• Title/Summary/Keyword: K-562

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IL-1 and $TNF-{\alpha}$ release in human polymorphonuclear leukocytes after exposure to P. endodontalis LPS.

  • Park, Chan-Je;Lim, Sung-Sam
    • Proceedings of the KACD Conference
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    • 2001.11a
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    • pp.562.1-562
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    • 2001

  • Bacterial lipopolysaccharide (LPS) plays a major role in the development of periapical bone resorption. IL-1 and $TNF-{\alpha}$ are known to stimulate bone resorption and inhibit bone formation. Recent evidence has indicated that polymophonuclear leukocytes(PMNs) have the ability to release IL-1 and $TNF-{\alpha}$ Calcium hydroxide is an effective medicament in root canal infections, reducing the microbial titre within the canal. It has been proposed that the therapeutic effect of $CA(OH)_2$ may also be the result of direct inactivation of LPS.(omitted)

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The canal system of Mandibular Incisors.

  • Rhim, E.M.;Choi, H.Y.;Choi, G.W.
    • Proceedings of the KACD Conference
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    • 2001.11a
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    • pp.562.2-562
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    • 2001

  • The purpose of this study is to identificate root canal system including ideal access placement, root curvature, canal configuration, incidence of isthmus in mandibular incisors for success of endodontic treatment. 200 mandibular incisors were selected. The ideal access placement was determined as follows. The teeth were radiographed from mesiodistal and buccolingual views using intraoral dental film. The image was divided into coronal, middle and apical third using the proximal film. Straight line access was determined by measuring the faciolingual canal width and placing points at midway point between the buccal and lingual wall at the junction of the middle and apical third and at the juntion of coronal and middle third of the root canal.(omitted)

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User Evaluation of the Real-Time Mobile Learning System with Improved Student Instructor Interaction (개선된 학생 강사간의 상호작용을 지원하는 실시간 모바일 원격교육 시스템의 사용자 평가)

  • Hwang, Haedong;Lee, Jang Ho
    • Proceedings of the Korea Information Processing Society Conference
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    • 2015.10a
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    • pp.562-565
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    • 2015

  • 최근 모바일 기기의 사용이 급증하면서 모바일 단말기를 기반으로 하는 모바일 원격교육 시스템이 연구되고 있다. 우리는 태블릿 기반의 실시간 원격교욱 시스템을 개발한 경험이 있다. 이 시스템은 학생이 실시간으로 강사의 강의를 보고 들으며 슬라이드 및 애노테이션을 볼 수 있게 해준다. 또한 이 시스템은 학생이 채팅기능을 통해 강사에게 질문을 허용함으로써 강사 학생간의 상호작용을 지원한다. 그러나 이 시스템은 학생들이 채팅창에 가상키보드를 통해서만 입력하는 것을 허용하였기 때문에 입력 속도가 떨어지고 편의성이 저하되는 문제점이 있었다. 따라서 본 연구에서는 채팅기능의 Speech to Text 기능을 추가하여 학생들의 음성입력을 지원하도록 시스템의 강사 학생간의 상호작용 부분을 개선하였다. 그리고 강사 학생간의 상호작용에 대한 사용자 평가를 통하여 개선된 시스템이 기존의 시스템에 비하여 입력 속도 및 편의성 면에서 어느 정도 개선되었음을 알 수 있었다.

  • https://doi.org/10.3745/PKIPS.y2015m10a.562 인용 PDF

Effect of Extracts from Root Bark of Ulmus parvifolia on Inhibition of Growth and DNA Synthesis of Human Cancer Cells. (느릅나무 근피 추출물에 의한 인체 암세포 증식 및 DNA 합성 억제효과)

  • Lim, Sun-Young
    • Journal of Life Science
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    • v.17 no.9 s.89
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    • pp.1232-1236
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    • 2007

  • Growth and DNA synthesis inhibitory effects of extracts from root bark of Ulmus parvifolia on MG-63 human osteosarcoma cells, HT-29 human colon cancer cells and K-562 leukemia cancer cells were studied. The root bark extract of Ulmus parvifolia was extracted with methanol, hot water and juice. The methanol extract showed the highest inhibitory effect on growth of MG-63, HT-29 and K-562 cancer cells by >85%. The treatment of hot water and juice extracts from root bark of Ulmus parvifolia also inhibited growth of the above cancer cells with increasing concentration. DNA synthesis of MG-63 and HT-29 cancer cells was significantly inhibited by adding methanol, hot water and juice extracts from root bark of Ulmus parvifolia with increasing concentration, showing that the inhibitory effect of growth was more effective on HT-29 cancer cells. These results suggest that the methanol extract from root bark of Ulmus parvifolia may have specific active com-pounds on anticancer effect. The hot water extract also showed a strong inhibitory effect on growth of cancer cells, indicating that the active compounds may be stable to heat.

  • https://doi.org/10.5352/JLS.2007.17.9.1232 인용 PDF KSCI

Antioxidant value and Antiproliferative Efficacy of Mitragynine and a Silane Reduced Analogue

  • Goh, Teik Beng;Yian, Koh Rhun;Mordi, Mohd Nizam;Mansor, Sharif Mahsufi
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.14
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    • pp.5659-5665
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    • 2014

  • Background: To investigate the antioxidant value and anticancer functions of mitragynine (MTG) and its silane-reduced analogues (SRM) in vitro. Materials and Methods: MTG and SRM was analyzed for their reducing power ability, ABTS radical inhibition and 1,1-diphenyl-2-picryl hydrazylfree radicals scavenging activities. Furthermore, the antiproliferation efficacy was evaluated using MTT assay on K 562 and HCT116 cancer cell lines versus NIH/3T3 and CCD18-Co normal cell lines respectively. Results: SRM and MTG demonstrate moderate antioxidant value with ABTS assay (Trolox equivalent antioxidant capacity (TEAC): $2.25{\pm}0.02$ mmol trolox / mmol and $1.96{\pm}0.04$ mmol trolox / mmol respectively) and DPPH ($IC_{50}=3.75{\pm}0.04mg/mL$ and $IC_{50}=2.28{\pm}0.02mg/mL$ respectively). Both MTG and SRM demonstrate equal potency ($IC_{50}=25.20{\pm}1.53$ and $IC_{50}=22.19{\pm}1.06$ respectively) towards K 562 cell lines, comparable to control, betulinic acid (BA) ($IC_{50}24.40{\pm}1.26$). Both compounds showed concentration-dependent cytototoxicity effects and exert profound antiproliferative efficacy at concentration > $100{\mu}M$ towards HCT 116 and K 562 cancer cell lines, comparable to those of BA and 5-FU (5-Fluorouracil). Furthermore, both MTG and SRM exhibit high selectivity towards HCT 116 cell lines with selective indexes of 3.14 and 2.93 respectively compared to 5-FU (SI=0.60). Conclusions: These findings revealed that the medicinal and nutitional values of mitragynine obtained from ketum leaves that growth in tropical forest of Southeast Asia and its analogues does not limited to analgesic properties but could be promising antioxidant and anticancer or chemopreventive compounds.

  • https://doi.org/10.7314/APJCP.2014.15.14.5659 인용 PDF KSCI

lnhibitory Effect o fVarious Cruciferous Vegetable on the Growth of Human Cancer Calls (인체암세포증식에 있어 십자화과 채소의 억제효과)

  • 이선미;이숙희
    • Journal of Life Science
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    • v.7 no.3
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    • pp.234-240
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    • 1997

  • The anticarcingenic effect of methanol extracts from such cruciferous vegetables as cabbage, red cabbage, Korean cabbage, kale, cauliflower, broccoli, radish root, leafy radish, rape leaves and shepherd’s purse on the growth of human K-562 leukemia cells, MG-63 osteosarcoma cells, HT-29 colon cancer cells and AGS gastric cancer cells were studied. All of cruciferous vegetables inhibited more than 70% of the growth of K-52 leukemia cells and more than50% fo rhe growth fo AGS gastric cancer cells. Particularly, kale, broccoli and shepherd’s purse showed inhibition rates of 93.5%, 93,5% and 96.3% on the growth of AGS gastric cancer cells, respectively. In case of HT-29 colon cancer cells, the methanol extracts of cabbage, kale and shepherd’purse exhibited 82.4%, 72.15, 79.4% and 95.6% of inhibitory effects, respectively. The cabbage, kale, cauliflower and shepherd’s purse extracts also highly suppressed the proliferation of MG-63 cells. Generally the 10 cruciferous vegetable we studied strongly decreased the growth of various human cancer cells in vitro, however, kale and shepherd’s showed the most effective vegetable among them.

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