• Archives of Pharmacal Research
• /
• 제19권6호
• /
• pp.543-550
• /
• 1996

Analogues of $2(S)-5, 2^{l}, 5^{l}$-trihydroxy-7, 8-dimethoxyflavanone, a naturally-occurring compound, which had been reported to have potent antitumor activity, were synthesized and examined for the cytotoxicity against three cancer cell lines. Among the intermediate chalcones and synthetic 5-hydroxy-7, 8-dimethoxyflavanone analogues, $({\pm})2^{l}, 5^{l}-dibenzyloxy-5, 7, 8-trimethoxyflavanone$ exhibited about 2-8 times stronger activity than $2(S)-5, 2^{l}, 5^{l}$-trihydroxy-7, 8-dimethoxyflavanone against L1210, K562 and A549 cancer cell lines. In the structure-activity relationship, it is suggested that among analogues of 5-hydroxy-7, 8-dimethoxyflavanone, the existence of two oxygenated groups of para-relation at $C-2^{I} and C-5^{I}$ positions on flavanone B-ring, may be necessary to exhibit effective cytotoxic activity.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
• /
• pp.133.3-134
• /
• 2000

• 한국정보처리학회:학술대회논문집
• /
• 한국정보처리학회 2018년도 춘계학술발표대회
• /
• pp.562-565
• /
• 2018

A wide range of IoT applications use information collected from networks of sensors for monitoring and controlling purposes. However, the frequent appearance of fault data makes it difficult to extract correct information, thereby sending incorrect commands to actuators that can threaten human privacy and safety. For this reason, it is necessary to have a mechanism to detect fault data collected from sensors. In this paper, we present a trend-adaptive multi-scale principal component analysis (Trend-adaptive MS-PCA) model for data fault detection. The proposed model inherits advantages of Discrete Wavelet Transform (DWT) in capturing time-frequency information and advantages of PCA in extracting correlation among sensors' data. Experimental results on a real dataset show the high effectiveness of the proposed model in data fault detection.

• Bulletin of the Korean Chemical Society
• /
• 제31권3호
• /
• pp.561-562
• /
• 2010

• 대한화학회지
• /
• 제29권5호
• /
• pp.561-562
• /
• 1985

• 한국생물공학회:학술대회논문집
• /
• 한국생물공학회 2003년도 생물공학의 동향(XIII)
• /
• pp.560-562
• /
• 2003

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권17호
• /
• pp.7055-7059
• /
• 2014

Artemisia, as one of the largest genera in the tribe Anthemideae of the Asteraceae comprises an important part of Iranian flora. While cytotoxic and apoptotic properties have already been reported for some species of the genus there is not any report on cytotoxic effects of A. ciniformis. Petroleum ether (40-60), dichloromethane, ethyl acetate, ethanol and ethanol-water (50:50) extracts of the aerial parts of A. cinformis were subjected to cytotoxic and apoptotic evaluations on two cancer human cell lines (K562 and HL-60) and on J774 normal cells. Among multiple extracts evaluated for cytotoxicity, dichloromethane ($CH_2Cl_2$) and petroleum ether (PE) extracts were shown to possess the highest anti-proliferative effects on HL-60 and K562 cells with $IC_{50}$ values of 31.3 and $25.5{\mu}g/ml$ respectively. Apoptosis induction verified by sub-G1 peaks was seen in flow cytometry histograms. Increase in the amount of Bax protein, formation of DNA fragments, and cleavage of PARP to 24 and 89kDa sub units all confirmed induction of apoptosis by A. cinformis extracts. Taken together according to the result of the present study some extracts of A. cinformis could be considered as sources for natural cytotoxic compounds and further mechanistic and phytochemical studies are recommended to fully understand the underlying mechanisms of cnacer cell death as well as identification of responsible phytochemicals.

• JSTS:Journal of Semiconductor Technology and Science
• /
• 제13권6호
• /
• pp.562-568
• /
• 2013

This paper presents a design of a wireless power transfer system based on magnetic resonant coupling technology with in-band wireless communication. To increase the transmission distance and compensate for the change in the effective capacitance due to the varying distance, the proposed system used a loop antenna with a selectable capacitor array. Because the increased transmission distance enables multiple charging, we added a communication protocol operated at the same frequency band to manage a network and control power circuits. In order to achieve the efficient bandwidth in both power transfer mode and communication mode, the S-parameters of the loop antennas are adjusted by switching a series resistor. Our test results showed that the loop antenna achieved a high Q factor in power transfer mode and enough passband in communication mode.

• Bulletin of the Korean Chemical Society
• /
• 제35권2호
• /
• pp.562-568
• /
• 2014

In this work, synthesis, characterization and antimicrobial activity of series of imidazolines-oxazolines scaffolds 5a-f and 10a-d have been investigated. All the imidazolines-oxazolines derivatives were prepared from acid derivatives 1 and 6a-c, and enantiomerically pure (S)-2-amino-3-methyl-1-butanol in four steps with excellent optical purity. The structures of all newly synthesized compounds have been elucidated by $^1H$, $^{13}C$ NMR, GCMS, and IR spectrometry. Their purity was confirmed using elemental analysis. Some newly synthesized compounds were examined to in-vitro antimicrobial activity. Among the prepared products 10d was found to exhibits the most active against all tested bacteria and fungi with minimal inhibitory concentration (MIC) ranged between 21.9 and $42.6{\mu}g/mL$.

• Journal of Plant Biotechnology
• /
• 제37권4호
• /
• pp.562-566
• /
• 2010

SOD2-transgenic $T_3$ petunia line (A2-36-2-1-1-35) was treated with different levels of methyl viologen (MV) to determine its resistance to oxidative stress. Four (4) levels of MV (0, 100, 200, and $400\;{\mu}M$) were applied. The SOD2-transgenic $T_3$ petunia line exhibited a very significant oxidative stress resistance at the highest MV concentration ($400\;{\mu}M$) treatment compared to non-transgenic plant. RNA and protein expression of SOD2 transgene and higher parenchyma cell density in the transgenic petunias exhibiting resistance to oxidative stress proves its contribution to the expression of its resistance to oxidative stress.