• Title/Summary/Keyword: Journal publication

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Lack of Effects of HER-2/neu on Prognosis in Colorectal Cancer: a Meta-analysis

  • Han, Jun;Meng, Qing-Yang;Liu, Xiao;Xi, Qiu-Lei;Zhuang, Qiu-Lin;Wu, Guo-Hao
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.14
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    • pp.5551-5556
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    • 2014

  • Background: The prognostic value of human epidermal growth factor receptor-2 (HER-2/neu) for survival of patients with colorectal cancer (CRC) is still ambiguous. We therefore performed a meta-analysis to evaluate its prognostic significance. Materials and Methods: We searched the MEDLINE and EMBASE databases for published literature investigating associations between HER-2/neu status and overall survival of patients with CRC. A meta-analysis was performed using a DerSimonian-Laird model and publication bias was investigated by Begg's and Egger's tests. Subgroup analysis was also conducted according to the study design type, study quality score, cut-off value for HER-2/neu overexpression, publication region, patient number and publication year. Results: A total of 17 eligible studies involving 2,347 patients were identified for this meta-analysis. The combined hazard ratio (HR) was 1.31 (95% confidence interval (CI): 0.96-1.79), suggesting that HER-2/neu overexpression was not significantly associated with overall survival of patients with CRC. However, subgroup analysis revealed that HER-2/neu overexpression had an unfavorable impact on survival when the analysis was restricted to subgroups of study quality score ${\leq}5 $(HR=1.56, 95%CI: 1.17-2.10), Asian patients (HR=1.74, 95%CI: 1.22-2.49), patient number ${\leq}106$ (HR=1.57, 95%CI: 1.01-2.44), publication year before 2003 (HR=1.59, 95%CI: 1.02-2.49), and prospectively designed study (HR=3.62, 95%CI: 1.42-9.24). The effect disappeared in subgroups of study quality scores > 5 (HR=0.69, 95%CI: 0.33-1.44), non Asian patients (HR=1.14, 95%CI: 0.77-1.70), patients' number > 106 (HR=1.07, 95%CI: 0.67-1.72), publication year after 2003 (HR=1.13, 95%CI: 0.76-1.69), and retrospectively designed study (HR=1.22, 95%CI: 0.89-1.67). Conclusions: Our meta-analysis suggests that HER-2/neu overexpression might not be a significantly prognostic indicator for patients with CRC. Further studies are required to confirm these results.

  • https://doi.org/10.7314/APJCP.2014.15.14.5551 인용 PDF KSCI

A Meta-Analysis of the Relationship of Child-Abuse to Psycho-social Maladjustment: (아동학대유형과 심리사회적 부적응의 관계에 대한 메타분석)

  • Yoon, Hyemee
    • Korean Journal of Social Welfare Studies
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    • v.48 no.1
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    • pp.173-206
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    • 2017

  • The purpose of this meta-analysis was to address two questions: (1) To what extent are types of child abuse related to psycho-social maladjustment of the abused? (2) Do relations found in this study vary by the gender, sample size, year of publication, types of publication, and respondents' age? The materials of this study were based on 14 variables obtained from 104 published and unpublished (doctoral disserations and master's theses) research papers over a span of 26 years(1990-2016). Child abuse related variables were categorized into physical abuse, emotional abuse, neglect, and abuse while psycho-social maladjustment grouped as internal (anxiety, depression, withdrawal, and anxiety/depression) and external problem behaviors(aggression, problem behavior, and delinquency). Major findings were: Medium effect size of emotional abuse, abuse, physical abuse, neglect on psycho-social maladjustment among the abused were calculated. Emotional abuse was highly related to every internal and external problem behaviors. Neglect was found to have higher effect size in external problem behaviors than internal problem behaviors. Publication types moderated the association between types of child abuse and internalization while year of publication, number of samples and publication types showed moderation effects on the relation between types of child abuse and externalization. Finding suggest that future studies on child sexual abuse and those on intervention outcome are required and use of well validated instruments are essential.

  • https://doi.org/10.16999/kasws.2017.48.1.173 인용