• Title/Summary/Keyword: Kim Jeong-hee

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Enhancement of nerve growth factor production and release by buthanol fraction of Liriope platyphylla in C6 cells and rat cultured astrocyte

  • Hur, Jin-Young;Lee, Pyeong-Jae;Kim, Jeong-Min;Kim, Ho-Cheol;Kim, Sun-Yeou
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.135.3-136
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    • 2003
  • Liriope platyphylla (LP) Wang et Tang has been used for tonic, anti-tussive and expectorant in Korea. In the current study, we found that buthanol fraction of Liriope platyphylla-conditioned media of C6 and primary astrocyte induced the neurite outgrowth of PC 12 cells, which effect was reversed by addition of NGF-antibody. We demonstrated that buthanol fraction of Liriope platyphylla increased the expression and secretion of NGF through RT-PCR and ELISA. (omitted)

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Heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats

  • Kim, Eun Jin;Oh, Hyun-A;Choi, Hyuck Jai;Park, Jeong Hill;Kim, Dong-Hyun;Kim, Nam Jae
    • Journal of Ginseng Research
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    • v.37 no.1
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    • pp.87-93
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    • 2013
  • To evaluate the effect of the saponin of heat-processed ginseng (Sun ginseng, SG), we investigated the protective effect of SG total saponin fraction against adenine-induced chronic renal failure in rats. SG saponin significantly decreased the levels of urea nitrogen and creatinine in the serum, but increased the urinary excretion of urea nitrogen and creatinine, indicating an improvement of renal function. SG saponin also inhibited adenine-induced kidney hypertrophy and edema. SG saponin reduced serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and lactate dehydrogenase activities increased by adenine. Based on these findings, the ameliorating effect of SG on chronic renal failure may result from its saponin.

Iridoid Glycosides Isolated from Oldenlandia diffusa Inhibit LDL-Oxidation

  • Kim Dong-Hyun;Lee Hyo-Jung;Oh Young-Jun;Kim Min-Jung;Kim Sung-Hoon;Jeong Tae-Sook;Baek Nam-In
    • Archives of Pharmacal Research
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    • v.28 no.10
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    • pp.1156-1160
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    • 2005
  • An iridoid glycoside, oldenlandoside III (5) was isolated from the n-butanol fraction of methanol extracts of the aerial parts of Oldenlandia diffusa Roxb. along with six others previously characterized iridoid glycosides; geniposidic acid (1), scandoside (2), feretoside (3), 10-O-ben-zoylscandoside methyl ester (4), asperulosidic acid (6) and deacetylasperulosidic acid (7). Compounds 1, 2, and 7 inhibited LDL-oxidation, and showed $63.3{\pm}2.0,\;62.2{\pm}1.6,\;and\;63.8{\pm}1.5\%$ inhibition, respectively, at a concentration of 20 ${\mu}g/mL$.