• Title/Summary/Keyword: Johns Hopkins University

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Validation of Adult Fall Assessment Scale Korean Version for Adult Patients in General Hospitals in Korea (한국형 낙상 위험 사정도구의 타당성 평가연구)

  • Choi, Eun Hee;Ko, Mi Suk;Lee, Shin Ae;Park, Jung Ha
    • Journal of Korean Clinical Nursing Research
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    • v.26 no.2
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    • pp.265-273
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    • 2020
  • Purpose: The purpose of this study was to test the predictive validity of the Fall Assessment Scale-Korean version (FAS-K) and to find the most appropriate cutoff score to screen high-risk fall groups in adult patients in general hospitals in Korea. Methods: We performed a prospective evaluation study in medical and surgical ward patients at two major general hospitals in Seoul. Data were collected from Nov. 1, 2018 to Feb. 28, 2019, nurses performed 651 observation series. The researcher measured the fall risk assessment score by applying FAS-K, MFS (Morse Fall Scale), and JHFRAT (Johns Hopkins Hospital Fall Risk Assessment tool) to the patients twice a week between 10 am and 12 noon. Data were analyzed using Pearson's corelation coefficients, and the sensitivity, specificity, predictive value, and the area under the curve (AUC) of the three tools. Results: The FAS-K was positively correlated with the MFS (r=.70, p<.001) and the JHFRAT (r=.82, p<.001). According to the receiver operating characteristics (ROC) curve analysis of the FAS-K, sensitivity, specificity, and positive and negative prediction values were 85.3%, 49.4%, 8.5%, and 98.4%, respectively, when the FAS-K score was 4. Therefore, the cut-off score of the FAS-K to identify groups with high fall risk was 4. Conclusion: The FAS-K is a valid tool for measuring fall risk in adult inpatients. In addition, the FAS-K score, 4, can be used to identify high-risk fall groups and know specific points in time to provide active interventions to prevent falls.

Validity and Reliability of the Korean Version of Assessment of Health Literacy in Breast and Cervical Cancer Screening (유방암과 자궁경부암 수검자용 한국판 건강정보이해력 측정도구의 타당도와 신뢰도 검증)

  • Shin, Hye Sook;Chi, Eunlim;Han, Hae-Ra
    • Journal of Korean Academy of Nursing
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    • v.51 no.6
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    • pp.769-781
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    • 2021
  • Purpose: Health literacy is a significant determinant of health and health behaviors such as cancer screening. Despite its significance, there are limited instruments available to assess health literacy targeting Koreans. The purpose of this study was to test the psychometric properties of Korean translation of a validated health literacy instrument in cancer screening-Korean version of assessment of health literacy in breast and cervical cancer screening (K-AHL-C). Methods: A total of 555 women aged 20~65 participated in the online survey study. Of 52 items addressing five domains included in the original version, we focused on 36 items addressing three key domains closely associated with cancer screening: familiarity, health navigation, and comprehension. Results: During content validation, two items from the health navigation domain were removed, yielding 34 items. Using Rasch analysis and confirmatory factor analysis, we found the evidence of construct validity of K-AHL-C. The Korean version was also significantly correlated with measures of Functional Health Literacy scale, cancer prevention behaviors, and subjective health status, suggesting convergent validities respectively. Finally, K-AHL-C had acceptable reliability coefficients (α) ranging from 0.71 to 0.92 for each domain and the total scale. Conclusion: These psychometric properties support the K-AHL-C is a valid and reliable instrument for measuring Koreans' health literacy in cancer screening. Also it is expected to use the instrument to detect breast and cervical cancer early and improve the screening rate, and ultimately to contribute to the promotion of women's health and women's health nursing practice.

Object Recognition Using Convolutional Neural Network in military CCTV (합성곱 신경망을 활용한 군사용 CCTV 객체 인식)

  • Ahn, Jin Woo;Kim, Dohyung;Kim, Jaeoh
    • Journal of the Korea Society for Simulation
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    • v.31 no.2
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    • pp.11-20
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    • 2022
  • There is a critical need for AI assistance in guard operations of Army base perimeters, which is exacerbated by changes in the national defense and security environment such as force reduction. In addition, the possibility for human error inherent to perimeter guard operations attests to the need for an innovative revamp of current systems. The purpose of this study is to propose a real-time object detection AI tailored to military CCTV surveillance with three unique characteristics. First, training data suitable for situations in which relatively small objects must be recognized is used due to the characteristics of military CCTV. Second, we utilize a data augmentation algorithm suited for military context applied in the data preparation step. Third, a noise reduction algorithm is applied to account for military-specific situations, such as camouflaged targets and unfavorable weather conditions. The proposed system has been field-tested in a real-world setting, and its performance has been verified.

In-depth Correlation Analysis of SARS-CoV-2 Effective Reproduction Number and Mobility Patterns: Three Groups of Countries

  • Setti, Mounir Ould;Tollis, Sylvain
    • Journal of Preventive Medicine and Public Health
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    • v.55 no.2
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    • pp.134-143
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    • 2022
  • Objectives: Many governments have imposed-and are still imposing-mobility restrictions to contain the coronavirus disease 2019 (COVID-19) pandemic. However, there is no consensus on whether policy-induced reductions of human mobility effectively reduce the effective reproduction number (Rt) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several studies based on country-restricted data reported conflicting trends in the change of the SARS-CoV-2 Rt following mobility restrictions. The objective of this study was to examine, at the global scale, the existence of regional specificities in the correlations between Rt and human mobility. Methods: We computed the Rt of SARS-CoV-2 using data on worldwide infection cases reported by the Johns Hopkins University, and analyzed the correlation between Rt and mobility indicators from the Google COVID-19 Community Mobility Reports in 125 countries, as well as states/regions within the United States, using the Pearson correlation test, linear modeling, and quadratic modeling. Results: The correlation analysis identified countries where Rt negatively correlated with residential mobility, as expected by policymakers, but also countries where Rt positively correlated with residential mobility and countries with more complex correlation patterns. The correlations between Rt and residential mobility were non-linear in many countries, indicating an optimal level above which increasing residential mobility is counterproductive. Conclusions: Our results indicate that, in order to effectively reduce viral circulation, mobility restriction measures must be tailored by region, considering local cultural determinants and social behaviors. We believe that our results have the potential to guide differential refinement of mobility restriction policies at a country/regional resolution.

MAGNETIC HELICITY PUMPING BY TWISTED FLUX TUBE EXPANSION

  • CHAE JONGCHUL;MOON Y.-J.;RUST D. M.;WANG HAIMIN;GOODE PHILIP R.
    • Journal of The Korean Astronomical Society
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    • v.36 no.1
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    • pp.33-41
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    • 2003
  • Recent observations have shown that coronal magnetic fields in the northern (southern) hemisphere tend to have negative (positive) magnetic helicity. There has been controversy as to whether this hemispheric pattern is of surface or sub-surface origin. A number of studies have focused on clarifying the effect of the surface differential rotation on the change of magnetic helicity in the corona. Meanwhile, recent observational studies reported the existence of transient shear flows in active regions that can feed magnetic helicity to the corona at a much higher rate than the differential rotation does. Here we propose that such transient shear flows may be driven by the torque produced by either the axial or radial expansion of the coronal segment of a twisted flux tube that is rooted deeply below the surface. We have derived a simple relation between the coronal expansion parameter and the amount of helicity transferred via shear flows. To demonstrate our proposition, we have inspected Yohkoh soft X-ray images of NOAA 8668 in which strong shear flows were observed. As a result, we found that the expansion of magnetic fields really took place in the corona while transient shear flows were observed in the photosphere, and the amount of magnetic helicity change due to the transient shear flows is quantitatively consistent with the observed expansion of coronal magnetic fields. The transient shear flows hence may be understood as an observable manifestation of the pumping of magnetic helicity out of the interior portions of the field lines driven by the expansion of coronal parts as was originally proposed by Parker (1974).

Application of Apoptogenic Pretreatment to Enhance Anti-tumor Immunity of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)-secreting CT26 Tumor Cells

  • Jun, Do-Youn;Jaffee, Elizabeth M;Kim, Young-Ho
    • IMMUNE NETWORK
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    • v.5 no.2
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    • pp.110-116
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    • 2005
  • Background: As an attempt to develop a strategy to improve the protective immune response to GM-CSF-secreting CT26 (GM-CSF/CT26) tumor vaccine, we have investigated whether the apoptogenic treatment of GM-CSF/CT26 prior to vaccination enhances the induction of anti-tumor immune response in mouse model. Methods: A carcinogeninduced mouse colorectal tumor, CT26 was transfected with GM-CSF gene using a retroviral vector to generate GM-CSF-secreting CT26 (CT26/GM-CSF). The CT26/GM-CSF was treated with ${\gamma}$-irradiation or mitomycin C to induce apoptosis and vaccinated into BALB/c mice. After 7 days, the mice were injected with a lethal dose of challenge live CT26 cells to examine the protective effect of tumor vaccination in vivo. Results: Although both apoptotic and necrotic CT26/GM-CSF vaccines were able to enhance anti-tumor immune response, apoptotic CT26/GM-CSF induced by pretreatment with ${\gamma}$-irradiation (50,000 rads) was the most potent in generating the anti-tumor immunity, and thus 100% of mice vaccinated with the apoptotic cells remained tumor free for more than 60 days after tumor challenge. Conclusion: Apoptogenic pretreatment of GM-CSF-secreting CT26 tumor vaccine by ${\gamma}$-irradiation (50,000 rads) resulted in a significant enhancement in inducing the protective anti-tumor immunity. A rapid induction of apoptosis of CT26/GM-CSF tumor vaccine at the vaccine site might be critical for the enhancement in anti-tumor immune response to tumor vaccine.

The Experiences and Challenges of Caregivers of Frail or Chronically Ill Elderly: An Integrative Review

  • Han, Hae-Ra
    • Perspectives in Nursing Science
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    • v.3 no.1
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    • pp.47-60
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    • 2006
  • BACKGROUND: Social, legal, and economic factors have changed the delivery of care to elderly who are frail and/or chronically ill. Increasing number of the elderly are now treated in the community, while living with or in close proximity to their family. It is evident that families play a major role of support for elderly persons in our society. This paper provides a review and analysis of studies that have investigated informal caregiving issues encompassing physical, psychological, emotional, and social domains. RESULTS OF THE REVIEW: Family caregiving often interfered with workplace and other responsibilities, creating physical, emotional, and financial stress for caregivers. Relatively high volumes of research addressed caregiving issues in the families of Alzheimer patients and in the areas of emotional and psychological impact of caregiving. Few studies explicitly investigated the role of informal caregivers in the management of other chronic conditions such as stroke or depression or physical consequences of long-term caregiving. While most studies were focused on negative aspects of caregiving, a few studies found it rewarding. Often the burden, stress, and socio-economic effects on the family caregiving for an elderly person were not sufficiently appreciated. CONCLUSIONS: Positive outcomes for both the caregiver and the care recipient are more likely to occur when effective levels of collaboration exist between health professionals and caregivers. As a first step, a better understanding of the caregiving experience such as caregiver characteristics, care recipient characteristics, and social stigma is important for nurses to minimize the burden of care so that appropriate interventions can be developed. In addition, further studies are needed to examine the role and needs of informal caregivers in the care of increasing number of frail and/or chronic ill elderly treated in the community.

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Generation of Renal Cell Carcinoma-specific CD4+/CD8+ T Cells Restricted by an HLA-39 from a RCC Patient Vaccinated with GM-CSF Gene-Transduced Tumor Cells

  • Jun, Do Youn;Moutner, Joseph;Jaffee, Elizabeth
    • IMMUNE NETWORK
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    • v.3 no.2
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    • pp.96-102
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    • 2003
  • Background: Granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-transduced tumor cell vaccines induce very potent systemic anti-tumor immunity in preclinical and clinical models. Our previous phase I clinical trial in patients with metastatic renal cell carcinoma (RCC) has demonstrated both immune cell infiltration at vaccine sites and T cell-mediated delayed-type hypersensitivity (DTH) response to whole tumor cell vaccines. Methods: To investigate the immune responses to autologous genetically- modified tumor cell vaccines, tumor-specific $CD8^+$ T cell lines were generated from peripheral blood lymphocytes (PBL) of a RCC patient 1.24 by repeated in vitro stimulation with either B7.1-transduced autologous RCC tumor cells or B7.1-transduced autologous tumor cells treated with interferon gamma ($IFN{\gamma}$), and cloned by limiting dilution. Results: Among several RCC-specific cytotoxic T lymphocytes (CTLs), a $CD4^+/CD8^+$ double positive T cell clone (17/A2) appeared to recognize $IFN{\gamma}$-treated autologous RCC restricted by HLA-B39. The 17/A2 also recognized other HLA-B39 positive RCC tumor cells after $IFN{\gamma}$ treatment. Conclusion: These results demonstrate that autologous RCC vaccination successfully generates the tumor-specific CTL 17/A2, and suggest that the presentation and recognition of the tumor antigen by the 17/A2 might be upregulated by $IFN{\gamma}$.

A Strategy for Administration and Application of a Patient Safety Culture Survey (환자안전문화 측정을 위한 설문조사 수행 및 결과 활용 기법)

  • Lee, Gyeong-sil;Park, Mi-jin;Na, Hae-ran;Jeong, Heon-jae
    • Quality Improvement in Health Care
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    • v.21 no.1
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    • pp.80-95
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    • 2015
  • Objectives : A safety culture is the bedrock for all patient safety improvement initiatives; thus, many resources have been invested in measuring hospital culture. However, many of these endeavors have failed to yield meaningful results. This article proposes a practical checklist to ensure successful administration of a safety culture survey and describes current methodologies for analyzing survey results to develop safety improvement programs. Methods : We reviewed currently used safety culture surveys and summarized their strengths and weaknesses. We also reviewed studies using safety culture surveys and found several pitfalls leading to failure in survey administration. With this information, we developed a checklist that covers critical items in the survey process. We also reviewed newly developed methodologies for survey results analysis and application and described them using the Korean version of the Safety Attitudes Questionnaire as an example. Results : The checklist consists of three steps: survey preparation, administration, and analysis and application. Each step contains clear action items. The content even describes how to get buy-in from hospital executives and manage communication channels with them. Also, common misunderstandings regarding survey scores are described and possible solutions are suggested. In the analysis section, we demonstrate new methods for obtaining more accurate survey results and how to utilize these methods to develop and implement hospital-wide safety improvement programs. Conclusion : A successful safety culture survey is the foundation of all future safety improvement projects. This review is intended to guide hospitals in enhancing safety.

FUV observation of the comet C/2001 Q4 (NEAT) with FIMS

  • Lim, Yeo-Myeong;Min, Kyoung Wook;Feldman, Paul D.;Han, Wonyong;Edelstein, Jerry
    • The Bulletin of The Korean Astronomical Society
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    • v.37 no.2
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    • pp.107.1-107.1
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    • 2012
  • We present the results of far-ultraviolet (FUV) observations of comet C/2001 Q4 (NEAT) obtained with Far-ultraviolet Imaging Spectrograph (FIMS) on board the Korean microsatellite STSAT-1, which operated at an altitude of 700 km in a sun-synchronous orbit. FIMS is a dual-channel imaging spectrograph (S channel 900-1150 ${\AA}$, L channel 1350-1750 ${\AA}$, ${\lambda}/{\Delta}{\lambda}$ ~ 550) with large image fields of view (S: $4^{\circ}.0{\times}4^{\prime}.6$, L: $7^{\circ}.5{\times}4^{\prime}.3$, angular resolution 5'-10') optimized for the observation of diffuse emission of astrophysical radiation. Comet C/2001 Q4 (NEAT) was observed with a scanning survey mode when it was located around the perihelion between 8 and 15 May 2004. Several important emission lines were detected including S I (1425, 1474 ${\AA}$), C I (1561, 1657 ${\AA}$) and several emission lines of CO $A^1{\Pi}-X^1{\Sigma}^+$ system in the L channel. Production rates of the notable molecules, such as C I, S I and CO, were estimated from the photon fluxes of these spectral lines and compared with previous observations. We compare the flux and the production rates in the radius of $3{\times}10^5$ km with $20{\times}10^5$ km from the central coma. We obtained L-channel image which have map size $5^{\circ}{\times}5^{\circ}$ The image was constructed for the wavelength band of L-channel (1350 - 1710 ${\AA}$. We also present the radial profiles of S I, C I, CO obtained from the spectral images of the central coma. The radial profiles of $2{\times}10^6$ km region are compared with the Haser model.

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