• Journal of Environmental Science International
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• v.16 no.8
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• pp.973-983
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• 2007

The eco-hydrologic effects of maintenance water supply on Oncheon stream are studied using hydrologic, hydraulic and ecologic models. SWMM (Storm Water Management Model) is used for long-term simulation of runoff quantity and water quality from Oncheon stream watershed. Using the output hydrologic variables from SWMM, HEC-RAS (River Analysis System) is then used to simulate the hydraulics of water flow through Oncheon stream channels. Such hydrologic, hydraulic and water quality output variables from SWMM and HEC-RAS are served as input data to execute PHABSIM (Physical Habitat Simulation) for the purpose of predicting the micro-habitat conditions in rivers as a function of stream flow and the relative suitability of those conditions to aquatic life. It is observed from the PHABSIM results that the weighted usable area for target fishes has the maximum value at $2m^3/s$ of instream flow. However, mid and down stream areas that have concrete river bed and covered region are unsuitable for fish habitat regardless of instream flow increment. The simulation results indicate that the simple maintenance water supply is limited in its effect to improve the ecological environment in Oncheon stream. Therefore, it is imperative to improve water quality and to recover habitat conditions simultaneously.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8539-8548
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• 2014

Mitogen-activated protein kinase (MAPK) is an important signaling pathway in living beings in response to extracellular stimuli. There are 5 main subgroups manipulating by a set of sequential actions: ERK(ERK1/ERK2), c-Jun N(JNK/SAPK), p38 MAPK($p38{\alpha}$, $p38{\beta}$, $p38{\gamma}$ and $p38{\delta}$), and ERK3/ERK4/ERK5. When stimulated, factors of upstream or downstream change, and by interacting with each other, these groups have long been recognized to be related to multiple biologic processes such as cell proliferation, differentiation, death, migration, invasion and inflammation. However, once abnormally activated, cancer may occur. Several components of the MAPK network have already been proposed as targets in cancer therapy, such as p38, JNK, ERK, MEK, RAF, RAS, and DUSP1. Among them, alteration of the RAS-RAF-MEK-ERK-MAPK(RAS-MAPK) pathway has frequently been reported in human cancer as a result of abnormal activation of receptor tyrosine kinases or gain-of-function mutations in genes. The reported roles of MAPK signaling in apoptotic cell death are controversial, so that further in-depth investigations are needed to address these controversies. Based on an extensive analysis of published data, the goal of this review is to provide an overview on recent studies about the mechanism of MAP kinases, and how it generates certain tumors, as well as related treatments.

• Economic and Environmental Geology
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• v.53 no.4
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• pp.425-440
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• 2020

The study area is located in the southern part of the M'aider Paleozoic basin in the Moroccan Eastern Anti-Atlas. It is an arid region, characterized by minimal vegetation cover, which can provide an ideal environment to apply remote sensing. In this study, remote sensing and field investigations were integrated for lithological and structural lineaments mapping. The Landsat 8 OLI data were processed in order to understand the role of lithology and geological structures in the distribution of mineral deposits in the study area. To achieve this purpose, the Color Composite (CC), the Principal Component Analysis (PCA) and Band Rationing transformation (BR) tests were performed. The results of remote sensing techniques coupled with field investigations have shown that the zones of high lineaments densities are highly correlated with the occurrences of barite mineralization. These findings depict a spatial relationship between structural lineaments and the mineralization distribution zones. Therefore, the barite and Iron oxides mineralization veins, which occur mainly in the Ras Kammouna district, seem to have a structural control. The methodological approach used in this study examining lithological mapping and lineament extractions can be used to explore mineral deposits in arid regions to a high degree of efficiency.

• Proceedings of the Korean Ceranic Society Conference
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• 2004.10a
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• pp.84.2-84.2
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• 2004

• Proceedings of the Korean Society of Applied Pharmacology
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• 2002.07a
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• pp.234-234
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• 2002

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2005.04a
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• pp.17-17
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• 2005

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.214.2-215
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• 2001

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2001.10b
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• pp.156-156
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• 2001

• Proceedings of the PSK Conference
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• 2002.04a
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• pp.174.1-174.1
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• 2002

• BMB Reports
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• v.34 no.5
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• pp.484-488
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• 2001

STATs are proteins with a dual function: signal transducers in the cytoplasm and transcriptional activators in the nucleus. Among the six known major STATs (STAT1-6), STAT3 has been implicated in the widest range of signaling pathways that regulate cell growth and differentiation. As a part of our on-going investigation on the pleiotropic functions of STAT proteins, we examined the role of STAT3 as a molecular adaptor that links diverse cell growth signaling pathways. We observed that STAT3 can be specifically activated by multiple cytokines, such as IL-3, in transformed fibroblasts and IL-4 or IFN-$\gamma$ in primary immune cells, respectively. The selective activation of STAT3 in H-ras-transformed NIH3T3 cells is associated with an increased expression of phosphoserioe STAT3 in these cells, compared to the parental cells. Notably phosphoresine-STAT3 interacts with oncogenic ras, shown by immunoprecipitation and Western blots. The results suggest the role of STAT3 in rasinduced cellular transformation as a molecular adaptor linking the Jak/STAT and Ras/MAPK pathways. In primary immune cells, IL-4 and IFN-$\gamma$ each induced (in addition to the characteristic STAT6 and STAT1 homodimers) the formation of STAT3-containing complexes that bind to GAS probes, which correspond to the $Fe{\varepsilon}$ Rll and $Fe{\gamma}$ RI promoter sequences, respectively. Since IL-4 and IFN-$\gamma$ are known to counter-regulate the expression of these genes, the ability of STAT3 to form heterodimeric complexes with STAT6 or STAT1 implies its role in the fine-tuned control of genes that are regulated by IL-4 and IFN-$\gamma$.