• Title/Summary/Keyword: K-Ras

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Design of Closed Seawater Recirculating Aquaculture System for Korean Rockfish Sebastes schlegeli Culture

  • Peng, Lei;Oh, Sung-Yong;Jo, Jae-Yoon
    • Ocean and Polar Research
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    • v.26 no.1
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    • pp.102-111
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    • 2004
  • Recirculating aquaculture system (RAS) consists of different treatment compartments that maintain water quality within the ranges commonly recommended for fish cultures. However, common RASs still exert considerable environmental impact since concentrations of organic matter and nutrients in their effluents are high. Compared with the traditional RAS, the model RAS developed here use a sedimentation basin for digestion purposes and then use the released volatile organic matter to stimulate a denitrification process. Different treatment compartments for solids, total ammonia nitrogen, and nitrate removal have been reviewed. This paper provides the basic information on designing different treatment compartments as well as the engineering criteria in closed seawater RAS, consisting of circular tanks for fish cultures; dual drain systems, sedimentation basins and foam fractionators for removal of solids; nitrification biofilters for TAN removal; denitrification biofilters for nitrate removal; and aerators for aeration. The main purpose is to outline a common procedure in designing of closed RAS for marine fish culture with an emphasis on easy management and low expense, as well as reduction of the environmental impact.

Development of Carbon Nanotubes and Polymer Composites Therefrom

  • Jain, P.K.;Mahajan, Y.R.;Sundararajan, G.;Okotrub, A.V.;Yudanov, N.F.;Romanenko, A.I.
    • Carbon letters
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    • v.3 no.3
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    • pp.142-145
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    • 2002
  • Multiwall carbon nanotubes (MWNT) were produced using the arc-discharge graphite evaporation technique. Composite films were developed using MWNT dispersed in polystirol polymer. In the present work, various properties of the polymeric thin film containing carbon nanotubes were investigated by optical absorption, electrical resistivity and the same have been discussed.

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Expression of Oncogene Product in the Colorectal Carcinoma (결장암 및 직장암에서 암유전자 산물의 발현)

  • Shim, Young-Ran;Jang, Woo-Young;Choi, Kyoung-Chan;Choi, Joon-Hyuk;Choi, Won-Hee;Shim, Min-Chul
    • Journal of Yeungnam Medical Science
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    • v.12 no.2
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    • pp.210-225
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    • 1995
  • The expression of $p62^{c-myc}$ and $p21^{ras}$ can be seen in many solid tumor, but the pattern and incidence of expression were different according to organ, countries, and examiners, thus it is not definitely defined. Total 67 colorectal carcinoma in paraffin sections are analysed by immunohistochemically for evaluation of the $p62^{c-myc}$ and $p21^{ras}$ expression according to the age, sex, chief complaints, location, differentiation, modified Dukes stage, using the specific monoclonal antibodies. The results were summarized as follows : The age of patients ranged from 32 years to 82 years. The mean age was 57.6 years. The expression of $p62^{c-myc}$ and $p21^{ras}$ was not correlated with age. Male was 29 cases(43.3%) and female was 38 cases(56.7%). The male to female ratio was 1:1.31. The expression of $p21^{ras}$ was increased in female(p<0.05). Abdominal pain(43.7%) was the most frequent chief complaint. The most frequent tumor location was rectum(44.8%). The expression of $p62^{c-myc}$ was increased in the rectum(p<0.05). The 65 cases(97.0%) out of 67 cases showed positive reaction of $p62^{c-myc}$ in the nucleus, cytoplasmic membrane, and cytoplasm. The 62 cases(92.5%) out of 67 cases showed positive reaction of $p21^{ras}$ in the cytoplasmic membrane and cytoplasm. The positive rate of $p62^{c-myc}$ and $p21^{ras}$ was 97.0% and 91.4% in well differentiated adenocarcinoma, 100.0% and 95.0% in moderately differentiated adenocarcinoma, 90.0% and 90.0% in poorly differentiated adenocarcinoma, 100.0% and 100.0% in mucinous carcinoma. The positive rate of $p62^{c-myc}$ and $p21^{ras}$ was 94.1% and 88.2% in Dukes stage $B_1$, 96.0% and 96.0% in Dukes stage $B_2$, 100.0% and 100.0% in Dukes stage $C_1$, 100.0% and 88.9% in Dukes stage $C_2$, and 100.0% and 100.0% in Dukes stage D. The expression of $p62^{c-myc}$ in metastatic colorectal carcinoma showed diffuse and strongly positive reaction than primary colorectal carcinoma. The expression of $p21^{ras}$ in primary colorectal carcinoma showed diffuse and strongly positive reaction than metastatic colorectal carcinoma.

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Feasibility Analysis of HEC-RAS for Unsteady Flow Simulation in the Stream Channel with a Side-Weir Detention Basin (강변저류지가 있는 하도에서의 부정류 흐름 모의를 위한 HEC-RAS의 적용성 검토)

  • Kim, Seo-Jun;Hong, Sang-Jin;Yoon, Byung-Man;Ji, Un
    • Journal of Korea Water Resources Association
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    • v.45 no.5
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    • pp.495-503
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    • 2012
  • It is necessary to perform the precise analysis of unsteady flow for effective design of the side-weir detention basin installed in the river. Generally, the HEC-RAS program, which is a 1D unsteady numerical model, is mostly used to simulate the unsteady flow for rivers. However, it is difficult to have confidence of unsteady flow results simulated by HEC-RAS due to the lack of experimental data and field monitoring data for the channel with a side-weir detention basin. Therefore, the purpose of this study is to validate or verify the simulation results calculated by HEC-RAS through the experiments for the open channel with a side-weir detention basin using specially-designed unsteady discharge-supply system. The experimental cases included unsteady flows in the straight channel with and without a side-weir detention basin. Especially, for the case with a detention basin, the experiment was performed to consider only the free flow condition over the side-weir. The study results showed that values of water level and discharge obtained from HEC-RAS coincided reasonably with experimental results with the maximum error of 3% for water level and 1% for discharge in the case of the flow without the side-weir detention basin and 4% for water level and 2% for discharge with the side-weir detention basin.

Accuracy Analysis of HEC-RAS for Unsteady Flow Simulation considering the Flow Pattern Variations over the Side-weir of Side-Weir Detention Basin (강변저류지 횡월류부의 흐름 형태 변화를 고려한 HEC-RAS의 하도 내 부정류 모의 정확도 분석)

  • Kim, Sanghyuk;Yoon, Byungman;Kim, Dongsu;Kim, Seojun
    • Journal of Korea Water Resources Association
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    • v.49 no.1
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    • pp.29-39
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    • 2016
  • Accurate quantitative assessment of flood control effect of side-weir detention basin as a flood countermeasure was highly required, in which one-dimensional HEC-RAS model has been widely utilized in practice. When the submerged overflow occurred particularly driven by limited storage capacity of a given detention basin, HEC-RAS model could not be sufficiently applicable by guaranteeing acceptable accuracy without reliable benchmark dataset. From this perspective, a dedicated unsteady experiment was planned and carried out to physically realize such submerged overflow for accommodating better accuracy. Subsequently, the experimental results were applied to validate and calibrate HEC-RAS unsteady modeling to provide flood control effect of the detention basin for various inflow scenarios. After following this procedure, the modelled results indicated that there appeared within -5% of difference in stage height and maximum 2.4% accuracy to assess the flood control effect, thereby ensuring the calibrated HEC-RAS unsteady model to be accurate with practically acceptable error range.

Frequency of K-RAS and N-RAS Gene Mutations in Colorectal Cancers in Southeastern Iran

  • Naseri, Mohsen;Sebzari, Ahmadreza;Haghighi, Fatemeh;Hajipoor, Fatemeh;Razavi, Fariba Emadian
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.9
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    • pp.4511-4515
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    • 2016
  • Background: K-RAS and N-RAS gene mutations cause resistance to treatment in patients with colorectal cancer. Based on this, awareness of mutation of these genes is considered a clinically important step towards better diagnosis and appropriate treatment. Materials and Methods: Fifty paraffin-embedded blocks of colorectal cancer were obtained from Imam Reza Hospital of Birjand, Iran. Following DNA extraction, the samples were analyzed for common mutations of exons 2, 3 and 4 of KRAS and NRAS genes using real time PCR and pyrosequencing. Results: According to this study, the prevalence of mutations was respectively 28% (14 out of 50) and 2% (1 out of 50) in KRAS and NRAS genes. All the mutations were observed in patients >50 years old. Conclusions: Mutations were found in both KRAS and NRAS genes in colorectal cancers in Iranian patients. Determining the frequency of these mutations in each geographical region may be necessary to benefit from targeted cancer therapy.

Channel Characteristics of Sincheon Experimental Catchment using HEC - RAS model (HEC-RAS 모델을 이용한 신천 시험유역의 하도 특성연구)

  • Park, Byeongky;Lee, Myunggu;Hong, Changsu;Lee, Jaekwan;Lee, Young Joon;Choi, Joongdae
    • Journal of Environmental Science International
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    • v.25 no.1
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    • pp.41-56
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    • 2016
  • In recent localized heavy rainfalls have been arising from abnormal climate change. People are concerning about damages with increasing the frequency of flooding. Therefore, we need to understand river hydraulic characteristics and management to reduce damage from flooding. To study hydraulic characterization of Sincheon experimental catchment HEC-RAS (Hydrologic Engineering Center River Analysis System) model which provided by U.S Army Corps of Engineers (USACE) was applied. This study analyzed and compared water level the frequency flood for 100 years and 200 years by clark unit Hydrography. The change of the water level of Daejeon bridge, Sincheon bridge and Singi bridge showed increased for all conditions. The flow rate for the Daejeon bridge and the Sincheon bridge showed an increase, but the Sinki bridge showed a decreasing flow rate overally, except for 1hour-100 years. The verification result showed that the model was able to simulate the water level with 0.4709 coefficient of determination and error ration ranging from 1 to 3%.