• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8657-8660
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• 2014

Background: Yanting is one of high risk areas for esophageal cancer and the screening program was therefore initiated there. This study was aimed to investigate the dietary behaviors on the risk of esophageal squamous cell carcinoma (ESCC), among the individuals with normal and abnormal esophagus mucosa. Materials and Methods: A frequency matched case-controls study was proposed to estimate the different distribution of dietary behavior between individuals of control, esophagitis and cancer groups. Cancer cases were selected from hospitals. Esophagitis cases and controls were selected from screening population for ESCC. Health workers collected data for 1 year prior to interview, in terms of length of finishing a meal, temperature of eaten food and interval between water boiling and drinking. Chi-square, Kruskal-Wallis tests and unconditional logistic regression model were used to estimate differences and associations between groups. Results: Compared with controls, length of finishing a meal ${\geq}15mins$ was related to a reduced OR for cancer (OR=0.46, 95%CI, 0.22-0.97) and even compared with cases of esophagitis, the OR of cancer was reduced to 0.30 (95%CI, 0.13-0.72). The OR for often eating food at a high temperature was 2.48 (95%CI 1.06, 5.82) for ESCC as compared with controls. Interval between water boiling and drinking of ${\geq}10mins$ was associated with lower risk of cancer: the OR was 0.18 compared with controls and 0.49 with esophagitis cases (p<0.05). Conclusions: Length of eating food ${\geq}15mins$ and interval between water boiling and drinking ${\geq}10mins$ are potentially related to reduced risk of esophageal SCC, compared with individuals with normal and abnormal esophageal mucosa. Recommendations to Yanting residents to change their dietary behaviors should be made in order to reduce cancer risk.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.5C
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• pp.199-210
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• 2012

The effects of tunnelling in weak weathered rock on the behaviour of a pre-existing single pile and pile groups ($3{\times}3$ and $5{\times}5$ pile groups) above a tunnel have been studied by carrying out three-dimensional (3D) elasto-plastic numerical analyses. Numerical modelling of such effects considers the response of the single pile and pile groups in terms of tunnelling-induced ground and pile settlement as well as changes of the shear transfer mechanism at the pile-soil interface due to tunnelling. Due to changes in the relative shear displacement between the pile and the soil at the pile-soil interface with tunnel advancement, the shear stresses and axial pile force distributions along the pile change drastically. Based on the computed results, upward shear stresses are induced up to about Z/L=0.775 from the pile top, while downward shear stresses are mobilised below Z/L=0.775, resulting in a reduction in the axial pile force distribution with depth equivalent to a net increase in the tensile force on the pile. A maximum tensile force of about $0.36P_a$ developed on the single pile solely due to tunnelling, where $P_a$ is the service axial pile loading prior to tunnelling. The degree of interface shear strength mobilisation at the pile-soil interface was found to be a key factor governing pile-soil-tunnelling interaction. Overall it has been found that the larger the number of piles, the greater is the effect of tunnelling on the piles in terms of pile settlement, while changes of the axial pile forces for the piles in the groups are smaller than for a single pile due to the shielding effect. The reduction of apparent allowable pile capacity due to tunnelling-induced pile head settlement was significant, in particular for piles inside the groups.

• Journal of Korean Tunnelling and Underground Space Association
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• v.14 no.5
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• pp.529-545
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• 2012

Three-dimensional (3D) finite element analyses have been performed to study the behaviour of a single pile to open face tunnelling in stiff clay. Several key factors such as tunnelling-induced ground and pile settlement, and shear transfer mechanism have been studied in detail. Tunnelling resulted in the development of pile settlement larger than the Greenfield soil surface settlement. In addition, due to changes in the shear transfer between the pile and the soil next to the pile with tunnel advancement, axial force distributions along the pile change drastically. The apparent allowable pile capacity was reduced up to about 30% due to the development of tunnelling-induced pile head settlement. The skin friction on the pile was increased with tunnel advancement associated with the changes of soil stresses and ground deformation and hence axial pile force distribution was reduced. Maximum tunnelling-induced tensile force on the pile was about 21% of the designed pile capacity. The zone of influence on the pile behaviour in the longitudinal direction may be identified as ${\pm}1$-2D (D: tunnel diameter) from the pile centre (behind and ahead of the pile axis in the longitudinal direction) based on the analysis conditions assumed in the current study. Negative excess pore pressure was mobilised near the pile tip, while positive excess pore pressure was computed at the upper part of the pile. It has been found that the serviceability of a pile experiencing adjacent tunnelling is more affected by pile settlement than axial pile force changes.

• Journal of Korean Ophthalmic Optics Society
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• v.8 no.1
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• pp.35-39
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• 2003

The display technology on the retina is the key role in inspecting the condition of the patients. 2-dimensional retina image is widely used in the eye examination as of today. Recently, 3-dimensional retina image ones have been introduced to this area, but the quality of the image is not fully satisfied to the operator. For the purpose of developing 3-D retina imaging instrument, the optimization of a 3-D retina imaging system using Code-V tool was investigated in this thesis. He-Ne laser having the wavelength 632.8 nm was used to make a power source to detect the retina. Several lenses and mirrors installed on sledge which were developed to perform focus control on 3-D device were designed to make a beam focusing and direct line. Polygon scanner having 24 mirror facets and galvanometer making tilting movement were utilized to make a 2-D laser plane. Also, design of eye ball had been fulfilled to see the focus of the 2-D plane. Reflected ray from retina detected on the sensor array with the same path. All cognitive components were optimized for aberration correction in order to focus on retina. Results of optimization were compared to those of initial designed optics system. On the basis of above results, the result of third aberration has been corrected to stable values to the optical system. MTF evaluating the resolution of an image has been closely correlated to the diffraction limit and PSF indicating the strength distribution of an image has shown the SR value as 0.9998 having high performance. The possibility of new and powerful 3-D retina image instrument was verified by simulating each component of the instrument by Code-V.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5415-5420
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• 2013

Background: Cell cycle deregulation is a major component of carcinogenesis. The p53 tumor suppressor gene plays an important role in regulating cell cycle arrest, and mouse double minute 2 (MDM2) is a key regulator of p53 activity and degradation. Abnormal expression of p53 and MDM2 occurs in various cancers including lung cancer. Methods: We investigated the distribution of the p53 Arg72Pro (rs1042522) and MDM2 SNP309 (rs2279744) genotypes in patients and healthy control subjects to assess whether these single nucleotide polymorphisms (SNPs) are associated with an increased risk of lung adenocarcinomas in Chinese female non-smokers. Genotypes of 764 patients and 983 healthy controls were determined using the TaqMan SNP genotyping assay. Results: The p53 Pro/Pro genotype (adjusted OR = 1.55, 95% CI = 1.17-2.06) significantly correlated with an increased risk of lung adenocarcinoma, compared with the Arg/Arg genotype. An increased risk was also noted for MDM2 GG genotype (adjusted OR = 1.68, 95% CI = 1.27-2.21) compared with the TT genotype. Combined p53 Pro/Pro and MDM2 GG genotypes (adjusted OR = 2.66, 95% CI = 1.54-4.60) had a supermultiplicative interaction with respect to lung adenocarcinoma risk. We also found that cooking oil fumes, fuel smoke, and passive smoking may increase the risk of lung adenocarcinomas in Chinese female non-smokers who carry p53 or MDM2 mutant alleles. Conclusions: P53 Arg72Pro and MDM2 SNP309 polymorphisms, either alone or in combination, are associated with an increased lung adenocarcinoma risk in Chinese female non-smokers.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.10
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• pp.4359-4368
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• 2011

Among several macroeconomic missteps blamed for the recent global financial crisis including the social problems of income distribution and the lack of proper financial remedies, two of them have received particular attention: the global BOP(Balance of Payment) imbalance and the misguided monetary policy. Such BOP imbalance was blamed for massive foreign exchange investment flows from Asia into the U.S., triggering the financial and real estate bubble in America. The latter refers to the excessively loose monetary policy of the U.S. Federal Reserve, which pushed financial institutions and households into reckless investment behavior in search of higher returns. Given the abuse of certain innovative financial techniques and new investment instruments that have been created in recent decades, both collateralized debt obligations (CDOs) and credit default swaps (CDS) enjoyed a symbiotic and toxic relationship prior to the financial crisis This paper is organized as follows: The first section analyzes the real causes of the recent financial crisis. The second details the role of CDOs and CDS. Then, to identify key determinants of the CDS spreads in an emerging capital market, the sample data of major Korean firms' CDS spreads are used to estimate the risk premium by utilizing the multiple regression analysis. The empirical test result indicates that Korean 3-year treasury bond rate(TYIELD), market to book value ratio(MV/BV), and assets size(INASSETS) are shown to demonstrate statistically significant influences on the changes of the CDS premium for sample firms.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37C no.11
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• pp.1094-1103
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• 2012

Recently, software industry regarding national defense increases system development of distributed simulation system of M&S based to overcome limit of resource and expense. It is one of key technologies for offering of mutual validation among objects and reuse of objects which are discussed for developing these systems. RTI, implementation of HLA interface specification as software providing these technologies uses Federation Object Model for exchanging information with joined federates in the federation and each federate has a characteristic that is supposed to have identical FOM in the federation. This technology is a software which is to provide the core technology which was suggested by the United state's military M&S standard framework. Simulator, virtual simulation, and inter-connection between military weapons system S/W which executes on network which is M&S's core base technology, and it is a technology which also can be used for various inter-connection between S/W such as game and on-line phone. These days although RTI is used in military war game or tactical training unit field, there is none in Korea. Also, it is used in mobile-game, distribution game, net management, robot field, and other civilian field, but the number of examples are so small and informalized. Through this developing project, we developed the core technique and RTI software and provided performance of COTS level to improve communication algorithms.

• Journal of the Korean Association of Geographic Information Studies
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• v.16 no.1
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• pp.15-25
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• 2013

The RIMGIS(River Information Management GIS) has been developed since 2000 for public service and practical applications of related works after the standardization of national river data such as the river facility register report, river survey map, attached map, and etc. The RIMGIS has been improved in order to respond proactively to change in the information environment. Recently, Smart River-based river information services and related data have become so large as to be overwhelming, making necessary improvements in managing big data. In this study a plan was suggested both to respond to these changes in the information environment and to provide a future Smart River-based river information service by understanding the current state of RIMGIS, improving RIMGIS itself, redesigning the database, developing distribution, and integrating river information systems. Therefore, primary and foreign key, which can distinguish attribute information and entity linkages, were redefined to increase the usability of RIMGIS. Database construction of attribute information and entity relationship diagram have been newly redefined to redesign linkages among tables from the perspective of a river standard database. In addition, this study was undertaken to expand the current supplier-oriented operating system to a demand-oriented operating system by establishing an efficient management of river-related information and a utilization system capable of adapting to the changes of a river management paradigm.

• Economic and Environmental Geology
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• v.49 no.2
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• pp.155-165
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• 2016

Quartz schist - quartzite is often intercalated in metasedimentary rocks of Ogcheon belt or aligned parallel to the boundary between Yeongnam massif and Ogcheon belt. However, stratigraphic sequence and or geologic age of the rocks has been still variable among authors as Precambrian or Paleozoic. In this study, we carried out SHRIMP U-Pb age data of detrital zircons from Yeongam and Yeongsanpo areas and compared ours with other zircon ages from other areas. The detrital zircons from the studied area show no age younger than 1.8 Ga but yielded clusters at Neoarchean (2.5 Ga) and Paleoproterozoic (1.8 Ga). On the other hand, the age range of zircon U-Pb dating of Paleozoic quartzites yielded from Archean to middle Paleozoic and clusters at Paleoproterozoic, Neoproterozoic and Paleozoic. The characteristics of the zircon age range and the dominant age peak might become a key to classify the Proterozoic to Paleozoic quartz schists-quartzites, which ages are still remained under controversy. Based on the statistical results of the zircon ages in this study, quartz schist - quartzite from Yeongam and Yeongsanpo is considered to be deposited during Proterozoic.

• Journal of Korean Society for Atmospheric Environment
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• v.34 no.1
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• pp.101-119
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• 2018

In this study, we analyzed long-term measurements and air quality simulation results of four criteria air pollutants ($PM_{10}$, $O_3$, $NO_2$, and $SO_2$) for 10 years, from 2006 to 2015, with emphasis on trends of annual variabilities. With the observation data, we conducted spatial interpolation using the Kriging method to estimate spatial distribution of pollutant concentrations. We also performed air quality simulations using the CMAQ model to consider the nonlinearity of the secondary air pollutants such as $O_3$ and the influence of long-range transport. In addition, these simulations are used to deduce the effect of long-term meteorological variations on trends of air quality changes because we fixed the emissions inventory while changing meteorological inputs. The nation-wide inter-annual variability of modeled $PM_{10}$ concentrations was $-0.11{\mu}g/m^3/yr$, while that of observed concentrations was $-0.84{\mu}g/m^3/yr$. For the Seoul Metropolitan Area, the inter-annual variability of observed $PM_{10}$ concentrations was $-1.64{\mu}g/m^3/yr$ that is two times rapid improvement compared to other regions. On the other hand, the inter-annual variability of observed $O_3$ concentrations is 0.62 ppb/yr which is larger than the simulated result of 0.13 ppb/yr. Magnitudes of differences between the modeled and observed inter-annual variabilities indicated that decreasing trend of $PM_{10}$ and increasing trend of $O_3$ are more influenced by emissions and oxidation states than meteorological conditions. We also found similar patterns in $NO_2$. However, $NO_2$ trends showed greater regional and seasonal differences than other pollutants. The analytic approach used in this study can be applicable to estimate changes in factors determining air quality such as emissions, weather, and surrounding conditions over a long term. Then analysis results can be used as important data for air quality management planning and evaluation of the chronic impact of air quality.