• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2004.05a
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• pp.62-62
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• 2004

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.05a
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• pp.89-90
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• 2003

• Applied Biological Chemistry
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• v.51 no.4
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• pp.309-315
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• 2008

The methanol extract from the aerial parts of Aceriphyllum rossii was fractionated into ethyl acetate, n-BuOH and $H_2O$ layers through solvent fractionation. Repeated silica gel column chromatography of EtOAc and n-BuOH layers afforded five flavonol glycosides. They were identified as astragalin (1), kaempferol 3-O-${\alpha}$-L-rhamnopyranosyl (1${\rightarrow}$6)-${\beta}$-D-glucopyranoside (2), rutin (3), kaempferol 3-O-${\alpha}$-L-rhamnopyranosyl (1${\rightarrow}$4)-${\alpha}$-L-rhamnopyranosyl 1${\rightarrow}$6)-${\beta}$-D-glucopyranoside (4), and quercetin 3-O-${\alpha}$-L-rhamnopyranosyl (1${\rightarrow}$4)-${\alpha}$-L-rhamnopyranosyl (1${\rightarrow}$6)-${\beta}$-D-glucopyranoside (5) on the basis of spectroscopic data. All of them showed an inhibition in farnesyl protein tranferase (FPTase) activity, and rutin (3) inhibited the growth of rat H-ras cell and the cell migration of human umbilical vein endothelial cells (HUVECs).

• Journal of Korea Water Resources Association
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• v.44 no.12
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• pp.975-990
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• 2011

In this study, to develop an assessment method for spatio-temporal riverbed changes, a 1-dimensional model (HEC-RAS) and a 2-dimensional model (CCHE2D) were built and applied. As for the analysis of a riverbed's long-term change in a real stream, three new assessment methods were developed, which are called the "Sediment section cumulative curve", "Sediment section moment", and "Sediment probability distribution function." These methods were used to assess the characteristics of riverbed changes using a consistent valuation standard and to understand changes in quantities intuitively. From the results of this study, sediment characteristics of cross sections can be detected effectively by applying the "Sediment section cumulative curve" method to determine whether there is any sedimentation or erosion in total emission. The amount of sedimentation or erosion occurring in the right or left banks, which divided by center column, could be presented as one criterion by applying the "Sediment section moment" method. This approach could be utilized as an indicator for sediment predictions. Spatio-temporal sediment variables can be presented quantitatively by determining the mean and uncertain boundaries through the "Sediment probability distribution function", and finally, the results can be illustrated for each cross section to provide intuitive recognition.

• Journal of Korea Water Resources Association
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• v.41 no.5
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• pp.483-489
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• 2008

Recently, we have a growing interest in the washland construction for the function of flood defense in flood season and also as an ecosystem in non flood season. Therefore this study performed the hydraulic and hydrologic analysis for washland construction plan as sustainable flood defense alternative in flood season and wetland application possibility. The study area is Topyoung-cheon basin in Changnyeong-gun, Gyeongnam. A Topyoung-cheon basin includes a Woopo wetland which is the largest nature wetland in Korea and a Topyoung-cheon is ond of the tributaries of Nakdong river. We assume that the artificial washland is constructed in upperstream and downstream of Woopo wetland, and In flood season, the hydraulic analysis for the investigation of the effectiveness of flood level mitigation is performed by HEC-RAS model. Simulation of model is performed from 7 scenarioes of washland construction. As the result in flood season, the flood level is reduced by maximum 0.56 meter as we construct the washlands by 7 scenarios. Also, we performed hydrologic analysis for the investigation of water balance in washland in non flood season using SWAT model. From the result of water balance analysis, we found that the minimum water level of washland was maintained in about 1.3 meter for one year.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.05a
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• pp.59-59
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• 2003

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.05a
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• pp.89-90
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• 2003

Extracts of Artemisia asiatica Nakai (Asteraceae) have been shown to have anti-inflammatory and anti-oxidative activities. Eupatilin (5,7-dihydroxy-3,4,6-tri-methoxy-flavone), one of the pharmacologically active ingredients derived from Artemisia asiatica, has been shown to induce apoptosis in promyelocytic leukemia (HL-60) cells. (omitted)

• Animal Systematics, Evolution and Diversity
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• v.27 no.1
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• pp.97-100
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• 2011

In this paper, we report for the first time on a species of Eupithecia from Korea. Three females of Eupithecia praepupillata Wehrli, 1927, were collected from the northeastern part of South Korea. With this addition, a total of 53 species of Eupithecia from Korea have been recorded. Diagnosis and description of the species are provided with figures of the genitalia.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.11b
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• pp.135-135
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• 2002

Cyclooxygenase-2 (COX-2) is an inducible enzyme expressed in response to a variety of cytokines and other proinflammatory stimuli. It has been known that aberrant up-regulation of COX-2 is associated with resistance to apoptosis.(omitted)

• Development and Reproduction
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• v.20 no.1
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• pp.1-10
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• 2016

Molecular targeting for the altered signaling pathways has been proven to be effective for the treatment of many types of human cancer, including colorectal cancer (CRC). The dual phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor BEZ235 has shown to exhibit potent antitumor activity against solid tumors. Autophagy is a cellular lysosomal catabolic process to maintain metabolic homeostasis, which has been known to be induced in response to many therapeutic agents in cancer cells. This process is negatively regulated by mTOR and often acts as prosurvival or prodeath mechanism following cancer therapeutics. The current study was designed to investigate the antiproliferation activity of BEZ235 and to evaluate the role of autophagy induced by BEZ235 using HCT15 CRC cells bearing ras oncogene mutation. We found that BEZ235 decreases cell viability, which was mostly dependent on $G_1$ arrest of cell cycle via suppression of cyclin A expression. BEZ235 affects PI3K/Akt/mTOR signaling pathway by increasing the phosphorylation of AKT at $Ser^{473}$ and RAS/RAF/MEK/ERK pathway by decreasing the phosphorylation of ERK at $Tyr^{204}$. BEZ235 also stimulated autophagy induction as evidenced by the increased expression of LC3-II and abundant acidic vesicular organelles (AVOs) in the cytoplasm. In addition, the combination of BEZ235 with autophagy inhibitor chloroquine, a known antagonist of autophagy, counteracted the antiproliferation effect of BEZ235. Thus, our study indicates that autophagy induced in response to BEZ235 treatment appears to act as cell death mechanism in HCT15 CRC cells.