• Journal for History of Mathematics
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• v.20 no.3
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• pp.127-146
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• 2007

From 1876 to 1883, British mathematician James Joseph Sylvester worked as the founding head of Mathematics Department at the Johns Hopkins University which has been known as America's first school of mathematical research. Sylvester established the American Journal of Mathematics, the first sustained mathematics research journal in the United States. It is natural that we think this is the most exciting and important period in American mathematics. But we found out that the International Congress of Mathematicians held at the World's Columbian Exposition in Chicago, August 21-26, 1893 was the real turning point in American's dedication to mathematical research. The University of Chicago was founded in 1890 by the American Baptist Education Society and John D. Rockefeller. The founding head of mathematics department Eliakim Hastings Moore was the one who produced many excellent American mathematics Ph.D's in early stage. Many of Moore's students contributed to build up real American mathematics research power in early 20 century The University also has a well-deserved reputation as the "teacher of teachers". Beginning with Sylvester, we analyze what E.H. Moore had done as a teacher and a head of the new department that produced many mathematical talents such as L.E. Dickson(1896), H. Slaught(1898), O. Veblen(1903), R.L. Moore(1905), G.D. Birkhoff(1907), T.H. Hilderbrants(1910), E.W. Chittenden(1912) who made the history of American mathematics. In this article, we study how Moore's vision, new system and new way of teaching influenced American mathematical society at early stage of the top class mathematical research. and the meaning that early University of Chicago case gave.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.5
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• pp.459-466
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• 2016

Adipogenic differentiation of mesenchymal stem cells (MSCs) is critical for metabolic homeostasis and nutrient signaling during development. However, limited information is available on the pivotal modulators of adipogenic differentiation of MSCs. Adaptor protein Lnk (Src homology 2B3 [SH2B3]), which belongs to a family of SH2-containing proteins, modulates the bioactivities of different stem cells, including hematopoietic stem cells and endothelial progenitor cells. In this study, we investigated whether an interaction between insulin-like growth factor-1 receptor (IGF-1R) and Lnk regulated IGF-1-induced adipogenic differentiation of MSCs. We found that wild-type MSCs showed greater adipogenic differentiation potential than $Lnk^{-/-}$ MSCs. An ex vivo adipogenic differentiation assay showed that $Lnk^{-/-}$ MSCs had decreased adipogenic differentiation potential compared with wild-type MSCs. Interestingly, we found that Lnk formed a complex with IGF-1R and that IGF-1 induced the dissociation of this complex. In addition, we observed that IGF-1-induced increase in the phosphorylation of Akt and mammalian target of rapamycin was triggered by the dissociation of the IGF-1R-Lnk complex. Expression levels of a pivotal transcription factor peroxisome proliferator-activated receptor gamma ($PPAR-{\gamma}$) and its adipogenic target genes (LPL and FABP4) significantly decreased in $Lnk^{-/-}$ MSCs. These results suggested that Lnk adaptor protein regulated the adipogenesis of MSCs through the $IGF-1/Akt/PPAR-{\gamma}$ pathway.

• Journal of the Economic Geographical Society of Korea
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• v.26 no.3
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• pp.337-357
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• 2023

Universities and local governments in Korea are simultaneously experiencing the difficulties of a decrease in the youth population and a decrease in the school-age population, and close cooperation between universities and local governments is urgently needed to solve this problem. Representative methods of such cooperation include the establishment of a regional innovation system and the theories of innovation clusters and triple helix models. In addition to these theories, the aim is to derive sustainable conditions for the local government-university cooperation model by examining various cases of cooperation at home and abroad. This is the purpose of this paper. In particular, through case studies of cooperation between local governments and universities at home and abroad, three types of models (job, education, and housing) were analyzed, and common conditions and requirements for sustainable cooperation were proposed. In order for cooperation between local governments and universities to continue and produce successful results, mutual benefit creation, infrastructure construction and operation appropriate for capabilities, flexibility, and mutual responsibility are necessary. Furthermore, a model that suits the capabilities of local governments and universities must be found, and in this process, the university's research capabilities and commercialization capabilities of research results are especially important. In addition, it is essential to establish a new cooperation system between local governments, universities, and the central government.

• Journal of Veterinary Clinics
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• v.30 no.2
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• pp.95-99
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• 2013

This study was performed to evaluate the seasonal variation of intraocular pressure (IOP) values in normal Sapsaree dogs. Sapsaree dogs (n = 474) clinically free from ophthalmic disease were included in this study, and both eyes were examined in each dog. An applanation tonometer (Tonopen$^{(R)}$ XL) was used to measure IOP values in both eyes. Data obtained from both eyes were stratified by factors thought to affect IOP values including age, gender, hair coat type as well as season of measurement. The IOP results were compared by ANCOVA to verify the effect each factor had on IOP, and an ANOVA test followed by a Bonferroni post hoc test was used for further analysis. The overall mean ${\pm}$ SD IOP value was $19.1{\pm}3.7$ mmHg (range: 8 to 28 mmHg) in the present study. Only seasonal variation showed a significant effect (P < 0.001), on IOP values. IOP values measured in winter ($20.4{\pm}3.4$ mmHg) and summer ($17.1{\pm}3.6$ mmHg) were significantly higher and lower, respectively, than those measured in other seasons. These results suggest a seasonal variation has a significant effect on the IOP of normal dogs. This may prompt further research and possible modification of current veterinary ophthalmic references.

• Journal of Veterinary Clinics
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• v.26 no.6
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• pp.515-519
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• 2009

Antibodies to Anaplasma phagocytophilum and Ehrlichia chaffeensis were detected by the immunofluorescent antibody (IFA) test in sera collected from cats, thoroughbred horses and Holstein cattle in Gwangju, Jeonju and Jeju Island of Korea. Two hundred fifty four sera (33 feral and pet cats, 92 grazing horses and 129 grazing cattle) were obtained from Republic of Korea. Antibodies to A. phagocytophilum (titer $\geq$ 80) were detected in 6 of the 33 feral and pet cats (18.2%), and 1 seropositive cat (3.0%) also had antibodies to E. chaffeensis. Only 1 of 129 (0.8%) cattle and 2 of 92 (2.2%) horses had antibodies to A. phagocytophilum. Antibodies to E. chaffeensis were not detected in either of these animals. This is the first report of serological evidence of A. phagocytophilum and E. chaffeensis from cats, cattle and horses in Korea. These rickettsial agents could have an important impact on human health or impact animal health with economic losses among industrial grazing animals in Korea.

• 한국노년학
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• v.28 no.4
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• pp.991-1007
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• 2008

Purpose: The purpose of this study was to compare depression and quality of life(QOL) according to the severity of insomnia in elderly. Method: The survey participants were 463 community-dwelling adults aged 65 or older. Severity of insomnia was measured by assessing a time-length to get to sleep, the number of breaks in sleep, a time-length to get to sleep after awakening, and a usual sleep pattern. Depression and QOL was measured, respectively, a modified Zung's depression scale and SF-36. The data were collected from May to June in 2005 and analyzed using the SPSS program for descriptive statistics, ${\chi}^2$-test, t-test, and ANOVA with Scheffe test. Results: A majority of the participants(75.6%) presented mild(65.0%) or severe(10.6%) insomnia. Severity of insomnia was different depending on sex, a marriage status, and sleep patterns such as hours of sleep on average, time to go to bed, and time of awakening(p<0.05). Depression and QOL were related to the severity of insomnia(p<0.05). The elderly suffering from insomnia needs nursing interventions considering demographics and sleep patterns in oder to prevent depression and to improve QOL. Future research is in need for predicting and preventing depression and QOL in elderly.

• Nutrition Research and Practice
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• v.11 no.5
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• pp.402-411
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• 2017

BACKGROUND/OBJECTIVES: The role of a school's nutrition environment in explaining students' eating behaviors and weight status has not been examined in an Asian setting. The purpose of this study was to create a school nutrition environment index and to pilot test the index in elementary and middle schools in urban South Korea. SUBJECTS/METHODS: This study used a mixed-methods approach. Environment assessment tools were developed based on formative research, which comprised literature reviews, in-depth interviews, and focus group discussions. Key elements from the formative research were included in the assessment tool, which consisted of a structured survey questionnaire for school dietitians. Fifteen school dietitians from 7 elementary and 8 middle schools in Seoul completed the questionnaire. RESULTS: The formative research revealed four main sections that guided a summary index to assess a school's nutrition environment: resource availability, education and programs, dietitians' perceptions and characteristics, and school lunch menu. Based on the literature reviews and interviews, an index scoring system was developed. The total possible score from the combined four index sections was 40 points. From the 15 schools participating in the pilot survey, the mean school nutrition-environment index was 22.5 (standard deviation ${\pm}3.2$; range 17-28). The majority of the schools did not offer classroom-based nutrition education or nutrition counseling for students and parents. The popular modes of nutrition education were school websites, posters, and newsletters. CONCLUSIONS: This paper illustrates the process used to develop an instrument to assess a school's nutrition environment. Moreover, it presents the steps used to develop a scoring system for creation of a school nutrition environment index. As pilot testing indicated the total index score has some variation across schools, we suggest applying this instrument in future studies involving a larger number of schools. Future studies with larger samples will allow investigation of the validity and reliability of this newly developed tool.

• Molecules and Cells
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• v.40 no.12
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• pp.954-965
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• 2017

Mammalian genomes are well established, and highly conserved regions within odorant receptors that are unique from other G-protein coupled receptors have been identified. Numerous functional studies have focused on specific conserved amino acids motifs; however, not all conserved motifs have been sufficiently characterized. Here, we identified a highly conserved 18 amino acid sequence motif within transmembrane domain seven (CAS-TM7) which was identified by aligning odorant receptor sequences. Next, we investigated the expression pattern and distribution of this conserved amino acid motif among a broad range of odorant receptors. To examine the localization of odorant receptor proteins, we used a sequence-specific peptide antibody against CAS-TM7 which is specific to odorant receptors across species. The specificity of this peptide antibody in recognizing odorant receptors has been confirmed in a heterologous in vitro system and a rat-based in vivo system. The CAS-TM7 odorant receptors localized with distinct patterns at each region of the olfactory epithelium; septum, endoturbinate and ectoturbinate. To our great interests, we found that the CAS-TM7 odorant receptors are primarily localized to the dorsal region of the olfactory bulb, coinciding with olfactory epithelium-based patterns. Also, these odorant receptors were ectopically expressed in the various non-olfactory tissues in an evolutionary constrained manner between human and rats. This study has characterized the expression patterns of odorant receptors containing particular amino acid motif in transmembrane domain 7, and which led to an intriguing possibility that the conserved motif of odorant receptors can play critical roles in other physiological functions as well as olfaction.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.27 no.3
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• pp.155-162
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• 2014

Using an isogeometric approach, a continuum-based shape design optimization method is developed for steady state power flow problems at high frequencies. In case the isogeometric method is employed to the shape design optimization, the NURBS basis functions used in CAD geometric modeling are directly utilized to embed the exact geometry into the computational framework so that the design parameterization for shape optimization is much easier than that in the finite element method and consequently provides the enhanced smoothness of design perturbations. Thus, exact geometric models can be used in both the response and the shape sensitivity analyses, where normal vector and curvature are continuous over the whole design space so that enhanced shape sensitivity can be expected. Through numerical examples, the developed isogeometric sensitivity is compared with finite difference one to provide excellent agreement. Also, it turns out that the proposed method works very well in the shape optimization problems.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.27 no.3
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• pp.137-145
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• 2014

We present a design sensitivity analysis(DSA) method for multiscale problems based on bridging scale decomposition. In this paper, we utilize a bridging scale method for the coupled system analysis. Since the analysis of full MD systems requires huge amount of computational costs, a coupled system of MD-level and continuum-level simulation is usually preferred. The information exchange between the MD and continuum levels is taken place at the MD-continuum boundary. In the bridging scale method, a generalized Langevin equation(GLE) is introduced for the reduced MD system and the GLE force using a time history kernel is applied at the boundary atoms in the MD system. Therefore, we can separately analyze the MD and continuum level simulations, which can accelerate the computing process. Once the simulation of coupled problems is successful, the need for the DSA is naturally arising for the optimization of macro-scale design, where the macro scale performance of the system is maximized considering the micro scale effects. The finite difference sensitivity is impractical for the gradient based optimization of large scale problems due to the restriction of computing costs but the analytical sensitivity for the coupled system is always accurate. In this study, we derive the analytical design sensitivity to verify the accuracy and applicability to the design optimization of the coupled system.