• YAKHAK HOEJI
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• v.58 no.3
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• pp.190-199
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• 2014

The Korean Pharmaceutical Codex (KPC) analytical method of ambroxol hydrochloride and clenbuterol hydrochloride formulation is complicated and needed to carry out multiple processes during the test. To improve the low efficiency of analytical procedure that makes pharmaceutical laboratory consume much time and high cost to conduct the test of this formulation, this study was performed for simplifying the pretreatment process and optimizing conditions of the HPLC assay. The analytical procedure using HPLC was developed to establish analytical specification for ambroxol hydrochloride and clenbuterol hydrochloride formulations. The newly developed analytical method has good linearity ($R^2$ >0.999), specificity, precision (RSD<1.0%) and the recovery ranges of 98.50~101.84% for ambroxol, 98.29~101.35% for clenbuterol syrup and 98.66~101.71% for clenbuterol tablets. The LOQs were 0.204 ${\mu}g/ml$ for ambroxol, 0.021 ${\mu}g/ml$ for clenbuterol syrup and 0.073 ${\mu}g/ml$ for clenbuterol tablets. The new method was performed with commercially available samples to confirm analytical conditions and validated to be suitable for saving time and cost to control the quality of routine manufactured products. This analytical method will be used for revising the monograph of ambroxol hydrochloride and clenbuterol hydrochloride formulation in next supplement of KPC.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.28 no.1
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• pp.23-30
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• 2022

This study investigated the characteristics for rice husk pulverization and surface modification of biomass byproducts composed of rice husk, corn extract gourd, wheat bran, and soybean curd. The size of particles of rice husk was at 6.44 ㎛ and represented the most affordable material for preparing the bio-degradable film among the tested byproducts. The silane treatment and adding 2% of ESO (Epoxidized soybean oil) and 3-aminopropyl triethoxysilane solution mixed in a 1:1 ratio were best to the surface modification and SEM-based particle shape. Above the results, adding 2% of mixed solution after silane treatment of rice husks processed through an air classifying mill (ACM) allows for its use as a raw material of bio-degradable plastic film.

• Journal of Medicine and Life Science
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• v.20 no.2
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• pp.67-72
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• 2023

Carbapenem-resistant Enterobacteriaceae (CRE) infections have increased rapidly over the past decade and are recognized as a severe health threat in Korea and worldwide. This study aimed to identify the status and characteristics of CRE infection in Jeju province and provide important basic data for the prevention and management of CRE infection. A descriptive epidemiological analysis was performed on reported cases of CRE infection in Jeju Province between 2018 and 2021 using the integrated management system for disease, an infectious disease reporting system from the Korea Disease Control and Prevention Agency. The annual difference and distribution trends of CRE infection were analyzed using CRE isolates, carbapenemase-producing CREs (CP-CRE) and their genotypes, and the type of medical institution in Jeju Province. CRE infections steadily increased in Jeju from 2018 to 2021, and the proportion of CP-CRE among the CREs also showed a statistically significant increase each year. Among the CRE isolates, Klebsiella pneumoniae (KPC, 62.13%) was the most common, and among the CP-CRE genotypes, KPC (81.62%) showed the highest distribution and increased each year. As the distribution of CP-CRE in have increased over the past 4 years, measures to prevent the spread and outbreak of CRE infections are warranted. The results of this study are expected to be used as basic data for prevention and management of CRE infections in the province.

• Annals of Clinical Microbiology
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• v.22 no.1
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• pp.9-13
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• 2019

Background: The isolation of carbapenemase-producing Enterobacteriaceae (CPE) has become increasingly common. Continuous surveillance for these organisms is essential because their infections are closely related to outbreaks of illness and are associated with high mortality rates. The aim of this study was to develop and evaluate multiplex PCR as a means of detecting several important CPE genes simultaneously. Methods: We aimed to develop a multiplex PCR that could detect seven CPE genes simultaneously. The multiplex PCR was composed of seven primer sets for the detection of KPC, IMP, VIM, NDM-1, GES, OXA-23, and OXA-48. We designed different PCR product sizes of at least 100 bp. We evaluated the performance of this new test using 69 CPE-positive clinical isolates. Also, we confirmed the specificity to rule out false-positive reactions by using 71 carbapenem-susceptible clinical strains. Results: A total of 69 CPE clinical isolates showed positive results and were correctly identified as KPC (N=14), IMP (N=13), OXA-23 (N=12), OXA-48 (N=11), VIM (N=9), GES (N=5), and NDM (N=5) by the multiplex PCR. All 71 carbapenem-susceptible clinical isolates, including Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa, showed negative results. Conclusion: This multiplex PCR can detect seven CPE genes at a time and will be useful in clinical laboratories.

• Journal of Astronomy and Space Sciences
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• v.13 no.1
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• pp.55-62
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• 1996

We present UBV CCD photomety of the metal-poor globular cluster M30. The data were obtained using the 40 inch telescope at Mt. Stromlo and Siding Spring Observatory (MSSSO). We used DAOPHOT CCD reduction package in order to obtain Color-Magnitude Diagram (CMD). We have derived some fundametal parameters of the globular cluster such as metal abundance ([Fe/H]), helium abundance (Y), and distance modulus (m-M) from the CMD. The derived parameters were [Fe/H]=-2.50, Y=0.28, and (m-M)=14.64. From the latter, the distance of 8.3kpc is obtained. Despite the photometric uncertainty near the main-sequence turnoff, we estimate the age of M30 to be 1.6${\pm}$3 Gyrs from the Revised Yale Isocyrones. If [O/Fe]=+0.4, this age will be reduced to 14.2${\pm}$3 Gyrs.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.75.3-75.3
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• 2015

Large area infrared surveys are often accompanied with follow-up optical spectroscopic surveys that has a significant legacy value even for other areas of research. Using these spectral database, we have performed a search for MgII absorption lines in the optical spectrum of background quasar. Over the ~4deg2 of AKARI North Ecliptic Pole survey field and Spitzer First Look Survey field, 18 and 16 MgII absorber systems are identified respectively. The redshift range for the background quasars was 1.0<$z_{qso}$<3.4, while the redshift range for the absorber was 0.6<$z_{abs}$<1.6. Galaxies responsible for MgII absorptions are identified in the deep optical images (CFHT r-band), yet the identification still remains ambiguous for 60% of the systems due to the limited image depth and the source crowdedness. The impact parameter ranges 20-60kpc, and the rest-frame equivalent width of MgII absorption ranges $0.7-4{\AA}$. The most critical part in the identification of MgII absorber galaxies is the existence of deep optical images in addition to the high S/N quasar spectrum with R>3000.

• Journal of The Korean Astronomical Society
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• v.38 no.2
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• pp.245-248
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• 2005

We present mm observations with the IRAM 30m radiotelescope of the HCN (J=1-0) and HCO+ (J=1-0) emission lines from Giant Moleculat Clouds (GMC) in the disk of the Andromeda Galaxy, The selected GMC targets have various morphology and environments, including locations within spiral arms or in interarm regions and with galactocentric radii ranging from 2.4 to 15.5 kpc over the disk. The radial distributions of the ratios HCN/CO and HCO+ /CO are discussed and their values are compared to other galaxies.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.40.1-40.1
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• 2013

We perform a set of N-body/SPH simulations of galaxy interactions between early- and late-type galaxies with the mass ratio of 2 to 1. We show that mass transfer during a fly by interaction (the closest approach distance ~50kpc) can cause the morphology transformation of an early-type galaxy to a late type. In our simulations, we vary the orbital parameters of the interactions and the cold gas fraction of the late-type galaxy to compare how the morphology transformation is affected by the amount of mass transfer and orbital angular momentum of cold gas accreted to the early type. We also include hot halo gas in the galaxy models and show the location of the tidal bridge can be influenced by the shock generated during the collision.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.50.1-50.1
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• 2013

Blue Compact Dwarf galaxies (BCDs) are systems which have been experiencing the bursts of star formation in their central region. As one of the origins of active star formation, tidal interaction (merger or fly-by between dwarf galaxies) has been suggested. A pair of BCDs, ESO 435-IG20 and ESO 435-IG16, are suspected to be a good example of such case. They are located at a similar redshift and separated only by ~130 kpc at their distances. In addition a bridge-like HI structure has been found between these two BCDs in the HIPASS survey. In this study, using the ATCA HI data of a much better resolution, we probe the gas morphology and kinematics of individual galaxies. We discuss how tidal interaction is responsible for the high star formation rate in this BCD pair.

• New & Renewable Energy
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• v.3 no.4
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• pp.90-97
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• 2007

Gasification has been regarded as a very important technology to decrease environmental pollution and to obtain higher efficiency. The coal gasification process converts carbon containing coal into a syngas, composed primarily of CO and $H_2$. And the coal syngas can be used as a source for power generation or chemical material production. This paper illustrates the opeartion characteristics and results of pilot-scale coal syngas production facilities. The entrained-bed pilot scale coal gasifier was operated normally in the temperature range of $1,300{\sim}1,400^{\circ}C,\;2{\sim}3kg/cm^2$ pressure. And Indonesian KPC coal produced syngas that has a composition of $46{\sim}54%\;CO,\;20{\sim}26%\;H_2,\;and\;5{\sim}8%\;CO_2$.