• Journal of Nutrition and Health
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• v.52 no.1
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• pp.17-25
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• 2019

Purpose: Obesity is a major health problem of global significance because it is clearly associated with an increased risk of health problems, such as nonalcoholic fatty liver disease (NAFLD), diabetes, cardiovascular diseases, and cancer. Lonicera caerulea (LC) originates from high mountains or wet areas and has been used as a traditional medicine in northern Russia, China, and Japan. LC contains a range of bioactive constituents, such as vitamins, minerals, and polyphenols. This study examined the anti-obesity effects of LC during differentiation in preadipocytes. Methods: The cell viability assay was performed after the differentiation of 3T3-L1 cells for 7 days. Oil Red O staining was used to visualize the changes in lipid droplets in 3T3-L1 cells and mouse adipose-derived stem cells (MADSCs). The mRNA expression of obesity-related genes was determined by quantitative real-time PCR. Results: According to the results of Oil Red O staining, the lipid levels and size of lipid droplets in the adipocytes were reduced and the LC extract (LCE, 0.25-1 mg/mL) markedly inhibited adipogenesis in a dose-dependent manner. The treatment of LCE also decreased the mRNA expression of peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$), CCAAT/enhancer binding protein-${\alpha}$ ($C/EBP{\alpha}$), and sterol regulatory element binding protein 1 (SREBP1) in 3T3-L1 cells. Western blot analysis showed that the $PPAR{\gamma}$, $C/EBP{\alpha}$, and SREBP1 protein levels in both 3T3-L1 and MADSC were reduced in a dose-dependent manner. Conclusion: These results suggest that LCE can inhibit adipogenic differentiation through the regulation of adipogenesis-related markers.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.11a
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• pp.976-979
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• 2000

This paper describes a Life Cycle Engineering approach which is able to optimize a product under technical, ecological and economical requirements. The methodology of Life Cycle Engineering comes with a holistic approach for the analysis of processes, products, systems or services. The Life Cycle Engineering approach is combining environmental and economical parameters and using the technical requirements for setting the baseline for the studies. This paper also describes the approach method for ？ㄴ composed in large numbers sub-parts.

• Journal of Korean Society of Water and Wastewater
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• v.27 no.2
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• pp.223-232
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• 2013

In this study, carbon emissions and energy consumption were evaluated to establish a design strategy which has low energy consumption and carbon emission production, by using life cycle energy (LCE) and life cycle $CO_2(LCCO_2)$ calculation methods in life cycle management(LCM) tools. After improvement design projects, the energy consumption and $CO_2$ emission were calculated and compared in three sewage treatment plants (STPs), which are A STP, B STP, and C STP. The reduction of carbon emissions was 28,020.1 ton $CO_{2-}e/yr$, 37,399.6 ton $CO_{2-}e/yr$ and 8,788.3 ton $CO_{2-}e/yr$, respectively. Production of energy was 792 TOE/yr, 1,235 TOE/yr and 1,023 TOE/yr, respectively. As a result, the estimation of energy and energy self-sufficiency was 5.1 %, 14.5 % and 23.5 %, respectively. The result of this study shows the LCM can be contributed to establish strategy for energy and carbon emission reduction in sewage treatment plants.

• Preventive Nutrition and Food Science
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• v.21 no.3
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• pp.227-235
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• 2016

Obesity is a major risk factor for various metabolic diseases such as cardiovascular disease, hypertension, and type 2 diabetes mellitus. In this study, we prepared ethanol extracts from Agastache rugosa (ARE), Chrysanthemum zawadskii (CZE), Mentha arvensis (MAE), Perilla frutescens (PFE), Leonurus sibiricus (LSE), Gardenia jasminoides (GJE), and Lycopus coreanus (LCE). The anti-oxidant and anti-adipogenic effects were evaluated. The $IC_{50}$ values for ascorbic acid and LCE against 2,2-diphenyl-1-picrylhydrazyl radicals were $246.2{\mu}g/mL$ and $166.2{\mu}g/mL$, respectively, followed by ARE ($186.6{\mu}g/mL$), CZE ($198.6{\mu}g/mL$), MAE ($337.1{\mu}g/mL$), PFE ($415.3{\mu}g/mL$), LSE ($548.2{\mu}g/mL$), and GJE ($626.3{\mu}g/mL$). In non-toxic concentration ranges, CZE had a strong inhibitory effect against 3T3-L1 adipogenes (84.5%) than those of the other extracts. Furthermore, the anti-adipogenic effect of CZE is largely limited in the early stage of adipogenesis, and we revealed that the inhibitory role of CZE in adipogenesis is required for the activation of Wnt signaling. Our results provide scientific evidence that the anti-adipogenic effect of CZE can be applied as an ingredient for the development of functional foods and nutri-cosmetics for obesity prevention.

• Applied Chemistry for Engineering
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• v.34 no.4
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• pp.347-356
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• 2023

Liquid crystal elastomer (LCE) fibers have been widely applied in various fields, such as soft robots and biomimetic actuators, in a one-dimensional form. LCEs possess the characteristics of both fluidity and solid order, as well as the elasticity of rubber, and exhibit stimulus-response based on these properties. In particular, by programming the responsiveness to various stimuli such as heat, light, electric fields, and magnetic fields in terms of shape-changing, various movements such as lifting, twisting, and rotating can be realized with high degrees of freedom. Therefore, LCE fibers have the potential for application in various fields such as artificial muscles, soft robots, wearable technologies, and sensing technologies. The research on liquid crystal elastomer fibers is evaluated to have high applicability in various fields in the Fourth Industrial Revolution as a smart material that can include various functionalities beyond simple fibers. In this review, we introduce the structure and basic characteristics of liquid crystal elastomer fibers, the latest research trends on orientation-based fabrication methods, and various applications such as artificial muscles, smart fabrics, and soft robots.

• Journal of Korean Society of Water and Wastewater
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• v.26 no.2
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• pp.303-312
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• 2012

Water supply and sewerage systems are the large-scale urban infrastructure ejecting large amount of environmental load over the life-cycle. Therefore, it is important not only to optimize in the aspect of economical superiority and process efficiency but also to consider earth scale environmental impact. This study aimed to suggest the establishment of life cycle management(LCM) system as an integrated management solution in urban water supply and sewerage systems. As a result, the methodology for LCM system consisting of life cycle assessment(LCA), life cycle cost(LCC), life cycle $CO_{2}(LCCO_{2})$ and life cycle energy(LCE) was developed. Also, several case studies using the latest statistics data of water supply and sewerage systems were carried out to investigate the field applicability of LCM.

• Proceedings of the KIEE Conference
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• 1993.07a
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• pp.427-429
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• 1993

In this paper, GIS (Geographical Information System) for KODAS (Korea Distribution Automation System) will be presented. It has been developed to display the status of distribution power line facilities with background geographical map information (eg. address, street, railways and building) and provides various menu screen that can be handled easily. We will discuss computer system I/F between Host computer and GIS, DB structure for GIS and It's functions.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2012.10a
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• pp.55-57
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• 2012

Suez운하를 이용할 경우 부산항에서 로테르담항까지의 수송거리가 11,340마일이 북극해 항로를 이용할 경우 6,860마일로 36%가 줄고 수송기간도 10일 이상 단축되므로 북극해항로를 통한 유럽과 아시아간의 상업적인 수송이 이뤄진다면 해운회사들의 물류비용이 대폭 절감될 것으로 전망된다. 이런 시점에서 2011년 9월 한-러 국장급 해운회담이 열렸으며, 2011년 11월 23일 부산 누리마루 APEC House에서 "북극해항로 상업운항의 현황과 전망"이라는 주제로 국제세미나가 개최 되었다. 현재 북극해 항로를 통과한 선박이 2007년 2척, 2008년 3척, 2009년 4척, 2010년 10척이었던 것이 2011년에는 34척 총 82만톤의 통과 수송이 이뤄졌고, 러시아 북극내의 물동량은 2백20만톤에 달할 것으로 전망되었으며, 2012년의 통과 물동량은 100만톤을 상회 할 것으로 전망된다. 이에 북극해 항로에 대한 소개와 빙하지역을 항해하는 선박에 대한 운항지침에 대하여 검토해보고저 한다.

• Journal of Korean Society of Environmental Engineers
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• v.38 no.6
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• pp.334-342
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• 2016

Conventional eco-design has been implemented based only on the environmental aspects of a product. Key components of a product identified from the analysis of the environmental aspects have been the target for improvement in the conventional eco-design. The use of eco-design index (EDI) considering both the environmental and economic aspects, and utility value (UV) of a product can be envisaged as an alternative way of implementing and assessing the eco-design. The objective of this study was to propose the logic of the EDI and apply it to the components for performing printing function of the multi-function printer. The EDI was formulated by quantifying the UV, life cycle environmental impact (LCE) and life cycle cost (LCC) of the components of a product, here components of the printer. Of the eight components investigated, roller was identified as the best performing consumable in both the environmental and economic aspects. However, its UV was the lowest among the eight. The EDI of the roller was mere $4^{th}$ in ranking out of the eight. Transfer belt ranked $8^{th}$ and $5^{th}$ in the environmental and economic aspects, respectively, while $2^{nd}$ in the utility value with its EDI ranked $3^{rd}$. This indicates that not only the environmental aspects but also economic and utility value aspects should be considered when identifying the key components for improvement in the eco-design.

• Structural Engineering and Mechanics
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• v.47 no.5
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• pp.679-700
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• 2013

Two new predictive design methods are presented in this study. The first is a hybrid method, called neuro-fuzzy, based on neural networks with fuzzy learning. A total of 280 experimental datasets obtained from the literature concerning concentric punching shear tests of reinforced concrete slab-column connections without shear reinforcement were used to test the model (194 for experimentation and 86 for validation) and were endorsed by statistical validation criteria. The punching shear strength predicted by the neuro-fuzzy model was compared with those predicted by current models of punching shear, widely used in the design practice, such as ACI 318-08, SIA262 and CBA93. The neuro-fuzzy model showed high predictive accuracy of resistance to punching according to all of the relevant codes. A second, more user-friendly design method is presented based on a predictive linear regression model that supports all the geometric and material parameters involved in predicting punching shear. Despite its simplicity, this formulation showed accuracy equivalent to that of the neuro-fuzzy model.