• Title/Summary/Keyword: Kolon

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Extraction and Determination of Phytosterols from Corn Oil Foots

  • Kim, Sang-Ho;Park, Sang-Hoo;Ahn, Byung-Goo;Yi, Jeong-Sang;Park, Moo-Sin;Lee, Byeong-Ryong;Kim, Kweon
    • Archives of Pharmacal Research
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    • v.13 no.3
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    • pp.282-284
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    • 1990

  • By saponification and extraction of corn oil foots abandoned as waste during oil refining, a mixture of phytosterols was obtained, and its major components were determined as .betha.-sitosterol, campesterol and stigmasterol by gas chromatographic analysis. The mixture is very cheap and regarded as an excellent substrate for direct fermentation of C-17 keto steroid intermediate for various steroid pharmaceuticals.

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Anti-tumor Activity of Paclitaxel Prodrug Conjugated with Polyethylene Glycol

  • Lee, Keyong-Ho;Chung, Yong-Jun;Kim, Youn-Chul;Song, Seog-Jeong
    • Bulletin of the Korean Chemical Society
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    • v.26 no.7
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    • pp.1079-1082
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    • 2005

  • The purpose of this study was to develop a method for increasing the solubility of paclitaxel in water to reduce its toxicity and make the drug more feasible for chemotherapy. A series of highly water soluble paclitaxel polyethylene glycol (PEG) esters were synthesized and evaluated for their anti-tumor activity and toxicity. The solubility of 7-polyethylene glycol paclitaxel carbonate 5 was 840 mg/mL and the acute toxicity ($LD_{50}$) was 286 mg/kg. Because of its reduced toxicity, compound 5 showed a dramatic reduction of tumor volume without any loss of animals in long-term treatment (daily consecutive injections for 15 days).

  • https://doi.org/10.5012/bkcs.2005.26.7.1079 인용 PDF KSCI

Characters of $\beta$-Lactamase Inhibitor Produced by Streptomyces sp. (방선균의 일주가 생성하는 $\beta$-Lactamase Inhibitor의 특성)

  • Kim, J.C.;Kwirk, M.Y.;Lee, J.S.;Lee, H.S.
    • Microbiology and Biotechnology Letters
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    • v.16 no.5
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    • pp.398-401
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    • 1988

  • Streptomyces sp. producing $\beta$-lactamase inhibitor were isolated from soil. The culture conditions for the production of the $\beta$-lactamase inhibitor were evaluated and isolation produce of the $\beta$-lactamase inhibitor from the culture broth was also established. Some characters of the partially purified $\beta$-lactamase were determined.

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