustion treatments on autonomic nervous system function of cancer patients through the evaluation of heart rate variability (HRV) biofeedback testing. Materials and Methods : Six cancer patients from inpatient care unit of Dunsan Oriental Hospital, Daejeon University were given three moxibustion treatment sessions every other day over one week period on five Oriental Medicine meridian points CV4, CV6, CV12, KD1, and PC8. HRV biofeedback was conducted before and after each treatment sessions. Three areas of analyses were done from the test conducted; Time Domain Analysis, Frequency Domain Analysis and Autonomic Nervous System (ANS) balance analysis. Results : Time Domain Analysis has shown increased Standard Deviation of all Normal R-R Intervals (SDNN), and decreased Mean Heart Rate and Physical Stress Index (PSI) levels, with statistical significance (P<0.05). In Frequency Domain Analysis, series of moxa treatments have increased Total Power (TP), Very Low Frequency Oscillation Power (VLF), High Frequency Oscillation Power (HF), normalized HF values while decreasing Low Frequency Oscillation Power (LF), normalized LF and LF/HF ratio with statistical significance (P<0.05). The values of ANS activity, ANS balance, Stress resistance, Stress index, have also shown significant changes. For cardiac stability stroke volume power (SP) and Blood Vessel Tension (BVT) were followed, which were both increased after treatment. All changes were statistically significant (P<0.05). Conclusion : The results have shown a positive correlation between the moxibustion treatments and autonomic nervous system responses on cancer patients through the HRV biofeedback testing. This study suggests possible application of moxibustion treatments for managing ANS functions of cancer patients, although additional studies with larger population are necessary to confirm the data.

• The Journal of Pediatrics of Korean Medicine
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• v.25 no.3
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• pp.77-84
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• 2011

Objectives: This study was performed to investigate the effect of hot spring therapy on children weight, body composition and heart rate variability. Methods: The study was carried out from 30 children who visited the spa from August 1, 2011 to August 31, 2011. We measured the change of weight, body composition, and heart rate variability after hot spring therapy for an hour per day. Results: The subject was consisted of 13 boys and 17 girls. This study revealed that their weight got lost from a hot spring therapy, which was statistically significant. Their body mass index(BMI) was decreased in from a hot spring therapy, which was not statistically significant. Total body water, muscle, protein, and mineral were decreased from a hot spring therapy, which was statistically significant. We measured HRV(heart rate variability) before and after the hot spring therapy. The mean HRT was increased, which was statistically insignificant. SDNN(standard deviation of the NN interval) and RMSSD(square root of the mean of the sum of the square of differences) were not different before and after the hot spring therapy. ln TP was decreased insignificantly. ln VLF was not affected before and after hot spring therapy. ln LF and ln HF was decreased, LF norm was increased, and HF norm was decreased, which were not statistically significant. Also, LF/HF ratio was increased insignificantly. Conclusions: From these results, we concluded that the weight, total body water, muscle, protein, and mineral got lost from the hot spring therapy. However, the HRV was not affected from the hot spring therapy.

• Korean Journal of Acupuncture
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• v.30 no.4
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• pp.305-318
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• 2013

Objectives : The aim of this study was to examine the effect of electroacupuncture(EA) at an acupoint, HT8(Sobu), on normal humans by using power spectral analysis. We examined the effect on the Heart Rate Variability(HRV), and the balance of the autonomic nervous system. Methods : Thirty-two healthy volunteers participated in this study. EEG(Electroencephalogram) power spectrum exhibits site-specific and state-related differences in specific frequency bands. A thirty-two channel EEG study was carried out on thirty-two subjects(14 males; mean age=23.5 years old, 18 females; mean age=21.5 years old). HRV and EEG were simultaneously recorded before and after acupuncture. Results : In the ${\alpha}$(alpha) band, during the HT8-acupoint treatment, the power values in the ${\alpha}$(alpha) band significantly decreased(p<0.05) at 28 channels. In the ${\beta}$(beta) band significantly decreased(p<0.05) at 26 channels. In ${\delta}$(delta) band significantly decreased(p<0.05) at 18 channels. In ${\theta}$(theta) band significantly decreased(p<0.05) at 20 channels. ${\alpha}/{\beta}$ values were increased at 6 channels and decreased at 10 channels.${\beta}/{\theta}$ values were increased at 10 channels and decreased at 19 channels. Mean-RR(RR-interval), Complexity, RMSSD(Root mean square of successive differences), SDSD(Standard deviations differences between adjacent normal R-R intervals), norm HF showed a significantly increased and mean-HRV, norm LF, LHR(LF/HF Ratio) showed a significantly decreased after HT8-acupoint treatment(p<0.05). Conclusions : These results suggest that EA at the HT8 mostly causes significant changes on alpha(28 channels), beta(26 channels), delta(18 channels), theta(20 channels) bands and mean-HRV, mean-RR, complexity, RMSSD, SDSD, norm LF, norm HF and LHR. If practicing EA at the HT8, it will regulate the function of the cerebral cortex, decrease activity of the sympathetic and increase parasympathetic nervous activity.

• Journal of Korea Society of Industrial Information Systems
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• v.20 no.6
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• pp.37-46
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• 2015

The wireless electrocardiographic monitoring system(WDMS) is designed to be long term monitoring for the early detection of cardiac disorders. The current version of the WDMS can identify two types of cardiac rhythms in real-time, such as atrial fibrillation(AF) and normal sinus rhythm(NSR), which are very important to track cardiac-rhythm disorders. In this study, we proposed the analysis method to discriminate the characteristics statistically evaluated in both time and frequency domains between AF and NSR using various parameters in the heart rate variability(HRV). And we applied various ECG detection methods (e.g., difference operation method) and compared the results with those of the discrete wavelet transform(DWT) method. From the statistically results, we found that the parameters such as STD RR, STD HR, RMSSD, NN50, pNN50, RR Trian, and TNN(p<0.05) are significantly different between the AF and NSR patients in time domain. On the other hand, the frequency domain analysis results showed a significant difference in VLF power($ms^2$), LF power($ms^2$), HF power($ms^2$), VLF(%), LF(%), and HF(%). In particular, the parameters such as STD RR, RMSSD, NN50, pNN50, VLF power, LF power and HF power were considered as the most useful parameters in both AF and NSR patient groups. Our proposed method can be efficiently applied to early detection of abnormal conditions and prevent the such abnormals from becoming serious.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.4
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• pp.56-65
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• 2012

Purpose: This study aims to analyze Heart Rate Variability(HRV) in women with fibroadenoma compared with non-fibroadenoma women. Methods: We studied 82 patients visiting Kang-Nam Kyung-Hee Korean Hospital Medical Examination Center from January, 2010 to November, 2011. The subjects were categorized in two groups, fibroadenoma group(n=16) and non-fibroadenoma group (n=66). We investigated the difference of HRV between two groups. Results: The square root of the mean squared difference of successive NNs (RMSSD) in fibroadenoma group is significantly lower than non-fibroadenoma group. LF/HF ratio in fibroadenoma group is significantly higher than non-fibroadenoma group. There was no significant difference in low frequency(LF) and high frequency (HF). However, normalized LF in fibroadenoma group is significantly higher than non-fibroadenoma group. In addition, normalized HF in fibroadenoma group is significantly lower than non-fibroadenoma group. Conclusions: Fibroadenoma group is related to autonomic nerve imbalances that is assumed by psychological problems.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.3
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• pp.99-110
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• 2008

Purpose: Premenstrual syndrome(PMS) is a collection of physical, psychological and emotional symptoms related to a women's menstrual cycle. The symptoms are related with Autonomic Nervous system. The purpose of this study is to investigate the activity of Autonomic Nervous system in women with premenstrual syndrome(PMS) by using Heart Rate Variability(HRV). Methods: We studied 26 patients visiting ㅇㅇ hospital from 26th December 2005 to 26th April 2006. Activity of Autonomic Nervous system was assesed by means of Heart Rate Variability(HRV). The subjects were categorized in two groups, PMS group(10) and non-PMS group(16). We studied the difference of HRV between two groups by Mann-Whitney U-test using SPSS for windows (version 12.0). Results: SDNN of PMS group was non-significantly lower than non-PMS group. RMS-SD of PMS group was significantly lower than non-PMS group. Mean PR of PMS group was non-significantly higher than non-PMS group. TP, VLF, LF, HF norm of PMS group was non-significantly lower than non-PMS group. HF of PMS group was significantly lower than non-PMS group. LF norm, LF/HF ratio of PMS group was non-significantly higher than non-PMS group. Conclusion: The results suggest that PMS can be related to decreased activity of parasympathetic nervous system. HRV can be useful to diagnose PMS. The more studies to diagnose PMS would be needed.