• Journal of Nutrition and Health
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• 제52권1호
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• pp.17-25
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• 2019

본 연구에서는 댕댕이나무 열매 추출물이 3T3-L1과 마우스 지방유래줄기세포의 지방 분화유도 및 지방생성에 미치는 영향을 살펴보았다. 3T3-L1에 댕댕이나무 열매 추출물을 처리하였을 때, 농도의존적으로 지방구의 생성을 줄였고 지방세포 분화에 있어서 중요한 전사인자인 $PPAR{\gamma}$, $C/EBP{\alpha}$, SREBP1의 발현을 억제시켜 지방 합성이 감소됨을 확인하였다. 또한, 마우스 지방에서 분리한 줄기세포의 지방 분화과정에서도 댕댕이나무 열매 추출물이 $PPAR{\gamma}$, $C/EBP{\alpha}$, SREBP1의 단백질 발현을 감소시켜 지방 축적을 농도 의존적으로 억제하였다. 이상의 결과로 댕댕이나무 열매 추출물은 세포독성이 없는 농도에서 지방 세포의 분화를 억제 하는 것으로 확인되어 항비만 기능성 소재로서의 활용 가능성이 있을 것으로 사료된다.

• 방송공학회논문지
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• 제24권2호
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• pp.306-314
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• 2019

영상의 해상도가 빠른 속도로 증가하기 때문에 계속된 전송 대역폭의 증가에도 불구하고 여전히 효과적인 영상 압축 방법에 대한 연구의 요구가 계속 되고 있다. 이와 같은 요구를 충족하기 위해서 영상의 해상도를 줄인 뒤 압축하여 전송한 뒤에 복원 시에 초해상화 기법을 사용하여 원 해상도로 복원하는 방법에 대한 연구가 제안되었다. 이 방법은 입력 영상의 해상도를 낮추기 때문에 동일한 크기로 압축한다고 할 때, 픽셀 당 비트의 수가 증가되어 영상 압축에서 발생되는 손실을 줄여 복원 영상을 화질을 높일 수 있다. 하지만, 이러한 초해상화를 이용한 비디오 압축 방법의 경우 모든 목표 전송 대역에서 효과적인 것이 아니다. 영상 해상도를 줄이면서 발생되는 손실의 크기와 압축에서 발생되는 손실의 크기를 비교해서 영상 압축에서 발생되는 왜곡이 더 큰 경우에만 기존 압축 성능보다 향상된 결과를 얻을 수 있다. 특히, HEVC의 경우 이전의 표준 압축에 비해 상당히 높은 압축 성능을 가지고 있기 때문에 압축 왜곡이 더 커지는 경우가 상당히 저 대역폭 전송 에서만 생기는 것을 실험적으로 확인할 수 있었다. 본 논문에서는 다양한 영상에서 HEVC 기반 초해상화를 이용한 비디오 코딩을 적용해보고 효과적으로 적용될 수 있는 목표 대역폭을 측정해보았다.

• 대한건축학회논문집:계획계
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• 제34권8호
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• pp.117-128
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• 2018

The central of Ulsan was formed and has been developed in alluvial plains the Riverfront of Taehwa River and Dongcheon River Fortresses including Gyebyeonseong of the late Silla, Chisoseong of the Goryeo, Ulsan Gyeonsangjwabyeongyeongseong, Ulsaneupseong, Ulsanwaeseong and Yeompoyeongseong as well as Gugangseowon and Old Ulsanhyanggyo and other facilities well display such fact. In the southern areas of Taehwa River, Byeokpajeong of Samsan, Buddhist temples and pavilion architectures used to be located. In its upstream areas, Eonyangeupseong, Eonyanghyanggo, Banguseowon and Daegokcheon Petroglyph exist as well. As such, the Riverfront of Taehwa River are a central space where the civilization of Ulsan has grown and developed, and are regarded as a core scenic asset of Ulsan. However, the look and nature of Taehwa River changed significantly due to Ulsan irrigation project and the construction of modern bridges such as Ulsangyo and Ulsan railway bridge during the period of Japanese occupation. The old look of the area started to be ruined by water contaminations and developments of waterfront lands that resulted from the development of Ulsan Industrial Center in 1962. The water quality of Taehwa River has been improved as a result of allotting a huge budget and administrative powers before and after 1997, the year when Ulsan was elevated to a metropolitan city. However, the surrounding views around Taehwa River changed greatly due to various urban development projects including apartment complex constructions. This is because the development of the Riverfront started from a land utilization project, in which the construction of apartment complexes was included in the initial phase; as a result, the areas were changed to be private scenic assets for those apartments. Aware of such issue, this study aims to identify major scenic elements that were present in the period before such developments in the river's surrounding areas from literature and geography materials; and to reveal how various urban development projects that have been performed from the period of Japanese occupation have changed the scenic elements of Riverfront of Taehwa River. The purpose of this study is to identify qualitative and quantitative changes in scenic elements of the Riverfront of Taehwa River as well as the characteristics of the resulting changes in the surrounding scenery.

• 한국수산과학회지
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• 제55권2호
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• pp.171-182
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• 2022

The habitat degradation caused by large-scale reclamation leads to devastating impacts, such as fine sediment and mud shrimp Upogebia major settlement on Manila clam Ruditapes philippinarum aquaculture in the eastern Cheonsu Bay tidal flats, Republic of Korea. Despite these impacts, there is a lack of studies on the influence of fine sediments on tidal flats that constitute key mud shrimp habitats. This study provides information on the seawater-sediment environment and the influence of dissolved inorganic nitrogen (DIN) fluctuations depending on mud shrimp burrow hole density. Additionally, it discusses countermeasures for Manila clam habitat management. The results show that mean DIN effluxes in areas with a high-density of burrow holes were up to 4 times (0.12 mmol m^-2 d^-1) higher than those in sites of low-density (0.03 mmol m^-2 d^-1) within the Saho and Songhak-ri tidal flats. To manage interference within the competition zone of Songhak-ri tidal flat, it is important to utilize the settlements of spawning season in all three dimensions. Consequently, additional studies in other tidal flats are essential and research in zones where mud shrimps and juvenile clams coexist will help to determine the priorities in the efficient management of clam aquaculture.

• 한국컴퓨터정보학회논문지
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• 제28권3호
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• pp.45-58
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• 2023

KVMF 1.0 프로토콜은 비트 단위의 가변형 메시지 처리를 통해 다양한 무기 체계 간 데이터통신이 가능하도록 표준 메시지와 통신 방법을 정의한 육군 표준 전술 데이터링크 프로토콜이다. 이 프로토콜은 지난 10년간 다양한 육군 무기 체계에 적용되어 왔고, 현대전의 핵심인 NCW(Network Centric Warfare)의 구현을 가능하게 하여 육군의 작전 수행 능력이 한 단계 업그레이드되는데 기여하였다. KVMF 1.0 프로토콜이 적용된 이후, 시간의 흐름에 따라 새로운 기술이 적용된 신규 무기 체계가 도입되었고 신규 무기 체계는 무기 체계의 특성에 따른 새로운 메시지를 탑재하게 되었다. 이에 따라 기존에 전력화된 무기 체계와의 메시지 버전 차이에 따른 호환 문제가 발생하게 되었고 미래의 지속적인 메시지 개정 소요를 고려하면 앞으로도 이러한 문제가 연속하여 대두될 것으로 예상되었다. 따라서 이러한 메시지 호환성 문제를 해결하기 위한 방안이 필요하게 되었고 본 논문에서는 상/하위 버전간 호환성이 보장되는 KVMF 2.0 프로토콜 설계안을 제시하였다. 본 논문에서는 제시한 호환 방안을 소프트웨어로 구현하였으며, 상/하위 버전 간 연동 환경을 구성하여 시험을 통해 설계안이 성공적으로 동작함을 확인하였다. 이를 통해 본 KVMF 2.0 프로토콜 설계안을 무기 체계에 적용하면 기 전력화 체계와의 연동은 물론, 미래의 무기 체계와도 연동할 수 있는 상/하위 버전 간 호환성 확보가 될 수 있을 것이라 기대할 수 있게 되었다.

• 한국컴퓨터정보학회논문지
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• 제27권8호
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• pp.49-59
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• 2022

본 논문에서는 2020년 기준 단백질 서열을 이용한 기능과 구조 예측 분야에서 가장 많이 사용되고 있는 딥러닝 모델인 CNN과 LSTM/GRU 모델을 동일한 조건 하에 비교 평가한 연구를 토대로 새로운 효소 기능 예측 모델인 PSCREM을 설계하였다. CNN 합성곱 시 누락되는 세부 패턴을 보존하기 위하여 서열 진화정보를 이용하였으며 중첩 RNN을 통해 기능적으로 중요한 의미를 가지는 아미노산 간의 관계 정보를 추출하고 특징 맵 제작에 참조하였다. 사용된 RNN 계열의 알고리즘은 LSTM과 GRU로 보통 stacked RNN 기법으로 100 units 이상 2~3회 쌓는 것이 일반적이나 본 논문에서는 10, 20 unit으로 구성한 뒤 중첩시켜서 특징 맵 제작에 사용하였다. 모델에 들어가는 데이터는 단백질 서열 데이터로 PSSM profile로 가공한 뒤 사용되었다. 실험 결과 효소 번호 첫 번째 자리를 예측하는 문제에 대해 86.4%의 정확도를 나타냄을 입증하였고, 효소 번호 3번째 자리까지 예측 정확도 84.4%의 성능을 내는 것을 확인하였다. PSCREM은 Overlapped RNN을 통해 단백질 기능에 관련된 고유 패턴을 더 잘 파악하며 Overlapped RNN은 단백질 기능 및 구조 예측 추출 분야에 새로운 방법론으로서 제안된다.

• 한국물환경학회지
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• 제39권2호
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• pp.162-174
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• 2023

In order to prevent water pollution caused by organic matter, Total Organic Carbon(TOC) has been adopted indicator and monitored. TOC can be divided into Dissolved Organic Carbon(DOC) and Particulate Organic Carbon(POC). POC is largely precipitated and removed during stream flow, which making DOC environmentally significant. However, there are lack of studies to define spatio-temporal distributions of DOC in stream affected by various land use. Therefore, it is necessary to estimate the past DOC concentration using other water quality indicators to evaluate status of watershed management. In this study, DOC was estimated by correlation and regression analysis using three different organic matter indicators monitored in mixed land-use watersheds. The results of correlation analysis showed that DOC has the highest correlation with TOC. Based on the results of the correlation analysis, the single- and multiple-regression models were developed using Biochemical Oxygen Demand(BOD), Chemical Oxygen Demand(COD), and TOC. The results of the prediction accuracy for three different regression models showed that the single-regression model with TOC was better than those of the other multiple-regression models. The trend analysis using extended average concentration DOC data shows that DOC tends to decrease reflecting watershed management. This study could contribute to assessment and management of organic water pollution in mixed land-use watershed by suggesting methods for assessment of unmeasured DOC concentration.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.269-269
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• 2022

Pre-harvest sprouting (PHS) on rice panicles is getting problematic in recent several years in Korea due to climate changes such as high temperature and more frequent typhoons during harvesting season. PHS negatively affects grain quality severely and also yield. Genetic improvement of Korean varieties (Oryza sativa ssp. japonica) through a marker assisted-backcross breeding (MAB) with the known PHS resistant genes must be one of ideal solutions. However, the final breeding products of MAB occasionally exhibit unwanted traits, especially the cross between genetically distant parents. This might be caused by linkage drag and/or presence of the gene-unlinked donor introgressions, resulting that the final products could not be released to the farmers. The major PHS resistance gene, Sdr4 (Seed dormancy 4) originated from an indica cultivar, Kasalath was selected as a donor gene. In order to avoid unexpected phenotypes in the breeding products, we performed a precision marker-based breeding (PMBB) consisting of foreground, recombinant, and background selections (FS, RS, and BS) which aim to develop 'single small introgression lines' (~100 kb introgression). Korean varieties (Ilpum and Gopum) were crossed with Kasalath. We developed Sdr4-allele specific markers for FS and a set of polymorphic flanking markers near the Sdr4 (-350kb and +420kb) for RS. To minimize linkage drag, the small introgression (< 125kb) containing Sdr4 was selected in Ilpum background (BC₂F₄) through 1^st RS with ~1,200 F₂ or BC₁F₂ plants (one side trimmed) and then 2^nd RS with ~1,000 progenies from the 1^st RS selected plants (another side trimmed). After RS, the selected lines were genotyped by using Infinium 7K SNP chip to detect other donor introgressions and the lines were backcrossed. Currently BS is on-going from the backcross-derived progenies with BS markers to remove residual introgressions. During the PMBB process, genetic effect of Sdr-4-Kasalath allele was confirmed in Ilpum and Gopum backgrounds by PHS phenotyping using the segregating BC₂F₃ or BC₁F₄ materials. The Sdr4 PMBB lines in Ilpum background (< 125kb introgression) will be valuable genetic resources to improve PHS resistance in modem popular temperate japonica varieties.

• IMMUNE NETWORK
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• 제21권2호
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• pp.14.1-14.17
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• 2021

Scrub typhus develops after the individual is bitten by a trombiculid mite infected with Orientia tsutsugamushi. Since it has been reported that pneumonia is frequently observed in patients with scrub typhus, we investigated whether intranasal (i.n.) vaccination with the outer membrane protein of O. tsutsugamushi (OMPOT) would induce a protective immunity against O. tsutsugamushi infection. It was particular interest that when mice were infected with O. tsutsugamushi, the bacteria disseminated into the lungs, causing pneumonia. The i.n. vaccination with OMPOT induced IgG responses in serum and bronchoalveolar lavage (BAL) fluid. The anti-O. tsutsugamushi IgA Abs in BAL fluid after the vaccination showed a high correlation of the protection against O. tsutsugamushi. The vaccination induced strong Ag-specific Th1 and Th17 responses in the both spleen and lungs. In conclusion, the current study demonstrated that i.n. vaccination with OMPOT elicited protective immunity against scrub typhus in mouse with O. tsutsugamushi infection causing subsequent pneumonia.

• Food Science and Biotechnology
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• 제17권1호
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• pp.161-165
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• 2008

The trypsin inhibitor activities (TIA) of various potato cultivars were evaluated by measuring the inhibition of trypsin inhibitor activity using N-benzoyl-DL-arginine-p-nitroanilide (BAPNA) as substrate. The TIA values of 5 potato cultivars (1.99 to 2.88 mg/g) were significantly different among cultivars (p<0.05). When the TIA values of commercially processed potatoes were determined, no TIA was detected. During cooking, the $IT_{50}$ (time required to reach 50% inhibition of TIA) values were decreased as heating temperature and time increased. The ITso of moist heating was estimated to be 0.34 min at $100^{\circ}C$, whereas for deep-fat frying the $IT_{50}$ was 0.13 min at $180^{\circ}C$ and 5.28 min for oven baking at $100^{\circ}C$. The $IT_{50}$ value of microwave cooking was 0.194 min at medium heat, and which was similar to that of pressure cooking at $120^{\circ}C$ (0.185 min). Moreover, there was a negative relationship between temperature (${\geq}80^{\circ}C$) and $IT_{50}$ values ($R^2=0.99$, p<0.01). The TIA of potato was completely inactivated by moist heating at $100^{\circ}C$ within 5 min, whereas the pressure cooking at $120^{\circ}C$ and deep-fat frying at $180^{\circ}C$ within 60 and 30 sec, respectively. Based on our results, deep-fat frying is the most effective cooking method to reduce TIA in potatoes.