• Molecules and Cells
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• 제44권11호
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• pp.843-850
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• 2021

The rapid increase in collateral omics and phenotypic data has enabled data-driven studies for the fast discovery of cancer targets and biomarkers. Thus, it is necessary to develop convenient tools for general oncologists and cancer scientists to carry out customized data mining without computational expertise. For this purpose, we developed innovative software that enables user-driven analyses assisted by knowledge-based smart systems. Publicly available data on mutations, gene expression, patient survival, immune score, drug screening and RNAi screening were integrated from the TCGA, GDSC, CCLE, NCI, and DepMap databases. The optimal selection of samples and other filtering options were guided by the smart function of the software for data mining and visualization on Kaplan-Meier plots, box plots and scatter plots of publication quality. We implemented unique algorithms for both data mining and visualization, thus simplifying and accelerating user-driven discovery activities on large multiomics datasets. The present Q-omics software program (v0.95) is available at http://qomics.sookmyung.ac.kr.

• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9453-9458
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• 2014

Background: Breast cancer is the second leading cause of cancer death for women in the United States. Differences in survival of breast cancer have been noted among racial and ethnic groups, but the reasons for these disparities remain unclear. This study presents the characteristics and the survival curve of two racial and ethnic groups and evaluates the effects of race on survival times by measuring the lifetime data-based half-normal model. Materials and Methods: The distributions among racial and ethnic groups are compared using female breast cancer patients from nine states in the country all taken from the National Cancer Institute's Surveillance, Epidemiology, and End Results cancer registry. The main end points observed are: age at diagnosis, survival time in months, and marital status. The right skewed half-normal statistical probability model is used to show the differences in the survival times between black Hispanic (BH) and black non-Hispanic (BNH) female breast cancer patients. The Kaplan-Meier and Cox proportional hazard ratio are used to estimate and compare the relative risk of death in two minority groups, BH and BNH. Results: A probability random sample method was used to select representative samples from BNH and BH female breast cancer patients, who were diagnosed during the years of 1973-2009 in the United States. The sample contained 1,000 BNH and 298 BH female breast cancer patients. The median age at diagnosis was 57.75 years among BNH and 54.11 years among BH. The results of the half-normal model showed that the survival times formed positive skewed models with higher variability in BNH compared with BH. The Kaplan-Meir estimate was used to plot the survival curves for cancer patients; this test was positively skewed. The Kaplan-Meier and Cox proportional hazard ratio for survival analysis showed that BNH had a significantly longer survival time as compared to BH which is consistent with the results of the half-normal model. Conclusions: The findings with the proposed model strategy will assist in the healthcare field to measure future outcomes for BH and BNH, given their past history and conditions. These findings may provide an enhanced and improved outlook for the diagnosis and treatment of breast cancer patients in the United States.

• Journal of Microbiology and Biotechnology
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• 제34권4호
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• pp.958-968
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• 2024

In recent years, there has been a growing recognition of the important role that long non-coding RNAs (lncRNAs) play in the immunological process of hepatocellular carcinoma (LIHC). An increasing number of studies have shown that certain lncRNAs hold great potential as viable options for diagnosis and treatment in clinical practice. The primary objective of our investigation was to devise an immune lncRNA profile to explore the significance of immune-associated lncRNAs in the accurate diagnosis and prognosis of LIHC. Gene expression profiles of LIHC samples obtained from TCGA database were screened for immune-related genes. The optimal immune-related lncRNA signature was built via correlational analysis, univariate and multivariate Cox analysis. Then, the Kaplan-Meier plot, ROC curve, clinical analysis, gene set enrichment analysis, and principal component analysis were performed to evaluate the capability of the immune lncRNA signature as a prognostic indicator. Six long non-coding RNAs were identified via correlation analysis and Cox regression analysis considering their interactions with immune genes. Subsequently, tumor samples were categorized into two distinct risk groups based on different clinical outcomes. Stratification analysis indicated that the prognostic ability of this signature acted as an independent factor. The Kaplan-Meier method was employed to conduct survival analysis, results showed a significant difference between the two risk groups. The predictive performance of this signature was validated by principal component analysis (PCA). Additionally, data obtained from gene set enrichment analysis (GSEA) revealed several potential biological processes in which these biomarkers may be involved. To summarize, this study demonstrated that this six-lncRNA signature could be identified as a potential factor that can independently predict the prognosis of LIHC patients.

• 한국조명전기설비학회:학술대회논문집
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• 한국조명전기설비학회 2007년도 춘계학술대회 논문집
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• pp.366-368
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• 2007

In this paper, the Time-varying Failure Rate (TFR) of power distribution system equipment is extracted from the recorded failure data of Korea Electric Power Corporation (KEPCO). For TFR extraction, it is used that the fault data accumulated by KEPCO during 10 years. The TFR is approximated to bathtub curve using the exponential (random failure) and Weibull (aging failure) distribution function. In addition, Kaplan-Meier estimation is applied to TFR extraction because of incomplete failure data of KEPCO. Finally, Probability plot and regression analysis is applied. It is presented that the extracted TFR is more effective and useful than Mean Failure Rate (MFR) through the comparison between TFR and MFR.

• Genomics & Informatics
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• 제13권3호
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• pp.86-89
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• 2015

Because there are clear molecular differences entailing different treatment effectiveness between Korean and non-Korean cancer patients, identifying distinct molecular characteristics of Korean cancers is profoundly important. Here, we report a web-based data repository, namely Korean Cancer Genome Database (KCGD), for searching gene signatures associated with Korean cancer patients. Currently, a total of 1,403 cancer genomics data were collected, processed and stored in our repository, an ever-growing database. We incorporated most widely used statistical survival analysis methods including the Cox proportional hazard model, log-rank test and Kaplan-Meier plot to provide instant significance estimation for searched molecules. As an initial repository with the aim of Korean-specific marker detection, KCGD would be a promising web application for users without bioinformatics expertise to identify significant factors associated with cancer in Korean.

• 대한골관절종양학회지
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• 제1권1호
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• pp.17-22
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• 1995

From Sept. 1986 to Dec. 1992, seventy three cases of Enneking's stage IIB osteosarcoma of extremities, which were proved histologically, took neoadjuvant chemotherapy and completed our protocol. Their average age was 16.7 years(7 to 57). For neoadjuvant chemotherapy, 37 cases took high dose methotrexate(HDMTX)-adriamycin(ADR)-cisplatin(CDDP) regimen(HDMTX group) and 36 cases took ADR-CDDP(ADR-CDDP group). The average follow up was 17 months(2-63). According to Kaplan-Meier's plot, 5-year continuously disease free survival for whole 73 cases of neoadjuvant group was 45.2%, for HDMTX group 68.4%, for ADR-CDDP group 26.6%. There was significant stastical difference between these two groups(p<0.001), with log-rank test. There can be a different survival according to the chemotherapeutic protocols. Better results can be achieved through refined protocol and effective chemotherapeutic agents.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7987-7990
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• 2015

Chronic lymphocytic leukemia (CLL)is the most common leukemia in adults in Western countries but is relatively rare in Asia. Immune hemolytic anemia, Evan's syndrome, lymphadenopathy, organomegaly and B symptoms are the main complaints of patients in CLL. The present retrospective analysis evaluated a group of 109 patients with CLL over a 9-year period, studying correlations between sex, age and overall survival. The patients were hospitalized in the Clinic of Hematology and Oncology, Kermanshah, Iran, between 2006 and 2014. Data analysis for sex and age was performed using IBM SPSS19 and overall survival was plotted by Kaplan-Meier plot, Log-rank test in Graph Pad prism 5 Software for five-year periods. The mean age of diagnosis for CLL patients was 60.73 years, 59.6% male. Survival rate patients was 64% and mean overall survival was 38.5 months. In the Rai system, fourteen patients (12.8%) had stage III and twenty eight patients (25.7%) had stage IV. Most frequent clinical features in patients with CLL were lymphadenopathy (38.7%) and organomegaly (34%), respectively. There is not relationship between sex and age in patients but overall survival rate in females was higher than in males. In Asian countries, CLL is more in male and in age above 60 years. Complaints about lymphadenopathy and virus infection are prevalent.

• 대한전기학회논문지:전력기술부문A
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• 제54권11호
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• pp.548-556
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• 2005

Reliability evaluation of power distribution system is very important to both power utilities and customers. It present the probabilistic number and duration of interruption such as failure rate, SATDI, SAIFI, and CAIDI. However, it has a fatal weakness at reliability index because of accuracy of failure rate. In this paper, the Time-varying Failure Rate(TFR) of power distribution system equipment is extracted from the recorded failure data of KEPCO(Korea Electric Power Corporation) in Korea. For TFR extraction, it is used that the fault data accumulated by KEPCO during 10 years. The TFR is approximated to bathtub curve using the exponential(random failure) and Weibull(aging failure) distribution function. In addition, Kaplan-Meier estimation is applied to TFR extraction because of incomplete failure data of KEPCO. Finally, Probability plot and regression analysis is applied. It is presented that the extracted TFR is more effective and useful than Mean Failure Rate(MfR) through the comparison between TFR and MFR

• 대한골관절종양학회지
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• 제4권1호
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• pp.30-36
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• 1998

Squamous cell carcinoma is a neglected disease entity in orthopedic oncology. The purpose of this study was to analyze overall survival and the role of surgery on survival and to evaluate the significance of possible prognostic factors. From Oct, 1986 to Aug, 1996, 57 patients were enlisted and 42 patients ere eligible. Inclusion criteria included more than one year follow-up and no distant metastasis at the first visit. Staging and survival followed AJC classification and Kaplan-Meier plot. Stage II included 17 cases and stage III, 25 cases. Thirty-eight patients underwent operations, chemotherapy, and/or radiotherapy, and the remaining four had operations only. The chemotherapeutic regimen was adriamycin-cisplatin. The average follow-up period was 45 months. The ten-year actuarial survival rate of whole patients was 65.4%. Location of primary lesion, stage, pathologic grading, and intensity of chemotherapy in the same stage showed a significant difference in survival. Nine out of 42 patients had local recurrence. Seven patients had inadequate wide margins and two had intralesional margins. Average period of recurrence from operation was 13(4-35)months. The operation itself had no impact on survival but a surgical margin of no less than 3cm from the lesion was important for local control. Pathological grade and staging were significant variables for long term survival. Acral lesion had a significantly higher chance of regional and distant metastasis but actual survival showed no difference. In stage II, aggressive chemotherapy could delay or reduce the chance of regional or distant metastasis.

• 대한정형외과학회지
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• 제56권1호
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• pp.42-50
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• 2021

목적: 종양인공관절 주위 골절은 안정된 고정의 어려움과 골유합 후에도 골질 약화로 해리 및 재골절 위험이 많다. 피질골 지주 중첩 동종골 이식술을 종양인공관절 주위 골절에 적용하면 내고정도 쉽고, 골유합 기간도 단축되며, 합병증도 줄일 수 있을 것이라고 생각하였다. 본 연구는 종양인공관절 주위 골절 27예(30 골절)의 골절의 양상과 치료 후 재건 술식에 따른 생존율 및 합병증, 중첩 동종골 이식술 추가 여부에 따라 골유합 기간 및 기능적 결과가 차이가 있는지 분석하였다. 대상 및 방법: 골절 치료 시 판형 동종골 이식을 한 군 16예와 시행하지 않은 군 14예를 비교하였다. 분석항목은 종양인공관절 치환술부터 골절까지 기간, 골절의 양상, 골유합 기간 차이, 합병증, 및 기능적 결과를 기술하였다. 결과: 골절 양상은 unified classification system (UCS) B형이 21예(70.0%, 21/30)로 가장 많았으며 그 중 B1이 14예(46.7%, 14/30), B2가 1예(3.4%, 1/30), B3가 6예(20.0%, 6/30)였고 C형이 9예(30.0%, 9/30)였다. Kaplan-Meier 법에 의한 30 재건 부위의 5년, 10년 생존율은 각각 84.5%±4.18%, 42.2%±7.83%였다. 전체 30예의 골유합 기간은 평균 5.1개월(범위, 2.0-11.2개월)이었다. 동종골 이식군은 평균 3.5개월(범위, 2.0-6.26개월)로 고식적 고정군의 평균 7.2개월(범위, 4.0-11.2개월)보다 짧았다(p<0.0001). 최종 기능평가상 동종골 이식군은 평균 26.1점으로 고식적 고정군의 평균 20.9점보다 높았다(p<0.0001). 합병증은 4예로 모두 동종골을 사용하지 않은 군에서 있었다. 결론: 종양인공관절 주위 골절은 드물고 골유합도 비교적 잘 이루어지나 유합 후 합병증 최소화가 중요하다. 판형 중첩 동종골 이식술은 골유합 기간을 단축, 골질 증가, 해리위험성 감소 효과가 있으며 종양인공관절 주위 골절에 유용한 방법이다.