• Journal of Pharmacopuncture
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• v.9 no.2
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• pp.93-97
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• 2006

Objective : This study was to evaluate the effectiveness of Bee Venom acupuncture therapy on external epicondylitis. Methods : We divided chronic arthritis of ankle patient into 2 groups; one group combined bee venom acupuncture therapy and acupuncture therapy, another group was only acupuncture therapy. To estimate the effectiveness of treatment that applied for two groups, we used visual analog scale(VAS). We compared the VAS score of two groups statistically. Results : 1. As a result of evaluation by using visual analog scale(VAS), treatment score at final was marked more higher than score before treatment on each groups. 2. treatment at final, acupuncture and bee venom acupuncture therapy group had significant result on visual analog scale(VAS) compared with acupuncture therapy group. Conclusion : Bee Venom acupuncture therapy can be used with acupuncture therapy for highly effective treatment for external epicondylitis.

• Journal of Pharmacopuncture
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• v.9 no.2
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• pp.167-171
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• 2006

Objective : This study was to evaluate the effect of Bee venom-Acupuncture therapy on patients with sprain of the wrist. Methods : We investigated 31 cases of patients with sprain of the wrist. We flip a coin and divide patients into two groups. Bee venom-Acupuncture was performed at on group, and the other group we didn't do it. We evaluated the treatment effect of each group by using the visual analog scale(VAS). Results : 1. As a result of evaluation by using the VAS, the score after treatment was marked lower than that before treatment within each group. 2. After treatment, Bee venom-Acupuncture therapy group showed significant difference on visual analog scale(VAS) compared with acupuncture therapy group. Conclusion : These results suggested that Bee venom-Acupuncture treatment should be more effective in the patient with sprain of the Wrist joint.

• Journal of Pharmacopuncture
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• v.7 no.1 s.12
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• pp.71-75
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• 2004

Objectives : This study was conducted to establish a standard and classify suitability in the treatment of limb impediment among the children with development disabilities using bee venom and eight principles herbal acupuncture. Methods : 10 patients with pediatric development disabilities with limb impediment as the main symptoms were chosen in this study. Bee venom herbal acupuncture and eight principles herbal acupuncture treatments were rendered and evaluated responses as well as pursuing most proper treatment methods. Results : 1. Bee venom herbal acupuncture showed a significant effects when used as supplement treatment technique for the children with partial movement, but insignificant for the children whom were unable to move. 2. Bee venom was effective for severe limb impediment and limb asthenia, whileas eight principles herbal acupuncture effective for mild limb impediment and spasticity. 3. Bee venom herbal acupuncture used in conjunction with eight principles herbal acupuncture for treating limb impediment among the children with development disabilities showed general improvement by intensifying muscular strength.

• Journal of Pharmacopuncture
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• v.10 no.2 s.23
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• pp.93-98
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• 2007

Objectives : The aim of this study was to observe variation of Bee Venom content from the collection period. Methods : Content analysis of Bee Venom was rendered using HPLC method by standard melittin Results : Analyzing melittin content using HPLC, 478.97mg/g at june , 493.89mg/g at july, 468.18mg/g at August and 482.15mg/g was containing in Bee Venom at september. So the change of melittin contents was no significance from June to September. Conclusion : Above these results, we concluded carefully that collecting time was not important factor for the quality control of Bee Venom, restricted the period from June to September.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.4
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• pp.982-986
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• 2008

This study was performed to evaluate the oriental obese therapeutic effect with Sweet Bee Venom Mesotherapy on obese female patient of 53th years old with $Tae\bar{u}min$. We applied herbal medication, electrolipolysis, auricular acupuncture to her during 6 weeks. But, Body fat mass(Kg) and Percent Body Fat(%) was increased. After that, We treated with Sweet Bee Venom Mesotherapy on Chung-wan, Sang-wan, both Yang-mun, both $Ch'\bar{o}nch'\bar{u}$, both $Taeh\bar{o}ng$, both $Taeg\bar{o}$, both $Pokky\bar{o}l$, Kihae acupoint of abdomen during 5 weeks. We had a results of such as decreasing change of Body fat mass(Kg) and Percent Body Fat(%) with Body composition analyzer(Inbody 3.0, Biospace, Korea). And Subcutaneous Fat was decreased at all abdominal acupoints after Sweet Bee Venom Mesotherapy with Ultrasonography(LOGIQ200MD, USA). Therefore we have suggested that Sweet Bee Venom Mesotherapy have possibility to be utilized for oriental obese treatment.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.1
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• pp.236-242
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• 2004

Cerebral ischemia resulting from transient or permanent occlusion of cerebral arteries leads to neuronal cell death and eventually causes neurological impairments. Bee venom has been used for the treatment inflammatory disease. In the present study, the effects of bee venom on apoptosis and cell proliferation in the hippocampal dentate gyrus following transient global ischemia in gerbils were investigated using immunohistochemistry for cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), caspase-3, and 5-bromo-2'-deoxyuridine (BrdU). It was shown that apoptotic cell death and cell proliferation in the hippocampal dentate gyrus were significantly increased following transient global ischemia in gerbils and that treatment of bee venom suppressed the ischemia-induced increase in apoptosis and cell proliferation in the dentate gyrus. The present results also showed that 1 mg/kg bee-venom treatment suppressed the ischemia-induced increasing apoptosis, cell proliferation, and COX-2 expression in the dentate gyrus. It is possible that the suppression of cell proliferation is due to the reduction of apoptotic cell death by treatment of bee venom. In the present study, bee venom was shown to prosses anti-apoptotic effect in ischemic brain disease, and this protective effect of bee venom against ischemia-induced neuronal cell death is closely associated with suppression on caspase-3 expression.

• Journal of Acupuncture Research
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• v.29 no.1
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• pp.75-87
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• 2012

Objectives : The purpose of this study is to inquire into the effect of different concentrations of bee venom pharmacopuncture to inhibit genesis of pro-inflammatory cytokines and to inhibit nuclear factor (NF)-${\kappa}B$ activation on type II collagen induced arthritis. Methods : The experiment was divided into category of the normal group (NOR)-no treated group, control group (CON)-CIA (collagen induced arthritis) induced group, and 4,000 : 1 bee venom group (BV-L)- 4000:1 bee venom pharmacopuncture treated group after CIA, and 2000:1 bee venom group (BV-H)- 2,000 : 1 Bee venom pharmacopuncture treated group after CIA. RA was induced in the mice via injecting $50{\mu}{\ell}$ C II mixed CFA. The bee venom pharmacopuncture was applied on $ST_{35}$ for 19 days from the 3rd day of RA inducement. To research the effect on the expression of IKK ($I{\kappa}B$ kinase), iNOS (inducible nitric oxide synthase) & COX-2 (cyclooxygenase-2) mRNA, RT-PCR was performed on synovial membrane cells from the knee joint of CIA mice. Results : The PMA-induced $I{\kappa}B$ kinase (IKK), inducible nitric oxide synthase (iNOS) and cyclooxygenase -2 (COX-2) mRNA expression were dose-dependantly decreased in bee venom treated with synoviocytes. In mice treated with bee venom pharmacopuncture, foot thickness and the damage of synovial membranes of the joint was lessened, and the activation of RA-related pro-inflammatory cytokines such as MIF, TNF-${\alpha}$ and MMP-9 was significantly decreased. The activation of iNOS and COX-2 was suppressed by the inhibition of NF-${\kappa}B$. In addition, each data was shown that 2,000 : 1 bee venom pharmacopuncture was more effective than 4,000 : 1 bee venom pharmacopuncture. Conclusions : It is speculated that bee venom pharmacopuncture has the therapeutic effect of palliating the damage of the synovial membrane and inflammation on RA by suppressing of NF-${\kappa}B$ activation.

• Journal of Korean Medicine Rehabilitation
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• v.15 no.1
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• pp.171-180
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• 2005

Objectives : We got a good effect in two patients not by subcutaneous but by subcutaneous but by intra-articular bee venom injection treatments at traumatic arthritis of elbow joint, so report it. Methods : We used only intra-articular bee venom injection treatments at acute traumatic arthritis of elbow joint. After measured the VAS(visual analogue) and ROM(range of motion) of elbow joint, we bee venom injection effect. Results and Conclusions : The symptoms(swelling, pain) and the functions of elbow joint were quickly improved through intra-articular bee venom injection treatments. One case was improved that Rt. elbow joint flexion was increased from $60^{\circ}$ to $150^{\circ}$, extension was increased from $20^{\circ}$ to $0^{\circ}$. The other case was improved that Lt. elbow joint flexion was increased from $90^{\circ}$ to $150^{\circ}$, extension was increased from $30^{\circ}$ to $0^{\circ}$, and both were decreased in VAS. The results suggest that bee venom intra-articular injection has acute pain reduction, anti-inflammation effect.

• Journal of Korean Medicine Rehabilitation
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• v.20 no.1
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• pp.219-230
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• 2010

According to previous reports, intra-articular bee venom injection is very effective for synovitis, intra-articular lesions. In this article, we report 4 cases of well-treated meniscal tear with intra-articular bee venom injection. We used intra-articular bee venom injection on meniscal tear diagnosed by MR imaging and prescribed herbal medication, physiotherapy if necessary. Outcomes were measured by Visual Analogue Scale(VAS) and Lysholm Knee Scoring Scale. Patients who are treated by intra-articular bee venom injection had a significant effect on the pain reduction, improved range of motion and knee function. Further well-designed, controlled studies and more cases are needed to define the effect of intra-articular bee venom injection on knee.

• Journal of Acupuncture Research
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• v.19 no.4
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• pp.225-233
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• 2002

Objective : There are little report on treatment of Diffuse Idiopathic Skeletal Hyperostosis(DISH) in Traditional Korean Medicine. We suggest to treat DISH with a Korean Bee-Vonom Therapy and would like to suggest treatment plan for the further treatments. Methods : Under the assumption that Korean Bee-Venom Therapy may be affective for treatment DISH, the following points were administreted :Hua-Tuo-Jia-Ji-Xue Results : After 14 weeks of treatment-especailly Korean Bee-Venom Therapy, a remarkable improvement was made for DISH. Conclusion : Significant improvement in DISH was obtained with through Korean Bee-venom Therapy, Four needle technique, Common Acupucture Treatment and Herbal medication. Although this case yielded favorable result, more study should be made to prove the effectiveness of Korean Bee-Venom Therapy for treating DISH.