• YAKHAK HOEJI
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• v.33 no.3
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• pp.167-174
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• 1989

KR-1008 and KR-30006 are 1,4-dihydropyridine derivatives, new vasodilatory calcium antagonists from KRICT. Calcium antagonistic properties of the compounds were studied in the isolated heart (Langendorff preparation), pulmonary artery (vasodilation), and in the papillary muscle (negative inotropic effect) of the guinea pig. Antihypertensive effect were also investigated after i.v. or oral administration in the SHR (spontaneously hypertensive rat). They produced a sigificant inhibition of Ca-induced contraction in the guinea pig pulmonary artery at the concentrations of above $10^{-8}M$. The negative inotropic effect of the electrically stimulated papillary muscle appeared from the concentration of $10^{-6}M$, which is about hundred times higer than the concentration of vasodilation effect. Left ventricular pressure also decreased from the concentration of $3\;{\times}\;10^{-6}M$ in KR-1008 and KR-3006 in the Langendorff heart preparations. Coronary flow rate increased from $10^{-6}M$ in KR-1008 and nicardipine and appeared no change in KR-30006. The antihypertensive effect of KR-1008 (EC 20: $2.9\;{\mu}g/kg$) was potent more than nicardipine (EC 20: $3.4\;{\mu}g/kg$) and than Kr-30006 (EC 20: $6.8\;{\mu}g/kg$) was, after i.v. bolus injection in the anesthetized SHR. The antihypertensive effect in the conscious SHR appeared 30 minutes after oral administration of 10 mg/kg and persisted 4 hrs in KR-1008 and 12 hrs in KR-30006. Heart rate tended to increase for 0.5-1 hr after oral administration of the test compounds.

• Proceedings of the KSR Conference
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• 2011.05a
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• pp.1002-1008
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• 2011

Turnout is a mechanical installation enabling railway trains to be guided from one track to another at a railway junction. there are classified variously according to rail type, sleeper type, fastening system, track type. Construction of concrete track are on the increase recently to secure the safety of track structure as well as to reduce the maintenance cost. SFC fastening system used the plain track a lot and for those reasons, The fast clip turnout demand growing to improving efficiency of the maintenance cost by unification of fastening clip on whole line. in this study is about development of the fastening system for new turnout using fast clip. this fastening system assembled elasticity pad underneath a base plate. its can change stiffness how to adjust contact surface area of elasticity pad Developed fastening system have passed test according to rule of KRS-TR0014-09R (rail fastening system) and Performance Certification by KR.