• Title/Summary/Keyword: LAT

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Characteristics in Size Distributions and Morphologies of Wear Particles Depending on Types of Abrasion Testers

  • Eunji Chae;Seong Ryong Yang;Sung-Seen Choi
    • Elastomers and Composites
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    • v.58 no.2
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    • pp.87-94
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    • 2023
  • Abrasion tests of an SBR compound were conducted using four different types of abrasion testers (cut and chip, Lambourn, DIN, and LAT100). The abrasion test results were analyzed in terms of size distributions and morphologies of the wear particles. Most wear particles were larger than 1000 ㎛. The wear particle size distributions tended to decrease as the particle size decreased. Except for the Lambourn abrasion test, the wear particles smaller than 212 ㎛ were rarely generated by the other three abrasion tests, implying that small wear particles were produced through friction by introducing talc powder. Shapes of the wear particles varied depending on the abrasion testers. The wear particles generated from the Lambourn abrasion tester had stick-like shapes. The cut and chip abrasion test showed a clear abrasion pattern, but the DIN abrasion test did not show any specific abrasion pattern. The Lambourn and LAT100 abrasion tests showed irregular abrasion patterns.

적응 다채널 디지탈 필터와 적응 비임 형성기

  • 윤대희;이봉환
    • 전기의세계
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    • v.36 no.12
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    • pp.882-891
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    • 1987
  • 본고에서는 간섭 신호원이 정지하고 있는 경우와 움직이는 경우 Griffiths등이 제안한 적응 비임형성기를 적응 다채널 TDL, LAT 및 ESC 필터를 사용하여 구현한 후 컴퓨터 시뮬레이션을 통하여 그 성능을 고찰해 보았다.

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Physiological, Pharmacological and Toxicological Implications of Heterodimeric Amino Acid Transporters

  • Kanai, Yoshikatsu;Endou, Hitoshi
    • The Korean Journal of Physiology and Pharmacology
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    • v.8 no.3
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    • pp.117-127
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    • 2004
  • The heterodimeric amino acid transporter family is a subfamily of SLC7 solute transporter family which includes 14-transmembrane cationic amino acid transporters and 12-transmembrane heterodimeric amino acid transporters. The members of heterodimeric amino acid transporter family are linked via a disulfide bond to single membrane spanning glycoproteins such as 4F2hc (4F2 heavy chain) and rBAT $(related\;to\;b^0,\;^+-amino\;acid\;transporter)$. Six members are associated with 4F2hc and one is linked to rBAT. Two additional members were identified as ones associated with unknown heavy chains. The members of heterodimeric amino acid transporter family exhibit diverse substrate selectivity and are expressed in variety of tissues. They play variety of physiological roles including epithelial transport of amino acids as well as the roles to provide cells in general with amino acids for cellular nutrition. The dysfunction or hyperfunction of the members of the heterodimeric amino acid transporter family are involved in some diseases and pathologic conditions. The genetic defects of the renal and intestinal transporters $b^{0,+}AT/BAT1\;(b^{0,+}-type\;amino\;acid\;transporter/b^{0,+}-type\;amino\;acid\;transporter\;1)$ and $y^+LAT1\;(y^+L-type\;amino\;acid\;transporter\;1)$ result in the amino aciduria with sever clinical symptoms such as cystinuria and lysin uric protein intolerance, respectively. LAT1 is proposed to be involved in the progression of malignant tumor. xCT (x-C-type transporter) functions to protect cells against oxidative stress, while its over-function may be damaging neurons leading to the exacerbation of brain damage after brain ischemia. Because of broad substrate selectivity, system L transporters such as LAT1 transport amino acid-related compounds including L-Dopa and function as a drug transporter. System L also interacts with some environmental toxins with amino acid-related structure such as cysteine-conjugated methylmercury. Therefore, these transporter would be candidates for drug targets based on new therapeutic strategies.

Successful Angiographic Embolization of Superficial Circumflex Iliac Artery Rupture Caused by Blunt Abdominal Trauma: A Case Report (복부 둔상에 의한 얕은엉덩휘돌이동맥 파열의 혈관조영색전술을 통한 성공적인 치료: 증례보고)

  • Lee, Sang Bong;Park, Sung Jin;Yeo, Kwang Hee;Kim, Ho Hyun;Park, Chan-Yong;Kim, Jae Hun;Kim, Chang Wan;Choi, Seon Uoo;Kim, Seon Hee;Hwang, Jung Joo;Cho, Hyun Min
    • Journal of Trauma and Injury
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    • v.28 no.1
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    • pp.39-42
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    • 2015
  • Lat. abdominal wall hematoma with active bleeding is very rare but need prompt bleeding control. We report successful treatment by angiographic embolization of superficial circumflex iliac artery rupture caused by blunt trauma. A 60-year-old woman presented painful, enlarging, lat. abdominal wall mass with ecchymosis caused by blunt abdominal trauma. Contrast leakage of superficial circumflex iliac a. within the lt. ext. oblique m. hematoma was confirmed by abdominal computed tomography. Angiographic embolization was performed successfully. Patient was discharged at 4th day after trauma without complication. Angiographic embolization is important treatment option of lat. abdominal wall hematoma with active bleeding replacing emergency surgery.

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ODA project - Develop Cooperation between Viet Nam and Korea in Agriculture

  • Khoa, Hoang Viet Bach;Le, Le Ba;Kim, Moung-Su;Byeon, Ji-Hui;Lim, Jong-Min;Jang, Hye-Ri;Cho, Joon-Hyeong
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2011.10a
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    • pp.15-15
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    • 2011
  • Vietnam is one of a country with an important strategic position in economic development in the Asia Pacific region. In addition, Vietnam has a longtime agricultural more than 70% of agricultural labor. With favorable natural conditions, agricultural growth in Vietnam is'key'to the developing countries. However, Vietnam's agriculture has still encounter many problems due to drought, climatic conditions, natural disasters. The level of development and agricultural production is weak, the process of post-harvest storage is limited and particularly agricultural competitiveness with other countries is obstacles. In fact, the Government of Vietnam decided to cooperate with other countries have highly developed agriculture such as America, Korea, Japan... hoping to get help and promote agricultural development in a sustainable manner. Since 1992, Vietnam and Korea established formal diplomatic relations. During 20 years of cooperation and development, We have been obtained many satisfactory results not only in fields invest infrastructure, technological science but also exchange experience especially in the agricultural sector. From the Korea ODA project, Vietnam's agriculture in general has made significant progress. With vision, ODA projects continues to support the Central Highlands region in which the Da Lat city, Lam Dong province. Pass the cooperation between Dongguk University and Da Lat University has many positive results. Hopefully in the near future, the relationship between Vietnam and Korea in general will continue to grow strongly, the Korea ODA project will be continue to support Vietnam's agriculture in general and in particularly for the Central Highlands which in Da Lat City, Lam Dong province.

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Detection of Toxoplasma gondii in experimentally infected porcine blood and tissues by polymerase chain reaction (Polymerase chain reaction을 이용한 실험적 감염 돼지의 혈액과 조직으로부터 Toxoplasma gondii 검출)

  • Suh, Myung-deuk;Shin, Gee-wook
    • Korean Journal of Veterinary Research
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    • v.41 no.1
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    • pp.89-98
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    • 2001
  • This study was conducted to detect the toxoplasma specific-DNA in circulating blood and organs collected from slaughtered pigs at slaughtering house and experimentally infected pigs with Toxoplasma gondii tachyzoites by polymerase chain reaction(PCR), and also PCR was applied to diagnose for acute phase of swine toxoplasmosis as a newly developed diagnostic test. The sensitivity of oligonucleotide primer, T-1 & T-2, designed from toxoplasma B1 gene amplification method was compared with Tp parasite detection by mouse inoculation(MI). On the other hand, latex agglutination test(LAT) was conducted to detect the serum antibodies comparing with the detection of toxoplasma by PCR and MI. The results obtained were summarized as follows. PCR was able to determine at the lowest level of $10^0/ml$ T. gondii in blood samples which were blended with a serial diluted T gondii in vitro. On the other hand, $10^2/5g$ of T gondii could detect from a variety of tissues including lung, diaphragm, liver, heart, spleen and brain in vitro. The primer was proved to specifically determine T gondii in blood and tissues in vitro but it did not detect Neospora caninum used as a negative control. DNA of T. gondii was effectively extracted by freezing, thawing and grinding twice both tissues mixed with T gondii in vitro and in experimentally infected pig's tissues. PCR detected specific DNA in the blood of experimentally infected pigs at 108 hrs and 120 hrs post-infection, it was the same time that the pigs showed fever and parasitaemia. In case of tissue, specific DNA was, however, detected only lung from experimentally infected pigs. Even though the duration of acute phase was from 3 to 7 days post-infection, but the latex agglutination test (LAT) results appeared from 8 days post-infection. A comparison of sensitivity in determining T gondii in blood samples between PCR and MI, PCR positive rate ranged from 25 to 33.3%, but that of MI covered from 75 to 100%.

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Allopurinol-induced severe cutaneous adverse reactions: A report of three cases with the HLA-B58:01 allele who underwent lymphocyte activation test

  • Kim, Eun-Young;Seol, Jung Eun;Choi, Jae-Hyeog;Kim, Na-Yul;Shin, Jae-Gook
    • Translational and Clinical Pharmacology
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    • v.25 no.2
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    • pp.63-66
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    • 2017
  • Allopurinol-induced severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome are reportedly associated with the $HLA-B^{\star}58:01$ genotype. Three patients who developed SCARs after allopurinol administration were subjected to HLA-B genotyping and lymphocyte activation test (LAT) to evaluate genetic risk and to detect the causative agent, respectively. All three patients given allopurinol to treat gout were diagnosed with DRESS syndrome. Symptom onset commenced 7-24 days after drug exposure; the patients took allopurinol (100-200 mg/d) for 2-30 days. HLA-B genotyping was performed using a polymerase chain reaction (PCR)-sequence-based typing (SBT) method. All patients had a single $HLA-B^{\star}58:01$ allele: $HLA-B^{\star}13:02/^{\star}58:01$ (a 63-year-old male), $HLA-B^{\star}48:01/^{\star}58:01$ (a 71-year-old female), and $HLA-B^{\star}44:03/^{\star}58:01$ (a 22-year-old male). Only the last patient yielded a positive LAT result, confirming that allopurinol was the causative agent. These findings suggest that patients with $HLA-B^{\star}58:01$ may develop SCARs upon allopurinol administration. Therefore, HLA-B genotyping could be helpful in preventing serious problems attributable to allopurinol treatment, although PCR-SBT HLA-B genotyping is time consuming. A simple genotyping test is required in practice. LAT may help to identify a causative agent.

Evaluation of the usefulness of IGRT(Image Guided Radiation Therapy) for markerless patients using SGPS(Surface-Guided Patient Setup) (표면유도환자셋업(Surface-Guided Patient Setup, SGPS)을 활용한 Markerless환자의 영상유도방사선치료(Image Guided Radiation Therapy, IGRT)시 유용성 평가)

  • Lee, Kyeong-jae;Lee, Eung-man;Lee, Jeong-su;Kim, Da-yeon;Ko, Hyeon-jun;Choi, Shin-cheol
    • The Journal of Korean Society for Radiation Therapy
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    • v.33
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    • pp.109-116
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    • 2021
  • Purpose: The purpose of this study is to evaluate the usefulness of Surface-Guided Patient Setup by comparing the patient positioning accuracy when image-guided radiation therapy was used for Markerless patients(unmarked on the skin) using Surface-Guided Patient Setup and Marker patients(marked on the skin) using Laser-Based Patient Setup. Materials And Methods: The position error during IGRT was compared between a Markerless patient initially set up with SGPS using an optical surface scanning system using three cameras and a Marker patient initially set up with LBPS that aligns the laser with the marker drawn on the patient's skin. Both SGPS and LBPS were performed on 20 prostate cancer patients and 10 Stereotactic Radiation Surgery patients, respectively, and SGPS was performed on an additional 60 breast cancer patients. All were performed IGRT using CBCT or OBI. Position error of 6 degrees of freedom was obtained using Auto-Matching System, and comparison and analysis were performed using Offline-Review in the treatment planning system. Result: The difference between the root mean square (RMS) of SGPS and LBPS in prostate cancer patients was Vrt -0.02cm, Log -0.02cm, Lat 0.01cm, Pit -0.01°, Rol -0.01°, Rtn -0.01°, SRS patients was Vrt 0.02cm, Log -0.05cm, Lat 0.00cm, Pit -0.30°, Rol -0.15°, Rtn -0.33°. there was no significant difference between the two regions. According to the IGRT standard of breast cancer patients, RMS was Vrt 0.26, Log 0.21, Lat 0.15, Pit 0.81, Rol 0.49, Rtn 0.59. Conclusion:. As a result of this study, the position error value of SGPS compared to LBPS did not show a significant difference between prostate cancer patients and SRS patients. In the case of additionally performed SGPS breast cancer patients, the position error value was not large based on IGRT. Therefore, it is considered that it will be useful to replace LBPS with SGPS, which has the great advantage of not requiring patient skin marking..

Agricultural Status of Lam Dong Province in Vietnam and the Strategy for Korea-Vietnam ODA International Cooperation Program in Agriculture (베트남 람동성의 농업현황 및 한-벳 ODA 농업협력사업 전략)

  • Cho, Joon-Hyeong;Jang, Hye-Ri;Lim, Jong-Min;Lee, Sok-Young;Kim, Wan-Seok
    • Journal of the Korean Society of International Agriculture
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    • v.23 no.5
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    • pp.465-474
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    • 2011
  • Agricultural environment of Lam Dong province, which is located in central highland area, is totally different from that of other lower areas in Vietnam. In Lam Dong province, abundant plant resources were naturally grown such as pine trees, taxus, and wild orchids, which can grow in high mountainous area. In Lam Dong, the field proportion of perennial crops was higher than that of annual crops. However, the field proportion and yields of vegetables were highest among the all cultivated crops, estimating 38% (36,552ha) and 72% (993,082MT), respectively. Especially in Da Lat, vegetables, flowers, orchids, and industrial crops were mainly produced because this area is geographically close to Ho Chi Minh city. And also in Da Lat, 64% (8,447ha) and 36% (4,777ha) of farm fields were used for producing annual and perennial crops, respectively, and the yields of fresh vegetables in this area was estimated to 213,478MT which was 21.5% of the whole yields in Lam Dong province. Thus Korea, Taiwan, Japan, France, and Holland have invested to agriculture in Da Lat for producing and exporting flowers, vegetables, and tea. In 2009, flower cultivation area of Da Lat was over 55% in Lam Dong province and average amount of values were 9,781 million USD, which was higher than that of al other crops. Thus following strategies could be suggested for the development of agriculture in Lam Dong province. The first, agricultural cooperation with Da Lat, Lam Dong, should be characterized to horticulture and floriculture, followed by supporting both appropriate R&D techniques and equipments. And then agricultural system should be made in relationship with the local companies. Finally, agricultural cooperation program should be conducted toward the direction for both donor and recipient countries.