• Annals of Geriatric Medicine and Research
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• v.22 no.4
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• pp.159-166
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• 2018

The Korean Geriatrics Society was founded on October 3, 1968. Over the 50 years since then, the Society has incessantly strived to stay attuned to the aging society and to achieve an increasingly greater research impact in the field of gerontology and geriatric medicine. The Society has passed through periods of preparation for a leap forward, followed by rapid growth, expansion, and maturity. As a result, the Society has gained a firm foothold at home and abroad as a leading research society for both qualitative and quantitative achievements in geriatric medicine. At this juncture, with an ultra-aging society being just around the corner, we are celebrating its 50th anniversary and anticipating our second half-century with great enthusiasm about our mission and role as a leading geriatric research organization.

• The Journal of Korean Academic Society of Nursing Education
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• v.10 no.1
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• pp.7-19
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• 2004

This study has a purpose to devise an education program in relation to Gerontology and geriatrics applicable to Korean nurses through literature review and analysis of education programs utilized by the Geriatric Education Centers (GECs) of USA. Educational contents on gerontology and geriatrics are very diverse in precedent literatures. The education programs of GECs for health care personnel are equally very diverse. Among educational contents, subjects considered important are age-related changes, health problems of the aged, pharmacology, death, fall and osteoporosis, delirium, dementia, depression, urinary incontinence, communication with elderly. Methods used in education program are mainly seminar, workshop and lecture through internet. In addition, case study, small-group discussion and conference are also adopted. The program proposed in this study for nurses in relation to gerontology and geriatrics consists of 32 hours' education; 6 hours for age-related changes, 10 hours for health problems of the elderly, 14 hours for health problems in old age and 2 hours of communication technique. Educational method proposed is to utilize lecture through internet, direct education, workshop, practical exercise, case study and role play in parallel. This study proposed an education program on the basis of precedent literature and the program of GECs. Therefore, it is desirable to develop in the future more practical education program applicable to and required in practicing fields. Of course, this development needs to be based on nurses' educational needs by field in relation to gerontology and geriatrics.

• Korean Institute of Interior Design Journal
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• v.18 no.5
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• pp.183-190
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• 2009

Increase in the elderly population has given rise to various social problems throughout Korean society, and what is more, although the greater demand of medical treatment, its development is still in its early stages. Given that Specialized Geriatrics Hospital has stood amid a range of spatial complication and it should faithfully reflect the needs of elderly population, we need a better understanding of Specialized Geriatrics Hospital. This study suggested the foundation to plan of Specialized Geriatrics Hospital through analyzing and evaluating spatial configuration of Specialized Geriatrics Hospital by "Space Syntax" and "J-Graph" The study focused on Specialized Geriatric Hospitals existing in Korea which owned more than 100 beds. The result of this study is summarized as follows; First, the rate of separated convex showed that the portions of the Treatment of outpatients and Supply have increased, but onthe other hand the portion of the The ward has been on the decrease. Second, in the case of Treatment of outpatients, it was structured Tree-shaped and the Tree-shaped could be separated with two types: waiting room and wailing room with lounge. in the case of The ward, it was structured Tree-shaped and also Ring-shaped. The more recently opened Geriatrics Hospital, the closer to Ring-shaped. Third, the access to the Ccentral treatment was low though the access to the core of the each floor was high. Fourth, in the progress of intelligibility, the fact that its value has decreased is becoming a serious problem of medical development for the elderly population finally, according to J-graph's analysis, the hallway made the spatial depth of rooms and public space more deepened. This caused by scattered arrangement of public spaces. As the only planning were considered in this study, It therefore needs more diversified approaches considering physical factors such like real distance and area.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.2
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• pp.103-111
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• 2019

The study is to investigate effects of andrographolide on experimental autoimmune myocarditis (EAM). Lewis rats were immunized on day 0 with porcine cardiac myosin to establish EAM. The EAM rats were treated with either andrographolide (25, 50, 100 mg/kg/day) or vehicle for 21 days. An antigen-specific splenocytes proliferation assay was performed by using the cells from control rats immunized with cardiac myosin. Survival rates, myocardial pathology and myocardial functional parameters (left ventricle end-diastolic pressure, ${\pm}dP/dt$ and left ventricular internal dimension) of EAM rats received andrographolide were significantly improved. Andrographolide treatment caused an decrease in the infiltration of $CD3^+$ and $CD14^+$ positive cells in myocardial tissue. Moreover, andrographolide treatment caused a reduction in the plasma levels of tumor necrosis factor-alpha, interleukin-17 (IL-17) and myosin-antibody, and an increase in the level of IL-10 in EAM rats. Oral administration of andrographolide resulted in the decreased expression of p-PI3K, p-Akt without any change of PI3K and Akt. Further results indicate andrographolide significantly inhibited myosin-induced proliferation in splenocytes, and this effect was inhibited by co-treatment of SC79 (Akt activator). Our data indicate andrographolide inhibits development of EAM, and this beneficial effect may be due to powerful anti-inflammatory activity and inhibitory effect on PI3K/Akt pathway.

• Proceedings of the Ginseng society Conference
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• 1998.06a
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• pp.312-321
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• 1998

We used the saponin Rgi extracted from Panax ginseng to study its effects on lymphocytes of 10 young and 19 elderly persons. The proliferate response of Iymphocytes cocultured for 72h with PHA and saponin was measured by using MTT method and the'H-TdR incorporation procedure. PHA and Rgl had stimulative effects on the phenotype of Iymphocytes (p<0.001). Rgl also increased the fluidity of lymphocyte membrane of the aged (p<0.001). The CD2s and CDfsRA positive cells of Iymphocytes in the elderly were lower than those of the young people,8.6clo $\pm$ 2.7olo vs 10.43% : 3.5%, 20.95% $\pm$ 15.5clQ vs 50.86% :4.3olo, respectively. More CDfsRO positive cell lymphocy populations were seen in the aged. The CEfsRO positive cells of the young people were 39.63% $\pm$ 3.2%. We discussed the cause of declined immune function of Lymphocytes of aged person and the mechanism of the effect of P. ginseng on Lymphocytes. Key words: Saponin, Lymphocytes, Aged person, Stimulatory effect, and Panax ginseng

• Proceedings of the Ginseng society Conference
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• 1980.09a
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• pp.137-141
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• 1980

• Journal of dental hygiene science
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• v.9 no.3
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• pp.303-310
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• 2009

The purpose of this study was to evaluated for its validity and assessment of oral health impact profile 14 as a tool for evaluating of life related with oral health status for the ADL inpatients in geriatrics hospital and as a basic data for establishing geriatric oral health policies. The sample of this study consisted of 120 in ADL inpatients in geriatrics hospital in Pusan and Ulsan city, through face-to-face interviews of sample extraction method. In conclusion, the analysis results of the short OHIP14 forms have an effect on necessity of cure, filled teeth and current oral stale, spouse, intension. Through this results, OHIP14 could be used as an indicator to measure the quality of life related with oral health status for the ADL inpatients in geriatrics hospital as well as elderly general people.

• Journal of Microbiology and Biotechnology
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• v.24 no.7
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• pp.998-1003
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• 2014

Aspartate aminotransferase (AST; E.C. 2.6.1.1), a vitamin B6-dependent enzyme, preferentially promotes the mutual transformation of aspartate and ${\alpha}$-ketoglutarate to oxaloacetate and glutamate. It plays a key role in amino acid metabolism and has been widely recommended as a biomarker of liver and heart damage. Our study aimed to evaluate the extensive preparation of AST and its application in quality control in clinical laboratories. We describe a scheme to express and purify the 6His-AST fusion protein. An optimized sequence coding AST was synthesized and transformed into Escherichia coli BL21 (DE3) strain for protein expression. Ideally, the fusion protein has a volumetric productivity achieving 900 mg/l cultures. After affinity chromatography, the enzyme activity of purified AST reached 150,000 U/L. Commutability assessment between the engineered AST and standard AST from Roche suggested that the engineered AST was the better candidate for the reference material. Moreover, the AST showed high stability during long-term storage at $-20^{\circ}C$. In conclusion, the highly soluble 6His-tagged AST can become a convenient tool for supplying a much better and cheaper standard or reference material for the clinical laboratory.

• Journal of Ginseng Research
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• v.47 no.4
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• pp.506-514
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• 2023

Dementia has become one of the most important diseases threatening human health. Alzheimer's disease (AD) and vascular dementia (VaD) have the highest incidence rates among the types of dementia, but until now, therapeutic methods have been limited. Panax ginseng has been used in China for thousands of years to treat dementia, and modern medical studies have found that it contains multiple active components, such as ginsenosides, polysaccharides, amino acids, volatile oils and polyacetylenes, many of which have therapeutic effects in treating AD and VaD. Studies have found that ginsenosides have multitarget therapeutic effects in treating dementia, such as regulation of synaptic plasticity and the cholinergic system, inhibition of Aβ aggravation and tau hyperphosphorylation, anti-neuroinflammation, anti-oxidation effects and anti-apoptosis effects. Other active components of Panax ginseng, such as gintonin, oligosaccharides, polysaccharides and ginseng proteins, also have therapeutic effects on AD and VaD. The effectiveness of ginseng-containing Chinese medicine compounds has also been confirmed by clinical and basic investigations in treating AD and VaD. In this review, we summarized the potential therapeutic effects and related mechanisms of Panax ginseng in treating AD and VaD to provide some examples for further studies.

• 대한약리학회:학술대회논문집
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• 2006.10a
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• pp.89.1-89.1
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• 2006