• Title/Summary/Keyword: Kyung Shin Ho

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Treadmill exercise enhances motor coordination and ameliorates Purkinje cell loss through inhibition on astrocyte activation in the cerebellum of methimazole-induced hypothyroidism rat pups

  • Shin, Mal-Soon;Kim, Bo-Kyun;Lee, Shin-Ho;Kim, Tae-Soo;Heo, Yu-Mi;Choi, Jun-Ho;Kim, Chang-Ju;Lim, Baek-Vin
    • Korean Journal of Exercise Nutrition
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    • v.16 no.2
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    • pp.73-84
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    • 2012

  • Thyroid hormones are important for the development of the brain including the cerebellum. In the present study, we investigated the effect of treadmill exercise on the survival of Purkinje neurons and the activation of astrocytes in the cerebellar vermis of hypothyroidism-induced rat pups. On the day of perinatal 14, pregnant rats were divided into two groups (n = 5 in each group): the pregnant control group and the pregnantmethimazole (MMI)-treated group. For the induction of hypothyroidism in the rat pups, MMI was added to the drinking water (0.02% wt/vol), from the day of perinatal 14 to postnatal 49. After delivery, male rat pups born from the pregnant control group were assigned to the control group. Male rat pups born from the MMI-treated group were divided into the hypothyroidism-induction group, the hypothyroidism-induction with treadmill exercise group, and the hypothyroidism-induction with thyroxine (T4) treatment group (n = 10 in each group). The rat pups in the exercise group were forced to run on a treadmill for 30 min once a day for 4 weeks, starting on postnatal day 22. In the hypothyroidism-induced rat pups, motor coordination was reduced and Purkinje cell death and reactive astrocytes in the cerebellar vermis were increased. Treadmill exercise enhanced motor coordination, increased the survival of Purkinje neurons, down-regulated reactive astrocytes, and enhanced brain-derived neurotrophic factor (BDNF) and receptor tyrosine kinase B (TrkB) expressions in the hypothyroidism-induced rat pups. These results suggest that treadmill exercise has beneficial effects in terms of protecting against thyroid dysfunction by increasing T3 and T4 and the related protein, BDNF, as well as TrkB, inhibition on astrocyte activation and the reduction of Purkinje cell loss regarding the cerebellum in hypothyroidism rat pups.

  • https://doi.org/10.5717/jenb.2012.16.2.73 인용

KMAG payload instrument of Korea Pathfinder Lunar Orbiter

  • Jin, Ho;Kim, Khan-Hyuck;Son, Derac;Lee, Seongwhan;Lee, Hyojeong;Lee, Jung-Kyu;Lee, Mangyu;Lee, Seungah;Shin, Jehyuck;Garrick-Bethell, Ian
    • The Bulletin of The Korean Astronomical Society
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    • v.42 no.2
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    • pp.89.2-89.2
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    • 2017

  • Korea Pathfinder Lunar Orbiter (KPLO) is a first Korean Lunar exploration mission. KPLO is equipped with four payloads in Korea and one payload in United States. KMAG is one of Korean payloads to measure the Moon's magnetic field. Moon has a no dipole magnetic field such as earth's global magnetic field. But there are many curious crustal magnetic anomalies. these features still do not well understood. This is a main scientific objective of KMAG payload and the study of space environment around moon is a second objective. KMAG has three magnetometers which are mounted in the edge of the 1.2 meter boom. This paper shows a KMAG's requirements, instrument description, and a preliminary function test results.

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