• Proceedings of the PSK Conference
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• 2000.04a
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• pp.208.2-209
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• 2000

• Korean Journal of Pharmacognosy
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• v.35 no.4 s.139
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• pp.265-270
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• 2004

The phylogenetic relationship of Polygonatum species were examined by RAPD analysis. Polygonatum Rhizoma is called 'Whang-jung', and used Polygonatum sibiricum Redoute in defined as a source plant in Korean Pharmacopoeia. Polygonati Odorati Rhizoma is called 'Wui-yu', and P. odoratum Druce var. pluriflorum Ohiwi and related species are defined is source plants in Korean Herbal Pharmacopoeia. In UPGMA analysis, Polygonum was divided into two major groups. Polygonatum sibiricum and P. stenophyllum was placed in a cluster. On the other hand, P. falcatum A. Gray was included in the other cluster comprising. P. odoratum and related species, which are used as source plants for Polygonati Odorati Rhizome.

• Korean Journal of Medicinal Crop Science
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• v.19 no.6
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• pp.407-413
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• 2011

This study was analyzed and investigated to evaluate ecological distribution of medicinal plants in Miho Stream of Korea. Totality 463 taxa of vascular plants were appeared in lower part of Miho Stream. Medicinal plants were distributed 253 taxa, which were 54.6% of the total vascular plants appeared. Medicinal plants of official drug compendium(Korean pharmacopoeia) were 85 taxa. Medicinal plants were distributed most of the forest area, and followed field surrounding, stream surrounding and paddy surrounding respectively. The distribution of life form hemicryptophyte was the most frequent. Plant community of appearing area of medicinal plants was classified into Salix koreensis, Phragmites japonica, Echinochloa crusgalli, Artemisia selengensis, Miscanthus sacchariflorus, Setaria faberii, Panicum dichotomiflorum, Bidens frondosa, Humulus japonicus, Monochoria vaginalis var. plantaginea, Eleocharis kuroguwai, Erigeron acris, Pinus densiflora, Pinus rigida, Quercus acutissima, Quercus serrata, Robinia pseudoacacia and Castanea crenata community. Medicinal plants in plant communities that occur frequently were Humulus japonicus, Corylus heterophylla and Liriope spicata.

• Korean Journal of Oriental Medicine
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• v.12 no.3 s.18
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• pp.79-90
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• 2006

This study was investigated to determine the quality monitoring of distributed materials from Glycyrrhizae Radix (26 samples), Atractylodis Rhizoma Alba (24 samples) according to storage period after $1{\sim}3$ year. We have estimated by identification, purity, loss on drying, ash, acid insoluble ash, extract content, essential oil content, assay and microbial contamination. As a result, Glycyrrhizae Radix (26 samples) were satisfied with the standard of K.P. (Korean Pharmacopoeia) and WHO's microbial contamination limit standard. In the Atractylodis Rhizoma Alba (24 samples), 2 samples were not satisfied with the standard of K.P.(Korean Pharmacopoeia) and WHO's microbial contamination limit standard. The results make practical application of the basic data for the quality control of herbal medicine in storage.

• The Journal of Korean Medicine
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• v.37 no.1
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• pp.53-61
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• 2016

Background: It has been some controversy about the interpretation of the sentence including 'Youngin Eunhyung' that was listed in the classic, Dongeui bogam (first published 1610). The purpose of this study is to demonstrate another assumption to interpretate the meaning of 'Youngin Eunhyung' in the sentence. Methods and Results: It was identified that the quotation of the original text of the sentence. The original text was Zhenglei bencao (Categorized Pharmacopoeia) (First edition in 1082) by Tang Shenwei and Shiliao bencao (Pharmacopoeia for Healing through Nutrition). (First edition in 721-739) by Meng Shen. It was found that there were the missing of five chinese characters in the sentence of Dongeui bogam, that it meant that 'to get rid of the watery pus in the anterior chamber of eyeball'. So, I understand that the meaning of the sentence is related with one of the ophthalmologic disease. All the evidence supports this assumption, including the mystery of another sentence of the 'blue dog'. Conclusions: It is concluded that the treatment using in Dongeui bogam that means to alleviate the symptom of obstruction or indistinction of the vision field was caused by hypopyon. However, further scientific research is warranted to provide to support this opinion.

• Journal of Korean Academy of Nursing
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• v.42 no.4
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• pp.568-578
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• 2012

Purpose: The purpose of this cross-sectional study was to examine current status of IT-based medication error prevention system construction and the relationships among system construction, medication error management climate and perception for system use. Methods: The participants were 124 patient safety chief managers working for 124 hospitals with over 300 beds in Korea. The characteristics of the participants, construction status and perception of systems (electric pharmacopoeia, electric drug dosage calculation system, computer-based patient safety reporting and bar-code system) and medication error management climate were measured in this study. The data were collected between June and August 2011. Descriptive statistics, partial Pearson correlation and MANCOVA were used for data analysis. Results: Electric pharmacopoeia were constructed in 67.7% of participating hospitals, computer-based patient safety reporting systems were constructed in 50.8%, electric drug dosage calculation systems were in use in 32.3%. Bar-code systems showed up the lowest construction rate at 16.1% of Korean hospitals. Higher rates of construction of IT-based medication error prevention systems resulted in greater safety and a more positive error management climate prevailed. Conclusion: The supportive strategies for improving perception for use of IT-based systems would add to system construction, and positive error management climate would be more easily promoted.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.48
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• pp.79-95
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• 2003

To clarify the botanical origins of oriental medicines which have been argued or confused for plant origins, species of original plants were investigated through the textural research for oriental medicines and the comparison of Chinese, Korean, Japanese and North Korean Pharmacopoeia. Twenty oriental medicines were studied; Angelicae Gigantis Radix, Rhei Rhizoma, Atractylodis Rhizoma Alba, Aconiti Lateralis Radix Preparata, Acanthopanacis Cortex, Osterici Radix, Cnidii Rhizoma, Saposhnikovae Radix, Magnoliae Cortex, Paeoniae Radix, Liriopis Tuber, Zanthoxyli Fructus, Achyranthis Radix, Sinomeni Caulis et Rhizoma, Polygonati Rhizoma, Cinnamomi Cortex, Visci Herba et Loranthi Ramulus, Fritillariae Thunbergii Bulbus, Pogostemonis Herba, and Curcumae Longae Radix.

• Korean Journal of Pharmacognosy
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• v.40 no.4
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• pp.309-314
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• 2009

Licorice(Glycyrrhizae Radix et Rhizoma) is recorded as the root of Glycyrrhiza uralensis Fischer or Glycyrrhiza glabra Linne or Glycyrrhiza inflata Bat.(Leguminosae) in Korean Pharmacopoeia $9^{th}$ edition (KP9) and Chinese Pharmacopoeia 2005(CP2005), Glycyrrhiza uralensis Fischer or Glycyrrhiza glabra Linne in Japanese Pharmacopoeia 2005(JP2005). It is established the content standard of Glycyrrhizin 2.5 % and liquiritin 1% in KP9 and CP2005. But, according to the reports, all Licorice species were not sufficient for content standard of liquiritin 1.0% for licorice in KP9 and CP2005. It shows different content of liquiritin among G. uralensis, G. glabra and G. inflata. Also, it was reported liquiritin, liquiritin apioside are transformed into liquiritigenin by human internal flora. Therefore, we have studied for the pre-treatment condition and analytical method of liquiritigenin; It was good efficinet in 2M HCl reflux(1 hr) for hydrolysis and in methylene chloride for solvent fractionation. And 1% acetic acid in DW(A) and acetonitrile(B) with gradient condition as a mobile phase was most effective in HPLC analytical condition. According to these experimental methods, we have anlayzed content of liquiritigenin about 77 Licorice sample. In this research, it was also examined the content of liquiritin and liquiritigenin for Glycyrrhizae Radix related growing area. According to the results, we suggested the content standard of glycyrrhizin more than 2.5%, liquiritigenin more than 0.7%(after hydrolysis) of licorice.

• YAKHAK HOEJI
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• v.59 no.3
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• pp.98-106
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• 2015

Analytical method for related substances can be categorized into two methods depending on the necessity of reference standard (RS). The analytical method of related substances with RS is fast and accurate, but it's very expensive and technically difficult to synthesize RS due to their complicated structure. Another method is using relative retention time (RRT) and relative response factor (RRF) which are already validated with RS. Validation of this method is not easy and time consuming, but once it has been developed, it can save cost and time. In this study, we developed the analytical method for related substances of fenofibrate using RRT and RRF. We validated the method by evaluating specificity, linearity, accuracy and precision according to the "Manual for Guideline Application for Validation of Analytical Procedures" of MFDS. Also, we calculated RRT and RRF between fenofibrate and fenofibrate related substances. The results of this study showed high specificity for fenofibrate and fenofibrate related substances. Correlation coefficient(r) of all substances were more than 0.99, and the recovery of fenofibrate, fenofibrate related substance I, II and III were 99.44%, 100.84%, 99.14% and 101.58%, respectively. Precision of fenofibrate and its related substances were ranged between RSD 0.29% and 0.93%. Quantification limits of fenofibrate, fenofibrate related substance I, II and III were determined to be $0.03{\mu}g/ml$, $0.05{\mu}g/ml$, $0.04{\mu}g/ml$ and $0.02{\mu}g/ml$, respectively by confirming signal to noise ratio of each chromatogram. The RRT for fenofibrate related substance I, II and III were determined to be 0.35, 0.41 and 1.34, respectively. Also, the RRF for fenofibrate related substance I, II and III were determined to be 1.28, 0.98 and 0.79, respectively. The developed method was applied to determine contents for fenofibrate related substances in commercial fenofibrate (active pharmaceutical ingredient). As a result, developed analytical methods of related substances will be used for revising the monograph of fenofibrate in Korean Pharmacopoeia revision and contribute quality control of drugs by improving cost and time consuming problem of RS.

• The Korea Journal of Herbology
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• v.25 no.4
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• pp.95-102
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• 2010

Objectives : Specifications by Processing Methods of Liriope platyphylla (LP) was not established in korea. We carried out method study for manufacture of LP. Above all, LP were purchased and were processed at four kinds. First group had hearts of swelling roots, not cut bodies(LP-A). Second group had not hearts of swelling roots, not cut bodies(LP-B). Third group had hearts of swelling roots, cut bodies(LP-C). Forth group had an aggregate of hearts of swelling roots(LP-D). Methods : We has gained losses on drying, contents of ethanol-soluble extracts, contents of water-soluble extracts and contents of spicatoside A. Results : 1. Losses on drying of all group were less than 18% that is a standard of chinese pharmacopoeia. 2. Contents of ethanol-soluble extracts at LP-C, LP-D were included more than contents of those in the other groups in significance levels. 3. Contents of water-soluble extracts at LP-A, LP-C were included more than contents of those in the other groups in significance levels. 4. Contents of spicatoside A in LP-B were included more than content of spicatoside A in the other groups in significance levels. Resultingly, standards of LP in korea were proposed compatible proposals suggested as below. 1. Losses on drying of LP were less than 15% that is less than that of chinese pharmacopoeia. 2. Form to boil in water must be cutting body with heart of swelling root. 3. Because there is no content of spicatoside A in heart of swelling root, it is not suited to purpose a index component. Conclusions : The subjects of loss on drying and form of LP to boil in water must be contained in korean pharmacopoeia. Moreover, because of much valuable LP in food and medicine, it is urgently required aspect of index component such as spicatoside B, spicatoside C, flavonoid, polysaccharide having medical actions and so on.