• 국제초고층학회논문집
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• 제12권3호
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• pp.203-208
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• 2023

The implementation of artificial intelligence (AI) design for tall building structures is an essential solution for addressing critical challenges in the current structural design industry. Generative AI technology is a crucial technical aid because it can acquire knowledge of design principles from multiple sources, such as architectural and structural design data, empirical knowledge, and mechanical principles. This paper presents a set of AI design techniques for building structures based on two types of generative AI: generative adversarial networks and graph neural networks. Specifically, these techniques effectively master the design of vertical and horizontal component layouts as well as the cross-sectional size of components in reinforced concrete shear walls and frame structures of tall buildings. Consequently, these approaches enable the development of high-quality and high-efficiency AI designs for building structures.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3403-3408
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• 2012

The molecular mechanisms involved in the progression of clear cell renal cell carcinomas (ccRCCs) are still unclear. The aim of this study was to analyse the relationships between expression of RALYL and clinical characteristics. In 41 paired samples of ccRCCs and adjacent normal tissues, we used real-time qPCR to evaluate the expression of RALYL mRNA. RALYL protein levels were determined in 146 samples of ccRCC and 37 adjacent normal tissues by immunohistochemistry. Statistical analysis was used to explore the relationships between expression of RALYL and the clinical characteristics (gender, age, tumor size, T stage, N stage, M stage, survival times and survival outcome) in ccRCC. In addition, these patients were follow-up period 64 months (range: 4~116months) to investigate the influence on prognosis. We found significantly differences between ccRCC tissues and normal tissues (p<0.001, paired-sample t test) in mRNA levels of RALYL. Immunohistochemistry analyses in 146 ccRCC samples and 37 adjacent normal tissues showed significantly lower RALYL protein levels in ccRCC samples (${\chi}^2$-test, p<0.001), inversely correlating with tumour size (p=0.024), T stage (0.005), N stage (p<0.001) as well as M stage (p=0.019), but not age (p=0.357) and gender (p=0.348). Kaplan-Meier survival analysis demonstrated that people with lower level of RALYL expression had a poorer survival rate than those with a higher level of RALYL expression, significantly different by the log-rank test (p=0.011). Cox regression analysis indicated that RALYL expression (p=0.039), N stage (p=0.008) and distant metastasis (p<0.001) were independent prognosis factors for the overall survival of ccRCC patients. We demonstrated that the expression of RALYL was significantly low in ccRCC and correlated with a poor prognosis in a large number of clinical samples. Our findings showed that RALYL may be a potential therapeutic target as well as a poor prognostic factor.

• 정보처리학회논문지C
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• 제12C권4호
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• pp.473-480
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• 2005

센서 네트워크는 다양한 환경에 설치되어 대상 탐지나 환경 감시 등, 유용한 정보를 제공하는데 사용될 수 있다. 이러한 센서 네트워크에서 센서 노드 간 키를 설정하는 것은 안전한 통신을 위한 가장 기본적인 요구 사항이다. 따라서 본 논문에서는 센서 네트워크에서의 효율적 키 설정을 위해 클러스터에 기반한 구조와 다항식(polynomial)을 사용한 pairwise key 설정 방법을 제안하였다. 제안한 메커니즘에서는 네트워크를 클러스터링하여 각 클러스터 별로 유일한 다항식을 할당하고, 동일 클러스터에 있는 센서들은 클러스터헤드로부터 분배받은 다항식 부분정보(polynomial share)를 사용하여 자신의 전송 범위에 있는 이웃 노드들과 pairwise key를 생성할 수 있다. 그러나 통신하고자 하는 두 센서가 서로의 전송 범위 내에 있으나 다른 클러스터에 존재할 경우 클러스터헤드를 통하여 두 센서 간의 경로키를 전송하여 공유함으로써 두 센서는 안전하게 통신할 수 있다. 경로키의 수가 많아지는 경우 오버헤드가 높아지므로 경로키 수가 적을수록 유리한데, 그 수는 클러스터의 크기, 센서 노드의 수, 센서의 전송 범위, 센서의 밀집도에 따라 다르게 나타나고 시간도 이에 따라 다르기 때문에 적절한 조건을 제공함으로써 경로키 설정을 줄일 수 있다. 따라서 적절한 클러스터 크기와 센서의 전송 범위를 고려하면 제안한 메커니즘의 효율성을 더욱 높일 수 있음을 시뮬레이션을 통해서 확인할 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5181-5186
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• 2014

Tumors have evolved numerous mechanisms by which they can escape from immune surveillance. One of these is to produce immunosuppressive cytokines. Transforming growth factor-${\beta}$(TGF-${\beta}$) is a pleiotropic cytokine with a crucial function in mediating immune suppression, especially in the tumor microenvironment. TGF-${\beta}$ produced by T cells has been demonstrated as an important factor for suppressing antitumor immune responses, but the role of tumor-derived TGF-${\beta}$ in this process is poorly understood. In this study, we demonstrated that knockdown of tumor-derived TGF-${\beta}$ using shRNA resulted in dramatically reduced tumor size, slowing tumor formation, prolonging survival rate of tumor-bearing mice and inhibiting metastasis. We revealed possible underlying mechanisms as reducing the number of myeloid-derived suppressor cells (MDSC) and $CD4^+Foxp3^+$ Treg cells, and consequently enhanced IFN-${\gamma}$ production by CTLs. Knockdown of tumor-derived TGF-${\beta}$ also significantly reduced the conversion of na$\ddot{i}$ve $CD4^+$ T cells into Treg cells in vitro. Finally, we found that knockdown of TGF-${\beta}$ suppressed cell migration, but did not change the proliferation and apoptosis of tumor cells in vitro. In summary, our study provided evidence that tumor-derived TGF-${\beta}$ is a critical factor for tumor progression and evasion of immune surveillance, and blocking tumor-derived TGF-${\beta}$ may serve as a potential therapeutic approach for cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10713-10718
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• 2015

Purpose: To investigate the prognostic value of serum amyloid A (SAA) in patients with hepatocellular carcinoma (HCC) undergoing surgery. Materials and Methods: Preoperative serum samples of 328 patients with HCC who underwent curative resection and of 47 patients with benign liver lesion were assayed. Serum levels of SAA were measured by enzyme-linked immunosorbent assay and its correlations with clinicopathological characteristics and survival were explored. Results: Levels of SAA were significantly higher in patients with HCC than those with benign liver lesion. There were strong correlations between preoperative serum SAA level and tumor size and more advanced BCLC stage. On univariate analysis, elevated SAA was associated with reduced disease-free survival and overall survival (p=0.001 and 0.03, respectively). Multivariate analyses showed that serum SAA level was an independent prognostic factor for overall survival (hazard ratio 2.80, p=0.01). Conclusions: High SAA serum level is a novel biomarker for the prognosis of HCC patients.

• Journal of Ginseng Research
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• 제46권2호
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• pp.255-265
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• 2022

Background: Ginsenoside Rb1, a bioactive component isolated from the Panax ginseng, acts as a remedy to prevent myocardial injury. However, it is obscure whether the cardioprotective functions of Rb1 are related to the regulation of endogenous metabolites, and its potential molecular mechanism still needs further clarification, especially from a comprehensive metabolomics profiling perspective. Methods: The mice model of acute myocardial ischemia (AMI) and oxygen glucose deprivation (OGD)-induced cardiomyocytes injury were applied to explore the protective effect and mechanism of Rb1. Meanwhile, the comprehensive metabolomics profiling was conducted by high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (HPLC-Q/TOF-MS) and a tandem liquid chromatography and mass spectrometry (LC-MS). Results: Rb1 treatment profoundly reduced the infarct size and attenuated myocardial injury. The metabolic network map of 65 differential endogenous metabolites was constructed and provided a new inspiration for the treatment of AMI by Rb1, which was mainly associated with mitophagy. In vivo and in vitro experiments, Rb1 was found to improve mitochondrial morphology, mitochondrial function and promote mitophagy. Interestingly, the mitophagy inhibitor partly attenuated the cardioprotective effect of Rb1. Additionally, Rb1 markedly facilitated the phosphorylation of AMP-activated protein kinase α (AMPKα), and AMPK inhibition partially weakened the role of Rb1 in promoting mitophagy. Conclusions: Ginsenoside Rb1 protects acute myocardial ischemia injury through promoting mitophagy via AMPKα phosphorylation, which might lay the foundation for the further application of Rb1 in cardiovascular diseases.

• Animal Bioscience
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• 제35권9호
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• pp.1303-1313
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• 2022

Objective: The current study aimed to perform whole-genome resequencing of Chinese indigenous Mongolian sheep breeds including Ujimqin, Sunit, and Wu Ranke sheep breeds (UJMQ, SNT, WRK) and deeply analyze genetic variation, population structure, domestication, and selection for domestication traits among these Mongolian sheep breeds. Methods: Blood samples were collected from a total of 60 individuals comprising 20 WRK, 20 UJMQ, and 20 SNT. For genome sequencing, about 1.5 ㎍ of genomic DNA was used for library construction with an insert size of about 350 bp. Pair-end sequencing were performed on Illumina NovaSeq platform, with the read length of 150 bp at each end. We then investigated the domestication and signatures of selection in these sheep breeds. Results: According to the population and demographic analyses, WRK and SNT populations were very similar, which were different from UJMQ populations. Genome wide association study identified 468 and 779 significant loci from SNT vs UJMQ, and UJMQ vs WRK, respectively. However, only 3 loci were identified from SNT vs WRK. Genomic comparison and selective sweep analysis among these sheep breeds suggested that genes associated with regulation of secretion, metabolic pathways including estrogen metabolism and amino acid metabolism, and neuron development have undergone strong selection during domestication. Conclusion: Our findings will facilitate the understanding of Chinese indigenous Mongolian sheep breeds domestication and selection for complex traits and provide a valuable genomic resource for future studies of sheep and other domestic animal breeding.

• Journal of Information Processing Systems
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• 제3권1호
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• pp.1-7
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• 2007

In mobile ad hoc networks, an application scenario requires mostly collaborative mobility behavior. The key problem of those applications is scalability with regard to the number of multicast members as well as the number of the multicast group. To enhance scalability with group mobility, we have proposed a multicast protocol based on a new framework for hierarchical multicasting that is suitable for the group mobility model in MANET. The key design goal of this protocol is to solve the problem of reflecting the node's mobility in the overlay multicast tree, the efficient data delivery within the sub-group with group mobility support, and the scalability problem for the large multicast group size. The results obtained through simulations show that our approach supports scalability and efficient data transmission utilizing the characteristic of group mobility.

• International Journal of Costume and Fashion
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• 제15권1호
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• pp.19-37
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• 2015

Expanding upon Zhang and Kim's (2013) study involving Chinese consumers, this study investigated key factors that influence U.S. consumers' attitude towards purchasing luxury fashion goods and purchase intent and examined what similarities and differences exist between the two consumer groups in relation to the key factors. A total of 414 respondents completed the online survey questionnaire. Structural Equation Modeling was utilized to analyze data. Brand consciousness, materialism, fashion innovativeness, and fashion involvement were significant factors that affect U.S. consumers' attitude towards luxury fashion goods. Overall, the findings of the current study were greatly inconsistent with Zhang and Kim's Chinese study. The inconsistency provides vital implications to luxury fashion retailers by showing that one size does not fit all and one strategy does not fit all markets.

• Mycobiology
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• 제38권1호
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• pp.65-69
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• 2010

Based on a literature survey and assessment of the important features of lichen genus Buellia (spore shape and size, anatomy of the exciple as well as analysis of the lichen substances), the present paper describes four new records of B. maritima, B. polyspora, B. spuria and B. stellulata from South Korea. Among them, B. maritima and B. polyspora are firstly reported in East Asia including in China, the Korean Peninsula and Japan. Brief description of all the new records along with earlier described species placed under genus Amandinea and Hafellia are provided with their distribution and chemistry. A key to all the Buellia species reported so far from South Korea is also provided.