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The Effect of Glasthma Syrup in Asthma: a study protocol for a triple-blind randomized controlled trial

  • Derakhshan, Ali Reza;Saeidinejat, Shahin;Khadem-Rezaiyan, Majid;Asnaashari, Amir-Mohammad-Hashem;Mirsadraee, Majid;Salari, Roshanak;Jabbari-Azad, Farahzad;Jalali, Shima;Jalali, Shabnam
    • Journal of Pharmacopuncture
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    • v.25 no.3
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    • pp.233-241
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    • 2022
  • Objectives: Asthma is a chronic disease, and the demand for herbal medicines in this field has increased in recent years. The new findings highlight the role of the gut-lung axis in the pathophysiology of asthma. Hence, this study will evaluate the safety and efficacy of Glasthma syrup, an herbal formula based on Persian medicine, in improving asthma and regulating intestinal permeability. The formula consists of five herbal ingredients that have anti-inflammatory effects on the respiratory tract, also known as gut tonics. Methods: The study will be conducted as a placebo-controlled, triple-blind, randomized trial. It will consist of a 4-week intervention followed by a 4-week follow-up period. The target sample size is 20 patients with moderate asthma aged 18 to 60 years. Eligible participants will be randomly assigned to either the experimental group or the control group in equal numbers. Patients in the experimental group will take Glasthma syrup (7.5 mL, twice a day), while patients in the control group will take a matching placebo. Both groups will receive a 4-week combination of a long-acting beta2 agonist and a leukotriene modulator as standard of care. Inhaled corticosteroids can be used as rescue medication as needed. Results: The primary outcomes are asthma symptom scale, lung function, and intestinal permeability. Secondary outcomes include quality of life, symptom recurrence rates, and blood tests. A safety assessment will also be conducted during the trial. Conclusion: In this trial, the effects of Glasthma syrup in patients with moderate asthma will be examined. The study will also assess the effects of the formulation on the gut-lung axis by simultaneously monitoring the gut permeability index, asthma symptoms, and lung function.

Item-Level Psychometrics of the 12 Items of the Coping Orientation to Problems Experienced Scale (스트레스 대처 척도 12개 항목에 대한 심리측정 속성)

  • Nam, Sanghun;Hilton, Claudia L.;Lee, Mi-Jung;Pritchard, Kevin T.;Bae, Suyeong;Hong, Ickpyo
    • Therapeutic Science for Rehabilitation
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    • v.11 no.3
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    • pp.65-80
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    • 2022
  • Objective : This study examined the psychometric properties of the 12-item Coping Orientation to Problems Experienced Scale (COPE) using Rasch analysis. COPE is one of the instruments used to measure stress-coping skills. Methods : The study participants were 480 community-dwelling older adults. We tested the instrument's unidimensionality assumption using principal component analysis (PCA). Item fit was examined using infit-and-outfit mean-square (MnSq) and standardized fit statistics (ZSTD). The precision and item difficulty hierarchies of the instrument were examined. The item-difficulty hierarchy was investigated to identify the easy and difficult items. We tested differential item functioning (DIF) for sex and age groups. Results : PCA revealed that the instrument met the unidimensionality assumption (eigenvalue = 1.78). Among the 12 items, item 2 was removed because of misfit (Infit MnSq = 1.33, Infit ZSTD = 5.05, Outfit MnSq = 1.56, Outfit ZSTD = 7.15). The remaining 11 items demonstrated a conceptual item-difficulty hierarchy. The person strata value was 3.10, which is equivalent to a reliability index value of 0.81. There was no DIF for the sex and age groups (DIF contrast <0.27). Conclusion : The findings indicated that the revised COPE-11 has adequate item-level psychometric properties and can accurately measure stress coping skills.

Effects of Mechanized Seeding on Growth and Yield of Sorghum -Sudangrass Hybrid (기계화 파종이 청예용 수수-수단그라스 교잡종의 생육 및 수량에 미치는 영향)

  • Kim, Young-Doo;Suh, Sug-Kee;Chae, Jae-Suk;Park, Moon-Soo;Chae, Kyu-In
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.36 no.4
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    • pp.360-365
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    • 1991
  • This experiment was conducted to determine mechanized seeding ability of barley drill seeder on the seeding time, growth and yield of sorghum-sudangrass hybrid. The time required for machine drill seeding was 42 minutes per l0a which was one-thirteenth of the time required by the manual drill seeding, and percentage of seedling establishment by machine drill seeding was better than that of manual drill seeding. Leaf area index in seeding rate with 30 x 5cm and 40 x 5cm of machine drill seeding was higher than those of manual drill seeding, the leaf distribution was better and the total nonstructural carbohydrate content of stubble after cutting was short increased than that of manual drill seeding, Content of feed composition was not significantly different between manual and machine drill seeding. At seeding rate of 40 x 5cm of machine seeding. dry matter and TDN yield were increased to 29% and 30% respectiyely, than those of manual drill seeding.

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Influence of Midsummer Drainage Times on Lodging and Growth of Rice in Direct Drill Seeding Culture on Puddled Soil (벼 무논골뿌림 재배시 중간낙수 회수가 도복 및 생육에 미치는 영향)

  • Kim, Sang-Su;Choi, Weon-Young;Seok, Soon-Jong;Lee, Seon-Yong;Kim, Jong-Ho;Cho, Dong-Sam
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.40 no.1
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    • pp.33-38
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    • 1995
  • This experiment was conducted to elucidate the effect of the midsummer drainage times on lodging characters, field lodging and yield in direct seeding rice culture in puddled soil. Dongjinbyeo was seeded at May 11 by seeding machine with 4cm of furrow depth and drained, one(50days after seeding DAS)) two (30DAS and 50DAS), and three times (30DAS, and 50DAS and 60DAS). The results are as follows. Culm length was shorten and the wall of N3, N4 were thicken as the drain-age times were increased. As the drainage times were increased breaking weights were increased but the lodging index were decreased. Lodging was occurred seriousely at none drainage, but wasn't occurred two or three times drainage. Yield was higher at 1~2 times drainage compared with none and three times drainage. Therefore, two times midsummer drainage is recommend-able water management method for direct seeding rice culture in puddled soil.

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The Vascular Plants of Forested Wetland in Daegu-Gyeongbuk, Korea - Focused on Daegu, Cheongdo, Gyeongju and Pohang - (대구, 경북지역 산림습원 일대의 관속식물상 - 대구, 청도, 경주, 포항을 중심으로 -)

  • Myung Hoon Yi;Sung Tae Yoo;Byung Do Kim;Jung Won Yoon;Jong Bin An;Hye Yeon Kwon
    • Korean Journal of Plant Resources
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    • v.36 no.1
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    • pp.32-61
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    • 2023
  • To investigate the distribution of vascular plants growing at Wetland in Daegu·Gyeongbook, we surveyed from June 2020 to October in 2021. The flora of wetland was classified as a total of 459 taxa comprising of 104 families, 286 genus, 406 species, 12 subspecies, 34 varieties, 6 forma, 1 hybrid. Among them, the rare plants species 5 taxa, endemic plants 11 taxa, floristic regional indicator plants 57 taxa, naturalized plants 27 taxa and wetland plants 74 taxa were recorded. The percentage of urbanization index was 8.44%, the naturalized ratio was 5.88%, respectively.

Hepatoprotective effect of fermented Schizandrae Fructus Pomace extract and Hoveniae Semen Cum Fructus extract combination mixtures against carbon tetrachloride-induced acute liver injured mice (사염화탄소 유발 급성 간 손상에 대한 발효 오미자박 및 헛개과병 추출물의 혼합 비율에 따른 간 보호효능)

  • Hye-Rim, Park;Kyung Hwan, Jegal;Beom-Rak, Choi;Jae Kwang, Kim;Sae Kwang, Ku
    • Herbal Formula Science
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    • v.31 no.1
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    • pp.53-65
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    • 2023
  • Objectives : Present study investigated the hepatoprotective effects and the optimal mixing ratio of fermented Schizandrae Fructus Pomace (fSFP) and Hoveniae Semen Cum Fructus (HSCF) extract combination in carbon tetrachloride (CCl4)-induced acute liver injury mice. Methods : ICR mice were orally administered with 200 mg/kg of fSFP, HSCF and mixtures of fSFP and HSCF [MSH (w:w); 1:1, 1:2, 1:4, 1:6, 2:1, 4:1, 6:1, and 8:1] for 7 consecutive days. Silymarin (100 mg/kg) was administered as a reference drug. 0.5 mL/kg of CCl4 was injected intraperitoneally to induce acute liver injury. Body weight gain, relative liver weight, serum chemistry, histopathological analysis, and hepatic endogenous antioxidants capacities were observed. Results : All diverse combinations of MSH significantly reduced relative liver weight increase by CCl4. In addition, MSH administrations significantly decreased the elevation of serum alanine aminotransferase and aspartate aminotransferase activities by CCl4. Histopathological observation indicated that all MSH treatments significantly reduced the increase of degenerated hepatocytes, inflammatory cell infiltration, and histological activity index score by CCl4. Moreover, all MSH administrations reduced the elevation of malondialdehyde contents, and ameliorated the reduction of hepatic glutathione contents, superoxide dismutase activity, and catalase activity. Among the various mixing ratio of MSH combinations, MSH 1:1 and 2:1 showed the most potent anti-oxidative stress, and hepatoprotective effect. Conclusion : Present results suggest that 1:1 and 2:1 combinations of MSH is promising herbal formulation with the hepatoprotective effect against oxidative stress.

Growth and Grain Yield under Different Direct Seeding Cultures in Rice (벼 직파재배 유형에 따른 생육 및 수량)

  • Choi, Weon-Young;Kim, Sang-Su;Sin, Hyun-Tak;Cho, Soo-Yeon;Choi, Sun-Young
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.42 no.1
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    • pp.14-21
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    • 1997
  • This experiment was conducted to identify the growth and yield differences in rice cultural types: Broadcasting on flooded paddy surface(BF), drilling on flooded paddy surface(DF), puddled-soil drill seeding(PD), drill seeding on dried paddy flat(DD), and machine transplanting of lO-day old seedling(MT) at National Honam Agricultural Experiment Station in 1995. Among the cultural types of direct seeding, the number of seedling stand showed high in order of DD>BF>DF>PD. Tillering at early growth stage was faster in MT and effective tiller showed higher in MT than in direct seeding. Growth duration from seeding to heading was longer in direct seeding than in MT for 2-13 days of Dongjinbyeo and 10-18 days of Nonganbyeo. Root distribution ratio at the surface soil revealed high in order of BF>DF>PD>DD and MT. Culm wall thickness of 4th internode was thicker in machine transplanting of 10-day old seedling than in direct seeding, and the depth of buried culm showed deep by turns of MT> DD>PD>DF and BF. The height of center gravity and moment related to lodging revealed higher in direct seeding than machine transplanting that resulted high lodging index by turns of BF>DF>DD> PD among the direct seeding cultural type. Lodging was occured seriously in the order of BF>DF>PD>DD =MT in Dongjinbyeo but wasn't significantly different in Nonganbyeo among the cultural type. The yield components and grain yield showed varietal differences but was not significantly different between in MT and in direct seeding, and among cultural types of direct seeding.

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Reducing Ammonia Emissions and Enhancing Plant Growth through Co-application of Microbes and Methanol in Sewage Sludge Treatment (하수슬러지 처리에서 미생물과 메탄올 적용을 통한 암모니아 배출 감소 및 식물 성장 향상 연구)

  • Jin-Won Kim;Hee-Gun Yang;Hee-Jong Yang;Myeong-Seon Ryu;Gwang-Su Ha;Su-Ji Jeong;Soo-Young Lee;Ji-Won Seo;Do-Youn Jeong
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.26 no.2
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    • pp.13-24
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    • 2023
  • Sewage sludge has been widely used as an organic fertilizer in agriculture. However, sewage sludge can cause serious malodor problems resulting from the decomposition of organic compounds in anaerobic conditions. The malodor of sewage sludge mainly occurs due to a low carbon to nitrogen ratio (C/N), high moisture, and low temperature, which are ideal conditions for ammonia emissions. Therefore, in this study, we investigated the reduction of the odor-causing ammonia nitrogen (NH3-N) in sewage sludge by co-application of microbes and methanol (MeOH). The physico-chemical properties of the municipal sewage sludge showed that the odor was mainly caused by a higher NH3-N content (2932.2 mg L-1). Supplementation with MeOH (20%) as a carbon source in the sewage sludge significantly reduced the NH3-N up to 34.2% by increasing C/N ratio. Furthermore, the sewage sludge was treated with the NH3-N reducing and plant growth promoting (PGP) bacteria Stenotrophomonas rhizophila SRCM 116907. The treatment with S. rhizophila SRCM 116907 significantly increased the seedling vigor index of Lolium perenne (10.3%) and Chrysanthemum burbankii (42.4%). The findings demonstrate that supplementing sewage sludge with methanol significantly reduces ammonia emissions, thereby mitigating malodor problems. Overall, the study highlights the potential of using a microbial and methanol approach to improve the quality of sewage sludge as an organic fertilizer and promote sustainable agriculture.

Strength Anisotropy through Artificial Weak Plane of Mudstone (인공연약면을 따른 이암의 강도이방성에 관한 연구)

  • Lee, Young-Huy;Jeong, Ghang-Bok
    • Journal of the Korean Geotechnical Society
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    • v.24 no.11
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    • pp.111-120
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    • 2008
  • The characteristic of induced anisotropy is investigated in this study for the Pohang mudstone involving the cut plane discontinuity. The uniaxial and triaxial compression tests are performed for anisotropic rocks with artificial joint to look into anisotropic strength characteristics. Both the uniaxial compressive strength and triaxial compressive strength show the lowest value at the angle of cut plane, ${\beta}=30^{\circ}$ and the shoulder type of anisotropy is obtained. Anisotropy ratio (Rc) in uniaxial compression measures 9.0, whereas Rc=1.29-1.98 in triaxial compression is appeared. A series of analyses are made with the test results to derive the suitable parameter values when it is applied to the Ramamurthy (1985) failure criterion. The result of uniaxial compression test is analyzed by introducing the n-index into Ramamurthy failure criterion. The result shows that, n=l is suitable for ${\beta}=0^{\circ}{\sim}30^{\circ}$ and n=3 is suitable for ${\beta}=30^{\circ}{\sim}90^{\circ}$. To analyze the result of triaxial compression test by Ramamurthy failure criterion, anisotropy ratio in uniaxial compression test is added to Ramamurthy's equation and material constants are estimated by modified Ramamurthy's equation. When these values are applied back to Ramamurthy failure criterion, the predicted values are well fitted to the test results. And strength anisotropy for failure criteria of Jaeger (1960), McLamore & Gray (1967) and Hoek & Brown (1980) are also investigated.

Radiologic Features and Surgical Outcome of Juxtafacet Cyst Associated with Degenerative Lumbar Disease (퇴행성 요추 질환에서 발생한 후관절 근접 낭종의 방사선적 특징 및 수술의 결과)

  • Kim, Whoan Jeang;Chang, Shann Haw;Yang, Hwa Yeol;Kwon, Won Jo;Sung, Hwan Il;Park, Kyung Hoon;Choy, Won Sik
    • Journal of the Korean Orthopaedic Association
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    • v.52 no.1
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    • pp.65-72
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    • 2017
  • Purpose: The purpose of this study was to evaluate the radiologic features of juxtafacet cyst and determine the correlation between these features and clinical outcome. Materials and Methods: We analyzed a total of 23 patients. The degree of facet joint degeneration was classified using the Fujiwara method. The facet joint angles were measured with an magnetic resonance imaging to determine whether there was a difference between the cystic lesion that was occupied and the cystic lesion that was not occupied. Disc degeneration was measured by the Pfirrmann classification method. The clinical result was evaluated using the Oswestry disability index score and visual analogue scale. Results: The L4-5 level of juxtafacet cyst was mostly affected, as found in previous studies. Facet joint arthritis was more severe within the side with the cystic lesion. Significant correlation was found between disc degeneration and juxtafacet joint cyst. All patients underwent wide decompression and fusion. Clinical result was excellent. No patients had signs of recurrence during the follow-up periods. Conclusion: Juxtafacet cyst has a significant correlation with facet joint degeneration. Therefore, aggressive surgical treatment-not just simple cyst excision-should be considered as the treatment option for juxtafacet cyst associated with degenerative lumbar disease.