• Title/Summary/Keyword: Kim Jae-kyung

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Preliminary Study for Development of Pattern Identification Tool for Radiation Pneumonitis (방사선폐렴 변증(辨證)도구 개발을 위한 기초연구)

  • Kim, Jae-hyo;Bhang, Yeon-hee;Do, Ha-yoon;Ahn, Jun-mo;Kim, Kwan-il;Lee, Beom-joon;Jung, Sung-ki;Jung, Hee-jae
    • The Journal of Internal Korean Medicine
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    • v.38 no.1
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    • pp.32-47
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    • 2017
  • Objective: The purpose of this study was to develop a standard tool for pattern identification of radiation pneumonitis. Methods: Textbooks, published studies, and references with comments about patterns were reviewed. Through the Delphi method, we determined pattern identifications based on advice from a committee of experts composed of 13 Korean respiratory internal medicine professors. Results: Using the Delphi method, four pattern identifications were chosen: Qi Deficiency (氣虛), Yin Deficiency (陰虛), Heat Toxin (熱毒), and Phlegm Dampness (痰濕). The tool was developed in a question-and-answer format with 35 questions. Conclusions: A pattern identification tool that can discriminate the patterns of radiation pneumonitis for standardized diagnosis was developed through expert consultation. Further study of its validity and reliability is necessary.

Association Analysis between Polymorph isms of NOTCH4 Gene and Schizophrenia in Korean Population

  • Lee, Seo-Kyong;Kang, Sung-Wook;Kim, Su-Kang;Kim, Hak-Jae;Kim, Tae;Park, Jin-Kyung;Cho, Ah-Rang;Kim, Jong-Woo;Park, Hyun-Kyung;Kim, Youn-Jung;Choe, Bong-Keun;Song, Ji-Young
    • Molecular & Cellular Toxicology
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    • v.5 no.2
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    • pp.160-164
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    • 2009
  • Notch signaling plays a crucial role in development of the nervous system. Neurodevelopmental hypothesis on etiology of schizophrenia has been implicated. The aim of this study is to determine whether single nucleotide polymorphisms (SNPs) of Notch homolog 4 (Drosophila) (NOTCH4) gene are associated with schizophrenia. This study included 283 schizophrenia patients diagnosed according to DSM-IV and 301 normal control subjects. Control subjects without history of psychiatric disorders were recruited. Four missense SNPs [rs915894 (exon 3, Lys117Gln), rs2071282 (exon 4, Pro204Leu), rs422951 (exon 6, Thr320Ala), and rs17604492 (exon 18, Gly942Arg)] of NOTCH4 gene were genotyped by the direct sequencing method. Multiple logistic regression models (codominant, dominant, and recessive models) were employed to evaluate odds ratio, 95% confidence interval, and p value. For analysis of genetic data, SNPStats, Haploview, HapAnalyzer, SNPAnalyzer, and Helixtree programs were also used. Of 4 SNPs, rs2071282 was weekly associated with schizophrenia in two alternative models (codominant model, P=0.049; dominant, P=0.041). However, these associations were not significant after Bonferroni correction. At 4 SNPs, one linkage disequilibrium (LD) block was made. This block consisted of rs915894 and rs2071282. In haplotype analysis, AC haplotype was weakly associated with schizophrenia (dominant, P=0.04). This association was disappeared after Bonferroni correction. Our result shows possibility that some SNPs of NOTCH4 gene may be weekly associated with development of schizophrenia in Korean population. However, replication result by other population will be needed.