• Pediatric Infection and Vaccine
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• 제20권3호
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• pp.139-146
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• 2013

목적: 한국은 2000년에 소아마비 무발생국가로 공인되었으며, WHO의 권고에 의해 2005년부터는 경구용소아마비 생백신 대신 주사용 사백신을 사용하기 시작했다. 본 연구는 2006년부터 국내에서 사용되기 시작한 주사용 소아마비 백신(Poliorix$^{TM}$)의 안전성 및 이상반응을 우리나라 영아들을 대상으로 알아보고자 한다. 방법: 2006년부터 2012년까지 6년 동안 다기관공동연구로 조사하였으며, 2, 4, 6개월의 기초접종과 4-6세의 추가 접종 후 7일 이내 및 31일 이내의 이상반응 및 안전성에 대해 조사하였다. 결과: 총 639명 중 등록대상자 중 617명은 기초접종, 22명은 추가접종을 실시하였으며, 639명 중 73명(11.4%)에서 명시되지 않은 이상반응을 보고하였으며, 이중 가장 많은 증상은 상기도 감염증상으로 접종 후 7일 이내에 639명 중 16명(2.5%)에서 보고되었다. 1명에서 grade 3 이상의 장염증상을 보고하였으며, 11명(1.7%)에서 중대한 이상반응을 보고하였으나, 이들은 모두 연구 종료 이전에 호전되었다. 결론: 6년 동안의 시판 후 조사에서, 건강한 우리나라 영아들을 대상으로 한 주사용 소아마비 사백신(Poliorix$^{TM}$) 접종은 국내 건강한 소아에서 안전하고 내약성이 충분하였다.

• 구강회복응용과학지
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• 제25권1호
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• pp.73-82
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• 2009

인산칼슘시멘트(calcium phosphate cement)는 우수한 생체친화성 및 골전도성을 가지고 있어 골이식재로 많이 사용되어 왔다. 인산칼슘시멘트의 중요한 물성 중 하나인 흐름성은 유변학적 성질을 측정하여 확인할 수 있지만, 인산칼슘시멘트의 유변학적 성질에 관한 연구는 많이 진행되어 있지 않다. 이 실험의 목적은 인산칼슘시멘트를 hydroxyprophyl methylcellulose (HPMC) 수용액 및 polyacrylic acid (PAA) 수용액과 각각 혼합하여 주사용 인산칼슘시멘트를 만들고, 각각의 용액의 농도(35%와 17.5%의 HPMC, 2%와 1%의 PAA)와 온도($25^{\circ}C$ and $37^{\circ}C$)가 유변학적 성질에 미치는 영향을 연구하기 위한 것이다. 실험에 사용된 인산칼슘시멘트는 dicalcium phosphate dihydrate (DCPD)이며 유변학적 성질은 자동화된 rheometer를 사용하여 측정하였다. 통계분석은 Mann-whitney test를 사용하였다. 높은 농도의 경화액과 혼합된 인산칼슘시멘트는 (35% HPMC와 2% PAA)는 낮은 농도의 경화액과 혼합된 인산칼슘시멘트 (17.5% HPMC와 1% PAA)보다 각각 유의성 있게 높은 점도를 보였다. HPMC 수용액과 혼합된 인산칼슘시멘트는 $37^{\circ}C$에서 $25^{\circ}C$보다 유의성 있게 높은 점도를 보였다. PAA 수용액과 혼합된 인산칼슘시멘트는 $37^{\circ}C$에서 $25^{\circ}C$보다 낮은 점도를 보였으나 통계적 유의성은 없었다. 또한 실험에 사용된 모든 종류의 인산칼슘시멘트는 의사가소성(pseudoplastic)을 보였다.

• 디지털융복합연구
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• 제14권1호
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• pp.327-338
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• 2016

본 연구의 목적은 이상지질혈증군과 정상군을 구분하여 한국인 남녀에서 이상지질혈증 발생과 건강생활 실천의 영향을 파악하기 위함이다. 연구대상은 제5기(2010년~2012년) 국민건강영양조사에서 공개된 제3차년도(2012년) 자료 중에서 건강 설문 자료를 분석대상으로 하였으며, 대상자는 우리나라의 질병 발생 양상 및 의료 환경 등을 고려해 만든 한국지질 동맥경화학회(KSLA: Korean Society of Lipidology and Atherosclerosis, 2009)의 이상지질혈증 치료지침을 적용하여 만 19세 이상 이상지질혈증군 2,092명(남자 1,042명, 여자 1,050명)과 정상군 1,944명(남자 740명, 여자 1,204명)인 4,036명이었다. 본 연구는 SPSS 18.0 프로그램을 이용하여 서술적 통계의 t-test와 ${\chi}^2-test$, 로지스틱 회귀분석을 사용하였다. 본 연구의 결과를 토대로 이상지질혈증 관련 건강생활 실천 프로그램은 혈청 지질 농도에 차이를 보이고 있는 한국인 남녀의 특성을 고려하여 적용하여야 하며, 이를 위해 지속적인 연구 및 건강생활 실천의 효과를 적용한 체계적인 국가 차원의 맞춤교육이 필요하다고 사료된다.

• Pediatric Infection and Vaccine
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• 제22권3호
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• pp.136-142
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• 2015

대한소아감염학회는 2015년 우리나라에서 처음으로 중동호흡기증후군(Middle East Respiratory Syndrome, MERS, 메르스) 환자가 발생하여 보건의료 응급 상황 발생의 긴박했던 시기에 이에 대한 대처에 참여하였다. 우리 학회는 메르스 발생 시 학회 홈페이지에 관련 공고문을 즉시 게시하였고 소아청소년에서의 메르스 환자의 발생시 의심 환자의 검사와 진단 및 국민안심병원 운영을 위해 소아청소년 MERS (중동호흡기) 검사 지침, 국민안심병원 소아청소년과 운영지침을 발빠르게 배포하였다. 이는 메르스 의심환자에 대한 접근에서 소아청소년에서 흔한 호흡기 질환 환자들이 메르스로 오인되어 불필요한 공포, 검사 및 격리를 당하지 않도록 하기 위함이었다. 이를 통해 소아청소년 환자를 진료하는 의사들과 이들의 보호자들을 안심시켰고 결국 많은 심리적 공포와 의료 비용을 감소시켰으며 메르스 종식 시 돌이켜보니 이는 결국 적절한 조치와 가이드라인이었음이 증명되었다. 앞으로 대한소아감염학회와 회원이 유관기관과 긴밀한 협조와 소통을 할 수 있는 체계 시스템을 구축해야 하며 상급의료기관의 소아청소년 감염전문의 필수 상주 및 이에 의한 감염관리료 제도 장착과 수가 신설 및 개선을 유도하는 등의 추진이 필요하다.

• 대한간호학회지
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• 제22권4호
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• pp.636-652
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• 1992

This study identified the impact of childhood cancer on the Korean family. The purpose was to contribute knowledge for family nursing and pediatric hospice care practice with sick children and their families. This descriptive study was conducted during a 6 month period with children who were being treated for cancer at six university hospitals in Seoul. The data were gathered from members of 68 families ; 24(Group A), with a child newly diagnosed with cancer : 27(Group B), with a child under treatment and without complications, and 17 (Group C), with a child in relapse. Medical records, structured questionnaires and interviews were used for data collection. The questionnaires and interview schedules had been used previously in Martinson's research in the USA and China. The findings, conclusions, and suggestions are as follows. 1. The impact of childhood cancer on the family. Members of the family experienced fear, helplessness, guilty feelings, and anger at the time of the initial diagnosis and at relapse. Mothers complained of headache, anorexia and poor appetite, weight loss, sleep disturbance, and bad dreams. Many of the fathers either lost or changed jobs, and all working mothers stopped working. Half the parents reported changes in their marital relationships such as frequent quarrels but also stronger unity. Family members perceived cancer as the most frightening disease. Change in their world view was expressed as living on faith understanding suffering, determining to live a better life, wanting to live an upright life and valuing health as the most important. Religious activities are found most helpful through this difficult experience. Financial debt due to the treatment and care of the sick child, burdened 22 families. The above mentioned impact was most evidant in Group B(those presently undergoing treatment) and Group C(those in relapse). Findings indicate that nursing care should embrace the family of a child who is being treated for cancer. 2. Characteristics of the child with cancer The majority of the children in this sample had a diagnosis of leukemia. Their mean age was 6.8 and the ratio of boys to girls was 1.12 ; 1. The mean hospitalization frequency was 13.5 times and the mean duration of illness was 16.8 months. Most of 1.he children perceived cancer as the most frightening disease ; 32.7% of the children described their sickness as serious. Children in Group C were hospitalized more frequently, stayed in hospital for longer periods, and expressed their sickness as quite serious more often than the other two groups. These findings indicate how much comprehensive pediatric hospice nursing care services are needed along with relevant research and nursing education. 3. Characteristics of the families. The mean age of the father was 39.5 and the mother, 36,6 ; they are in their most productive life period. Mothers especially expressed feelings of financial uneasiness and powerlessness about giving up their jobs, and guilty feelings for not providing enough care and concern to other children due to taking care of the sick one. The burden of caring for the sick child can bring negative changes in family dynamics which they think provoke potential health problems in members of the family These findings suggest a need for nursing support and counselling resources. Findings also suggest the need for ethical inquiry about such questions as who should give information to the child in regard to diagnosis and prognosis, when, and how. Other suggestions included : 1) Quality health care for childhood cancer such as home care and pediatric hospice programs should be established. 2) Special and practical consideration for long-term patients should be made in the present insurance coverage. The reimbursement period for long-term patients should be lengthened. 3) Further in-depth qualitative studies are needed. 4) Education programs including guided practice experience for pediatric hospice care practitioners are needed.

• Annals of Clinical Neurophysiology
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• 제12권1호
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• pp.21-26
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• 2010

Background: Although quantitative sensory test (QST) is being used with increasing frequency for measuring sensory thresholds in clinical practice and epidemiologic studies, there has been no age-matched normative data in Korean adults. The objective of this study is to evaluate the value of QST in diabetic polyneuropathy with normal range in Korean adults. Methods: The Computer Aided Sensory Examination IV 4,2 (WR Medical Electronics Co., Stillwater, Minnesota, U.S.A.), with 4,2,1 stepping algorithm was used to determine vibration and cold perception threshold in 70 normal controls and 19 patients with diabetic polyneuropathy aged from 21 to 79 years. The data were used to define age-matched upper and lower normal limits and normal range of side to side difference. We also evaluated the duration of diabetes, serum HbA1C level, and findings of nerve conduction study (NCS) and QST in patients with diabetic polyneuropathy. Results: In normal adults, sensory thresholds slightly increased with age, and a slight side-to-side difference was observed. The diagnostic sensitivity of QST was not higher than NCS in patients with diabetic polyneuropathy (36.8% vs. 42.1%, p=0.716), especially among elderly patients. Conclusions: QST might be used as a complementary test for NCS in the diagnosis of diabetic polyneuropathy. Although the QST is a simple method for the evaluation of peripheral nerve function, there are some limitations. Most of all, because the QST measuring is dependent on the subjective response of patients, the degree of concentration and cooperation of the patients can significantly affect the result. And thus, attention should be paid during the interpretation of QST results in patients with peripheral neuropathy.

• 한국건강관리협회지
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• 제2권1호
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• pp.1-8
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• 2004

Background : Since 2001 the Korean Association of Health Promotion has attempted to establish her own reference valves that can be used in her all fifteen branch laboratories instead of using those adapted from the published data or there commended data by the reagent companies supplied as inserts. However, the previous two reference values derived from the statistics(year 2001 and 2002) were need to adjust to apply to actual practice. Besides there was an unavoidable situation that the reagent has to be changed to other companies in 2002 that creates another statistical problem. Subsequently, the third attempt to derive the reference ranges of tests in KAHP to solve those problems and define common)v acceptable reference ranges was done and and reported here. Methods : Al1 the results performed during January 2, 2003 through September 30, 2003 were collected in Excel tile format. All the data include dthe necessary information such as age and sex. The age was grouped in six; baby(0-3y), children(4-l2y), adolescent(13-l8y), adult(19-S4y), younger elderly (65-79y),old elderly(oyer 80y), with references of statistics in medical informatics and WHO classification. The data were statistically analyzed with SAS 6.04 for-Gaussian distribution as the previous two occasions. None of the tests showed Gaussian distribution. These procedures had been repeated twice or three times after trimming out the results lying outside three standard deviations. Though, all the tests showed non-Gaussian distribution. Subsequently, the reference ranges were defined in the range from the point of lower 2.5% to the point of higher 97.5 %. And in case the lower range could be "0", the reference ranges were defined in the range of 0 to 95%.Results : The reference ranges of most of 56 test items were newly assigned. Also with adaptation of the recommendation of WHO etc. on fasting blood sugar, hemoglobin, cholesterol. Among these there were eight tests that needed reference ranges by the age groups and nine tests by the sex. Conclusions : The third attempt will credit more the reference range of all15 laboratories of Korean Association of Health Promotion, which will be essential part of the better service to the patient and clients to visit KAHP.

• Nutrition Research and Practice
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• 제14권2호
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• pp.102-108
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• 2020

BACKGROUND/OBJECTIVES: In Oriental medicine, certain foods may be beneficial or detrimental based on an individual's constitution; however, the scientific basis for this theory is insufficient. The purpose of this study was to investigate the effect of body constitution, based on the Sasang type of Korean traditional medical classification system, on the bioavailability of soy isoflavones of Cheonggukjang, a quick-fermented soybean paste. SUBJECTS/METHODS: A pilot study was conducted on 48 healthy Korean men to evaluate the bioavailability of isoflavone after ingestion of food based on constitution types classified by the Sasang typology. The participants were classified into the Taeeumin (TE; n = 15), Soyangin (SY; n = 15), and Soeumin (SE; n = 18) groups. Each participant ingested 50 g of Cheonggukjang per 60 kg body weight. Thereafter, blood was collected, and the soy isoflavone metabolites were analyzed by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Ntrikinetic analysis of individual isoflavone-derived metabolites was performed. RESULTS: Our nutrikinetic analysis identified 21 metabolites derived from isoflavones in the blood samples from 48 healthy Korean men (age range, 21-29 years). Significant differences were observed in the time to maximum concentration (T_max) and elimination half-life (t_1/2) for nine metabolites among the three groups. The T_max and t_1/2 of the nine metabolites were higher in the SE group than in the other groups. Moreover, the absorption rates, as determined by the area under the plasma-level curve (AUC) values of intact isoflavone, were 5.3 and 9.4 times higher in the TE group than in the SY and SE groups, respectively. Additionally, the highest AUC values for phase I and II metabolites were observed in the TE group. CONCLUSIONS: These findings indicate that isoflavone bioavailability, following Cheonggukjang insgestion, is high in individuals with the TE constitution, and relatively lower in those with the SE and SY constitutions.

• 한국비블리아학회지
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• 제27권4호
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• pp.105-123
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• 2016

본 연구는 영국, 미국, 우리나라에서 많이 사용되는 독서치료 도서목록에 수록된 성인 대상 독서치료용 도서의 스펙트럼을 분석한다. 영미권 독서치료 도서목록이 독서치료를 주관하는 기관이나 단체에 따라 구성상의 다양성을 보이는 것에 비해 우리나라의 성인용 독서치료 도서는 주관 기관에 따른 차이 없이 논픽션이 압도적인 비중을 차지한다. 세부적인 카테고리에서 영미권 대학 및 공공기관의 독서치료 추천도서목록에서 가장 높은 순위를 차지하는 논픽션 도서는 의학 서적을 포함하는 "건강, 운동, 다이어트" 관련 도서이며, 이것은 이들 기관에서 독서치료가 임상적 치료 효과가 있는 어느 정도 전문적인 영역으로 인정받고 있음을 보여준다. 반면에 우리나라의 독서치료 도서목록에 수록된 도서들은 인문(심리), 자기계발, 문학(에세이) 등 이른바 "자기계발 이데올로기와 결합한 심리학 서적"이 60% 이상을 차지한다. 연구자는 독서치료가 정신의학, 심리학, 문헌정보학, 인문학적 배경을 바탕으로 하는 학제적 실천이라는 인식 하에, 독서치료가 인문학적 통찰에 의존함으로써, 참자가들에게 단순히 책을 읽고 문제적 상황이나 증상 이전의 상태를 회복하게 하는 것이 아니라 삶과 세계에 대한 깊은 성찰을 통하여 내적으로 성숙한 인간으로 변모하는 데 도움을 주어야 한다고 제안한다.

• 한국한의학연구원논문집
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• 제9권1호
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• pp.35-50
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• 2003

In Korean traditional medicine, there are 4 major diagnoses. They are 'Mang (Watching)', 'Mun (Listening)', 'Mun (Asking)', and 'Jeul (Touching)'. These ways are closely related to each other. Among the four, 'Jeul' is the most famous one because it is the final way of checking the pulse for the cure. Pulse checking has been used as an essential way of diagnosis, but there are some difficulties in doing so in the business matter. To overcome these problems the theories should be studied profoundly and heterogeneously. More importantly, these endeavors must be pursued on the basis that pulse-checking must be. done along with other diagnostic ways to diagnose more precisely and practically. Therefore, I want to study and analyze the pragmatic ways to help the business field. Wang Suk-Hua(王叔和) arranged the methods and theories of 'pulse-checking' that was used before Nea-kyung. The book is called Maek-kyung. But this is too complicated to use in the field. As a result Maek-kyul(脈訣) which is made of songs that help to memorize and practice was gain more popularity than the ${\lceil}$Maekkyung(脈經)${\rfloor}$ itself. But the songs are so simple and compact that the offsprings annotated this book again and made books consist of these annotations. Among these books ${\lceil}$Chandobangronmaekkyulgipsung(纂圖方論脈訣集成)${\rfloor}$(1349) which was written in Won(元) dynasty was imported to Cho-sun(Korea) and used as the most important book on pulse-checking. So I will study ${\lceil}$Maekkyul(脈訣)${\rfloor}$ which contains the essence of ${\lceil}$Chandobangronmaekkyulgipsung(纂圖方論脈訣集成)${\rfloor}$. And I will also study ${\lceil}$Dojumaekkyul(圖註脈訣)${\rfloor}$ and ${\lceil}$Maekkyulyouhae(脈結乳解)${\rfloor}$ as conference. The former, written by Jang-sae-hyun(張世賢), contains narrative paintings and prescriptions according to pulses. And the latter, written by Wang Bang-bu(王邦傅), contains criticism of earlies annotations along with his own theory. ${\lceil}$Chandobangronmaekkyulgipsung(纂圖方論脈訣集成)${\rfloor}$ was chosen as a text book of medical examination according to ${\lceil}$Kyungkukdaejun(經國大典)${\rfloor}$ and had been used during Cho-sun, dynasty after closely corrected by Heo Jun(許浚). It means, during Cho-sun Dynasty, everyone who wants to become doctor had studied pulse-checking through this book, and also means Cho-sun medicine emphasizes practicality. This book and the pulse-checking part of ${\lceil}$Dongeibogam(東醫寶鑑)${\rfloor}$, which published later, made the main frame of pulse-checking during Cho'sun Dynasty. As above, studing ${\lceil}$Chandobangronmaekkyulgipsung(纂圖方論脈訣集成)${\rfloor}$ which was major textbook of pulse-checking in Cho-sun, helps to study pulse checking itself as an important way of diagnosis in Korean traditional medicine. And more than that it helps us to understand. the. practical development of pulse-checking dyring Cho-sun dynasty. With these reasons I studied ${\lceil}$Chandobangronmaekkyulgipsung(纂圖方論脈訣集成)${\rfloor}$ conferring ${\lceil}$Dojumaekkyul(圖註脈訣)${\rfloor}$ and ${\lceil}$Maekkyulyouhae(脈結乳解)${\rfloor}$ to understand ${\lceil}$Maekyung(脈經)${\rfloor}$ which is practical book of pulse-checking. During so I got some achievements and I report it as. follows.