• BMB Reports
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• 제48권10호
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• pp.583-588
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• 2015

Microtubule actin crosslinking factor 1 (MACF1), a widely expressed cytoskeletal linker, plays important roles in various cells by regulating cytoskeleton dynamics. However, its role in osteoblastic cells is not well understood. Based on our previous findings that the association of MACF1 with F-actin and microtubules in osteoblast-like cells was altered under magnetic force conditions, here, by adopting a stable MACF1-knockdown MC3T3-E1 osteoblastic cell line, we found that MACF1 knockdown induced large cells with a binuclear/multinuclear structure. Further, immunofluorescence staining showed disorganization of F-actin and microtubules in MACF1-knockdown cells. Cell counting revealed significant decrease of cell proliferation and cell cycle analysis showed an S phase cell cycle arrest in MACF1-knockdown cells. Moreover and interestingly, MACF1 knockdown showed a potential effect on cellular MTT reduction activity and mitochondrial content, suggesting an impact on cellular metabolic activity. These results together indicate an important role of MACF1 in regulating osteoblastic cell morphology and function.

• Journal of Magnetics
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• 제14권2호
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• pp.66-70
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• 2009

The dynamic magneto-mechanical behaviors in a type of iron-nickel-based ferromagnetic alloy with constant elasticity were investigated as a function of both the DC bias magnetic field ($H_{dc}$) and the frequency. The rectangular plate-like samples were excited to vibrate at a half-wavelength, longitudinal resonance by an AC magnetic field superimposed with various $H_{dc}$. The experimental results found that the strain coefficient at resonance reached 819.34 nm/A and the effective mechanical quality factor ($Q_m$) was greater than 2000. The ratio of the maximum variation of the Young's modulus over $H_{dc}$ to the value of the Young's modulus at a zero bias field was only ${\sim}0.83%o$ because of the so-called constant elasticity. The resonant strain coefficients and $Q_m$ are strongly dependent on $H_{dc}$, which indicates a promising potential for use in DC and quasistatic magnetic field sensing.

• Journal of Magnetics
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• 제16권3호
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• pp.271-275
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• 2011

This paper proposes a magnetoelectric (ME) composite transducer structure consisting of a magnetostrictive H-type Fe-Ni fork substrate and piezoelectric PZT plates. The fork composite structure has a higher ME voltage coefficient compared to other ME composite structures due to the higher quality (Q) factor. The ME sensitivity of the fork structure reaches 12 V/Oe (i.e., 150 V/cm Oe). The fork composite with two PZT plates electrically connected in series exhibits over 5 times higher ME voltage coefficient than the output of the rectangle structure in the same size. The experiment shows the composite of a Fe-Ni fork substrate and PZT plates has a significantly enhanced ME voltage coefficient and a higher ME sensitivity relative to the prior sandwiched composite laminates. By the use of a lock-in amplifier with 10 nV resolution, this transducer can detect a weak magnetic field of less than $10^{-12}$ T. This transducer can also be designed for a magnetoelectric energy harvester due to its passive high-efficiency ME energy conversion.

• 한국통신학회논문지
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• 제42권3호
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• pp.566-576
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• 2017

키-값 저장소(key-value store)는 Redis, Memcached 등의 다양한 NoSQL 데이터베이스에 응용되어 그 우수성을 보였다. 그리고 키-값 저장소 응용프로그램은 대부분의 환경에서 삽입 연산(insert) 보다 탐색 연산(lookup)이 많이 발생하기 때문에 탐색의 성능이 중요하다. 하지만 기존의 응용프로그램은 해시 테이블을 링크 리스트(linked list) 형태로 유지하기 때문에 탐색 연산이 느릴 수 있다. 따라서 탐색 연산을 상수 시간 내에 완료할 수 있는 쿠쿠 해싱(cuckoo hashing)이 학계의 주목을 받기 시작했고, 그 후 메모리 사용률이 더 높은 버킷화 쿠쿠 해싱(Bucketized Cuckoo Hashing, BCH)이 제안되었다. 본 논문에서는 BCH 구조를 기반으로 하여 삽입 정렬 방법으로 데이터를 입력하는 Sorting Cuckoo를 소개한다. Sorting Cuckoo를 이용하면 데이터가 정렬된 상태에서 탐색을 수행하기 때문에 상대적으로 적은 메모리 접근을 통해 키의 존재 여부를 판단할 수 있으며, 메모리 점유율(load factor)이 높을수록 BCH보다 탐색의 성능이 좋아진다. 실험 결과에 의하면 Sorting Cuckoo는 메모리 점유율이 95%인 상황에서 BCH보다 천만 번의 negative 탐색(데이터가 존재하지 않는 탐색)에서는 최대 25%(약 1900만회), 천만 번의 positive 탐색(데이터가 존재하는 탐색)에서는 최대 10%(약 400만 회)만큼 더 적은 메모리 접근을 이용하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5057-5061
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• 2012

Purpose: Chemotherapy-induced anemia (CIA) is one of the most important causes of anemia in cancer patients. This study was conducted to describe the prevalence and characteristics of CIA in solid cancer patients in the Chinese population, and to explore the relationship of white blood cell (WBC) or platelet decrease with CIA. Methods: Data on age, gender, tumor diagnosis, anti-cancer treatment and blood cell analyses were available from 220 untreated non-anemic cancer patients who received at least 2 cycles of chemotherapy, and the data were analyzed to assess their relationship with CIA or its severity. Results: 139 patients (63.2%) presented anemia, most being Grade 1 or 2. Esophageal and lung cancers were associated with a high prevalence. G3/4 leucopenia and decrease of platelets were identified as independent risk factors for the occurrence of CIA. Moreover, G3/4 leucopenia, decrease of platelet and G3/4 thrombocytopenia were found to be also associated with the severity of CIA. Cisplatin-containing regimens were a main potential factor in causing CIA, although significant association was only found on univariate analysis. Conclusion: Anemia or decrease in hematoglobin are common in Chinese cancer patients receiving chemotherapy. Cisplatin-containing regimens might be an important factor influencing the occurrence of CIA. Our analysis firstly described some risk factors, such as decrease of platelets or WBCs, severity of leucopenia or thrombocytopenia, associated with the occurrence and severity of CIA.

• 한국항해항만학회지
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• 제31권9호
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• pp.801-806
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• 2007

The analytical hierarchy process (AHP) enables decision makers to represent the interaction of multiple factors in complex and unstructured situations. The process requires the decision maker to develop a hierarchical structure of the factors in the given problem and to provide judgments about the relative importance of each of these factors and ultimately to specify a preference for each decision alternative with respect to each factor. The research presented in this paper applies the AHP to identify key players in promoting port competitiveness. The literature survey revealed four major criteria and 15 sub-criteria. The four factors are cost, service quality, facility/capacity and economic-social variable. 150 questionnaires suitable for AHP analysis were made and 77 were returned. It is found that in terms of cost, the first key player is terminal operator and the second key player is shipping companies calling Busan port; in terms of service quality, the first key player is terminal operator, and the second key player is shipping companies calling Busan port; in terms of facility/capacity, the first key player is port authority and the second key player is terminal operator; in terms of economic-social variable, the first key player is terminal operator, and the second key player is shipping companies calling Busan port.

• Nuclear Engineering and Technology
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• 제53권9호
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• pp.2977-2981
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• 2021

Corrosion fatigue crack growth (FCG) behavior of 316LN stainless steel was investigated in high-temperature pressurized water at different temperatures, load ratios (R = K_max/K_min) and rise times (t_R). The environmental assisted effect on FCG rate was observed when both the R and t_R exceeded their critical values. The FCG rate showed a linear relation with stress intensity factor range (ΔK) in double logarithmic coordinate. The environmental assisted effect on FCG rate depended on the ΔK and quantitative relations were proposed. Possible mechanisms of environmental assisted FCG rate under different testing conditions are also discussed.

• Structural Engineering and Mechanics
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• 제62권2호
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• pp.209-224
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• 2017

Elevated water tanks are considered as important structures due to its post-earthquake requirements. Elevated water tank on reinforced concrete frame staging is widely used in India. Different response reduction factors depending on ductility of frame members are used in seismic design of frame staging. The study on appropriateness of response reduction factor for reinforced concrete tank staging is sparse in literature. In the present paper a systematic study on estimation of key components of response reduction factors is presented. By considering the various combinations of tank capacity, height of staging, seismic design level and design response reduction factors, forty-eight analytical models are developed and designed using relevant Indian codes. The minimum specified design cross section of column as per Indian code is found to be sufficient to accommodate the design steel. The strength factor and ductility factor are estimated using results of nonlinear static pushover analysis. It was observed that for seismic design category 'high' the strength factor has lesser contribution than ductility factor, whereas, opposite trend is observed for seismic design category 'low'. Further, the effects of staging height and tank capacity on strength and ductility factors for two different seismic design categories are studied. For both seismic design categories, the response reduction factors obtained from the nonlinear static analysis is higher than the code specified response reduction factors. The minimum dimension restriction of column is observed as key parameter in achieving the desired performance of the elevated water tank on frame staging.

• International Journal of Aeronautical and Space Sciences
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• 제18권2호
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• pp.186-196
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• 2017

In order to resolve the trimming difficulty in rotor CFD calculations, a high-efficiency and improved "delta trim method" is established to compute the blade control settings that are necessary to identify the blade motion. In this method, a simplified model which combines the blade element theory and different inflow models is employed to calculate the control settings according to the target aerodynamic forces, then it is coupled into a CFD solver with unsteady Navier-Stokes equations by the delta methodology, which makes the control settings and aerodynamics calculated and updated in the meantime at every trim cycle. Different from the previous work, the current research combines the inflow model based on prescribed wake theory. Using the method established, the control settings and aerodynamic characteristics of Helishape 7A, AH-1G and Caradonna-Tung rotors are calculated. The influence of different inflow models on trimming calculations is analyzed and the computational efficiency of the current "delta trim method" is compared with that of the "CFD-based trim method". Furthermore, for the sake of improving the calculation efficiency, a novel acceleration factor method is introduced to accelerate the trimming process. From the numerical cases, it is demonstrated that the current "delta trim method" has higher computational efficiency than "CFD-based trim method" in both hover and forward flight, and up to 70% of the amount of calculation can be saved by current "delta trim method" which turns out to be satisfactory for engineering applications. In addition, the proposed acceleration factor shows a good ability to accelerate the trim procedure, and the prescribed wake inflow model is always of better stability than other simple inflow models whether the acceleration factor is utilized in trimming calculations.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3893-3900
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• 2015

It's known that having multiple sexual partners is one of the risk factors of human papillomavirus (HPV) infection which is a major cause of cervical cancer. However, it is not clear whether the number of sexual partners is an independent risk factor for cervical cancer. We identified relevant studies by searching the databases of MEDLINE, PubMed and ScienceDirect published in English from January 1980 to January 2014. We analyzed those studies by combining the study-specific odds ratios (ORs) using random-effects models. Forty-one studies were included in this meta-analysis. We observed that the number of sexual partners was associated with the occurrence of non-malignant cervical disease (OR=1.82, 95%CI 1.63-2.00) and invasive cervical carcinoma (OR=1.77, 95%CI 1.50-2.05). Subgroup analyses revealed that the association remained significant after controlling for HPV infection (OR=1.52, 95%CI 1.21-1.83 for non-malignant disease; OR=1.53, 95%CI 1.30-1.76 for invasive cervical carcinoma). We found that there was a non-linear relation of the number of sexual partners with both non-malignant cervical disease and invasive cervical carcinoma. The risk of both malignant and non-malignant disease is relatively stable in women with more than 4-7 sexual partners. Furthermore, the frequency-risk of disease remained significant after controlling for HPV infection.The study suggested that h aving multiple sexual partners, with or without HPV infection, is a potential risk factor of cervical cancer.