• 대한한방내과학회지
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• 제39권6호
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• pp.1105-1115
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• 2018

Objectives: The aim of this review is to investigate clinical studies on Oriental medicine treatment for aphasia after cerebrovascular disease. Methods: Using the keywords 'Aphasia', 'Oriental medicine', 'Stroke' 'Cerebral infarction', 'Cerebral hemorrhage', and 'Clinic', we searched domestic databases, including "NDSL (National Discovery for Science Leaders)", "Korean Traditional Knowledge Portal", "OASIS (Oriental Medicine Advanced Searching Integrated System)", and "RISS (Research Information Sharing Service)". Each keyword was not searched individually, but combined in various ways. To investigate recent trends, we limited our search to papers published after 2000. Papers that did not include a specific treatment method or did not match the subject "Aphasia after stroke" were excluded. Results: Using the searching method, 13 studies were found. Of these, 12 studies were in the form of case reports, while one was in the form of a non-randomized controlled trial. These studies showed positive results for the use of Oriental medicine in terms of the Korean version of the Western Aphasia Battery (K-WAB), the evaluation form on functional performance capability and accuracy of articulatory organs developed by Lee, aphasia screening test refered in 'Assessment in Speech-Language Pathology' and adapted properly to Korean, the Communicative Ability in Daily Living Test (CADLT), the Korean Version-Boston Naming Test (K-BNT), and language assessment items included in CNS, and NIHSS. Conclusions: Of the 12 case reports, 11 studies showed positive results of the use of Oriental medicine for treatment of aphasia after cerebrovascular disease. However, more sophisticated and large-scale clinical research on aphasia should be conducted.

• The Korean Journal of Physiology and Pharmacology
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• 제23권4호
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• pp.231-236
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• 2019

In drug discovery or preclinical stages of development, potency parameters such as $IC_{50}$, $K_i$, or $K_d$ in vitro have been routinely used to predict the parameters of efficacious exposure (AUC, $C_{min}$, etc.) in humans. However, to our knowledge, the fundamental assumption that the potency in vitro is correlated with the efficacious concentration in vivo in humans has not been investigated extensively. Thus, the present review examined this assumption by comparing a wide range of published pharmacokinetic (PK) and potency data. If the drug potency in vitro and its in vivo effectiveness in humans are well correlated, the steady-state average unbound concentrations in humans [$C_{u_-ss.avg}=f_u{\cdot}F{\cdot}Dose/(CL{\cdot}{\tau})=f_u{\cdot}AUCss/{\tau}$] after treatment with approved dosage regimens should be higher than, or at least comparable to, the potency parameters assessed in vitro. We reviewed the ratios of $C_{u_-ss.avg}$/potency in vitro for a total of 54 drug entities (13 major therapeutic classes) using the dosage, PK, and in vitro potency reported in the published literature. For 54 drugs, the $C_{u_-ss.avg}$/in vitro potency ratios were < 1 for 38 (69%) and < 0.1 for 22 (34%) drugs. When the ratios were plotted against $f_u$ (unbound fraction), "ratio < 1" was predominant for drugs with high protein binding (90% of drugs with $f_u{\leq}5%$; i.e., 28 of 31 drugs). Thus, predicting the in vivo efficacious unbound concentrations in humans using only in vitro potency data and $f_u$ should be avoided, especially for molecules with high protein binding.

• International Journal of Computer Science & Network Security
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• 제22권12호
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• pp.185-196
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• 2022

The Internet of Things (IoT) has become more and more widespread in recent years, thus attackers are placing greater emphasis on IoT environments. The IoT connects a large number of smart devices via wired and wireless networks that incorporate sensors or actuators in order to produce and share meaningful information. Attackers employed IoT devices as bots to assault the target server; however, because of their resource limitations, these devices are easily infected with IoT malware. The Distributed Denial of Service (DDoS) is one of the many security problems that might arise in an IoT context. DDOS attempt involves flooding a target server with irrelevant requests in an effort to disrupt it fully or partially. This worst practice blocks the legitimate user requests from being processed. We explored an intelligent intrusion detection system (IIDS) using a particular sort of machine learning, such as Artificial Neural Networks, (ANN) in order to handle and mitigate this type of cyber-attacks. In this research paper Feed-Forward Neural Network (FNN) is tested for detecting the DDOS attacks using a modified version of the KDD Cup 99 dataset. The aim of this paper is to determine the performance of the most effective and efficient Back-propagation algorithms among several algorithms and check the potential capability of ANN- based network model as a classifier to counteract the cyber-attacks in IoT environments. We have found that except Gradient Descent with Momentum Algorithm, the success rate obtained by the other three optimized and effective Back- Propagation algorithms is above 99.00%. The experimental findings showed that the accuracy rate of the proposed method using ANN is satisfactory.

• 정보보호학회논문지
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• 제33권2호
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• pp.281-293
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• 2023

산업제어시스템의 특성에 대한 공격자들의 이해 증가와 더불어 정보 기술과의 연결성이 확대되면서 산업제어시스템을 대상으로 하는 보안사고가 증가하고 있다. 이와 관련된 취약점의 수는 매년 급증하고 있지만, 모든 취약점에 대해 적시의 패치를 수행하는 것은 어렵다. 현재 취약점 패치의 기준으로 여겨지는 공통 취약점 평가체계는 취약점이 발견된 후의 무기화를 고려하고 있지않다는 한계점을 지니고 있다. 따라서 본 연구에서는 운영 기술 및 산업제어시스템 내 발생 취약점 정보가 포함된 공개 정보를 기반으로 시간의 흐름에 따라 변화하는 공격자의 기술 수준을 분류하기 위한 기준을 정의한다. 또한 해당 속성을 기존 심각도 점수 산출에 반영하여 취약점의 실제 위험성과 긴급성이 반영된 심각도를 평가하는 방안을 제안하고자 한다. 해당 평가 방안의 시계열적 특성 반영 및 운영기술 및 산업제어시스템 환경에서의 유효성을 확인하기 위해 실제 사고에 활용된 취약점에 기반한 사례연구를 수행하였다.

• Journal of Positioning, Navigation, and Timing
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• 제12권4호
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• pp.437-445
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• 2023

A space system refers to a network of sensors, ground systems, and space-craft operating in space. The security of space systems relies on information systems and networks that support the design, launch, and operation of space missions. Characteristics of space operations, including command and control (C2) between space-craft (including satellites) and ground communication, also depend on wireless frequency and communication channels. Attackers can potentially engage in malicious activities such as destruction, disruption, and degradation of systems, networks, communication channels, and space operations. These malicious cyber activities include sensor spoofing, system damage, denial of service attacks, jamming of unauthorized commands, and injection of malicious code. Such activities ultimately lead to a decrease in the lifespan and functionality of space systems, and may result in damage to space-craft and, lead to loss of control. The Cybersecurity Adversarial Tactics, Techniques, and Common Knowledge (ATT&CK) matrix, proposed by Massachusetts Institute of Technology Research and Engineering (MITRE), consists of the following stages: Reconnaissance, Resource Development, Initial Access, Execution, Persistence, Privilege Escalation, Defense Evasion, Credential Access, Discovery, Lateral Movement, Collection, Command & Control, Exfiltration, and Impact. This paper identifies cybersecurity activities in space systems and satellite navigation systems through the National Institute of Standards and Technology (NIST)'s standard documents, former U.S. President Trump's executive orders, and presents risk management activities. This paper also explores cybersecurity's tactics attack techniques within the context of space systems (space-craft) by referencing the Sparta ATT&CK Matrix. In this paper, security threats in space systems analyzed, focusing on the cybersecurity attack tactics, techniques, and countermeasures of space-craft presented by Space Attack Research and Tactic Analysis (SPARTA). Through this study, cybersecurity attack tactics, techniques, and countermeasures existing in space-craft are identified, and an understanding of the direction of application in the design and implementation of safe small satellites is provided.

• 천문학논총
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• 제38권3호
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• pp.125-145
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• 2023

This study investigates the integration of astronomy-related topics in the Korean national science curricula spanning from 1945 to 2023. We analyze the placement and extent of astronomy content across different school levels. Astronomy contents in the science curricula have changed in response to social needs (e.g., practical knowledge required for agriculture and fishery) and advancement in astronomical research (e.g., the discovery of exoplanets and the suggestion of new cosmological parameters). Contents addressing the motions of celestial objects and stellar physical properties have remained relatively consistent. In the latest 2022 revised national curriculum, scheduled for implementation in 2024, several elements, such as coordinate systems, have been removed, while the inquiry activities using digital tools are emphasized. The incorporation of the cosmic perspectives in the national curriculum, as well as astronomy education within the context of education for sustainable development, remains limited even in the most recent curriculum. For future life revisions, the active participation of researchers is needed to reflect the latest astronomical research progress and scientific characteristics in the field of astronomy.

• Asian-Australasian Journal of Animal Sciences
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• 제14권5호
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• pp.720-732
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• 2001

Skeletal muscle is of major economic importance since it is finally converted to meat for consumers. The increase in meat production with low costs of production may be achieved by optimizing muscle growth, whereas a high meat quality requires, among other factors, the optimization of intramuscular glycogen and fat stores. Thus, research in energy metabolism aims at controling muscle metabolism, but also liver and adipose tissue metabolism in order to optimize energy partitioning in favour of muscles. Liver is characterized by high anabolic and catabolic rates. Metabolic enzymes are regulated by nutrients through short-term regulation of their activities and long-term regulation of expression of their genes. Consequences of liver metabolic regulation on energy supply to muscles may affect protein deposition (and hence growth) as well as intramuscular energy stores. Adipose tissues are important body reserves of triglycerides, which result from the balance between lipogenesis and lipolysis. Both processes depend on the feeding level and on the nature of nutrients, which indirectly affect energy delivery to muscles. In muscles, the regulation of rate-limiting nutrient transporters, of metabolic enzyme activities and of ATP production, as well as the interactions between nutrients affect free energy availability for muscle growth and modify muscle metabolic characteristics which determine meat quality. The growth of tissues and organs, the number and the characteristics of muscle fibers depend, for a great part, on early events during the fetal life. They include variations in quantitative and qualitative nutrient supply to the fetus, and hence in maternal nutrition. During the postnatal life, muscle growth and characteristics are affected by the age and the genetic type of the animals, the feeding level and the diet composition. The latter determines the nature of available nutrients and the rate of nutrient delivery to tissues, thereby regulating metabolism. Physical activity at pasture also favours the orientation of muscle metabolism, towards the oxidative type. Consequently, breeding systems may be of a great importance during the postnatal life. Research is now directed towards the determination of individual tissue and organ energy requirements, a better knowledge of nutrient partitioning between and within organs and tissues. The discovery of new molecules (e. g. leptin), of new molecular mechanisms and of more powerful techniques (DNA chips) will help to achieve these objectives. The integration of the different levels of knowledge will finally allow scientists to formulate new types of diets adapted to sustain a production of high quality meat with lower costs of production.

• 정보처리학회논문지D
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• 제10D권3호
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• pp.447-458
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• 2003

기존의 데이터 마이닝 방법들은 기본적으로 지식 발견의 대상이 되는 데이터 집합이 마이닝 작업 시작 이전에 명확히 정의되는 것으로 가정하며 이러한 가정은 고정적으로 정의된 특정 데이터 집합에 내재된 정보 추출이 데이터 마이닝의 목적이 될 때 유효하다. 또한, 기존의 데이터 마이닝 방법들은 대용량의 데이터 집합에 대한 마이닝 결과를 얻는데 있어서 상당한 처리 시간을 요구한다. 따라서, 새로운 트랜잭션 데이터가 지속적으로 추가되는 데이터 스트림에서 추가된 트랜잭션의 정보들을 포함하는 최신의 마이닝 결과를 최대한 빠른 시간 안에 얻기를 기대하는 실시간 처리 환경에서는 기존의 데이터 마이닝 방법을 적용하는 것이 거의 불가능하다. 이러한 목적에 부합하기 위해서 본 논문에서는 새로운 데이터 마이닝 개념인 개방 데이터 마이닝을 제안한다. 개방 데이터 마이닝에서는 새로운 트랜잭션이 발생함에 따라 이전에 발생한 트랜잭션들에 대한 마이닝 결과가 새롭게 갱신되며 따라서 확장된 전체 트랜잭션 집합에 대한 마이닝 결과를 빠르게 얻을 수 있다. 이러한 방법을 효과적으로 구현하기 위해서는 새롭게 출현한 항목에 대한 지연추가와 이전 데이터 집합에 출현한 항목들 중에서 중요하지 않는 항목에 대한 전지작업이 병행되어야 한다. 논문에서 제안하는 알고리즘은 알고리즘의 특성을 파악하기 위한 일련의 다양한 실험을 통해서 검증된다.

• 한방재활의학과학회지
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• 제23권3호
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• pp.69-78
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• 2013

Objectives The purpose of this study was to investigate the effectiveness of the Gongjin-dan (Gongchen-dan, here in after GJD) in order to obtain the evidence for clinical application. Methods The GJD-related articles published from 1990 to 2013 were searched using "Korean Traditional Knowledge Portal", "Oriental Medicine Advanced Searching Integrated System (OASIS)", "Korean Association of Medical Journal Edition (Koreamed)", "Research Information Services (RISS4U)", "Korean Medicine Database (KMbase)", "National Discovery for Science Leader (NDSL)", "PubMed", "China National Knowledge Infrastructure (CNKI)". The search keywords were "Gongjin-dan", "Gongchen-dan". Thirty-nine articles were obtained. After excluding the eighteen article which did not meet inclusion criteria, finally twenty-one articles were included; five clinical articles and sixteen experimental articles. Results In clinical studies, GJD has the various effectiveness in cardiovascular diseases, alcoholic hepatitis, mild dementia, anemia. Also experimental studies related to the GJD show a variety of effects, such as anti-oxidative activity, neuroprotective activity, hepatoprotective activity, anti-inflammatory activity, immunological activity, reproductive recovery activity with fewer side-effects. Conclusions It has been suggested that there are various effects of GJD in treating a wide-range disease. However, in order to put GJD to use for many kinds of diseases in more reasonable ways, it is needed to publish well-design clinical trial based on the variety of results of experimental studies.

• 한국철학논집
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• 제27호
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• pp.197-222
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• 2009

강유위는 근대 중국 변법파의 대표적 인물로 동서고금을 가로지르는 그의 학문적 열정과 구세정신(救世精神)은 다양한 영역에서 괄목할 만한 성과를 만들어 냈다. 특히 전통을 비판적으로 수용하는 과정 속에서 그가 무기로 삼았던 서양 근대과학은 전통 '천도(天道)' 관념을 비판하는 데 매우 효과적이었으며, 이를 기초로 발전시킨 변화관과 연화(演化)사상은 그가 궁극적으로 추구하는 '대동사회(大同社會)'를 그려내는 데 막대한 영향을 미쳤다. 그는 서양의 근대 과학과 학술에 대해 강렬한 지적(知的) 욕구를 가지고 있었지만 체계적인 서학(西學) 교육을 받지 못했기에 여러 한계를 드러냈다. 그럼에도 불구하고 그의 사상역정은 양무운동 시기의 "기물(器物)"적 과학인식 태도를 벗어나 보편적 가치 체계로서 과학을 인식할 수 있는 계기를 마련했다는 점에서 매우 중요한 의의가 있다 강유위(康有爲)는 서양 진화론의 영향을 받아 비록 대동 이상을 제시하긴 하였지만 "대동극락(大同極樂)"이 "차안세계(此岸世界)"에서 절대로 실현될 수 없음을 잘 알고 있었기에 대동(大同)의 이상으로부터 이탈해 "천유(天遊)"경지로 관심을 돌리게 되었다. 즉 이상과 현실의 괴리, 그리고 그가 가정한 단선적(單線的) 대동주의(大同主義)의 실현 불가능에 대한 생각이 그를 "천유(天遊)" 경계로 나아가게 한 것이다. 강유위(康有爲)는 젊은 시절 그가 찬탄해 마지않았던 과학 기구가 사람의 인식능력을 확대시켜 "대도(大道)"에 가까이 가도록 해 준다는 점에는 여전히 동의하고 있었다. 하지만 "기물(器物)"과 인간 감관(感官)의 유한한 능력이 "천(天)"의 무한함에 비추어볼 때 보잘 것 없다는 것은 그를 절망적으로 만드는 점이었다. 그는 현실 사회와 정치를 개혁하는 데 있어서도 이런 비관적인 현실에 깊은 절망감을 느꼈다. 이런 비관주의적 경향은 그가 대동(大同) 이상을 추구하기보다 "천유(天遊)"경지에 경도되게 된 이유이며, 『대동서(大同書)』를 완성함과 동시에 곧바로 『제천강(諸天講)』을 저술함으로써 사람들이 혼란된 사회 속에서 인생 위안을 얻을 수 있는 "천유지학(天遊之學)"을 제창한 원인이라 할 수 있다.