• Journal of Chest Surgery
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• v.38 no.12 s.257
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• pp.835-843
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• 2005

Background: Cancer of the esophagus is one of the most malignant tumors with poor prognosis. The p53 gene alteration, over expression of Cyclin D1, and Ki67 index were thought to be the prognostic factors. However, their clinical significances in esophageal squamous cell carcinoma are controversial and p53 accumulation may not correlate with genetic mutation. The current study investigates their prognostic significance in squamous cell carcinoma of the esophagus. Material and Method: The Subjects studied were 124 esophageal squamous cell carcinoma patients who underwent esophagectomy. The mutation of p53, over expression of Cyclin D1, Ki67 labelling index, mitotic index were examined by using an immunohistochemical staining. We compared the results and investigated the correlation with the mutation of p53, overexpression of Cyclin D1, Ki67 labelling index, mitotic index and tumor size, and duration of survival. Result: There was no correlation between the results in immunohistochemical staining according to age, sex, tumor size, Iymph node status, and clinical stage of the disease. Mutant p53 protein was found in 69 cases (55.6$\%$). Median survival time was 21 months in cases with negative for mutant p53 protein and 22 months in positive cases. There was no significant difference in survival (p=0.46). Median survival time was 22 months in cases with negative for Cyclin D1 and 16 months in positive cases (p=0.18). Median and mean survival time was 22 months and 36 months when Ki67 labeling index was 40 or less (102 cases). Median and mean survival was 16 months and 23 months, when Ki67 labeling index was more than 40 (22 cases). There was significant difference in survival rate (p=0.011). Conciusion: Positivity of p53 and cyclin D1 was not useful in predicting the prognosis in our study. There was no significant correlation among mutant p53 protein accumulation, Cyclin D1 over expression, and Ki67 labeling index. However, in several studies, PCR single strand conformational polymorphism analysis of p53 showed a correlation to the prognosis. We thought that there was a significant discordance between p53 gene mutation and mutant p53 protein accumulation. When Ki67 labeling index was more than 40, prognosis was poorer, Ki67 seems to be a prognostic factor in our study. Therefore, we confirmed the possibility of using molecular markers as prognostic factors.

• Journal of Integrative Natural Science
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• v.9 no.2
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• pp.136-143
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• 2016

KiSS1-derived peptide receptor, a GPCR protein, binds with the hormone kiss peptin. They are important in the neuroendocrine regulation of reproduction and in the secretion of gonadotrophin-releasing hormone. Thus, analysing the structural features of the receptor becomes important. However, the three dimensional structure of the protein is unavailable. Hence in this study, we have performed the homology modelling of KiSS1-derived peptide receptor with 5 different templates. 30 models were constructed using two platforms - Easymodeller and ITasser. The optimal models were chosen based on the model validation. Two models were selected after validation. The developed models could provide useful for analysing the structural features of KiSS1-derived peptide receptor and their pathophysiological role in various disorders related to them.

• Korean Journal of Acupuncture
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• v.26 no.1
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• pp.139-159
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• 2009

Objective & Methods : The purpose of this study is to observe the effects of herbal-acupuncture with Lycii Fructus (LF-HA) at KI10 (Eumgok) on osteoporosis in ovariectomized (OVX) ddy mice. We carried out several experimental items which were known to be related with osteoporosis. Results : 1. Tibial BMD was significantly increased in the LF-HA group. 2. Tibial Ca level was significantly increased in the LF-HA group. 3. Osteoclast like cell in tibia was significantly decreased in the LF-HA group. 4. Histological change of tibia was improved, the trabecular bone thickness was significantly increased and the growth plate length was significantly decreased in the LF-HA group. Conclusion : These results suggest that LF-HA at KI10 has therapeutic effects on osteoporosis especially by way of suppressing osteoclast cells in ovariectomized ddy mice.

• The Journal of Internal Korean Medicine
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• v.30 no.3
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• pp.648-655
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• 2009

Peripheral neuropathy is a disease of multiple Peripheral nerves. Tingling, pins-and needles, numbness, burning and raw sensation are symptoms of peripheral neuropathy. These symptoms are frequently complained by patients who suffered from obstructive syndrome of Ki and blood (痺證). This case was reported to evaluate the effects of oriental medicine therapy on a patient with obstructive syndrome of Ki and blood (痺證). The subject was a female patient who had obstructive syndrome of Ki and blood (痺證). She complained of calf pain, cold sense, walking discomfort, insomnia, dyspepsia, anorexia etc. We administered the medicine with dispeling the cold pathogenic factor (寒邪), adjusting the constructive and defensive energy (調營衛), tonifying the Ki and blood (補氣血) by stage. After the treatment, the symptoms improved. This case suggests that oriental medicine therapy can be applicable to improve in symptoms with Peripheral neuropathy.

• Korean Journal of Oriental Medicine
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• v.3 no.1
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• pp.119-151
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• 1997

Conclusions for the relationship between a conceptional model of stress theory and its examination based on the Oriental medicine; 1. It was considered that a general conception of stress is included into the meaning of Ki in the Oriental medicine. 2. The response-based model to stress could be comparable to a conception of Ki-pathogens interchange In the Onental medicine. 3. The stimulus-based model may be explained as a modern conception of immoderation feeling related with an internal etiological factor, specially injury of seven emotions, among three groups of etiological factors for disease. 4. The feedback conception based on the interaction model could explain the principal of reversible emotion therapy in the nine Ki. 5. In the Oriental medicine, a study to clarify a emotional etiologic factor and its pathophysiologlcal mechanism has been continued for long time before establishment of stress theory.

• Journal of Korean Medical classics
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• v.19 no.2 s.33
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• pp.266-293
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• 2006

Accumulation of pathogens in chest refers to a syndrome of fullness, stuffiness and pain in the chest, diaphragm, epigastrium and abdomen, which is ascribable to accumulation of pathogenic heat with stagnancy of fluid or phlegm in the chest. Retching refers to vomiting with sound but without any vomitus. It is usually ascribable to adverse flow of ki due to deficiency of stomach, or by pathogenic heat or cold, and failure in descending of the stomach-ki. It may also be found in Soyang disease. Bloody purulent stool refers to passing stool with blood and pus. It is formed mainly due to invasion of the stomach and the intestines by epidemic pathogenic summer-heat, steaming of stagnateed damp-heat fighting against ki and blood, or improper diet, obstruction of bu-ki stagnation of blood and ki.

• Korean Journal Plant Pathology
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• v.14 no.6
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• pp.705-709
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• 1998

Temporal and spatial distribution of Korean rice blast fungus (Pyricularia grisea) race KI-409 that has been rapidely increased since 1993 and became predominant in 1995 in Korea were investigated. Varietal resistance of current commercial cultivars of rice to the race was also tested in this study. The race KI-409 was first isolated from rice cv. Namyangbyeo in 1985. Since 1985 the race had been isolated mainly from the rice cultivars having BL1 BL7 pedigree as a resistance source. Distribution ratio of the race in 1995 was 23.7% in average and became a predominant in the P. grisea population in Korea. The race distributed widely and found in all the eight provinces in Korea. Many commercial cultivars such as Chucheongbyeo as well as those with BL1 or BL7 as a genetic background were found to be susceptible to the race KI-409.

• Korean Journal of Pharmacognosy
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• v.39 no.2
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• pp.137-141
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• 2008

Korean folk medicine 'Ki Rin Cho' has been used to cure stanching and counteracting poison. The botanical origin of the crude drug has never been studied pharmacognostically. To clarify the botanical origin of 'Ki Rin Cho', the morphological and anatomical characteristics of Sedum species growing in Korea, i.e. S. aizoon, S. kamtschaticum and S. latiovalifolium were studied. As a result, 'Ki Rin Cho' was proved to be Sedum kamtschaticum and Sedum aizoon.

• Water Engineering Research
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• v.1 no.3
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• pp.199-208
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• 2000

The relationship between areal total phosphorus(TP) and areal hydraulic loading was identified and used as defining the trophic state of the reservoir. And three simple, conceptual TP models were tested against the measured in-reservoir TP concentration. The analyses were based on water quality data measured in the Ki Heung reservoir for two years. The results showed that Ki Heung reservoir has undergone eutrophic state, and Dillon's and Vollenweider's TP models were in close agreement with the measured annual mean TP concentration. However, the OECD's model understimated the measured annual mean TP concentration in the Ki Heung reservor. A discussion is given for the hypothetical application of TP loading plot which might be useful for establishing the TP control program in the resavoirs/lakes.

• Proceedings of the Korea Information Processing Society Conference
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• 2021.11a
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• pp.115-117
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• 2021

최근 인공지능 및 빅데이터 연구가 대두되면서 슈퍼컴퓨터와 같은 고성능컴퓨터를 이용하여 다양한 연구환경을 제공할 수 있어야 한다는 요구가 증가하고 있다. 이에 한국과학기술정보연구원(KISTI)에서는 슈퍼컴퓨터 등 고성능컴퓨터를 인프라로 활용하는 KI(KISTI Intelligent) Cloud를 개발하여 서비스하고 있다. 본 논문에서는 KI Cloud의 모니터링 기능의 설계 및 구현 방법을 기술하였다. KI Cloud는 다양한 자원으로부터 데이터를 효율적으로 수집하고, 데이터를 시각화할 수 있는 오픈소스인 Prometheus와 Grafana를 이용하여 모니터링 기능을 개발하였다.