• Korean Journal of Radiology
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• 제1권1호
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• pp.5-10
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• 2000

Objective: To describe the neuroradiologic findings of primary antiphospholipid antibody syndrome (PAPS). Materials and Methods: During a recent two-year period, abnormally elevated antiphospholipid antibodies were detected in a total of 751 patients. In any cases in which risk factors for stroke were detected - hypertension, diabetes mellitus, hyperlipidemia, smoking, and the presence of SLE or other connective tissue diseases - PAPS was not diagnosed. Neuroradiologic studies were performed in 11 of 32 patients with PAPS. We retrospectively reviewed brain CT (n = 7), MR (n = 8), and cerebral angiography (n = 8) in 11 patients with special attention to the presence of brain parenchymal lesions and cerebral arterial or venous abnormalities. Results: CT or MR findings of PAPS included nonspecific multiple hyper-intensity foci in deep white matter on T2-weighted images (5/11), a large infarct in the territory of the middle cerebral artery (4/11), diffuse cortical atrophy (2/11), focal hemorrhage (2/11), and dural sinus thrombosis (1/11). Angiographic findings were normal (5/8) or reflected either occlusion of a large cerebral artery (2/8) or dural sinus thrombosis (1/8). Conclusion: Neuroradiologic findings of PAPS are nonspecific but in young or middle- aged adults who show the above mentioned CT or MR findings, and in whom risk factors for stroke are not present, the condition should be suspected.

• 대한임상검사과학회지
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• 제47권4호
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• pp.237-242
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• 2015

aPTT 참고치의 정상범위 내에서 하한 측 10% (29.1~30.9 sec)와 상한 측 10% (38.0~41.9 sec)에 포함된 정상성인의 혈액응고인자 활성도를 분석하여 하한 측과 상한 측간에 혈액응고인자의 종류와 각각의 활성도가 성별, 연령 및 ABO 혈액형 등에 통계학적으로 유의한 차이를 보이는지 알아보고자 하였다. 성별에 따른 혈액응고인자들의 활성도 차이를 분석한 결과 하한 측에서 IX (p=0.0088)만 남성이 여성보다 높았으며, 상한 측에서 IX (p<0.0001)와 X (p=0.0013)은 남성이 여성보다 높았다. 연령군간 혈액응고인자들의 활성도 차이 검정은 하한 측에서 VIII (p<0.0001), IX (p=0.0050)는 60세 이상이 60세 미만보다 높았으며, XII (p=0.0285)는 60세 이상보다 60세 미만이 높았다. 상한 측에서 V (p=0.0219), VIII (p=0.0005), IX (p=0.0014)는 60세 이상이 60세 미만보다 높았다. O형과 non-O형의 혈액형 구분에 의한 혈액응고인자들의 활성도 차이는 VIII (p<0.001)은 양쪽 그룹에서 non-O형이 O형보다 높았으며, XII (p=0.016)는 상한 측에서 non-O형이 O형보다 낮았다.

• 대한수의학회지
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• 제43권3호
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• pp.383-392
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• 2003

Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are important regulators on the development of maternal tissues during pregnancy. This study was performed to examine the relationship between maternal IGFs/IGFBPs system (i.e: IGF-I, II, their receptors, and IGFBPs) in pre- and post-partum rats. The liver and kidney are important organs for the synthesis of IGFs and IGFBPs in adults. The levels of materanal IGFs and IGFBPs in serum, liver, and kidney were examined at 14 and 21 days of gestation and at 3, 7, 11, and 14 days after birth. The expression of IGFs and their receptors mRNA was also examined in fetal and maternal rat liver, kidney. IGF-I concentrations in maternal serum and liver were decreased during pregnancy. However, IGF-I concentration in maternal kidney was increased, having maximal effect at 14 days of gestation. IGF-I concentrations were decreased in serum, liver, and kidney of postpartum rat, compared to control (p < 0.05). On the other hand, IGF-II concentrations in serum, liver, and kidney were increased during pregnancy (p<0.05) and gradually decreased to control level in postpartum period. The levels of IGFBP-3 and IGFBP-2 are expressed in serum, liver, and kidney. However, IGFBP-3 is mainly expressed in serum and liver, and IGFBP-2 in kidney. The levels of IGFBP-3 and IGFBP-2 in maternal serum were markedly decreased during pregnancy and gradually recovered to control level during postpartum period by western ligand blotting. However, there was no change of IGFBP-3 and IGFBP-2 levels by western immunoblotting. The levels of IGFBP-3 and IGFBP-2 in maternal liver and kidney also showed the same pattern of serum, although the main IGFBP is different. In normal rat serum, IGF-I 150 kDa and 50 kDa carrier proteins were detected. The level of IGF-I 150 kDa carrier proteins in pregnant rat was decreased compared to normal rat, but that of 50 kDa carrier proteins was increased. IGFBP-3 protease activity was identified in pregnant rat serum and maternal placenta, and it was inhibited by EDTA ($Ca^{2+}$ chelating agent) and aprotinin (serine proteinase inhibitor). Taken together, these results suggest that the changes of IGFs and IGFBPs in maternal rats are regulated by liver and kidney IGFs and their receptors mRNA during the pregnancy.

• 대한치과교정학회지
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• 제33권4호
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• pp.223-233
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• 2003

치열 공간 부조화에 영향을 미치는 골격 및 치성요소를 알아보기 위하여 하악 치열궁내 총생을 보이는 성인 45명과 공극을 보이는 성인 39명의 I급 부정교합 환자와 정상적인 배열을 갖는 성인 40명을 선정하여 측모 두부방사선사진과 모형을 분석하여 다음과 같은 결론을 얻었다. 1. 공극군보다 총생군 ANB각이 컸다 2. 공극군보다 총생군이 하악골 및 상악골의 전하방 경사가 커서 안모의 수직적 양상이 심했다. 3. 총생군보다 공극군이 전두개저와 하악체 길이가 컸다. 4. ANB 각, 전안면 고경과 하악지 길이가 공간 부조화 양의 예측에 기여하며, 다음과 같은 회귀방정식이 산출되었다. space discrepancy=46.51-2.51ANB-0.58AFH+0.65RH $(R^2=0.40)$

• The Journal of Korean Physical Therapy
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• 제17권3호
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• pp.329-338
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• 2005

The determination of peripheral nerve conduction velocity is an important part to electrodiagnosis. Its value as neurophysiologic investigative procedure has been known for many years but normal value of digital nerve was not reported in Korea. To evaluate of digital nerve conduction velocity of median nerve for obtain clinically useful reference value and compare difference in each fingers. 71 normal volunteers(age, 19-65 years; 142 hands) examined who has no history of peripheral neuropathy, diabetic mellitus, chronic renal failure, endocrine disorders, anti-cancer medicine, anti-tubercle medicine, alcoholism, trauma, radiculopathy. Nicolet Viking II was use for detected conduction velocity and amplitude of digital nerves in median nerve. Data analysis was performed using SPSS. Descriptive analysis was used for obtain mean and standard deviation, ANOVA was used to compare each fingers and independent t-test was used to compare between Rt and Lt side also compare between different in genders. Conduction velocity of the right thumb was 49.77m/sec, index finger was 56.80m/sec, middle finger was 56.15m/sec and ring finger was 53.38m/sec. The left thumb was 50.48m/sec, index finger was 56.76m/sec, middle finger was 55.99m/sec and ring finger was 53.23m/sec. Amplitude of the right thumb was $64.30{\mu}V$, index finger was $73.95{\mu}V$, middle finger was $77.97{\mu}V$ and ring finger was $43.92{\mu}V$. The left thumb was $74.21{\mu}V$, index finger was $85.72{\mu}V$, middle finger was $88.06{\mu}V$ and ring finger was $47.28{\mu}V$. There were significantly difference between thumb, index, middle and ring fingers(p<.01) but there were no statistically difference between conduction velocity and amplitude of index and middle fingers(p>.01). The conduction velocity of index finger are faster than other fingers and amplitude of middle finger are greater than other fingers. The present results revealed that electodiagnosis can easily perform in index and middle finger for digital nerve of median nerve study.

• 대한물리의학회지
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• 제18권4호
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• pp.121-131
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• 2023

PURPOSE: The purpose of this study was to evaluate the effects of ice and hot packs on proprioception, balance, and muscle strength in knee extensor muscle fatigue. METHODS: A total of 31 male and female students in their twenties from a university in A, Chungnam, Korea, were selected as participants. Three experiments were conducted to assess static balance, dynamic balance, proprioception, and muscle strength before and after induction of muscle fatigue, and following intervention. RESULTS: In the case of stability typical (ST), a significant difference was observed in pillow with eye open (PO) when a Hot pack was applied (p < .05). The weight distribution index (WDI), showed significant differences in normal eye open (NO) and Normal eye closed (NC) tests when ice packs and hot packs were applied (p < .05). In the dynamic balance assessment using Y-balance, significant differences were observed in all values except for pre- and post-intervention in the medial and lateral directions (p < .05). The recovery of proprioceptive sensation showed a significant difference when ice packs were applied (p < .05). In muscle strength, significant differences were observed in all comparisons between measurement time points (p < .05). CONCLUSION: Rest was most effective for static balance, and cold and warm compresses were most effective in recovering dynamic balance. For proprioception, cold compresses were most effective. Muscle strength had a positive effect on recovery in all three intervention methods. These results show that cold and warm compresses can be useful in the recovery of various functions related to muscle fatigue.

• Journal of Nutrition and Health
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• 제47권4호
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• pp.258-267
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• 2014

본 연구에서는 2007~2010년 국민건강영양조사에 참여한 40세 이상 남녀 중 건강설문조사, 구강검진 및 영양조사 자료가 모두 존재하는 1,690명을 대상으로 한국인에게 부족한 영양소인 칼슘 및 리보플라빈, 그리고 칼슘과 리보플라빈의 주요급원식품인 우유 및 유제품 섭취량과 치주염과의 연관성을 파악하고자 하였다. 통계분석은 SAS 9.3 프로그램을 이용하여 분석하였고, 다음과 같은 결과를 얻었다. 1) 인구 사회학적, 건강 관련, 신체계측 변수와 치주질환과의 상관성을 분석한 결과 여성의 경우 연령대가 높을수록 (p < 0.0001) 치주염 유병률이 높았으며, 치주염군에서 평균연령 (p < 0.0001)과 체질량지수 (p < 0.0001)가 높았으나 남성의 경우 이와 같은 차이가 없었다. 남녀 모두 교육수준이 낮을수록 (p < 0.0001), 월평균 소득수준이 낮을수록 (남성 p < 0.0001, 여성 p = 0.0044) 비흡연자에 비해 흡연자에서 (남성 p < 0.0001, 여성 p = 0.0180) 치주질환 유병률이 높았으며, 음주횟수가 많을수록 (남성 p = 0.0036, 여성 p = 0.0075) 치주질환 유병률이 높았다. 2) 남성의 경우 정상군에 비해 치주염군에서 우유 및 유제품, 칼슘 및 리보플라빈 섭취량이 낮았다. 연령, 체질량지수, 에너지 섭취량, 소득수준, 흡연상태, 음주정도의 교란변수 보정 후 우유 및 유제품 섭취를 안했을 경우에 비해 섭취하였을 경우 치주염 유병률이 감소하였으나 (p = 0.0396), 칼슘 섭취량과 치주염 유병률 간의 연관성은 유의하지 않았다 (P-trend = 0.3504). 반면 리보플라빈 섭취량의 1사분위에 비해 3사분위에서 치주염에 이환될 확률이 2.91배 감소 (OR: 0.344, 95% CI: 0.153-0.773)하였으나 섭취량 증가에 따른 치주염 간의 상관성은 일관되게 나타나지 않았으며 (P-trend = 0.0855) 리보플라빈 섭취량을 한국인 영양섭취기준의 해당 성, 연령별 권장 섭취량 기준으로 미만 섭취하였을 경우보다 이상 섭취한 경우 치주염 유병 가능성이 1.87배 감소하였다 (OR: 0.535, 95% CI: 0.300-0.954). 여성의 경우 정상군에 비해 치주염군에서 리보플라빈 섭취량이 낮게 나타났으나 (p = 0.0067) 두 군간 우유 및 유제품, 칼슘 섭취량과는 유의적인 차이가 없었으며 섭취량과 치주염 유병률 간의 연관성 분석결과 통계적으로 유의하지 않았다. 이상의 결과에서 남성의 경우 우유 및 유제품, 리보플라빈 섭취량과 치주염과의 밀접한 연관성이 있음을 알 수 있으며, 이에 따라 개별적인 구강위생관리와 함께 식이섭취의 중요성을 강조하여 치주염 예방 관리를 권고할 것을 제언한다.

• Journal of Photoscience
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• 제9권2호
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• pp.267-268
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• 2002

A vertebrate retina is an organ belonging to the central nerve system (CNS), and is usually difficult to regenerate except at an embryonic stage in life. However, certain species of urodele amphibians, such as newts and salamanders, possess the ability to regenerate a functional retina from retinal pigment epithelial (RPE) cells even as adults. After surgical removal of neural retinas from adult newt eyes, the remaining RPE cells lose their pigment granules, transdifferentiate into retinal progenitor cells, which further differentiate into various retinal neurons, and then finally reform a functional neural network. To understand the molecular mechanisms of CNS regeneration, we attempted to investigate the genes expressing in regenerating newt retina. mRNAs were isolated from regenerating retinas at 18-19 days after the surgical removal of the normal retina, and a cDNA library (regenerating retinal cDNA library) were constructed. Our EST analysis of 112 clones in the regenerating cDNA library revealed that about 70% clones are closely related to the genes previously identified. About 40% clones are housekeeping genes, and about 15% clones encode proteins related to the regulation of gene expression and to the proliferation of the cells. Sequences similar to neural retina- and RPE-specific genes were not detected at all. These results led us to suppose that the regenerating retinal cells are in a state considerably different from those of neither neural retina nor RPE cells.

• Clinical and Experimental Pediatrics
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• 제48권4호
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• pp.433-437
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• 2005

위석은 비교적 흔하지 않은 질환이지만, 진단을 못할 경우 위궤양과 출혈, 장천공, 장중첩증, 장폐쇄, 복막염 등의 심각한 합병증을 동반할 수 있는 만성적 복통의 한 원인이며, 모발석 환아의 대부분은 발모벽과 식모증의 과거력이 있다. 저자들은 내원 4년 전까지 자기 머리카락을 뽑아서 먹는 습관이 있었고, 이후 간헐적 복통과 오심, 구토를 일으킨 11세 여아에서 모발석을 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 한국전문물리치료학회지
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• 제7권2호
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• pp.88-95
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• 2000

Thirty normal adults were tested to measure the electrical activity of the anterior (AD), middle (MD), and posterior portion (PD) of the deltoid muscle and sternal portion of the pectoralis major muscle (PM) during the performance of four upper extremity PNF diagonal patterns with elbow flexion angle in $0^{\circ}$, $45^{\circ}$, and $90^{\circ}$. The PNF patterns in which these muscles function optimally have been theoretically advanced by Kabat and further described by Knott and Voss. They theorize that the MD should be most active with shoulder flexion, abduction, and external rotation (D2F); the PD with shoulder extension, abduction, and internal rotation (D1E); the AD with shoulder flexion, adduction, and external rotation (D1F); and the PM with shoulder extension, adduction and internal rotation (D2E). The patterns were performed through range of motion, with an isometric contraction performed in the shortened range. When the EMG activity of AD, MD, PD and PM in its optimal patterns was measured, it does not have significant difference among fixed elbow flexion angle $0^{\circ}$, $45^{\circ}$, and $90^{\circ}$ (p>.05). In addition, suggestions were made for study of patients who exhibit imbalance of muscle strength and have muscle weakness.