• 제목/요약/키워드: Kitahara

검색결과 45건 처리시간 0.016초

Radiotherapy for locally recurrent rectal cancer treated with surgery alone as the initial treatment

  • Tanaka, Hidekazu;Yamaguchi, Takahiro;Hachiya, Kae;Okada, Sunaho;Kitahara, Masashi;Matsuyama, Katsuya;Matsuo, Masayuki
    • Radiation Oncology Journal
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    • 제35권1호
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    • pp.71-77
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    • 2017
  • Purpose: Although the technical developments of radiotherapy have been remarkable, there are currently few reports on the treatment results of radiotherapy for local recurrence of rectal cancer treated with surgery alone as initial treatment in this three-dimensional conformal radiotherapy era. Thus, we retrospectively evaluated the treatment results of radiotherapy for local recurrence of rectal cancer treated with surgery alone as the initial treatment. Materials and Methods: Thirty-two patients who underwent radiotherapy were enrolled in this study. The dose per fraction was 2.0-3.5 Gy. Because the treatment schedule was variable, the biological effective dose (BED) was calculated. Results: Local control (LC) and overall survival (OS) rates from the completion of radiotherapy were calculated. The 1-, 2-, 3-, 4-, and 5-year LC rates were 51.5%, 24.5%, 19.6%, 19.6%, and 13.1%, respectively. LC rates were significantly higher for the high BED group (${\geq}75Gy_{10}$) than for the lower BED group (<$75Gy_{10}$). All patients who reported pain achieved pain relief. The duration of pain relief was significantly higher for the high BED group than for the lower BED group. The 1-, 2-, 3-, 4-, and 5-year OS rates were 82.6%, 56.5%, 45.2%, 38.7%, and 23.2%, respectively. There was a trend toward higher OS rates in with higher BED group compared to lower BED group. Conclusion: For patients with unresectable locally recurrent rectal cancer treated with surgery alone, radiotherapy is effective treatment. The prescribed BED should be more than $75Gy_{10}$, if the dose to the organ at risk is within acceptable levels.

병어(Pampus argenteus) 자망의 망목선택성 (Mesh selectivity of gill nets for silver promfret, Pampus argenteus)

  • 장호영;조봉곤;박종수;이왕래
    • 수산해양기술연구
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    • 제43권3호
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    • pp.169-175
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    • 2007
  • To examine the mesh selectivity and optimum mesh size of gill nets for silver promfret Pampus argenteus, the field experiments were carried out during June 27th to July 3rd, 2005 at the coastal area of Imja island. The experimental gill nets for silver promfret were used in two set, which one set was consisted of 12 sheets, and each set was connected alternatively four defferent sheets those were 141mm, 148mm, 155mm and 164mm in mesh size. The analysis of mesh selectivity curve was done by Kitahara's method. The total number of fishes caught by experimental fishing of gill nets for silver promfret was 1,409, and it was consisted of 1,022 silver promfrets(72.5%), 123 croakers(8.7%), 70 red tongue soles(5.0%), 67 blue crabs(4.8%), 22 red seabreams(1.6%), and 105 other fishes(7.4%). The number of fishes caught by the mesh size was 244 at mesh 141mm(mean 6.8/sheet), 261 at mesh 148mm(mean 7.3/sheet), 295 at mesh 155mm(mean 8.2/sheet) and 222 at mesh 164mm(mean 6.2/sheet). The body weight of fishes caught by the mesh size was 102.1kg at mesh 141mm(mean 2.8kg/sheet), 112.9kg at mesh 148mm(mean 3.1kg/sheet), 132.8kg at mesh 155mm(mean 3.7kg/sheet), and 100.4kg at mesh 164mm(mean 2.8kg/sheet). The value of maximum l/m on mesh selectivity curve and the value of l/m on the selection range of 50% was estimated at 1.91 and from 1.63 to 2.23, respectively. Therefore, the optimum mesh size of gill nets for silver promfret was estimated 135mm, and the total length at the selection range of 50% was from 220mm to 301mm. But, it will be useful to use the mesh size of gill nets which is about 10-15% larger than the estimated optimum mesh size of gill nets considering the number of fishes caught, body length and body weight etc.

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

  • Ren, Yan;Kitahara, Cari Meinhold;de Gonzalez, Amy Berrington;Clero, Enora;Brindel, Pauline;Maillard, Stephane;Cote, Suzanne;Dewailly, Eric;Rachedi, Frederique;Boissin, Jean-Louis;Sebbag, Joseph;Shan, Larrys;Bost-Bezeaud, Frederique;Petitdidier, Patrick;Xhaard, Constance;Rubino, Carole;de Vathaire, Florent
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권13호
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    • pp.5187-5194
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    • 2014
  • Background: Numerous studies have suggested that selenium deficiency may be associated with an increased risk for several types of cancer, but few have focused on thyroid cancer. Materials and Methods: We examined the association between post-diagnostic fingernail selenium levels and differentiated thyroid cancer risk in a French Polynesian matched case-control study. Conditional logistic regression models were used to estimate odds ratios and 95% confidence intervals. Results: The median selenium concentration among controls was $0.76{\mu}g/g$. Significantly, we found no association between fingernail selenium levels and thyroid cancer risk after conditioning on year of birth and sex and additionally adjusting for date of birth (highest versus lowest quartile: odds-ratio=1.12, 95% confidence interval: 0.66-1.90; p-trend=0.30). After additional adjustment for other covariates, this association remained non-significant (p-trend=0.60). When restricting the analysis to thyroid cancer of 10 mm or more, selenium in nails was non-significantly positively linked to thyroid cancer risk (p-trend=0.09). Although no significant interaction was evidenced between iodine in nails and selenium in nails effect (p=0.70), a non-significant (p-trend =0.10) positive association between selenium and thyroid cancer risk was seen in patients with less than 3 ppm of iodine in nails. The highest fingernail selenium concentration in French Polynesia was in the Marquises Islands ($M=0.87{\mu}g/g$) and in the Tuamotu-Gambier Archipelago ($M=0.86{\mu}g/g$). Conclusions: Our results do not support, among individuals with sufficient levels of selenium, that greater long-term exposure to selenium may reduce thyroid cancer risk. Because these findings are based on post-diagnostic measures, studies with prediagnostic selenium are needed for corroboration.

서해안 문치가자미 자망의 망지재료에 따른 망목선택성 (Mesh selectivity of monofilament and multifilament nylon gill net for Marbled sole (Pleuronectes yokohamae) in the western sea of Korea)

  • 김인옥;박창두;조삼광;김현영;차봉진
    • 수산해양기술연구
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    • 제46권4호
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    • pp.281-291
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    • 2010
  • To estimate the mesh selectivity of monofilament and multifilament gill net for Marbled sole, Pleuronectes yokohamae, the field testes were carried out 12 times with five different mesh sizes (86.6, 101.0, 121.2, 137.7, 151.5mm) in the western sea of Korea, 2007-2009. The master curve of selectivity was estimated by the extended Kitahara's method. In the field testes, the total number of species and catch were 26 and 987, respectively. The catch number of marbled sole was 728 and occupied 73.8% in total catch. The optimum values of l/m for 1.0 of retention probability in monofilament and multifilament gill net were estimated 0.288 and 0.307, respectively and l/m was estimated to be 0.189, 0.203, 0.213, 0.222 and 0.230 in case of monofilament gill net and 0.171, 0.191, 0.205, 0.216 and 0.227 in case of multifilament gill net when the retention probability were 0.1, 0.2, 0.3, 0.4 and 0.5, respectively. The 0.5 selection range of multifilament gill net was wider about 1.5 times than that of monofilament gill net according as multifilament gill net was 0.216 and monofilament gill net was 0.148. So the multifilament gill net has a low selectivity than that of the monofilament gill net. To estimate the optimum mesh size on first maturity length 19.5cm of marbled sole, the retention probability value of 0.1 was adopted in consideration of using the gill net for marbled sole at present. The optimum mesh size were estimated to be 103.2mm and 114.0mm in monofilament gill net and multifilament gill net, respectively, on first maturity length 19.5cm of marbled sole.

심근관류 SPECT 검사의 정확도 검증을 위한 새로운 심장.흉부 팬텀의 개발 (Development of a New Cardiac and Torso Phantom for Verifying the Accuracy of Myocardial Perfusion SPECT)

  • 야마모토토모아키;김정민;이기성;타카야마테루히코;키타하라타다시
    • 대한방사선기술학회지:방사선기술과학
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    • 제31권4호
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    • pp.389-399
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    • 2008
  • 단일광자방출컴퓨터단층촬영(SPECT) 시 정확도의 개선을 위하여 산란과 감약의 보정, 분해능의 개선이 매우 중요하다. 특히 호흡이나 맥동에 대한 심장의 움직임은 보정 에러의 원인이 된다. 심장 팬텀이 보정방법에 대한 검증을 위해 사용되고 있으나, 현재 사용 중인 팬텀들은 실제 인체 데이터와 다른 점이 많이 나타나고 있다. 즉 팬텀을 사용한 결과는 임상데이터와 같게 취급할 수가 없다. 저자들은 흉곽의 인체 구조와 같은 신뢰성 있는 새로운 팬텀을 개발하였다. 새로운 팬텀은 폐와 심장의 전면, 측면 및 상부가 접하는 작은 종격구조를 가지고 있다. 용기는 아크릴로 만들었으며 종격은 물 등가물질을 사용하여 제조하였다. 폐는 에폭시레진의 고형 폴리우레탄 폼을 사용하였다. 5가지 크기의 심장은 게이트 심근관류 SPECT의 정량적 분석을 위하여 개발되었다. 심장팬텀들의 종격은 같은 포지션에 위치할 수 있도록 고안되었다. 완성된 팬텀은 간과 담낭에 부착되고 각각 높이 조절이 가능하다. 5개의 심실의 용적은 각각 150.0, 137.3, 83.1, 42.7과 38.6ml이다. 새로운 팬톰을 사용하여 SPECT 검사를 시행하고 보정법을 적용한 후에 영상의 차이를 검토하였다. 심장의 3차원 단층상이 효율적으로 재구성 되었으며 여러 가지 보정방법의 차이를 나타내기 위하여 주관적 평가도 시행하였다. 저자들은 SPECT영상과 QGS(Quantitative Gated SPECT) 결과로서 보정방법의 차이를 나타낼 수 있는 새로운 팬텀을 개발하여 보고하는 바이다.

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