• Title/Summary/Keyword: Korean Medical school

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노인요양시설에 있는 노인환자의 구강실태 및 치료수요도 (Oral health status and treatment need of institutionalized elderly patients)

  • 양순봉;문홍석;한동후;이호용;정문규
    • 대한치과보철학회지
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    • 제46권5호
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    • pp.455-469
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    • 2008
  • 문제제기: 노인요양시설은 치과진료영역 가운데 가장 취약한 상태에 놓여 있고 신체적, 정신적 장애로 인해 주관적 치료요구도를 파악할 수 없는 상태지만 이에 대한 기초적인 실태조사가 전무한 상태이다. 목적: 본 연구는 노인요양시설에서 노인환자들의 치아우식증에 의한 구강실태를 조사하고, 기능치아와 보철물로 이루어진 교합단위를 분석하여 그에 따른 치과치료수요도를 분석하는데 목적이 있으며 향후 적절한 진료방향을 수립하는데 기여하고자 한다. 연구재료 및 방법: 노인요양시설에서 758명의 노인환자와 D치과의원에 내원한 212명의 65세 이상인 노인을 대상으로 2000년 국민구강건강실태조사에서 작성된 치아우식검진지침에 입각하여 구강실태조사를 시행하였다. 결과: 노인요양시설의 노인에게서 고령으로 갈수록 대조군에 비해 악화되고 있는 구강상태를 알 수 있었고 매우 높은 치료수요를 파악할 수 있었다. 고찰: 노인환자의 구강건강관리를 위해서는 무엇보다도 이들을 보살피는 간병인과 간호 인력들이 가지고 있는 구강건강의 중요성에 대한 인식을 바꾸기 위한 노력이 절실히 필요한 상황이다. 이제는 무치악 환자에게 시행되고 있는 일회성 의치사업 일변도의 복지정책방향을 보건복지부와 일선 지방자치단체에서 사후관리를 원칙으로 한 전문가에 의한 무치악 환자의 의치사업으로 강화해야 하며 유치악의 노인환자들에 대한 정기적인 치과검진을 시행하고 이동진료 및 왕진시스템이 보완된 구강건강관리 및 보존, 수복진료 형태로의 전환을 고려할 시점이라 생각된다.

인공호흡기를 부착한 급성 호흡부전 환자에서 폐병변 부위에 따른 체위적용이 동맥혈 가스분압 및 폐포동맥간 산소 분압차에 미치는 영향 (The Effect of Positioning with Mechanically Ventilatory Acute Respitatory Failure Patients on Arterial Oxygen Partial Pressure and Alveolar-arterial Oxygen tension)

  • 황희정;박혜자
    • 성인간호학회지
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    • 제12권2호
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    • pp.234-244
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    • 2000
  • It is widely recognized that manipulation of body position takes advantage of the influences of gravity for improving oxygenation. The study aims to determine the effects of positioning(supine, prone, right lateral decubitus and left lateral decubitus positions) applied to the mechanically ventilatory acute respiratory failure patients on arterial oxygen partial pressure($PaO_2$), alveolar arterial oxygen tension difference($AaDO_2$), mean aterial pressure, peak inspiratory pressure and plateau pressure. Thirty two acute respiratory failure patients admitted to the medical intensive care unit at Kangnam St. Mary's Hospital, The Catholic University of Korea from March 1997 to January 1998, were divided into three groups by radiographic evidence of unilateral or bilateral lung disease. In group 1 with dominant right lung disease were twelve subjects, group 2 with dominant left lung disease had eight subjects and group 3 had twelve subjects with bilateral lung disease. The variables were measured in 30 minutes after each position of supine, prone, good lung down lateral decubitus and sick lung down lateral decubitus position. The position order was done at random by Latin squre design. The results are as follows; 1) With group 1 patients, the $PaO_2$ in the left lateral decubitus and prone position were $126.8{\pm}30.8$ mmHg and $106.7{\pm}36.8$ mmHg, respectively(p=0.0001). 2) With group 2 patients, the $PaO_2$ in the prone and the right lateral decubitus position were $121.7{\pm}44.7$ mmHg and $118.5{\pm}31.7$ mmHg, respectively (p=0.0018). 3) With group 3 patients, the $PaO_2$ was $143.6{\pm}36.6$ mmHg in the prone position (p=0.0001). 4) With group 1 patients, the $AaDO_2$ in the left lateral decubitus and the right lateral decubitus position were $178.1{\pm}29.7$ mmHg and $233.1{\pm}24.4$ mmHg, respectively(p=0.0001). 5) With group 2 patients, the $AaDO_2$ in the prone and the left lateral decubitus postion were $184.0{\pm}39.5$ mmHg and $231.0{\pm}23.9$ mmHg, respectively(p=0.0019). 6) With group 3 patients, the $AaDO_2$ in the prone and the supine postion were $377.1{\pm}35.6$ mmHg and $435.7{\pm}13.1$ mmHg, respectively (p=0.0001). 7) There were no differences among the mean arterial pressure, peak inspiratory pressure and plateau pressure for each of the supine, prone, left lateral decubitus and right lateral decubitus position. The results suggest that oxygenation may improve in mechanically ventilatory patients with unilateral lung disease when the position is good lung dependent and prone, and patients with bilateral lung disease when the position is prone without any effects on the mean arterial pressure and airway pressure. It is suggested that body positions improve ventilation/perfusion matching and oxygenation need to be specified in patient care plans.

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물리치료 임상실습 교과내용 개선을 위한 조사연구 (The Survey for Improvement in Clinical Practice Curriculum of Physiotherapy)

  • 장수경
    • 대한물리치료과학회지
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    • 제5권3호
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    • pp.659-674
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    • 1998
  • This Study was to investigate elaborated research themes and direction through specifying the problems of clinical practice education and looking for the direction of improvement. It was in the basis of the viewpoint of the educators that professors and therapists who were the subjects of this study. Perform this study, the 15 colleges' professors and the 55 hospitals' therapists was made up questionnaire, and the data was analysing by Chi-square test and percentage. The results were as follow : ${\cdot}$ In a personal history among the general qualities, professors have little clinical practice history(l-5 years, 53.3%), and therapists have little lecture career(1-5 years, 43.6%, have no 49.0%), ${\cdot}$ The 78.6% subjects were unsatisfied of clinical practice systems. ${\cdot}$ The correlation between clinical history, school career and lecture career and the satisfaction level of clinical practice systems has no(P<.005), ${\cdot}$ The subjects were agreed to that clinical practice curriculum should be changed(67.1%), reinforced(82.9%), and specified(90.0%). ${\cdot}$ The clinical practice credits are 11 points averagely. ${\cdot}$ In the clinical practice curriculum, it made no difference in the practicum of diseases, modality, and the therapeutic techniques between professors and therapists. ${\cdot}$ The 100% professors said that the practicum of the patients' assessment is necessary, and the 63.6% therapists were training for that. ${\cdot}$ The 66.7% professors said that the practicum of the clinical psychology is necessary, and only the 20.0% therapists were training for that. ${\cdot}$ The 93.3% professors said that the practicum of the patients' management is necessary, and the 50.9% therapists were training for that. ${\cdot}$ The 66.7% professors said that the practicum of the medical ethics is necessary, and the 34.5% therapists were training for that. ${\cdot}$ The 46.7% professors said that the practicum of the hospital administration is necessary, but the 54.5% therapists have not training. ${\cdot}$ The 33.3% professors said that the practicum of the pharmacology is necessary, but the 81.8% therapists have not training. ${\cdot}$ The 86.7% professors said that the practicum of the patient's education is necessary, and the 43.6% therapists have training. ${\cdot}$ The 66.7% professors said that the practicum of the prosthesis and brace is necessary, but the 14.5% therapists have not training. ${\cdot}$ The 60.0% professors said that the practicum of the exercise prescription is necessary, but the 25.5% therapists have not training. ${\cdot}$ The 53.5% professors said that the practicum of the emergency treatment is necessary, but the 52.7% therapists have not training. ${\cdot}$ Drawing up the plan about the curriculum of clinical practice, the professors (46.7%) were agreed to national master plan framing by an expert advisor, but the therapists (58.2%) said that the plan that make the most of hospitals' characteristics should be specified. ${\cdot}$ It was found that a clinical special therapists(54.5%) was good as a person in charge of clinical practice education, in that each therapist's own good time (34.5%) was. ${\cdot}$ It made use of the form framing by college(40.0%) as the clinical practice textbook, the form framing by hospital (42.9%) and each therapist(22.9%) as the plan, and the form framing by college (74.3%) as the measurement. ${\cdot}$ The most difficult point in clinical practice education was the lacks of the theory-praciticum linkage(78.2%). ${\cdot}$ It was found that the period of clinical practice was in the second semester-third grade (40.0%) and the desirable period was in the first semester-third grade(50.0%). ${\cdot}$ Professors (53.3%) were agreed that the desirable clinical practice duration was from four months to six months(60.0%), and the therapists (60.0%) were agreed that from one month to three months. ${\cdot}$ This study presented the lacks of rearing the experts, the lacks of cultural education, and the lacks of the theory-clinical practice linkage. There were need to develop the systematic programs, clinical practice textbooks, the measurements and the special hospital for clinical practice. And it was need to reduce the gab between of the hospitals for clinical practice, to cut down the costs. and to improve the labour conditions of leaders. In view of this findings, it takes notice of that both professor and therapist were dissatisfied at the present clinical practice systems. These results point out the problems of clinical practice systems, and do not make expect to us the successive and positive clinical practice. The general, specific and intensive plan about the problems and the direction of improvement that establishing the level of hospital for clinical practice and physiotherapy can be elaborated.

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가토 측뇌실내 Nicotine 및 Muscarine의 혈압상승작용에 관하여 (Pressor Action of Intracerebroventricular Nicotine and Muscarine in the Rabbit)

  • 이충경
    • 대한약리학회지
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    • 제27권1호
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    • pp.21-31
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    • 1991
  • 미주신경절단 가토에서 니코틴성약물인 nicotine과 DMPP뿐아니라 무스카린성 약물인 muscarine과 bethanechol은 측뇌실내 투여로 모두 혈압상승작용을 나타냈다. Nicotine과 DMPP에 대한 승압반응은 측뇌실내 mecamylamine처리로 현저히 감약되었으나 측뇌실내 pirenzepine처리에 의해서는 영향받지 않았고, muscarine과 bethanechol에 대한 승압반응은 pirenzepin에 의해서는 억제되나 mecamylamine에 의해서는 영향받지 않았다. 이는 뇌내의 니코틴성 수용체 및 무스카린성 수용체가 모두 혈압상승에 관여함을 가리키고 있다. Nicotine과 muscarine에 대한 승압반응은 regitine, reserpine, enalapril, saralasin, SK&F-100273, regitine과 enalapril, regitine과 saralasin의 정맥내 처리에 의해서는 억제되지 않았으며 nicotine에 대한 승압반응은 regitine과 SK&F-100273 두약물의 병용처리에 의해서 억제되었고 muscarine에 의한 승압반응은 regitine, enalapril과 SK&F-100273의 세가지 약물의 병용처리에 의해서만 억제되었다. Nicotine이나 muscarine에 의한 혈압상승상태에서 정맥내 regitine의 투여는 혈압하강을 일으켰으나 enalapril이나 SK&F-100273은 혈압하강을 일으키지 못하였다. Enalapril은 regitine처리나 regitine과 SK&F-100273병용처리 가토에서 nicotine에 의해 상승된 혈압을 하강시키지 못하였으나 SK&F-100273은 regitine처리 가토에서 nicotine에 의한 상승된 혈압을 하강시켰다. Enalapril은 이러한 SK&F-100273의 할압하강작용을 강화시키지 못하였다. Enalapril은 regitine 처리 가토에서 muscarine에 의하여 상승된 혈압은 하강시키지 못하였으나, regitine과 SK&F-100273병용처리 가토에서 muscarine에 의해 상승된 혈압은 하강시켰다. SK&F-100273은 regitine처리 가토에서 muscarine에 의해 상승된 혈압을 하강시키지 못했으나 regitine과 enalapril병용처리 가토의 상승된 혈압은 하강시켰다. 이상의 성적은 뇌실내 nicotine에 의한 혈압상승에는 말초에서 교감신경계와 vasopressin이 관여하며 muscarine에 의한 혈압상승에는 교감신경계, vasopressin 및 angiotensin계가 관여함을 시사하고 있다. Regitine의 정상 가토 혈압하강작용은 enalapril이나 SK&F-100273의 단독처리에 의해서는 영향받지 않았으나 이 두약물을 병용처리시에는 유의하게 강화되었고, 이는 가토 동맥압의 유지에 교감신경, renin-angiotensin 및 vasopressin계가 관여함을 시사하고 있다.

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도시지역 노인들의 도구적 일상생활 수행능력(IADL)에 영향을 미치는 요인 (Factors Affecting to the Instrumental Ability of Daily Living(IADL) in the Urban Elderly)

  • 이인학;문성기;김근조;박재영
    • The Journal of Korean Physical Therapy
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    • 제14권3호
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    • pp.238-272
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    • 2002
  • This study was intended to find out the factors affecting to the IADL, allowing objective assessment of physical function status of increasing elderly populations. The subjects of 635 elderly persons aged over 65 years old who live in Taejon metropolitan city were interviewed during the two-month period from June to July of 2000. The IADL of Older American Resources and Services(OARS), developed in Duke medical college of USA, was interpreted for use. The study results were statistically processed using SPSSWIN(ver 10.0) and conferred the following results: 1. Among the seven items of IADL, the women showed higher rates of 'yes' in items about using the telephone, getting to the places out of walking distance, going shopping for groceries, taking their own medicine while outnumbered by the men only in the item about managing their own money, without significant differences between them in items about preparing their own meals and doing their own housework. 2. In terms of IADL scores, $82.0\%$ of subjects showed the normal range of scores and $18.0\%$ were under the normal range, meaning dysfunction IADL. Specifications of general characteristics revealed that more dysfunctional were the male subjects, the higher age groups who are more than 75 years old, the higher educated groups, the groups who live in nursing homes, the groups without a spouse. 3. Based on daily activities, lower scores of IADL were found in the subjects who don't go out, who don't have recreational activities, who don't attend elderly gatherings in their neighborhood, who don't hold social meetings. Specifications of psychological traits revealed that more dysfunctional were IADL in the subjects who don't feel satisfied with their lives of the past or the present, who have a deep feeling of isolation, and who don't have the will to live. 4. Among 7 items of health habits, only the subjects who don't regular exercise had lower scores of IADL than those who do. According to HPI, the lower HPI, the more dysfunctional. 5. Based on the factors associated with IADL, the odds ratio of the subjects who don't live together with their families were 1.53 times that of the ones who do, who are educated 3.22 times that of the ones who are not, who don't have spouses 2.09 times that of the ones who do, who don't go out 4.35 times that of the ones who frequently go out, who don't recreational activities for an interest 2.64 times that of the ones who do, who don't attend elderly gatherings in their neighborhood 1.47 times that of the ones who do, who don't hold social meetings 2.23 times that of the ones who do, who don't feel satisfied with their present living 1.43 times that of the ones who do, who have a feeling of isolation 1.53times that of the ones who don'1, who have the weak will to live 3.21 times that of the ones who have the strong one, and who don't regular exercise 2.45 times that of the ones who do. 6. Logistic regression analysis of the study results found that such factors are significantly related as the degree of education, with/without spouse, social meetings, the will to live, and regular exercise, and that higher rates of dysfunctional subjects were in the more educated group, in the group without spouse, in the group who don't frequently go out, who don't have social meetings, who have the weak will to live, and who don't exercise.

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흡연자에서 관상동맥 내피세포 의존성 심근 혈류 예비능: $H_2^{15}O\;PET$ 찬물자극 검사에 의한 평가 (Evaluation of Endothelium-dependent Myocardial Perfusion Reserve in Healthy Smokers; Cold Pressor Test using $H_2^{15}O\;PET$)

  • 황경훈;이동수;이병일;이재성;이호영;정준기;이명철
    • 대한핵의학회지
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    • 제38권1호
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    • pp.21-29
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    • 2004
  • 목적: 젊은 흡연자 및 비흡연자에서 찬물자극 후 심근혈류 예비능을 $H_2^{15}O\;PET$을 이용하여 측정한 후 비교함으로써 흡연에 의한 관상동맥 내피세포의 기능저하를 평가하고자 하였다. 대상 및 방법: 젊은 흡연자 9명($23.8{\pm}1.1$세; $6.6{\pm}2.5$ pack-years) 및 비흡연자 9명($23.8{\pm}2.9$세)에 대하여 안정상태 및 찬물자극 후, 그리고 아데노신 주입 중에 $H_2^{15}O$를 순간주사하고 동적 PET영상을 획득한 뒤, NMF 방법으로 입력 방사능곡선 및 조직 방사능곡선을 처리하여 심근혈류량을 산출하였다. 결과: 흡연자군 및 비흡연자군 사이에 심박수혈압곱 및 안정시 혈류량에는 유의한 차이가 없었다. 그러나, 찬물자극 자극 후에는 심근혈류가 흡연자군에서 비흡연자군에 비하여 유의하게 낮았으며(흡연자군 심근혈류 : $1.25{\pm}0.34$ ml/g/min, 비흡연자군 심근혈류=$1.59{\pm}0.29$ ml/g/min ; p=0.019), 특히 안정시 심근혈류에 대한 찬물자극 후의 심근혈류의 비(내피세포 기능에 의한 심근혈류의 예비능)도 흡연자에서 유의하게 낮았다(흡연자군=$90{\pm}24%$, 비흡연자군=$122{\pm}28%$ ; p=0.024). 한편, 아데노신 주입시의 심근혈류는 두군 간에 유의한 차이가 관찰되지 않았다(흡연자군 심근혈류=$5.81{\pm}1.99$ ml/g/min, 비흡연자군 심근혈류=$5.11{\pm}1.31$ ml/g/min ; p=NS). 결론: 젊은 흡연자에서 찬물자극 후에 $H_2^{15}O\;PET$을 이용하여 측정하여 산출한 심근혈류의 예비능이 젊은 비흡연자에 비하여 감소되어 있어서 흡연에 의한 관상동맥 내피세포의 기능장애를 확인할 수 있었다.

폐암(肺癌)의 동서의결합치료(東西醫結合治療)에 관(關)한 문헌적(文獻的) 고찰(考察) (Bibliographic Study on the Therapy of Lung Cancer by Integrated Oriental and Western Medicine)

  • 황충연
    • 대한한의학회지
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    • 제16권2호
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    • pp.177-194
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    • 1995
  • 폐암(肺癌)의 치료법(治療法)에 대해 서의치료(西醫治療) 동의치료(東醫治療) 동서의(東西醫) 결합치료(結合治療)에 대해 최근문헌(最近文獻)을 중심(中心)으로 고찰(考察)해 본 결과(結果) 다음과 같은 결론(結論)을 얻었다. 1. 폐암(肺癌)의 서의치료법(西醫治療法)은 소세포암(小細胞癌)(SCLS)과 비소세포암(非小細胞癌)(NSCLS)으로 나누어 분기(分期) 및 증상(症狀)에 따라 수술치료(手術治療) 방사선치료(放射線治療) 화학치료(化學治療)를 단독(單獨)으로 또는 두가지 이상 복합(複合)해서 활용(活用)한다. 2. 폐암(肺癌)의 동의치료(東醫治療)는 초기(初期), 중기(中氣), 말기(末期)로 나누어 부정거사(扶正祛邪), 공보겸시(功補兼施), 기혈쌍보(氣血雙補)의 치법(治法)을 쓰거나 증상(症狀)에 따라 폐비기허형(肺脾氣虛型), 폐열음허형(肺熱陰虛型), 습담어조형(濕痰瘀阻型), 기혈어체형(氣血瘀滯型), 기음양허형(氣陰兩虛型)으로 분(分)하여 변증시치(辨證施治)하거나 혹은 단미(單味) 또는 복방(復方)으로 대증치료(對證治療)를 한다. 3. 폐암(肺癌)에 대(對)한 동서의결합치료(東西醫結合治療)를 함으로써 생존율(生存率)이나 생존(生存)의 질(質)에 있어서 현저(顯著)한 향상(向上)이 있는데 수술후(手術後) 동서결합치료(東西結合治療)는 수술후(手術後) 회복력(回復力)을 촉진(促進)시키고 생존율(生存率)을 높였다. 방사선치료(放射線治療)와의 결합치료(結合治療)는 방사선치료(放射線治療)에 의한 독부작용(毒副作用)을 감소(減少)시켜 치료효과(治療效果)를 높이고 생존율(生存率)을 높였다. 화학요법(化學療法)과 동의결합치료(東醫結合治療)는 화학요법(化學療法)의 독부작용(毒副作用)을 경감(輕減)시키고 생존(生存)의 질(質)과 생존율(生存率)을 높였다. 이상(以上)의 결과(結果)로 보아 폐암(肺癌)의 치료(治療)는 진단(診斷)에서부터 치료(治療)의 전과정(全過程)을 통(通)해서 서의치료(西醫治療)와 동의치료(東醫治療)를 결합(結合)하여 종합치료(綜合治療)를 하므로써 폐암(肺癌)의 치료효과(治療效果)를 높일 수 있는 새로운 치료법(治療法)으로 계속적인 연구(硏究)가 필요(必要)할 것으로 사료(思料)된다.

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고령자의 건강의식과 물리치료 인식에 관한 연구 (A Study of Health Consciousness and Physical Therapy Cognition of Old Ages)

  • 박환진;박래준;김한수
    • The Journal of Korean Physical Therapy
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    • 제12권2호
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    • pp.175-184
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    • 2000
  • This study which applies to the 403 healthy people who don't have particular diseases recently(193 urban aged. 210 rural aged) among male and female aged over 60 years old living in Daegu(city) and Gyungbook(agricultural village) is fulfilled from November 1st to December 31st by interview using the questioned paper which researcher developed, and reached to these tallowing conclusions. 1. Every aged men independent of the place residence answered positively yes but aged women had weak assurance of their health. Especially $38.6\%$ of rural aged women said yes and $51.4\%$ of rural aged women said no. 2. In the sleep and well-regulated life, urban and rural aged generally marked on the sound sleep. Compared with male and female, men answered they had better sleep and regulated life than women. 3. The percentage of the urban and rural aged's judgement on their activity was high and the percentage of the rural aged was lower than the percentage of the urban aged. 4. While $62.6\%$ of urban aged answered they were active. $38.6\%$ of rural female aged answered yes, This shows that the rural female aged regard their health is not good. 5. Compared with same generation. urban aged ranked lower than urban aged in the confidence of physical strength. Especially rural need women answered $42.1\%$ of them were weaker than the same generation. This shows that rural aged women don't have confidence in general physical activities. 6. Taking exercises three times a week which can influence on health cue to sixties and seventies aged ranked $26.1\%$, rarely do is $18.8\%$ and never do is$28.8\%$. Urban and rural aged do not exercise on the purpose of health. 7. The reason of exercise was to advance the physical strength and quality of motion$(34.9\%)$ to get rid of stress$(13.4\%)$ and to prevention of adult illness$(27.8\%)$, prevention of fatness$(15.3\%)$. Aged have a correct understanding that exercise can promote health and protect from the diseases of adult people because the items about the diseases of adult people was marked high. 8. Among the subject of total investigation, 209 persons answered. It showed necessary to recognize that the exercise is still important essential part between adult illness and health care. 9. The $67.7\%$ of urban aged men answered yes in the question of undergoing a physical examination but the rate of not undergoing a physical examination was high in rural aged and urban aged women. According to this, there were the difference of consciousness about health between urban and rural aged. and men and women. 10. Among the people who haying undergone the physical examination, $80.3\%$ of the aged went back to the hospital again because of the result. 11. In the case of stroke, most aged answered the would be placed under medical care. but $53.9\%$ of rural aged women answered they would rely on Chinese medicine. According to this. aged preferred Chinese medicine in some particular diseases. 2. The $58.1\%$ of whole object of this study answered that stroke would be recovered.

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화살나무 물 추출물의 구성성분과 생리활성 (Components and Biological Activity of Aqueous Extract Isolated from Winged Stem of Euonymus alatus)

  • 오봉윤;황수경;정미영;신홍식;박복희;이정호;김수현
    • 한국식품과학회지
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    • 제37권6호
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    • pp.898-904
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    • 2005
  • 본 연구는 화살나무의 줄기와 날개를 열수 추출하여 분자량 크기별로 네 분획(F I. F II, F III, F IV)으로 분리하여 각 분획물의 성분조성을 분석하였고, 이들 각 분획물의 생리활성을 알아보기 위해 DPPH를 이용한 유리 라디칼 소거능과 동물 세포에서 활성산소종 제거능에 대하여 조사하였다. 열수 추출물의 정성반응 결과, 네 분획물 모두 대부분 탄수화물이었고, 소량의 단백질을 함유하였으며, 일부 분획물에는 소량의 페놀 화합물 및 유기산이 함유되어 있었다. 주요 구성 성분인 총당과 총단백질 함량은 448mg/g과 21mg/g이었으며, 총 당의 함량은 F III가 가장 높았고, F IV, F II 및 F I의 순서였다. 네 분획물을 가수분해하여 이들의 구성당을 분석한 결과, 중성당은 mannose : fucose : galactose : glucose가 0.01 : 0.02 : 0.14 : 0.83의 비율로, 아미노당은 galactosamine : glucosamine이 0.01 : 0.99의 비율로 구성되어 있었으며, 전체 구성당 함량에서 중성당 : 아미노당의 비율은 0.94 : 0.04로 조성된 다당체였다. 분획물별로 총단백질과 구성 아미노산은 F IV가 가장 높았으며, F III, F II 및 F I의 순서로 함유하였다. 조 추출물에 함유된 아미노산의 종류와 양은 Glu>Asp>Pro>Gly>Leu>Val>Ser>Ala>Thr>Ile>Phe>Cys>His>Arg>Met>Lys>Try>Trp>Cys2의 순서로 19종의 아미노산이 분석되었으며, 특히 산성 아미노산과 중성 아미노산 함량이 높았다. 네 분획물을 각 농도별로 처리하여 DPPH 유리 라디칼 소거능을 조사한 결과는 $50-1,000{\mu}g/mL$ 처리했을 때 농도에 비례하여 네 분획물 모두에서 F IV, F III, F II 및 F I의 순서로 활성을 나타냈다. CHO-k1 동물 세포에서 활성산소종 제거능을 조사한 결과는, 분획물을 $1-100{\mu}g/mL$까지 처리한 농도에 비례하여 활성이 상승되는 것으로 나타났으나 $100{\mu}/mL$ 이상의 처리농도에서는 거의 변화를 보이지 않았다. 각 분획물별로 F IV이 가장 높은 활성을 보였으며, 그 다음 F III, F I이었으며, F II은 가장 낮은 활성을 나타냈다. 화살나무 열수 추출물 중에는 항산화능과 활성산소종 제거능을 나타내는 물질이 여러 가지 있을 것으로 추정되지만 분자량 크기별로 분획한 네 분획물의 정색반응과 성분조성을 조사한 결과, 주요 구성성분은 단백질이 결합되어 있을 가능성이 높으며, DPPH 유리 라디칼 소거능과 CHO-k1의 세포에서 활성산소종 제거능의 생리활성을 나타내는 다당체(bioactive carbohydrate)일 것으로 사료된다.

동적시력(KVA)과 동적 입체시의 비교 평가 (The Comparative Assessment of the KVA and Dynamic Stereoacuity)

  • 김영청;심현석;김상현
    • 한국안광학회지
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    • 제19권4호
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    • pp.519-525
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    • 2014
  • 목적: 본 연구는 동적시력(kinetic visual acuity, KVA)과 동적 입체시(dynamic visual acuity)를 측정하여 그 상관성과 양안의 굴절부등이 KVA, 동적 입체시와 상관성이 있는지를 조사하였다. 방법: 성인 남녀 63명(남30, 여33)을 대상으로 굴절이상자는 완전교정 후 KVA 측정장치(KOWA AS-4A)와 Howard-Dolman Test(하워드-돌먼 입체검사, H-D Test)를 2.5 m 검사거리로 하여 KVA와 동적 입체시를 각각 측정하였다. 결과: KVA는 전체 평균 $0.49{\pm}0.25$, 남자 $0.58{\pm}0.26$, 여자 $0.40{\pm}0.22$이였고, LogMAD(Log minimum angle of displacement)동적 입체시는 전체 평균 $1.27{\pm}0.44$($28.44{\pm}25.03$초), 남자 $1.28{\pm}0.44$($28.23{\pm}23.34$초), 여자 $1.27{\pm}0.45$($28.63{\pm}26.83$초)로 KVA는 남녀 간에 통계적으로 유의한 차이를 보였으나(p=0.00) 동적 입체시는 유의한 차이가 없었고(p=0.97), KVA와 동적 입체시 사이의 상관성은 크지 않았다(r=0.03). KVA를 크기에 따라 Low, Middle, High로 구분하였을 때 세 그룹간의 동적 입체시도 유의한 차이는 없었다(p=0.99). 양안의 굴절부등의 양을 1 D미만과 1 D이상 두 그룹으로 구분하였을 때 KVA와 동적 입체시는 각각 유의한 차이를 보이지 않았고(p=0.11, p=0.09), 굴절부등과 KVA(r=0.33), 동적 입체시 (r=0.18)의 각각 상관성도 크지는 않았으나 동적 입체시보다 KVA가 굴절부등과 상관성이 좀 더 큰 것으로 나타났다. 결론: 성인 남녀의 KVA는 남녀 간에 유의한 차이를 보였고, 남자가 여자보다 KVA가 더 높았으며, KVA의 크기에 따른 동적 입체시, 굴절부등에 따른 KVA와 동적 입체시는 각각 유의한 차이를 보이지 않았고 상관성도 크지 않았다.