• 대한두경부종양학회지
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• 제5권1호
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• pp.31-38
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• 1989

The result of neutron therapy on head and neck cancer using KCCH -Cyclotron neutron which had been using from October 1986 to September 1989 in the Korea Cancer Center Hospital. Among the total of 27 patients the cases of malignant salivary gland tumor were 14 and the cases of advanced head and neck cancer of AJCC stage IV were 13. The local control rate was 80% in malignant salivary gland tumor and 46.2% in advanced head and neck cancer. The 2 year survival rate was 60% in malignant salivary gland tumor and 38.5% in advanced head and neck cancer. Although there was no significant difference in prognosis according to the pathologic types, squamous cell carcinoma revealed a pattern of poor prognosis. The major complication from the neutron therapy had developed 7.1% in malignant salivary gland tumor and 23.1% in advanced head and neck cancer. In conclusion, neutron therapy is superior in the treatment of malignant salivary gland tumor and also effective in the treatment of advanced head and neck cancer when it can avoid to treat some site of low tolerance.

• 대한두경부종양학회지
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• 제4권1호
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• pp.13-19
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• 1988

Brachytherapy is known to be a good modality to achieve local control as a boost treatment following limited external irradiation, which may reduce the external beam related acute radiation sickness, particularly in head and neck cancer. The authors developed iridium-192 ribbons recently to replace the radium needles. Total of 13 head and neck cancer patients had been treated with Ir-192 ribbons during last one year from October 1986 to September 1987, and the results were analysed to assess the applicability of the fabricated sources. The conclusion is as follows; 1) Iridium implant achieved 54% (7/13) of complete response and 69% (9/13) of overall response rate in head and neck cancer. 2) Iridium is superior to radium and cecium in brachytherapy because of easier to use and lesser exposure to the personnel. 3) Afterloading technique is useful to modify dose distribution, to expand treatment site and method, and to develop interstitial hyperthermia.

• Radiation Oncology Journal
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• 제4권2호
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• pp.141-145
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• 1986

1981년 1월부터 1985년 12월까지 서울대학교병원 치료방사선과에서 운2명의 극소적으로 절제 불가능한 췌장암 환자를 방사선과 악물요법으로 치료하였다. 방사선은 2주의 간격을 두고 2000cGy씩 총 4000cGy를 조사하였으며 5-FU (5-fluorouracil)는 방사선 조사의 각 course의 첫 3일에 걸쳐 주입하였다. 방사선치료 종료 4주 후부터 FAM (5-FU, Adriamycin, Mitomycin)을 지속요법으로 사용하였다. 통증 완화는 $22\%(4/18)$에서 완전관해를, $39\%(7/18)$에서 부분관해를 보였다. 생존기간의 중앙치는 31주였으며 치료 전 Performance status가 중요한 예후인자였다. 국소적으로 절제불가능한 췌장암의 치료에 있어서 방사선과 FAM regimen의 병용은 통증완화 및 생존기간의 연장에 기여할 수 있는 바 이에 대한 보다 많은 연구와 고찰이 없어야 차겠다.

• Radiation Oncology Journal
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• 제6권2호
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• pp.163-168
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• 1988

성상세포종과 교아세포종으로 1979년부터 1985년까지 7년 간 서울대학교병원 치료방사선과에서 수술후 방사선치료를 시행한 49명의 환자에 대해 후향적 분석을 시행하여 다음과 같은 결과를 얻었다. 1. 3년 전체 생존율은 grade I, II, III 성상세포종에 대해 각각 $85.7\%,\;44.0\%,\;23.1\%$였으며, 교아세포종의 1년 및 2년 전체 생존율은 각각 $54.5\%,\;27.3\%$였다. 2. 종양의 분화도, 환자의 나이, 병소의 위치, 절제정도 등이 예후에 영향을 미치는 인자로 나타났다

• Radiation Oncology Journal
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• 제7권2호
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• pp.299-303
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• 1989

Authors have developed highly reproducible calibration method for the Micro-Selectron HDR Ir-192 system (Nucletron, Motherland). The new jig has a 10cm radius circular hole in the $30cm{\times}30cm{\times}0.2cm$ acrylic plate, and 5F flexible bronchial tubes are attached around the hole. The source moves along the circle in the tubes and the ionization chamber is placed verticaly at the center of the circular hole (center of the jig). Dose distribution near the center was derived theoretically, and measured with the film dosimetry system. Theoretical calculation and measurement show the error margin below $0.1\%$ for 1mm or 2mm position deviation. We have measured at 12 and 24 points of circle with 1, 6, 11 and 21 second dwell time of source in order to calculate the activity of the source. Measurements have been repeated daily for 50 days. The accuracy and the reproducibility are below $1\%$ error margin. The half life of the source from our measurement is estimated $73.4\pm0.4$ days.

• Radiation Oncology Journal
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• 제11권1호
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• pp.183-191
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• 1993

The homogeneous dose planning is one of the most important roles in radiation therapy. But, it is not easy to obtain a homogeneous dose to paranasal sinus region including the ethmoidal sinus with conventional irradiation techniques. In this experimental study, the authors tried to get a homogeneous dose at PNS region, but the nasal cartirage does not exceed the tolerance dose, with anterior-posterior beam and two both lateral wedged beams. Used three fields were shielded with full thickness of blocks to preserve the eye-balls and with blocks of one half value layer to create a homogeneous dose at the whole treatment volume. The dose computations are based on the three dimensonal structure with modified scatter contributions of partial shielders and attenuated beams in 6 MV photon beams. The dose distributions of mid-plane is examined with Kodak verification films and teflon-embedded TLD rod (1 mm diameter and 6 mm length) to confirm the computed dose. In our study, the whole PNS regions have shown within $85{\%}$ of the resultant isodose curves with relatively homogeneous dose distribution. The results of dose computation and measurements are agree well within $5{\%}$ uncertainties.

• Radiation Oncology Journal
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• 제12권2호
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• pp.191-199
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• 1994

Purpose : This study was undertaken to show the clinical results of combined radiotherapy and hyperthermia in primary hepatoma Materials and Methods : Between December 1989 and March 1993, 50 patients with hepatomas were treated by combined radiotherapy and hyperthermia. Among them, we analyzed retrospectively 33 patients who received the complete course of treatment. The ages of the patients ranged from 36 to 75(mean age: 55.5 years). Twenty-six patients ($78.8\%$) were men, and 7 ($21.2\%$ were women. According to Child's classification, nine patients ($27.3{\%}$) were A group, 9 ($27.3\%$) were B group, 15 ($45.4\%$) were C group. Radiation therapy was done by a 6 MV and 15 MV linear accelerator. Patients were treated with daily fractions of 150-180 cCy to doses of 2550 cGy -4950 cGy (median : 3000 cGy). Local hyperthermia was done by 8 MHZ RF capacitive heating device (Cancermia. Green Cross Co., Korea), 50-60 min/session, 1-2 sessions/wk, and 8.5 sessions (median number)/patient. We analyzed the prognostic factors including age, sex, tumor type, Child's classification, $\alpha$-fetoprotein, liver cirrhosis, ascites, portal vein invasion, esophageal varix, number of hyperthermia, chemotherapy, total bilirubin level, Karnofsky perfomance status. Results : The overall 1-year survival was $24.2\%$, with a mean survival of 10months. Of 33 patients, tumor regression (PR+MR) was seen in $30.4\%$, no response was seen in $52.2\%,\;17.4\%$ patient was progressed. In patients who had tumor regression, the overall 1-year survival was $42.1\%$ with a mean survival of 14 months. Factors influencing the survival were sex (p=0.05), tumor type (p=0.0248), Child's classification (p=0.0001), liver cirrhosis (p=0.0108), ascites (p=0.0009), and Karnofsky perfomance status (p=0.0028). Complications developed in 28 patients, including 18 hot pain,5 fat necrosis, 3 transient fever, 2 nausea and vomiting. Conclusion : In this study, the results suggests that combined radiotherauy and hyperthermia may improve the survival rate of hepatoma.

• Radiation Oncology Journal
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• 제10권2호
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• pp.163-169
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• 1992

1980년 1월부터 1991년 6월까지 경희대학교 부속병원 치료방사선과에서 수술후 방사선치료를 받은 뇌의 악성 성상세포종과 교아세포종 환자 53명을 대상으로 후향적 분석을 실시하였다. 48명이 추적 가능하였으며 5년생존율은 악성 성상세포종이 $29.4\%$였고 교아세포종이 $2.8\%$였으며 중앙생존기간은 각각 27개월, 11개월이었다. 조직 분화도, 나이, 수행능력, 방사선량이 통계학적으로 유의하게 의미있는 예후인자로 나타났다. 종양절제 정도, 증상발현 기간, 종양의 위치에따라 생존율의 차이를 보였으나 통계적인 유의성은 없었다.

• Radiation Oncology Journal
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• 제3권2호
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• pp.175-178
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• 1985

방사선 치료도중 혹은 치료후의 추적조사에서 이차장염에 의한 염증성 질환 및 방사선에 의해서 야기되는 소견과 합병된 이차 감염 등은 흔히 경험하고 있는 일로서 때로는 이로 인해 치명적일 수 있게 된다. 저자들은 경북지방에서 사육된 정상 잡종쥐를 사용하여 방사선 조사실험을 하던 중 피하조직과 양측 신장부위에 암중으로 생각되는 다발성의 종괴를 발견하여 병리학적 청사를 의뢰하였던 바, 다발성 농양으로 판명되어 말초혈액소견, 소변청사, 대변검사 및 병리학적 소견과 함께 보고하는 바이다.

• Radiation Oncology Journal
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• 제13권2호
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• pp.143-148
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• 1995

Purpose: We tried to evaluate the role of conventional radiotherapy alone or with neoadjuvant chemotherapy in the hypopharyngeal cancer by retrospective analysis. Materials and Methods: Between Jul.1985 and Sep.1992, 42 patients of hypopharyngeal cancer were treated by conventional radiotherapy alone or combined with neoadjuvant chemotherapy. The male to female ratio was 20:1 with a median age of 58 years, Twelve Patients were treated by conventional radiotherapy alone and 30 patients were treated by neoadjuvant chemotherapy and radiotherapy. Results: Seven Patients were Stage I,II and the patients with stage III and IV were 10 and 25, respectively at the time of presentation. The overall survival and disease-specific survival rates at 24 months were $12.9\%$ and $15.5\%,$respectively Two-year survival rates of stage I+II and III+IV patients were $50\%$ and $6.3\%,$ respectively(p(0.05). Sixteen Patients$(38\%)$ revealed CR and 26 patients$(62\%)$ revealed less than CR at the end of radiotherapy and their 2-year survival rates were $31.3\%\;and\;0\%,$ respectively(p(0.05). On univariate analysis, stage, T-stage, N-stage and treatment response were the significant prognostic factors, but only stage and treatment response were significant on multivariate analysis Conclusion : This conventional radiotherapy alone or with neoadjuvant chemotherapy does not seem to be sufficient in the treatment of most advanced hypopharyngeal cancer Therefore other treatment modalities such as hyperfractionation or concurrent chemoradiotherapy should be considered.