• 대한음성학회지:말소리
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• 제37호
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• pp.73-85
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• 1999

The prosodic characteristics of Korean particles in read speech were examined in this paper based on K-ToBI labeling system in order to see whether they are prosodically weak form like functions words in English. Acoustic measurements and statistical analysis were done focusing on the distribution of particles over a variety of prosodic positions, prosodic positional effects on the phonetic realization of particles, and acoustic strength of particles compared to those of their surrounding syllables. The panicles were distributed rather equally over all 4 prosodic positions with the highest frequency at IP-medial/AP-final position and the lowest at IP-medial/AP-medial position except that topic marker 'Un/nUn' showed preference for IP-final/AP-final position. There was a significant prosodic positional effect on the duration and F0 of the particles. Duration was the longest at IP-final/AP-final position and interestingly, at IP-medial/AP-medial position while F0 was the highest at IP-final/AP-medial Position as expected. The comparison of the acoustic properties of the particles with those of neighbor syllables showed that duration was generally significantly longer and energy also showed larger values, if not significant, in particles suggesting that the particles in Korean are not prosodically weaker like function words in English.

• 음성과학
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• 제12권4호
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• pp.129-139
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• 2005

This paper investigates any possible correlation between the information structure and the occurrence of clause internal pauses in the spontaneous discourse. One of the possible functions of pause is its capacity to signal the information structure of the discourse. However, this aspect was not much explored in Korean spontaneous speech. In the present study, information structure of spontaneous speech was defined for each word or word group on the basis of the information structure analysis model proposed by Van Donzel (1999) and Roulet (1991, 1997). Thus, at a local level (words or word groups) of discourse structure, a distinction was made between three types of information, new, given and inferable. The results showed that clause internal pauses tend to appear more frequently before new information than other types of information. However compared to the total number of words or word groups it was not noticed any specific ordering concerning different kind of information status and pausing. It was however found that clause internal pauses did not appear randomly. The majority of them occurred at the initial part of the clause or the sentence. This tendency was mostly related to the division of sentence (or clause) into topic and comment. Thus, the role of pauses as a marker of information structure seems to be less effective in spontaneous discourse.

• Journal of Gastric Cancer
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• 제17권4호
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• pp.319-330
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• 2017

Introduction: The extent of lymphadenectomy in the surgical treatment of gastric cancer is a topic of controversy among surgeons. This study was conducted to analyze the American National Cancer Database (NCDB) and conclude the optimal extent of lymphadenectomy for gastric adenocarcinoma. Methods: The NCDB for gastric cancer was utilized. Patients who received at least a partial gastrectomy were included. Patients with metastatic disease, unknown TNM stages, R1/R2 resection, or treated with a palliative intent were excluded. Joinpoint regression was used to identify the extent of lymphadenectomy that reflects the optimal survival. Cox regression analysis and Bayesian information criterion were used to identify significant survival predictors. Kaplan-Meier was applied to study overall survival and stage migration. Results: 40,281 patients of 168,377 met the inclusion criteria. Joinpoint analysis showed that dissection of 29 nodes provides the optimal median survival for the overall population. Regression analysis reported the cutoff ${\geq}29$ to have a better fit in the prognostic model than that of ${\geq}15$. Dissection of ${\geq}29$ nodes in the higher stages provides a comparable overall survival to the immediately lower stage. Nonetheless, the retrieval of ${\geq}15$ nodes proved to be adequate for staging without a significant stage migration compared to ${\geq}29$ nodes. Conclusion: The extent of lymphadenectomy in gastric adenocarcinoma is a marker of improved resection which reflects in a longer overall survival. Our analysis concludes that the dissection of ${\geq}15$ nodes is adequate for staging. However, the dissection of 29 nodes might be needed to provide a significantly improved survival.

• 한국발생생물학회지:발생과생식
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• 제8권1호
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• pp.1-9
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• 2004

프로테오믹스(proteomics, 단백질체학이라고도 함)의 잠재적 중요성은 간질환, 심장질환, 몇몇 종류의 암 등의 의학, 생식 독성, 발생 독성, 생체 독성 연구 분야에서도 명백하게 제시되었다. 그러나 단백질을 대상으로 연구하여 유전자 기능을 연구하는 프로테오믹스 연구를 각각의 분야에 접목시키려는 노력은 아직까지 빈약하다. 프로테오믹스는 기능을 갖는 단백질들의 발현을 종합적이고 정량적으로 측정하는 가장 직접적인 수단이고, 질병, 약물투여, 쇼크, 내분비계 장애물질 등 생물학적인 동요(perturbation)에 의하여 변하는 단백질들의 발현 양상 변화를 정확하게 관찰할 수 있게 한다. 그리고 생체내 유전자 발현의 궁극적인 양상을 규명할 수 있으며, 또한 유전자, 단백질 및 질병간의 연결고리를 제공한다. 기존의 biomarker는 다른 질병 표지자와 연관성이 높아 직접적인 biomaker와 정확한 연관을 판정하기 어렵다. 따라서 대량 발굴 탐색(high-throughput screening)이 가능한 2차원 전기 영동 분석과 MALDI-TOF또는 protein chip array와 SELDI-TOF에 의한 단백질 분자 구조 분석 기술 및 이들을 지원하는 생물정보학(bioinformatics)의 발전을 이용하여, 생식학 연구에 이용할 수 있는 표적 단백질 발굴 및 정성 정량적 연구에 적절한 이용이 가능할 것이다. 이러한 연구는 생식과정 중 배아 발생 및 조직 기관 발생 중 유전자 발현의 변화, 내분비계 장애물질 등 호르몬 및 독성 물질의 작용 기전, ecotoxicogenomics지표 marker의 변동 분석, 중간대사물질체학(metabolomics)에의 이용 등등의 연구에 필수적인 방법으로 발전할 것이다.