• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2683-2688
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• 2016

A salt compound of a curcumin analogue, potassium pentagamavunon-0 (K PGV-0) has been synthesized to improve solubility of pentagamavunon-0 which has been proven to have anti-proliferative effects on several cancer cells. The purpose of this study was to investigate cytotoxic activity and metastasis inhibition by K PGV-0 alone and in combination with achemotherapeutic agent, doxorubicin (dox), in breast cancer cells. Based on MTT assay analysis, K PGV-0 showed cytotoxic activity in T47D and 4T1 cell lines with $IC_{50}$ values of $94.9{\mu}M$ and $49.0{\pm}0.2{\mu}M$, respectively. In general, K PGV-0+dox demonstrated synergistic effects and decreased cell viability up to 84.7% in T47D cells and 62.6% in 4T1 cells. Cell cycle modulation and apoptosis induction were examined by flow cytometry. K PGV-0 and K PGV-0+dox caused cell accumulation in G2/M phase and apoptosis induction. Regarding cancer metastasis, while K PGV-0 alone did not show any inhibition of 4T1 cell migration, K PGV-0+dox exerted inhibition. K PGV-0 and its combination with dox inhibited the activity of MMP-9 which has a pivotal role in extracellular matrix degradation. These results show that a combination of K PGV-0 and doxorubicin inhibits cancer cell growth through cell cycling, apoptosis induction, and inhibition of cell migration and MMP-9 activity. Therefore, K PGV-0 may have potential for development as a co-chemotherapeutic agent.

• Asian Pacific Journal of Cancer Prevention
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• 제15권1호
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• pp.179-184
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• 2014

Chemoresistance of breast cancer to doxorubicin is mediated mainly through activation of NF-kB and over expression of HER2. Curcumin and its analogues (PGV-0 and PGV-1) exert cytotoxic effects on T47D breast cancer cells. Suppression of NF-kB activation is suggested to contribute to this activity. The present study aimed to explore the effects of curcumin, PGV-0, and PGV-1 singly and in combination with doxorubicin on MCF-7/Dox cells featuring over-expression of HER2. In MTT assays, curcumin, PGV-0, and PGV-1 showed cytotoxicity effects against MCF-7/Dox with IC50 values of $80{\mu}M$, $21{\mu}M$, and $82{\mu}M$ respectively. These compounds increased MCF-7/Dox sensitivity to doxorubicin. Cell cycle distribution analysis exhibited that the combination of curcumin and its analogues with Dox increased sub G-1 cell populations. Curcumin and PGV-1 but not PGV-0 decreased localization of p65 into the nucleus induced by Dox, indicating that activation of NF-kB was inhibited. Molecular docking of curcumin, PGV-0, and PGV-1 demonstrated high affinity to HER2 at ATP binding site. This interaction were directly comparable with those of ATP and lapatinib. These findings suggested that curcumin, PGV-0 and PGV-1 enhance the Dox cytotoxicity to MCF-7 cells through inhibition of HER2 activity and NF-kB activation.

• Geomechanics and Engineering
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• 제9권2호
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• pp.125-144
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• 2015

This paper presents the probabilistic seismic microzonation of densely populated Kolkata city, situated on the world's largest delta island with very soft alluvial soil deposit. At first probabilistic seismic hazard analysis of Kolkata city was carried out at bedrock level and then ground motion amplification due to sedimentary deposit was computed using one dimensional (1D) wave propagation analysis SHAKE2000. Different maps like fundamental frequency, amplification at fundamental frequency, peak ground acceleration (PGA), peak ground velocity (PGV), peak ground displacement (PGD), maximum response spectral acceleration at different time period bands are developed for variety of end users, structural and geotechnical engineers, land use planners, emergency managers and awareness of general public. The probabilistically predicted PGA at bedrock level is 0.12 g for 50% exceedance in 50 years and maximum PGA at surface level it varies from 0.095 g to 0.18 g for same probability of exceedance. The scenario of simulated ground motion revealed that Kolkata city is very much prone to damage during earthquake.

• 한국지구과학회지
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• 제41권3호
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• pp.238-247
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• 2020

미국 남캘리포니아 지진센터에서 개발한 광대역 강지진동 모사 플랫폼을 이용하여 한반도 중대규모 지진에 대해서 부지 효과를 고려한 강지진동 지진파형 모사를 수행하고 진도 감쇠 특성을 분석하였다. SCEC BBP는 시나리오 지진에 대해 광대역(0-10 Hz)으로 지진 파형을 생성 할 수 있는 소프트웨어 플랫폼이다. 본 연구에서는 5가지 모델링 방법론 중 Song Model을 사용하였다. 규모 6.0, 6.5, 7.0의 지진에 대해서 각각 약 50회의 지진 모델링을 수행하였으며 부지효과(V_S30)를 고려하기 전과 후에 계산된 합성 지진 파형으로부터 최대 지반 가속도(PGA), 최대 지반 속도(PGV)와 같은 최대지진동 대표값을 산출하였다. 산출된 최대지진동 대표값은 계기진도 변환식을 이용하여 진도분포로 변환하였다. 부지효과 고려 시에는 V_S30속도에 따라 연약지반 또는 충적층 지역에서 진도값이 증폭되어 나타남을 확인하였다.

• 한국지반공학회논문집
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• 제35권12호
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• pp.135-145
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• 2019

비탈면 붕괴는 크게 내적요인과 외적요인으로 분류할 수 있다. 내적요인은 토층 깊이, 사면경사, 흙의 전단강도 등의 기존에 비탈면의 형성과 함께 내재 되어있는 공학적 요인이며, 외적요인은 지진과 같은 하중이다. 이때 최대가속도(PGA), 최대속도(PGV), Arias계수(I), 고유주기(T_p), 스펙트럼 가속도(S_aT=1.0) 등은 지진의 외적요인으로 대변되는 값이다. 특히, 최대지반가속도(peak ground acceleration, PGA)는 지진의 지반 운동 크기를 정의하는 가장 대표적인 값이지만 동일한 최대 지반가속도 값을 가지는 진동이라도 지진의 지속시간에 따라 달라지는 사면에서의 변위를 충분히 고려하지 못하는 단점을 가지고 있다. 본 연구에서는 인공사면을 대상으로 2차원 평면변형률 조건의 수치해석을 수행하였으며, 다양한 지진 시나리오의 PGA를 0.2g로 스케일링하여 적용했을 때 비탈면에서 발생하는 응답특성을 분석하였다. 분석 결과, 비탈면의 상층부와 하층부의 응답은 활동면 발생 여부에 따라 차이를 보이며, 입력 지진파의 외적요인 보다는 소성변형을 유발시킨 진동 특성의 영향을 받는 것으로 나타났다.

• 한국방재학회:학술대회논문집
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• 한국방재학회 2008년도 정기총회 및 학술발표대회
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• pp.13-18
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• 2008

The 2005 west off Fukuoka earthquake with Mjma 7.0 occurred in the vicinity of Fukuoka city with 1.4 million populations, which had been regarded as rather seismically inactive in Japan. The strong motion records by K-net indicated PGV of 64 cm/s in Fukuoka city and some condominium buildings sustained extensive non-structural damages. In this study, we conducted a questionnaire survey for residents of 8 condominium buildings located in the downtown area of Fukuoka city after the earthquake. The results indicate that damaged nonstructural walls and distorted doors disrupted evacuation route for many occupants, and furniture and content damage on upper floors became severer resulting in higher rates of human casualty. Earthquake preparedness for indoor safety was raised after the earthquake, though further safety measures can be advised. In the phase of post-earthquake emergency and restoration period, residents' management organizations play important roles, so that neighborhood activities to promote communication networks are important in urban environment with aging population.

• 대한치과보철학회지
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• 제25권1호
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• pp.95-118
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• 1987

This study was undertaken to observe the elemental transition of Interface depending on different pretreatment methods, the number of filings, the kinds of porcelain powders and the various alloys in ceramo-metal restoration. The materials used in this study were Pors-on $4^{(R)}$ and Ceramco porcelain powder to compare the differences depending on the pretreatement methods and the number of firings. Ceramco porcelain powder and Vita porcelain powder were used to compare the differences of elemental transition depending on the porcelain powders. The $Parasil^{(R)},\;PGV^{(R)}$ and Pors-on $4^{(R)}$ as Pd-Ag alloy were used to compare the difference of elemental transition depending on the various alloys. The pretreatment methods were : no treatment, treatment under vacuum and air, treatment with 50 % hydrofluoric acid and double heat tretament. The number of firings were 3, 5 and 7 repeated firings All specimens were observed by SEM and concentration of elements were analyzed quantitatively with EPMA The results of this study were obtained as follows : 1. In the groups of air-treatment, concentration of Sn were the highest and widest. A high concentration of In were in the groups of vacuum and air treatment. 2. There were no significant differences in concentration of Sn between the group of vacuum, 5 minutes hydrofluoric acid and double heat treatment. (p>0.05) 3. As the period of time of hydrofluoric acid treatment increased, not only were the trace elements reduced but the main components such as Pd and Ag were also reduced. 4. Concentration of Sn and In increased and diffused with repeated firings but 5 repeated and 7 repeated firings groups had no significant differences. (p>0.05) 5. Sn were more concentrated in the group of Ceramco porcelaion powder than Vita porcelain powder. 6. The higher concentration of trace elements in the alloy, the more increasing concentration of Sn and In in the interface.