• Title/Summary/Keyword: Karnataka

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Therapeutic Assessment of Primaquine for Radical Cure of Plasmodium vivax Malaria at Primary and Tertiary Care Centres in Southwestern India

  • Kumar, Rishikesh;Guddattu, Vasudeva;Saravu, Kavitha
    • Parasites, Hosts and Diseases
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    • v.54 no.6
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    • pp.733-742
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    • 2016
  • Acquaintance is scanty on primaquine (PQ) efficacy and Plasmodium vivax recurrence in Udupi district, Karnataka, India. We assessed the efficacy of 14 days PQ regimen (0.25 mg/kg/day) to prevent P. vivax recurrence. Microscopically, aparasitemic adults (${\geq}18years$) after acute vivax malaria on day 28 were re-enrolled into 15 months' long follow-up study. A peripheral blood smear examination was performed with participants at every 1-2 month interval. A nested PCR test was performed to confirm the mono-infection with P. vivax. Of 114 participants, 28 (24.6%) recurred subsequently. The median (IQR) duration of the first recurrence was 3.1 (2.2-5.8) months which ranged from 1.2 to 15.1 months, including initial 28 days. Participants with history of vivax malaria had significantly higher risk of recurrence, with hazard ratio (HR) (95% CI) of 2.62 (1.24-5.54) (P=0.012). Severity of disease (11.4%, 13/114) was not associated (P=1.00) with recurrence. Of 28 recurrence cases, the nPCR proved that P. vivax mono-infection recurrence rate was at least 72.7% (16/22) at first recurrence. In Udupi district, PQ dose of 0.25 mg/kg/day over 14 days seems inadequate to prevent recurrence in substantial proportion of vivax malaria. Patients with a history of vivax malaria are at high risk of recurrences.

Pharmacognostical Evaluation of an Antioxidant Plant - Acorus calamus Linn

  • Govindarajan, Raghavan;Agnihotri, Adarsh Kumar;Khatoon, Sayyada;Rawat, Ajay Kumar Singh;Mehrotra, Shanta
    • Natural Product Sciences
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    • v.9 no.4
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    • pp.264-269
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    • 2003
  • The rhizome of Acorus calamus Linn. is commonly known as "Vacha" in indigenous systems of medicine. It is distributed in marshy tracts of Kashmir, Sirmaur (Himachal Pradesh), Manipur and the Naga hills. It is regularly cultivated in Koratagere Taluk in Karnataka and other parts of India. This study deals with the detailed pharmacognostical evaluation of the dried rhizomes of Acorus calamus collected from DehraDun (Uttaranchal), Lucknow (Uttar Pradesh). The commercial sample procured from Delhi market was also evaluated to observe the difference between collected and market samples. Dried rhizome is vertically compressed, pale yellow to dark brown and occasionally orangish brown in colour. Transverse section showed two distinct region with scattered, concentric vascular bundles surrounded by fibrous bundle sheath. Some vascular bundles just beneath the endodermis devoid of bundle sheath. Though the botanical and physico-chemical characters of all the samples were quite similar but some variations were observed in High Performance Thin Layer Chromatography (HPTLC) fingerprint profile, the essential oil content and total percentage of asarone which was found to be highest in Lucknow and lowest in Delhi market sample. These variations may be explained due to some edaphic factors or storage conditions. An attempt was also made to test antioxidant activity (in vitro) and it was found to be 88% at 0.2 g/ml concentration.

Pharmacognostical Evaluation of Leucas aspera Link.

  • Rai, Vartika;Agarwal, Manisha;Agnihotri, A.K.;Khatoon, S.;Rawat, A.K.S.;Mehrotra, S.
    • Natural Product Sciences
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    • v.11 no.2
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    • pp.109-114
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    • 2005
  • Leucas aspera Link. (Lamiaceae) is an important medicinal plant in indigenous systems of medicine in India and commonly known as 'Thumbai'. It has various ethnomedicinal values as various traditional communities find diverse medicinal properties. It is used as antipyretic, stimulant, expectorant and diaphoretic drug. The present communication deals with the detailed pharmacognostical evaluation of whole plant of L. aspera collected from five different geographical zones of the country-Uttar Pradesh, Orissa, Karnataka, West Bengal and Gujarat. The botanical characters and TLC fingerprint profile of all the samples were quite similar but some variations were observed in physicochemical parameters. However, some microscopical characters and TLC profile can be used as diagnostic characters for identification of L. aspera, for example amphistomachic leaves and two types of trichomes-abundant, non glandular, uniseriate, 1-3 celled and few glandular, 2-5 celled stalk with rounded tip. Presence of some components at $R_fs-0.56$, 0.65 and 0.76 under UV 366 and at $R_fs-0.31$, 0.43, 0.60, 0.76 and 0.82 under visible light after derivetization in TLC profile may also be used as diagnostic character.

Exploring the Usefulness of e-Resources for Engineering College Teachers and Scholars for their Academic and Research Activities - A Study

  • Puttaswamy, R.M.;Krishnamurthy, M.
    • Journal of Information Science Theory and Practice
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    • v.2 no.1
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    • pp.62-70
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    • 2014
  • The All India Council for Technical Education (AICTE), an apex body of controlling technical education in India, has made mandatory subscription of e-Resources to all its Engineering College Libraries. This policy has directly helped the teaching community, research scholars, and student's paternity, which has benefits for their teaching, research activities, and curriculum, respectively. This study emphasizes the usefulness of e-Resources among the teachers and scholars of engineering colleges in the Bangalore region under Visvesvaraya Technological University (VTU), Belgaum, Karnataka. Survey methodology has been used as the basic research tool for data collection with the help of questionnaires. 866 teaching faculties in VTU were selected randomly on the basis of willingness of users who access the e-Resources for their academic and research activities in the survey. The survey results were tabulated and analyzed with descriptive statistics methods using the SPSS 20 software package. The findings reveal that e-resources are useful for engineering college teachers and scholars for their academic and research activities.

Nearshore waves and longshore sediment transport along Rameshwaram Island off the east coast of India

  • Gowthaman, Rajamanickam;Kumar, V. Sanil;Dwarakish, Gowdagere Siddaramaish;Shanas, P.R.;Jena, Basanta Kumar;Singh, Jai
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.7 no.6
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    • pp.939-950
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    • 2015
  • Wave-induced Longshore Sediment Transport (LST) play an important role in the dynamics of the Dhanushkodi sandspit located southeast of Rameshwaram. The LST along the Dhanushkodi coast is studied based on data collected simultaneously in Gulf of Mannar (GoM) and Palk Bay (PB) using directional waverider buoys. The numerical model REF/DIF1 was used to calculate the nearshore waves and the LST rate was estimated using three different formulae. The model validation was done based on the measured nearshore waves using InterOcean S4DW. Numerical model LITPACK was also used for simulating non-cohesive sediment transport and the LITLINE module was used to study the shoreline evolution over 5 years. Low net annual LST along PB (${\sim}0.01{\times}10^6m^3$) compared to the GoM region ($0.3{\times}10^6m^3$) were due to the weak waves. Accretion in the region led to growth of the Dhanushkodi sandspit by 65 m during the period 2010-2015.

Analysis of Step-Down Converter with Low Ripple for Smart IoT Devices (스마트 사물인터넷 기기용 저리플 방식의 스텝다운 컨버터 분석)

  • Kim, Da-Sol;Al-Shidaifat, AlaaDdin;Gu, Jin-Seon;Kumar, Sandeep;Song, Han-Jung
    • Journal of the Korean Society of Industry Convergence
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    • v.24 no.5
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    • pp.641-644
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    • 2021
  • Wearable devices and IoT are being utilized in various fields, where all systems are developing in the direction of multi-functionality, low power consumption, and high speed. In this paper, we propose a DC -DC Step-down C onverter for IoT smart devices. The proposed DC -DC Step-down converter is composed of a control block of the power supply stage. It also consists of an overheat protection circuit, under-voltage protection circuit, an overvoltage protection circuit, a soft start circuit, a reference voltage circuit, a lamp generator, an error amplifier, and a hysteresis comparator. The proposed DC-DC converter was designed and fabricated using a Magnachip / Hynix 180nm CMOS process, 1-poly 6-metal, the measured results showed a good match with the simulation results.

Coupled evaluation of the free vibration characteristics of magneto-electro-elastic skew plates in hygrothermal environment

  • Mahesh, Vinyas;Kattimani, Subhaschandra;Harursampath, Dineshkumar;Trung, Nguyen-Thoi
    • Smart Structures and Systems
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    • v.24 no.2
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    • pp.267-292
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    • 2019
  • The present article addresses the coupled free vibration problem of skew magneto-electro-elastic plates (SMEE) considering the temperature-moisture dependent material properties. The plate kinematics follows Reddy's higher order shear deformation theory. With the aid of finite element methods, the governing equations of motion are derived considering the Hamilton's principle and solved by adopting condensation technique. The influence of different temperature and moisture dependent empirical constants on the frequency response of SMEE plate has been assessed. In addition, the natural frequencies corresponding to various fields are evaluated and the effect of empirical constants on these coupled frequencies is determined. A detailed parametric study has been carried out to assess the individual effects of temperature and moisture dependent empirical constants along with their combined effect, aspect ratio, length-to-width ratio, stacking sequence and boundary conditions. The results reveal that the external environment as well as the geometrical skewness has a significant influence on the stiffness of the SMEE plates.

HE NONCOMMUTATIVE ℓ1 - ℓ2 INEQUALITY FOR HILBERT C*-MODULES AND THE EXACT CONSTANT

  • Krishna, K. Mahesh;Johnson, P. Sam
    • Nonlinear Functional Analysis and Applications
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    • v.27 no.2
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    • pp.249-259
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    • 2022
  • Let 𝓐 be a unital C*-algebra. Then it follows that $\sum\limits_{i=1}^{n}(a_ia^*_i)^{\frac{1}{2}}{\leq}\sqrt{n}\(\sum\limits_{i=1}^{n}a_ia^*_i\)^{\frac{1}{2}}$, ∀n ∈ ℕ, ∀a1, …, an ∈ 𝓐. By modifications of arguments of Botelho-Andrade, Casazza, Cheng, and Tran given in 2019, for certain n-tuple x = (a1, …, an) ∈ 𝓐n, we give a method to compute a positive element cx in the C*-algebra 𝓐 such that the equality $$\sum\limits_{i=1}^{n}(a_ia^*_i)^{\frac{1}{2}}=c_x\sqrt{n}\(\sum\limits_{i=1}^{n}a_ia^*_i\)^{\frac{1}{2}}$$ holds. We give an application for the integral of Kasparov. We also derive a formula for the exact constant for the continuous ℓ1 - ℓ2 inequality.

FAULT DIAGNOSIS OF ROLLING BEARINGS USING UNSUPERVISED DYNAMIC TIME WARPING-AIDED ARTIFICIAL IMMUNE SYSTEM

  • LUCAS VERONEZ GOULART FERREIRA;LAXMI RATHOUR;DEVIKA DABKE;FABIO ROBERTO CHAVARETTE;VISHNU NARAYAN MISHRA
    • Journal of applied mathematics & informatics
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    • v.41 no.6
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    • pp.1257-1274
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    • 2023
  • Rotating machines heavily rely on an intricate network of interconnected sub-components, with bearing failures accounting for a substantial proportion (40% to 90%) of all such failures. To address this issue, intelligent algorithms have been developed to evaluate vibrational signals and accurately detect faults, thereby reducing the reliance on expert knowledge and lowering maintenance costs. Within the field of machine learning, Artificial Immune Systems (AIS) have exhibited notable potential, with applications ranging from malware detection in computer systems to fault detection in bearings, which is the primary focus of this study. In pursuit of this objective, we propose a novel procedure for detecting novel instances of anomalies in varying operating conditions, utilizing only the signals derived from the healthy state of the analyzed machine. Our approach incorporates AIS augmented by Dynamic Time Warping (DTW). The experimental outcomes demonstrate that the AIS-DTW method yields a considerable improvement in anomaly detection rates (up to 53.83%) compared to the conventional AIS. In summary, our findings indicate that our method represents a significant advancement in enhancing the resilience of AIS-based novelty detection, thereby bolstering the reliability of rotating machines and reducing the need for expertise in bearing fault detection.

Evaluation of Relative Fluoride Toxicity and Its Impact on Growth, Economic Characters and Fecundity of the Silkworm, Bombyx mori L.

  • Ramakrishna, S.;Nath, B.Surendra;Jayaprakash
    • International Journal of Industrial Entomology and Biomaterials
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    • v.8 no.2
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    • pp.151-159
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    • 2004
  • A detailed evaluation of relative toxicity of fluoride to die 5th instar larvae of PM and NB$_4$D$_2$ races of silkworm and the effects of lethal, sublethal and prevailing levels of fluoride in groundwater on the growth, economic characters and fecundity of the silkworm, Bombyx mori (Lepidoptera: Bombycidae) were studied. The feeding of mulberry, Morus alba leaves treated with lethal and sublethal doses of fluoride to PM and NB$_4$D$_2$ races of silkworms from the beginning of the 5th instar to the end of the feeding period resulted in significant reduction in growth, single cocoon weight, single shell weight, silk index, average filament length, and fecundity when compared to controls. These manges were more pronounced on exposure to lethal dose than sublethal dose and in general, the changes induced by fluoride were more striking in NB$_4$D$_2$ than PM, indicating the greater resistance of PM to higher fluoride levels. Groundwater quality in sericulturally important villages of Karnataka and Andhra Pradesh States has been studied with special reference to the presence of fluoride. On exposure to dose of prevailing levels in the waters of sericulturally important areas, die changes observed on growth, economic characters and fecundity were slightly lower when compared to controls and the decrease was found to be insignificant (P$\geq$0.05). It was concluded that, though minute dose (4.0 ppm) of fluoride did not have any toxic impact, it is toxic at higher concentrations to silkworms.