• The Journal of the Korea Contents Association
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• v.19 no.8
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• pp.293-302
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• 2019

The purpose of this study was to examine the reliability and validity of Stroke Impact Scale 3.0 (SIS 3.0). Here, the SIS 3.0 was completed by 154 stroke patients (mean = 62.7; standard deviation [SD] = 9.43). Construct validity was verified by analyzing the correlation between SIS 3.0 sub-domains, and convergent validity was investigated by analyzing the correlation between the Modified Barthel Index (MBI) and the Mini-Mental State Examination-Korean (K-MMSE) version. The characteristics of each item were analyzed by internal consistency and item discrimination based on the classical item theory. Construct and convergent validity were verified through this study. Although the item i included in the emotion domain showed low item discrimination, all but this item showed high discrimination. Internal consistency was also high in all sub-domains.

• Korean Journal of Clinical Pharmacy
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• v.33 no.4
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• pp.290-304
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• 2023

Background: Innovative Alzheimer's disease drugs received approval in the United States in 2021 and 2023. This study aims to assess the safety and efficacy of these novel treatments, elucidate their mechanisms of action, and compare their impact on cognitive function improvement with approved drugs. Methods: We conducted a comprehensive search of pivotal clinical studies related to Alzheimer's disease treatments in PubMed/Medline, Embase, and the Cochrane Library databases from January 1st, 2020 to December 31st, 2022. Meta-analysis was performed using RevMan 5.4 software. Results: A total of 14 studies were included in this systematic review. When compared to the placebo, the new drugs did not exhibit a statistically significant effect on MMSE (Mini-Mental State Examination) (mean difference= -0.04, 95% confidence intervals [CIs]: -0.31, 0.23, N=3662, I²=0%). However, they demonstrated a significant impact on ADAS-cog (Alzheimer's Disease Assessment Scale-Cognitive Subscale) (standardized mean difference= -0.15, 95% CIs: -0.2, -0.1, N=6710, I²=17%). When compared to the approved drugs, the new drugs showed a statistically significantly lower effect on MMSE (test for subgroup difference Chi²=23.13, N = 5870, p<0.00001) but showed only a trend of decreased efficacy on ADAS-cog (Chi²=1.16, N = 8670, p=0.28). Conclusion: New drugs yielded diverse clinical endpoint results compared to the placebo, and in comparison to existing approved drugs, they exhibited lower efficacy in improving cognitive function. The safety profile of these new drugs, as reported in clinical trials, was generally well-tolerated.

• Dementia and Neurocognitive Disorders
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• v.23 no.3
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• pp.117-126
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• 2024

Background and Purpose: The Korean-Mini Mental State Examination, 2nd edition (K-MMSE~2) was recently released. This study aimed to determine whether the K-MMSE~2: Standard Version (K-MMSE~2:SV) had the same test characteristics as the K-MMSE. Methods: A total of 1,514 healthy community-based participants aged 19 to 90 years were administered the K-MMSE~2:SV Blue Form along with the language items from the K-MMSE. The item and test characteristics and test information for the K-MMSE~2:SV and K-MMSE were compared using Item Response Theory analysis. Results: Item discriminations for the K-MMSE~2:SV and K-MMSE were above the moderate range for all items except Recall. Most of the items on the K-MMSE~2:SV and K-MMSE had item category difficulty in the very easy or easy range. The test information curve (TIC) showed that the K-MMSE~2:SV and K-MMSE provide almost the same amount of information (27.86 vs. 28.44), with both tests providing the most information at an ability level of -1.57. The generalizability (G) coefficient for the K-MMSE~2:SV and K-MMSE was 0.99. Conclusions: These results indicate that the K-MMSE~2:SV and K-MMSE are equally optimal tests for screening for mild cognitive impairment and early dementia. Given that the amount of test information provided by the two tests was almost identical, the shapes of the TICs were very similar, and the G coefficient was close to 1, we can conclude that the K-MMSE and K-MMSE~2:SV are equivalent tests.

• Therapeutic Science for Rehabilitation
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• v.11 no.2
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• pp.53-62
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• 2022

Objective : This study aimed to present basic data that could help in selecting or using evaluation tools in clinical settings. Methods : This study included 51 patients with stroke. The Cognitive Impairment Screening Test (CIST), Korean-Mini Mental State Examination, 2nd Edition (K-MMSE~2), and Clinical Dementia Rating (CDR) were used as evaluation tools. The correlation between evaluation tool scores was analyzed using Spearman's rank correlation coefficient, and the comparison of total scores between the CIST and K-MMSE~2 according to global CDR scores was analyzed using the Wilcoxon signed-rank test. Results : The correlation between the total CIST and K-MMSE~2 scores and global CDR scores was statistically significant (p<.01). The correlation between the sub-scores of the CIST and K-MMSE~2 showed a statistically significant correlation for all sub-scores (p<.01). The comparison of total scores between the CIST and K-MMSE~2 according to global CDR scores showed no statistically significant differences in all global CDR scores. Conclusion : This study showed that there was a correlation between CIST, K-MMSE~2, and CDR in patients with stroke. In the future, we hope that the results of this study will help to select or use cognitive function evaluation tools in clinical settings.

• The Journal of Korean Medicine
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• v.22 no.3
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• pp.169-178
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• 2001

After initial recovery from acute carbon monoxide (CO) intoxication, some patients occasionally undergo severe neuropsychiatric deterioration, which is called postanoxic delayed encephalopathy (sequelae). This is the clinical report about one patient, a 73-year-old man, diagnosed with delayed encephalopathy after acute CO intoxication. The symptoms of the patient were mental dysfunction including memory impairment and disorientation, abnormal behavior, incontinence and mutism. He had completely recovered after an aonxic episode, but the neurological symptoms that developed were preceded by an interval of apparent normality (the 'lucid interval'). We characterized him as suffering deficiency syndrome of the heart and prescribed for him Bokreongbosim-tang and Guipi-tang, and thereafter his symptoms were remarkably improved. For the evaluation of clinical improvement, we use the Modified Barthel Index (MBI), Canadian Neurologic Scale (CNS), and the Korean version of the Mini-Mental State Examination (K-MMSE)

• Journal of Oriental Neuropsychiatry
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• v.18 no.2
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• pp.163-171
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• 2007

Dementia is a syndrome charaterized by a decline in multiple fields of cognitive domains. This is the case of a vascular dementia patient with disorientation, memory impairment and mental disorders. The patient was treated with herb medicine, Sesimtang mixed Gujuntang. As a result of herb medication, patient’s memory and disorientation were improved and the score of K-DRS(Korea-Dementia Rating Scale) and MMSE-K(Mini-Mental State Examination-K) was ascended.

• Journal of Oriental Neuropsychiatry
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• v.16 no.2
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• pp.189-199
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• 2005

We experienced a 71year-old man who had a traumatic subdural hemorrhage as well as delirium, and whose condition was improved through oriental medical treatment. Herbal medicine Hwaeo-jeon is administered three times a day. We did Mini-Mental State Examination-Korean(MMSE-K) and Korean-Dementia Rating Scale(K-DRS). After being treated, the patient showed that symptoms of delirium(diminished or altered state of consciousness, impairment of cognitive abilities or physical function) was improved considerably. This result suggests that Hwaeo-jeon has good effects on delirium with Traumatic Subdural Hemorrhage.

• Journal of Oriental Neuropsychiatry
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• v.25 no.2
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• pp.123-132
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• 2014

Objectives: The purpose of this study was to investigate the levels of Yangseng (Traditional Health Behavior), depression, anxiety, cognitive function between the elderly women living alone and the aged in the living with family. Methods: The subjects of this study were 137 elderly women aged between 65 and 80. They were evaluated with the Tool in Measuring Yangseng (TMY), Korean Geriatric Depression Scale (KGDS), State-Trait Anxiety Inntory (STAI) and Korean of the Mini-Mental State Examination (MMES-K). Depending on whether or not they lived alone, they were divided into two groups; group living alone (L.A.) and group living with family (L.F.). Results: In TMY score, there were statistically significant differences in characteristics of Mind, Diet, Sleep and total score between L.A. (63 persons) and L.F. (74 persons). Group living alone (L.A.) had significantly higher score in KGDS and STAI compared with other group (L.F.). The values of KGDS and STAI comparing to the values of Mind, Diet, Sleep, Exercise and total score in this study resulted in negative correlations which showed statistically significant. Conclusions: Above results suggest that between L.A. and L.F, there are significant difference in physical and mental health. TMY is enough to estimate health of the aged. These results can be used for Yangseng health promoting program based on Korean traditional medicine.

• Journal of Industrial Convergence
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• v.19 no.5
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• pp.91-102
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• 2021

The purpose of this study was to systematically review about randomized controlled trials the characteristics and effect of cognitive function intervention for patient with dementia. We searched studies published from January 2010 to June 2021 in 5 databases. A total 1,104 studies were found and included 27 studies in final analysis. Methodological quality was assessment with the Cochrane's RoB(risk of bias) tool. Mini-Mental State Examination(MMSE) was the most used as the assessment tool for identifying the cognitive function. Cognitive function intervention were exercise, art, cognitive stimulation, reminiscence, music, multimodal cognitive rehabilitation, virtual reality, horticultural, computerized cognitive training, intentional snoezelen, beauty, cooking, korean traditional familiarity program. Most of the intervention except exercise 2, virtual reality 1, beauty 1 were effective in improving cognitive function. This study provided a clinical evidence for planning and implementing intervention for cognitive function intervention. In the future, various intervention studies suitable for the characteristics of dementia should be conducted by improving the quality of research methods.

• Journal of Oriental Neuropsychiatry
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• v.13 no.1
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• pp.117-125
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• 2002

Objectives: The purpose of this study was to investigate the clinical application of oriental medical therapy to a patient with memory disorders and quadriparesis caused by traffic accident. Methods: This study was carried out on a patient who was admitted to the Sangji oriental medical hospital, from January 21st in 2002 to May 2nd in 2002. We used 4 kinds of diagnosis(watching, asking, hearing, and toughing) and treated the patient with herbal medication and acupuncture therapy. Then we estimated the effect of memory disorders through MMSE-K(Mini mental State Examination-Korea) and K-DRS(Korean-Dementia Rating Scale). The numerical effect demonstrated ability of movement through range of motion. Results: Following the treatment the patient's mental state and the ability of movement improved. Conclusions: The present results suggest that oriental medical therapy has the positive effects on a patient with memory disorders and quadriparesis which were caused by traffic accident.