• Wind and Structures
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• v.24 no.1
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• pp.59-78
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• 2017

Non-stationarity and non-Gaussian property are two of the most important characteristics of wind. These two features are studied in this study based on wind speed records measured at different heights from a 325 m high meteorological tower during the synoptic wind storms. By using the time-frequency analysis tools, it is found that after removing the low frequency trend of the longitudinal wind, the retained fluctuating wind speeds remain to be asymmetrically non-Gaussian distributed. Results show that such non-Gaussianity is due to the weak-stationarity of the detrended fluctuating wind speed. The low frequency components of the fluctuating wind speeds mainly contribute to the non-zero skewness, while distribution of the high frequency component is found to have high kurtosis values. By further studying the decomposed wind speed, the mechanisms of the non-Gaussian distribution are examined from the phase, turbulence energy point of view.

• BMB Reports
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• v.57 no.2
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• pp.71-78
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• 2024

Melanoma is one of the most aggressive skin tumors, and conventional treatment modalities are not effective in treating advanced melanoma. Although immunotherapy is an effective treatment for melanoma, it has disadvantages, such as a poor response rate and serious systemic immune-related toxic side effects. The main solution to this problem is the use of biological materials such as hydrogels to reduce these side effects and amplify the immune killing effect against tumor cells. Hydrogels have great advantages as local slow-release drug carriers, including the ability to deliver antitumor drugs directly to the tumor site, enhance the local drug concentration in tumor tissue, reduce systemic drug distribution and exhibit good degradability. Despite these advantages, there has been limited research on the application of hydrogels in melanoma treatment. Therefore, this article provides a comprehensive review of the potential application of hydrogels in melanoma immunotherapy. Hydrogels can serve as carriers for sustained drug delivery, enabling the targeted and localized delivery of drugs with minimal systemic side effects. This approach has the potential to improve the efficacy of immunotherapy for melanoma. Thus, the use of hydrogels as drug delivery vehicles for melanoma immunotherapy has great potential and warrants further exploration.

• Genomics & Informatics
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• v.4 no.4
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• pp.182-187
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• 2006

6-Phosphogluconolactonase (6PGL) is one of the key enzymes in the ubiquitous pathways of central carbon metabolism, but bacterial 6PGL had been long known as a missing enzyme even after complete bacterial genome sequence information became available. Although recent experimental characterization suggests that there are two types of 6PGLs (DevB and YbhE), their phylogenetic distribution is severely biased. Here we present that proteins in COG group previously described as 3-oarboxymuconate cyclase (COG2706) are actually the YbhE-type 6PGLs, which are widely distributed in Proteobacteria and Fimicutes. This case exemplifies how erroneous functional description of a member in the reference database commonly used in transitive genome annotation cause systematic problem in the prediction of genes even with universal cellular functions.

• Journal of Microbiology
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• v.34 no.2
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• pp.184-191
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• 1996

The cellular fatty acids and quinones of streptomycetes isolated from volcanic soils were analysed. The strains contained fatty acids of 14 to 17 carbon chains, and 12-methyltetradecanoic acid and 14 methylpentadecanoic acid were dominant in most strains. The total profiles consisted of 74% branched fatty acid family, 16.8% linear family and 8.2% unsaturated family. The largest cluster of grey spore meases defined by numerical classification was separated from the remainders in the principal component analysis, but the other clusters were overlapped with one another. In the analysis of respiratory quinones, all of the strains contained either the menaquinone of 9 isoprene units with 6 hydrogenations of 8 hydrogenations as the major species. The distribution of menaquinones among the clusters could provide an important key in the chemotaxonomy of streptomycetes.

• The Journal of Society for e-Business Studies
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• v.9 no.2
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• pp.33-50
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• 2004

This paper presents the evaluation model which is included in a quantitative evaluation methodology for evaluation processes of validity and effectiveness of information budget investment and improving conformance of ROI(Return On Investment). That is, the right efficiency targets of information investment for the development project to GDOC (Government electronic Document Distribution Center), and KPls(Key Performance Indexes) which enable to evaluate objectively effectiveness in the preliminary and post evaluation phases are developed, and then the results were come out by practical investigation study using quantitative evaluation methodology.

• Earthquakes and Structures
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• v.17 no.5
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• pp.435-445
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• 2019

The collapses of curved bridges are mainly caused by the damaged columns, subjected to the combined loadings of axial load, shear force, flexural moment and torsional moment, under earthquakes. However, these combined loadings have not been fully investigated. This paper firstly investigated the mechanical characteristics of the bending-torsion coupling effects, based on the seismic response spectrum analysis of 24 curved bridge models. And then 9 reinforced concrete (RC) and circular column specimens were tested, by changing the bending-tortion ratio (M/T), axial compression ratio, longitudinal reinforcement ratio and spiral reinforcement ratio, respectively. The results show that the bending-torsion coupling effects of piers are more significant, along with the decrease of girder curvature and the increase of pier height. The M/T ratio ranges from 6 to 15 for common cases, and influences the crack distribution, plastic zone and hysteretic curve of piers. And these seismic characteristics are also influenced by the compression ratio, longitudinal reinforcement ratio and spiral reinforcement ratios of piers.

• Herbal Formula Science
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• v.18 no.1
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• pp.57-77
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• 2010

Objective : This study reviews the recent trend of oriental medical prescription research. The data examined are the articles published in the Korean Journal of Oriental Medical Prescription from 1990 to 2009. Method : The data are retrieved through the internet database Oriental Medicine Advanced Searching Integrated System (OASIS) and the collection of the Korean Journal of Oriental Medical Prescription. The number of articles examined is 385, published in 25 volumes of the journal. This study examines the nature of the articles, research methods, subjects, and author information. Research subjects are sorted out by the OASIS key words for the articles published before 1999, and by key word indexes cited in the abstracts for the articles published sinceafter. Results : Among the 385 articles collected, 206 are research articles, 143 philological articles, 35 case studies, and 1 special contribution. A majority of research articles are experimental studies (199 articles or 96.6%), while clinical reports (5 articles or 2.43%), and others studies (2 articles) occupy a small portion. Most of experimental studies (183 articles or 91%) examine the effectiveness of certain prescriptions or treatments. Among the effectiveness studies, 114 articles (62.3%) employ in vivo experiment design, 52 articles (28.42%) in vitro experiments, and 17 articles (9.29%) both in vivo and in vitro experiments. In terms of research subject, the most frequently indexed key words are hepatotoxicity among diseases (9 articles), Bojungikgitang (Bu-Zhong-Yi-Qi-Tang) among prescriptions (10 articles), Buja (Acontii Tuber) among meteria medica (4 articles), immunity and anti-oxidation among efficacy terminology (6 articles each), and Donguibogam(東醫寶鑑) among references in the key words (25 articles). Universities are the main affiliation of authors (76.42%), followed by university hospitals (6.71%), non-academic research institutes (5.55%), local clinics (4.67), academic research institutes (2.81%), hospitals (2.38%), and others (1.44%). The most affiliated institute of the first and correspondent authors is Wonkwang University. In terms of authorship, co-authorship outnumbers sole-authorship by 82.08% to 17.92%. The proportion of authors of a single article is 63.54% which is near the author productivity distribution described by Lotka's law.

• Nuclear Engineering and Technology
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• v.49 no.5
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• pp.905-913
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• 2017

Advanced reactor designs often feature longer operating cycles between refueling and new concepts of operation beyond traditional baseload electricity production. Owing to this increased complexity, traditional proportional-integral control may not be sufficient across all potential operating regimes. The prototypical advanced reactor (PAR) design features two independent reactor modules, each connected to a single dedicated steam generator that feeds a common balance of plant for electricity generation and process heat applications. In the current research, the PAR is expected to operate in a load-following manner to produce electricity to meet grid demand over a 24-hour period. Over the operational lifetime of the PAR system, primary and intermediate sodium pumps are expected to degrade in performance. The independent operation of the two reactor modules in the PAR may allow the system to continue operating under degraded pump performance by shifting the power production between reactor modules in order to meet overall load demands. This paper proposes a Takagi-Sugeno (T-S) fuzzy logic-based power distribution system. Two T-S fuzzy power distribution controllers have been designed and tested. Simulation shows that the devised T-S fuzzy controllers provide improved performance over traditional controls during daily load-following operation under different levels of pump degradation.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.79.2-79.2
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• 2013

The distributions of Horizontal Branch (HB) star color, temperature, and mass encode a great deal of information on the stellar evolutionary and (possibly) dynamical processes taking place in Globular Clusters (GCs). An accurate physical modeling of the Red Giant Branch (RGB) mass-loss process is key to solving the so-called second parameter problem. In my poster I will present the most recent advancements of an analytical model for mass-loss along the RGB. The model predicts the HB mass distribution with remarkable accuracy over a sample of 4 GCs. These results were submitted as a paper to ApJ (Pasquato et al. 2013, ApJ submitted), but here I expand on them presenting refinements to the model and a comparison with HB masses obtained from Galex ultraviolet observations.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.05a
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• pp.262-269
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• 2003

Recently, a multi facility, multi product and multi period industrial problem has been widely investigated in Supply Chain Management (SCM). One of the key issues in the current SCM research area involved reducing both production and distribution costs. The purpose of this study is to determine the optimum quantity of production and transportation with minimum cost in the supply chain network. We have presented a mathematical model that deals with real world factors and constructs. Considering the complexity of solving such model, we have applied the genetic algorithm approach for solving this model computational experiments using a commercial genetic algorithm based optimizer. The results show that the real size problems we encountered can be solved In reasonable time