• 제목/요약/키워드: Jin Eun-Young

검색결과 5,160건 처리시간 0.036초

Binding Model of Amentoflavone to Peroxisome Proliferator-Activated Receptor γ

  • Lee, Jee-Young;Kim, Jin-Kyoung;Lee, So-Jung;Lee, Eun-Jung;Shin, So-Young;Jin, Qinglong;Yoon, Do-Young;Woo, Eun-Rhan;Kim, Yang-Mee
    • Bulletin of the Korean Chemical Society
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    • 제33권5호
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    • pp.1475-1479
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    • 2012

  • Human peroxisome proliferator-activated receptor gamma ($hPPAR{\gamma}$) has been implicated in numerous pathologies, including obesity, diabetes, and cancer. In this study, we verified that amentoflavone is an agonist of $hPPAR{\gamma}$ and probed the molecular basis of its action. It was demonstrated that amentoflavone bound $hPPAR{\gamma}$ with high (picomolar) affinity and increased the binding between $hPPAR{\gamma}$ and steroid receptor coactivator-1 (SRC-1) by approximately 4-fold. Based on a docking study, for the first time, we propose a model of amentoflavone and $hPPAR{\gamma}$ binding in which amentoflavone forms three hydrogen bonds with the side chains of His323, Tyr327, and Arg280 in $hPPAR{\gamma}$ and participates in two hydrophobic interactions.

  • https://doi.org/10.5012/bkcs.2012.33.5.1475 인용 PDF KSCI