• Title/Summary/Keyword: KSM-2690 B

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Structure Elucidation and Antibacterial Activity of Oxazolomycin Family KSM-2690 B Derived from Actinomycete Collected in Jeju Island (제주도 방선균 유래 oxazolomycin 계열 KSM-2690 B의 구조 결정과 항균활성에 관한 연구)

  • Hyeongju Jeong;Jooyoung Kim;Soohyun Um;Kyuho Moon
    • Korean Journal of Pharmacognosy
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    • v.54 no.1
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    • pp.16-20
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    • 2023

  • KSM-2690 B (1), a peptide-polyketide hybrid compound, was discovered from an actinomycete strain (CJD 1) isolated from Dong-Baek hill on Jeju Island, Republic of Korea. The chemical structure of 1 was identified by using NMR, MS, and UV spectroscopic analyses. Careful analysis of 1D and 2D NMR data revealed that KSM-2690 (1) has an oxazole ring, a β-lactone-γ-lactam spirocycle ring, and both triene and diene structures. KSM-2690 B (1) showed inhibitory activities against E. coli at 200 ㎍/mL.

  • https://doi.org/10.22889/KJP.2023.54.1.16 인용 PDF HTML