• 생약학회지
• /
• 제47권4호
• /
• pp.389-398
• /
• 2016

Korea, China and Japan have developed individually their own official compendia for crude drugs to tune with the times. Recent globalization has enlarged trade volume among these countries, and so the necessity for new quality standards has increased. This study was accomplished to offer basic data and appropriate suggestions to rebuilding standard principles for quality control of crude drugs in Korean official compendia. For this, seven standard items related to quality control in official compendia of these countries were compared. The items were identification, loss on drying, total ash, acid-insoluble ash, extract content, essential oil content and assay. The official compendia of three countries were the Korean Pharmacopoeia Eleventh Edition, the Korean Herbal Pharmacopoeia 2015, Chinese Pharmacopoeia 2015 and Japanese Pharmacopoeia Seventeenth Edition. Based on this basic research, new principles for each standard of crude drugs were suggested.

• 대한본초학회지
• /
• 제32권1호
• /
• pp.55-62
• /
• 2017

Objectives : Crataegi Fructus has been used as traditional medicines for more digestion action, amenorrhea due to blood stasis, and hyperlipemia. The aim of this study was to compare of Crataegi Fructus in South Korea collected during three years according to the standards in monographs of the Korean Pharmacopoeia Eleventh edition (KP 11). Methods : Crataegi Fructus was carried out identification test (Qualitative reaction, Thin layer chromatography), heavy metal test, and total ash registered at KP. Add to we tested loss on dry, contents of ethanol-soluble extracts, and HPLC profiling. Results : Identification test (TLC) was on comparing with ursolic acid standard solution in $R_f$ value, all samples showed red purple spot ($R_f$ value 0.9). Ursolic acid spot in $R_f$ value 0.35 showed by changing mobile phase condition. Heavy metals showed contents for Pb, Cd, As, and Hg range of 0.0 ~ 0.5 ppm, 0.0 ~ 0.2 ppm, 0.0 ~ 0.3 ppm, and 0.0 ~ 0.1 ppm. Loss on drying was ranged from 5.5 to 11.9 %, total ash was between the range 2.7 ~ 4.0 %. Contents of ethanol-soluble extracts was ranged from 17.8 to 44.9 %. The content of chlorogenic acid was ranged from 0.0 to 0.1 % based on the chlorogenic acid standard curve. Conclusion : We have verified the current specification standard of Crataegi Fructus and standard that is not set. We hope that it will help the standardization of Crataegi Fructus.

• 대한본초학회지
• /
• 제32권2호
• /
• pp.97-105
• /
• 2017

Objectives : Gardeniae Fructus is a ripe fruit of Gardenia jasminoides Ellis, which has been used as traditional medicines for anti-inflammatory, diuretic, antipyretic, and antibacterial activity. The aim of this study was to compare of Gardeniae Fructus in South Korea collected during three years according to the standards in monographs of the Korean Pharmacopoeia Eleventh edition (KP11). Methods : 30 items of Gardeniae Fructus from two cultivation regions were classified into dried(n=15) & steamed (n=15) and tested according to the standards in monographs of the KP11. Gardeniae Fructus was carried out identification(comparison of colors, thin layer chromatography), heavy metals, residual pesticides, total ash, and assay registered at KP11. Add to we tested loss on dry, contents of ethanol-soluble extracts, and HPLC profiling. Results : In TLC chromatogram of identification test, the spot of gardenoside and geniposide were observed at $R_f$ value of about 0.3 and 0.5. Heavy metals and residual pesticides met the requirements of the standards for all samples. The results of total ash of each samples are measured maximum 4.87 %. According to HPLC for assay, the samples contain 4.80~6.10 % of geniposide and 0.45~1.83 % of gardenoside. Conclusion : We have verified the current specification standard of Gardeniae Fructus and standard that is not set. By the results, it is proposed a new draft of loss on drying and confirmed the content of gardenoside revised. HPLC standard chromatogram of Gardeniae Fructus is proposed. We hope that it will help the standardization of Gardeniae Fructus.

• 대한본초학회지
• /
• 제32권6호
• /
• pp.17-22
• /
• 2017

Objectives : Daily Dose of Apricot Kernel in Treatise on Cold Damage Diseases is usually written in the number, sometimes in the volume. The seed coat and acute end of Apricot Kernel must be removed, so author want to know its daily dose and proportion of seed coat and acute end. Methods : Assuming dosage by editions of Treatise on Cold Damage Diseases. And comparing it with measured weight of Apricot Kernel distributed in market. Results : The number of prescriptions including Apricot Kernel is ten, and eight of that are made to decoction, two of that are made to pill prescription. And two of decoction are made by reducing and uniting prescriptions. The daily dose of six decoction are 70, 47 or 35 in numbers. The 70 Apricot Kernel except seed coat and acute end are 1/2 Sheong ($33m{\ell}$) in volume, 3 Ryang (19.5 g) in weight. Weight of Apricot Kernel the most common in market is 0.28 ~ 0.38 g. 70 Apricot Kernel are 23.10 g, seed coats of that are 1.15 g, acute ends of that are 2.43 g, 70 Apricot Kernel except seed coat and acute end is 19.5 g. So, seed coat is 5%, acute end is 10% by proportion, which is the same with it assumed based on writings. Conclusions : 70 Apricot Kernel except seed coat and acute end are 1/2 Sheong, 3 Ryang, and it is 33 mL and 19.5 g respectively. It also correspond with current market goods.