• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2683-2688
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• 2016

A salt compound of a curcumin analogue, potassium pentagamavunon-0 (K PGV-0) has been synthesized to improve solubility of pentagamavunon-0 which has been proven to have anti-proliferative effects on several cancer cells. The purpose of this study was to investigate cytotoxic activity and metastasis inhibition by K PGV-0 alone and in combination with achemotherapeutic agent, doxorubicin (dox), in breast cancer cells. Based on MTT assay analysis, K PGV-0 showed cytotoxic activity in T47D and 4T1 cell lines with $IC_{50}$ values of $94.9{\mu}M$ and $49.0{\pm}0.2{\mu}M$, respectively. In general, K PGV-0+dox demonstrated synergistic effects and decreased cell viability up to 84.7% in T47D cells and 62.6% in 4T1 cells. Cell cycle modulation and apoptosis induction were examined by flow cytometry. K PGV-0 and K PGV-0+dox caused cell accumulation in G2/M phase and apoptosis induction. Regarding cancer metastasis, while K PGV-0 alone did not show any inhibition of 4T1 cell migration, K PGV-0+dox exerted inhibition. K PGV-0 and its combination with dox inhibited the activity of MMP-9 which has a pivotal role in extracellular matrix degradation. These results show that a combination of K PGV-0 and doxorubicin inhibits cancer cell growth through cell cycling, apoptosis induction, and inhibition of cell migration and MMP-9 activity. Therefore, K PGV-0 may have potential for development as a co-chemotherapeutic agent.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.179-184
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• 2014

Chemoresistance of breast cancer to doxorubicin is mediated mainly through activation of NF-kB and over expression of HER2. Curcumin and its analogues (PGV-0 and PGV-1) exert cytotoxic effects on T47D breast cancer cells. Suppression of NF-kB activation is suggested to contribute to this activity. The present study aimed to explore the effects of curcumin, PGV-0, and PGV-1 singly and in combination with doxorubicin on MCF-7/Dox cells featuring over-expression of HER2. In MTT assays, curcumin, PGV-0, and PGV-1 showed cytotoxicity effects against MCF-7/Dox with IC50 values of $80{\mu}M$, $21{\mu}M$, and $82{\mu}M$ respectively. These compounds increased MCF-7/Dox sensitivity to doxorubicin. Cell cycle distribution analysis exhibited that the combination of curcumin and its analogues with Dox increased sub G-1 cell populations. Curcumin and PGV-1 but not PGV-0 decreased localization of p65 into the nucleus induced by Dox, indicating that activation of NF-kB was inhibited. Molecular docking of curcumin, PGV-0, and PGV-1 demonstrated high affinity to HER2 at ATP binding site. This interaction were directly comparable with those of ATP and lapatinib. These findings suggested that curcumin, PGV-0 and PGV-1 enhance the Dox cytotoxicity to MCF-7 cells through inhibition of HER2 activity and NF-kB activation.

• Geomechanics and Engineering
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• v.9 no.2
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• pp.125-144
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• 2015

This paper presents the probabilistic seismic microzonation of densely populated Kolkata city, situated on the world's largest delta island with very soft alluvial soil deposit. At first probabilistic seismic hazard analysis of Kolkata city was carried out at bedrock level and then ground motion amplification due to sedimentary deposit was computed using one dimensional (1D) wave propagation analysis SHAKE2000. Different maps like fundamental frequency, amplification at fundamental frequency, peak ground acceleration (PGA), peak ground velocity (PGV), peak ground displacement (PGD), maximum response spectral acceleration at different time period bands are developed for variety of end users, structural and geotechnical engineers, land use planners, emergency managers and awareness of general public. The probabilistically predicted PGA at bedrock level is 0.12 g for 50% exceedance in 50 years and maximum PGA at surface level it varies from 0.095 g to 0.18 g for same probability of exceedance. The scenario of simulated ground motion revealed that Kolkata city is very much prone to damage during earthquake.

• Journal of the Korean earth science society
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• v.41 no.3
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• pp.238-247
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• 2020

This study simulated strong ground motion waveforms in the southern Korean Peninsula, based on the physical earthquake modeling of the Southern California Earthquake Center (SCEC) BroadBand Platform (BBP). Characteristics of intensity attenuation were investigated for M 6.0-7.0 events, incorporating the site effects. The SCEC BBP is software generates broadband (0-10 Hz) ground-motion waveforms for earthquake scenarios. Among five available modeling methods in the v16.5 platform, we used the Song Model. Approximately 50 earthquake scenarios each were simulated for M 6.0, 6.5, and 7.0 events. Representative metrics such as peak ground acceleration (PGA) and peak ground velocity (PGV) were obtained from the synthetic waveforms that were simulated before and after the consideration of site effects (V_S30). They were then empirically converted to distribution of instrumental intensity. The intensity that considers the site effects is amplified at low rather than high V_S30 zones.

• Journal of the Korean Geotechnical Society
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• v.35 no.12
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• pp.135-145
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• 2019

The slope collapse can be classified into internal and external factors. Internal factors are engineering factors inherent in the formation of slopes such as soil depth, slope angle, shear strength of soil, and external factors are external loading such as earthquakes. The external factor for earthquake can be expressed by various values such as peak ground acceleration (PGA), peak ground velocity (PGV), Arias coefficient (I), natural period (T_p), and spectral acceleration (S_aT=1.0). Specially, PGA is the most typical value that defines the magnitude of the ground motion of an earthquake. However, it is not enough to consider the displacement in the slope which depends on the duration of the earthquake even if the vibration has the same peak ground acceleration. In this study, numerical analysis of two-dimensional plane strain conditions was performed on engineered block, and slope responses due to seismic motion of scaling PGA to 0.2 g various event scenarios was analyzed. As a result, the response of slope is different depending on the presence or absence of sliding block; it is shown that slope response depend on the seismic wave triggering sliding block than the input motion factors.

• 한국방재학회:학술대회논문집
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• 2008.02a
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• pp.13-18
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• 2008

The 2005 west off Fukuoka earthquake with Mjma 7.0 occurred in the vicinity of Fukuoka city with 1.4 million populations, which had been regarded as rather seismically inactive in Japan. The strong motion records by K-net indicated PGV of 64 cm/s in Fukuoka city and some condominium buildings sustained extensive non-structural damages. In this study, we conducted a questionnaire survey for residents of 8 condominium buildings located in the downtown area of Fukuoka city after the earthquake. The results indicate that damaged nonstructural walls and distorted doors disrupted evacuation route for many occupants, and furniture and content damage on upper floors became severer resulting in higher rates of human casualty. Earthquake preparedness for indoor safety was raised after the earthquake, though further safety measures can be advised. In the phase of post-earthquake emergency and restoration period, residents' management organizations play important roles, so that neighborhood activities to promote communication networks are important in urban environment with aging population.

• The Journal of Korean Academy of Prosthodontics
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• v.25 no.1
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• pp.95-118
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• 1987

This study was undertaken to observe the elemental transition of Interface depending on different pretreatment methods, the number of filings, the kinds of porcelain powders and the various alloys in ceramo-metal restoration. The materials used in this study were Pors-on $4^{(R)}$ and Ceramco porcelain powder to compare the differences depending on the pretreatement methods and the number of firings. Ceramco porcelain powder and Vita porcelain powder were used to compare the differences of elemental transition depending on the porcelain powders. The $Parasil^{(R)},\;PGV^{(R)}$ and Pors-on $4^{(R)}$ as Pd-Ag alloy were used to compare the difference of elemental transition depending on the various alloys. The pretreatment methods were : no treatment, treatment under vacuum and air, treatment with 50 % hydrofluoric acid and double heat tretament. The number of firings were 3, 5 and 7 repeated firings All specimens were observed by SEM and concentration of elements were analyzed quantitatively with EPMA The results of this study were obtained as follows : 1. In the groups of air-treatment, concentration of Sn were the highest and widest. A high concentration of In were in the groups of vacuum and air treatment. 2. There were no significant differences in concentration of Sn between the group of vacuum, 5 minutes hydrofluoric acid and double heat treatment. (p>0.05) 3. As the period of time of hydrofluoric acid treatment increased, not only were the trace elements reduced but the main components such as Pd and Ag were also reduced. 4. Concentration of Sn and In increased and diffused with repeated firings but 5 repeated and 7 repeated firings groups had no significant differences. (p>0.05) 5. Sn were more concentrated in the group of Ceramco porcelaion powder than Vita porcelain powder. 6. The higher concentration of trace elements in the alloy, the more increasing concentration of Sn and In in the interface.