• Archives of Pharmacal Research
• /
• 제13권3호
• /
• pp.282-284
• /
• 1990

By saponification and extraction of corn oil foots abandoned as waste during oil refining, a mixture of phytosterols was obtained, and its major components were determined as .betha.-sitosterol, campesterol and stigmasterol by gas chromatographic analysis. The mixture is very cheap and regarded as an excellent substrate for direct fermentation of C-17 keto steroid intermediate for various steroid pharmaceuticals.

• 한국고분자학회지:고분자과학과기술
• /
• 제16권5호
• /
• pp.613-618
• /
• 2005

• Bulletin of the Korean Chemical Society
• /
• 제29권6호
• /
• pp.1103-1104
• /
• 2008

• 대한설비공학회:학술대회논문집
• /
• 대한설비공학회 2007년도 하계학술발표대회 논문집
• /
• pp.50-50
• /
• 2007

• 한국고분자학회지:고분자과학과기술
• /
• 제16권1호
• /
• pp.20-28
• /
• 2005

• Bulletin of the Korean Chemical Society
• /
• 제26권7호
• /
• pp.1079-1082
• /
• 2005

The purpose of this study was to develop a method for increasing the solubility of paclitaxel in water to reduce its toxicity and make the drug more feasible for chemotherapy. A series of highly water soluble paclitaxel polyethylene glycol (PEG) esters were synthesized and evaluated for their anti-tumor activity and toxicity. The solubility of 7-polyethylene glycol paclitaxel carbonate 5 was 840 mg/mL and the acute toxicity ($LD_{50}$) was 286 mg/kg. Because of its reduced toxicity, compound 5 showed a dramatic reduction of tumor volume without any loss of animals in long-term treatment (daily consecutive injections for 15 days).

• 한국미생물·생명공학회지
• /
• 제16권5호
• /
• pp.398-401
• /
• 1988

$\beta$-lactamase을 저해하는 물질을 생성하는 방선균의 일균주를 토양에서 분리하였다. 분리된 균으로부터 $\beta$-lactamase 저해물질을 생산하는 조건을 검토하였고, 아울러 배양액에서부터 동 물질을 분리정제하여 그 특성의 일부를 조사하였다. 그 결과 이 물질은 $\beta$-lactam ring을 가지고 있지 않았으며, $\beta$-lactam 항생물질에 대한 내성을 나타내는 E. coli 내성균주에 강한 항생력을 나타냄을 알았다.

• 한국고분자학회지:고분자과학과기술
• /
• 제4권6호
• /
• pp.470-476
• /
• 1993

• 대한설비공학회:학술대회논문집
• /
• 대한설비공학회 2004년도 하계학술발표 논문집
• /
• pp.239-239
• /
• 2004

• 한국고분자학회지:고분자과학과기술
• /
• 제4권5호
• /
• pp.352-357
• /
• 1993