• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5835-5838
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• 2014

Background: Gastric cancer is one of the most common causes of cancer death in Taiwan. The literature has previously shown that age, tumor site, T categories, and number of metastatic nodes significantly affect prognosis. The aim of this study was to determine the long-term survival of patients with gastric cancer, as well as the effect of particular prognostic factors on survival. Materials and Methods: This was a survival analysis study with retrospective design. We reviewed the records of 64 patients with adenocarcinoma of the stomach who had undergone gastrectomy with curative intent between 2009 and 2012 at a teaching hospital in southern Taiwan. Data extracted from patient documents included age, gender distribution, tumor location, and pathological grading. Results: The median follow-up time was 4 years, and there were 31 deaths attributed to gastric cancer. Kaplan-Meier analysis revealed that retrieval of less than 15 lymph nodes from a patient was a significant predictor of survival. A significant predictor of poorer survival was higher pathological grading. Conclusions: Our results indicate that the number of lymph nodes retrieved and pathological grading could be viewed as crucial prognostic factors affecting the survival of individuals with gastric cancer.

• 중환자간호학회지
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• 제12권1호
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• pp.57-70
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• 2019

Purpose : The purpose of this study was to identify the risk factors for falls in tertiary hospital inpatients and to suggest data for developing a nursing intervention program for preventing falls. Methods: Data were collected between January 1, 2017, to December 31, 2017. Kaplan-Meier estimation was used to measure the survival rate, and the log-rank test was used for the differences between the fall group and the non-fall group. The Cox proportional hazards model was used to identify the risk factors for falls. Results: The incidence rate of falls for the inpatients was 1.2 cases per 1,000 days of hospitalization. The risk factors for falls were more likely to be found among those who were aged ${\geq}81$, had not undergone surgery, had poor joint motion, had unsteady gait, needed help or supervision, used assistive devices, had comorbidity, and took at least two drugs. Conclusion: For the inpatients, the risk factors for falls included age, surgery, comorbidity, medication that could change mobility, joint motion, and use of patient care equipment. It is necessary to give special attention to inpatients who have any of these risk factors and to develop a falls risk assessment tool.

• 대한의생명과학회지
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• 제28권1호
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• pp.9-24
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• 2022

The aim of this study was to identify the expression of zinc finger E-box binding homeobox 1 (ZEB1), its prognostic significance, and correlation between ZEB1 and infiltrating immune cells in lung cancer. Correlation between ZEB1 and telomerase was also analyzed in different types of cancers. RNA sequencing analysis and survival rates of patients were confirmed by Gene Expression Profiling Interactive Analysis (GEPIA). The Kaplan-Meier plotter and PrognoScan databases were used to analyze the prognostic value of ZEB1 in various cancers. The Tumor IMmune Estimation Resource (TIMER) was used to determine the correlation between ZEB1 and infiltrating immune cells. Lower ZEB1 expression was lower in lung cancer and was related to poor prognosis in lung adenocarcinoma (LUAD). ZEB1 expression exhibited a significantly positive correlation with infiltration levels of immune cells in LUAD and lung squamous cell carcinoma. Furthermore, we found that the ZEB1 expression correlated with subunits of telomerase. Our findings suggest ZEB1 as a potential biomarker to be used for prognostic significance and tumor immunology in lung cancer. The correlation between the expression of ZEB1 and telomere-related gene will help in understand the cancer-promoting mechanisms.

• 대한골관절종양학회지
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• 제18권1호
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• pp.7-13
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• 2012

목적: 편평상피 세포암 환자의 치료 결과를 분석하여, 전반적인 생존율과 예상 가능한 예후인자들에 따른 생존율을 비교하고 분석하는데 있다. 대상 및 방법: 1999년 3월부터 2011년 2월까지 본원에서 병리학적으로 진단된 사지와 체부에 발생한 편평상피 세포암은 151예였고 수술적 치료를 시행한 환자는 51예였다. 연구는 이 중 12개월 이상 외래추적이 가능하였던 41예를 대상으로 하였다. 평균 연령은 64.4세였고, 남자와 여자는 각각 31명, 10명이었다. 수술은 광범위 절제 및 재건술(29예)과 절제연을 얻기 힘든 사지 말단부나 신경, 혈관계를 침범한 경우에 절단술(12예)을 시행하였다. 수술적 치료만 시행한 환자는 33예이고, 절제 후 항암화학치료 또는 방사선 치료를 시행한 환자는 8예가 있었다. 병기는 AJCC 분류에 따라 나누었으며 생존율은 Kaplan-Meier 법으로 계산하였고 군간의 생존율 비교는 Log-rank test를 이용하였다. 생존율과 관련된 예후 인자들로 원발 병소의 위치, 병인, 조직학적 분류, 병기, 수술방법, 추가 항암요법 여부를 조사하여 각각 생존율을 비교하였다. 결과: 평균 외래 추적은 평균 65.2개월(12-132개월)이었고 최종 추시 상 생존은 30예(73.1%)이었고 Kaplan-Meier에 의한 5년 생존율은 77%이었다. 전체 환자에서 총 3예(7.3%)의 국소 재발과 7예(17.0%)의 전이가 있었다. 국소재발 3예에서 재발시기는 평균 27개월(18-43개월)이었다. 원발 병소의 위치, 병인, 조직학적 분류, AJCC 분류에 따른 병기, 추가 항암요법에서 생존율은 통계적으로 유의한 차이가 없었으나 절단술을 시행한 환자는 광범위 절제술을 시행한 환자보다 생존율이 낮았다. 결론: 41예의 편평상피 세포암의 치료결과를 분석한 결과 5년 생존율이 77%이었고 예후에 영향을 미칠 수 있는 여러 인자 중에 수술 방법만이 통계적으로 유의하였다.

• 대한치과보철학회지
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• 제57권4호
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• pp.342-349
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• 2019

목적: 이 연구의 목적은 구치부 영역에서 임플란트 지지 고정 보철물의 재료에 따른 생존율과 성공률을 후향적으로 조사하는 것이다. 또한 임플란트 지지 고정성 보철물에서 발생하는 합병증의 양상을 관찰하고 실패에 영향을 주는 요인을 평가하는 것이다. 대상 및 방법: 2011년 1월부터 2018년 6월 사이에 전북대학교 치과병원 치과보철과에서 한 명의 보철전문의에 의해 구치부 임플란트 보철 수복을 시행한 환자를 대상으로 하였다. 의료기록을 통해 환자의 성별, 연령, 보철물의 재료, 위치, 유형 및 합병증을 조사하였다. 생존율 및 성공률 분석을 위해 Kaplan-Meier 분석법을 이용하였으며, 집단간 비교를 위해 Log-rank test를 사용하였다. 또한 Cox proportional hazards model을 이용하여 위험요소가 성공률에 미치는 영향을 분석하였다. 결과: 총 245명의 환자에서 364개의 임플란트 보철물이 관찰되었으며, 평균 추적관찰기간은 17.1개월이었다. 전체 임플란트 보철물의 3년, 5년 누적생존율은 각각 97.5%, 91.0%로 관찰되었으며, 총 5개의 임플란트 보철물이 실패하여 제거되었다. 임플란트 보철물의 3년, 5년 누적성공률은 각각 61.1%, 32.9%로 관찰되었으며, 재료, 성별, 연령, 보철물의 위치, 유형은 누적성공률에 영향을 미치지 않았다 (P > .05). 합병증은 인접면 접촉 상실 (53건), 유지력 상실 (17건), 임플란트 주위 점막염 (12건), 저위교합 (4건) 등의 순으로 발생하였다. 결론: 구치부에서 임플란트 지지 고정성 보철물의 높은 누적생존율을 고려할 때, 임플란트는 수복 재료와 상관없이 구치부에서 치아를 대체할 수 있는 신뢰할만한 치료방법으로 생각된다. 그러나 합병증이 빈번히 발생하기 때문에 정기적인 검사와 필요한 경우 수리 및 조정이 매우 중요하다.

• Journal of Chest Surgery
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• 제27권9호
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• pp.785-792
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• 1994

In this study, the authors analyzed the prognostic value of four clinical variables[age and sex of patients, association with myasthenia gravis and clinical stage] and histological type in 30 consecutive patients with thymoma, histologically classified as cortical[10],medullary[5] and mixed[15]type according to Marino and Muller-Hermelink classification. There were significant differences between the histological types in the frequency of the different tumor stages and myasthenia gravis and prognosis.Most of the cortical thymomas were at stage III and all of the medullary and most of the mixed tumors at stage I or II.Myasthenia gravis occurred more commonly in patients with cortical[30%] and mixed thymoma[60%] than in patients with medullary thymoma[10%]. Follow-up was conducted in 30 patients,with follow-up range from 3 months to 120 months[mean,47.3months]. 5 year actuarial survival was 100% for medullary thymoma, 73% for mixed thymoma, and 47% for cortical thymoma.The overall survival curve shows that 87.6% of the patients are alive at 2 years and 72.8% at 5 years. And 7 patients was dead during follow-up periods.By Kaplan-Meier technique, we found that the patients who had myasthenia gravis had better prognosis[P<0.05]. Medullary thymoma is a comparatively rare, benign tumor, and usually not associated with myasthenia gravis. Cortical thymoma must be regarded as malignant. Mixed thymoma is intermediate in its behavior between medullary and cortical thymoma. But these tumors should be considered potentially malignant despite of presence as stage I of II disease. Also, the patients with stageI,II had good prognosis and the patients with total resection had good prognosis[P<0.05].

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.863-866
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• 2016

Background: Extensive efforts have been made to investigate c-KIT expression in lung cancer specimens and its correlation with clinical outcomes, but the issue remains unresolved. Thus, this study will be conducted to clarify the prognostic value of c-KIT expression in lung cancer patients. Materials and Methods: We will search Pubmed, SCOPUS, and ISI web of sciences with no restriction of language. Studies with any design (except case reports or case series) evaluating correlations of c-KIT expression with survival or outcome in patients with lung cancer will be included. The outcome measures will include all types of survival indexes, including overall survival rate and disease free survival using Kaplan-Meier analysis and hazard ratios. Study selection and data extraction will be performed by two independent researchers. Quality assessment (assessment of risk of bias) and data synthesis will be implemented using Stata software version 11.1. Results: No ethical issues are predicted. These findings will be published in a peer-reviewed journal and presented at national and international conferences. Conclusions: This systematic review protocol is registered in the PROSPERO International Prospective Register of Systematic Reviews, registration number = CRD42015023391.

• 대한간호학회지
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• 제42권5호
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• pp.730-737
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• 2012

Purpose: This study was done to identify the time interval to pressure ulcer and to determine the optimal time interval for position change depending on pressure ulcer risk in patients using foam mattress in intensive care units. Methods: The Braden scale score, occurrence of pressure ulcers and position change intervals were assessed with 56 patients admitted to an intensive care unit from April to November, 2011. The time to pressure ulcer occurrence by Braden scale risk group was analyzed with Kaplan-Meier survival analysis and log rank test. Then, the optimal time interval for position change was calculated with ROC curve. Results: The median time to pressure ulcer occurrence was 5 hours at mild or moderate risk, 3.5 hours at high risk and 3 hours at very high risk on the Braden scale. The optimal time interval for position change was 3 hours at mild and moderate risk, 2 hours at high and very high risk of Braden scale. Conclusion: When foam mattresses are used a slight extension of the time interval for position change can be considered for the patients with mild or moderate pressure ulcer risk but not for patients with high or very high pressure ulcer risk by Braden scale.

• 대한간호학회지
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• 제44권5호
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• pp.573-580
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• 2014

Purpose: This study was conducted to analyze intubation survival rates according to characteristics and to identify the risk factors affecting deliberate self-extubation. Methods: Data were collected from patients' electronic medical reports from one hospital in B city. Participants were 450 patients with endotracheal intubation being treated in intensive care units. The collected data were analyzed using Kaplan-Meier estimation, Log rank test, and Cox's proportional hazards model. Results: Over 15 months thirty-two (7.1%) of the 450 intubation patients intentionally extubated themselves. The patients who had experienced high level of consciousness, agitation. use of sedative, application of restraints, and day and night shift had significantly lower intubation survival rates. Risk factors for deliberate self-extubation were age (60 years and over), unit (neurological intensive care), level of consciousness (higher), agitation, application of restraints, shift (night), and nurse-to-patient ratio (one nurse caring for two or more patients). Conclusion: Appropriate use of sedative drugs, effective treatment to reduce agitation, sufficient nurse-to-patient ratio, and no restraints for patients should be the focus to diminish the number of deliberate self-extubations.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6455-6459
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• 2014

Background: Nasopharyngeal carcinoma (NPC) is the fourth most common cancer in Malaysia. The objective of this study was to determine the five-year survival rate and median survival time of NPC patients in Hospital Universiti Sains Malaysia (USM). Methods: One hundred and thirty four NPC cases confirmed by histopathology in Hospital USM between $1^{st}$ January 1998 and $31^{st}$ December 2007 that fulfilled the inclusion and exclusion criteria were retrospectively reviewed. Survival time of NPC patients were estimated by Kaplan-Meier survival analysis. Log-rank tests were performed to compare survival of cases among presenting symptoms, WHO type, TNM classification and treatment modalities. Results: The overall five-year survival rate of NPC patients was 38.0% (95% confidence interval (CI): 29.1, 46.9). The overall median survival time of NPC patients was 31.30 months (95%CI: 23.76, 38.84). The significant factors that altered the survival rate and time were age (p=0.041), cranial nerve involvement (p=0.012), stage (p=0.002), metastases (p=0.008) and treatment (p<0.001). Conclusion: The median survival of NPC patients is significantly longer for age ${\leq}50$ years, no cranial nerve involvement, and early stage and is dependent on treatment modalities.