• The Korean Journal of Physiology and Pharmacology
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• 제11권5호
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• pp.171-174
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• 2007

Neuronal death is a common characteristic hallmark of a variety of neurodegenerative disorders including Alzheimer's disease and Parkinson's disease. However, there have been no effective drugs to successfully prevent neuronal death in those diseases, whereas oriental medicinal plants have to possess valuable therapeutic potentials to treat neurodegenerative diseases. In the present study, in an attempt to provide neuroprotective agents from natural plants, 80% methanol extracts of a wide range of medicinal plants, which are native to Jeju Island in Korea, were prepared and their protective effects on hydrogen peroxide-induced apoptotic cell death were examined. Among those tested, extracts from Smilax china and Saururus chinesis significantly decreased hydrogen peroxide-induced apoptotic cell death. The extracts attenuated hydrogen peroxide($H_2O_2$)-induced caspase-3 activation in a dose-dependent manner. Further, plant extracts restored $H_2O_2$-induced depletion of intracellular glutathione, a major endogenous antioxidant. The data suggest that Jeju native medicinal plants could potentially be used as therapeutic agents for treating or preventing neurodegenerative diseases in which oxidative stress is implicated.

• 식품산업과 영양
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• 제17권1호
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• pp.13-16
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• 2012

• Journal of Applied Biological Chemistry
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• 제50권4호
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• pp.215-220
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• 2007

One of the important functions of skin is protection from harmful environments. Many studies have explored how to prevent skin from wrinkling and the occurrence of pigmentation changes. Skin wrinkling and pigmentation changes could be caused by unusual disruption of connective tissue, the formation of free radicals and ultraviolet radiation. In this study, extracts obtained from 254 different kinds of Jeju medicinal plants were screened for inhibitory effects on tyrosinase and elastase, and for free radical scavenging effects. Four herbs, Phormium tenax, Morus bombycis, Morus alba, and Cudrania tricuspidata, were potent inhibitors of tyrosinase ($IC_{50}$ values 4.62, 5.46, 8.17, and 64.17 ${\mu}g$/mL, respectively). Aleurites fordii [$IC_{50}$: 5.29 ${\mu}g$/mL, 1,1-diphenyl-2-picrylhydrazyl (DPPH)], Distylium racemosum ($IC_{50}$: 6.14 ${\mu}g$/mL), Acer palmatum ($IC_{50}$: 5.44 ${\mu}g$/mL), and Spiraea salicifolia ($IC_{50}$: 5.25 ${\mu}g$/mL) showed good antioxidative effects. Furthermore, Distylium racemosum ($IC_{50}$: 7.51 ${\mu}g$/mL), Diospyros kaki ($IC_{50}$: 15.1 ${\mu}g$/mL), Cornus macrophylla ($IC_{50}:$ 16.59 ${\mu}g$/mL), and Psidium guajava ($IC_{50}$: 40.25 ${\mu}g$/mL) exhibited potent inhibitory effects on elastase. These results suggest that medicinal plants possessing several biological activities may be potent inhibitors of the processes involved in pigmentation increases and aging. Further investigations will focus on in vivo assays and on the chemical identification of the major active components responsible for whitening and anti-aging activity in the screened efficacious extracts.

• 한국약용작물학회지
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• 제28권5호
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• pp.354-359
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• 2020

Background: The recent, decline in Black-berry Magnolia Vine (Schisandra repanda; BMV) native to Jeju Island, Korea, has raised concerns about the causes of this decline. We investigated the native environment of S. repanda and evaluated its propagation through cuttings to provide preliminary data for its restoration in Jeju Island. Methods and Results: The native environment of the BMV in the Hallasan National Park was surveyed and the climatic variables (temperature and humidity) were analyzed. The effects of the sex of the donor plant (male/female) type of cutting (softwood/hardwood), and treatment with a plant growth regulator (indole-3-butylic acid/rootone) on the rooting of BMV were investigated. Additinallly, the rooting rate, root count, and root length, as well as temperature and humidity were measured in the vinyl moist chambers. BMV was observed in 63 plants distributed from 567 m to 1,364 m above sea level of the Hallasan National Park. In the cutting experiment, the rooting rate was 71.9%, and it was higer in female plants (75.0%) than in male plants (68.8%). Conclusions: The mass propagation of BMV through cuttings valuable for its restoration as without such safeguard measures, the population could face extinction within a few decades.

• 대한본초학회지
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• 제39권3호
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• pp.11-21
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• 2024

Objective : For the purpose of developing Korean Primulaceae plants, the literature published so far have been thoroughly investigated to prepare this article. Methods : Books and research papers about Herbology which published at Korea and other countries were examined. Results : The results of this study were as follows: 1. A total of 8 genera and 30 species of Primulaceae was found in the Korea, among which 4 genera and 9 species (approximately 30%) were medicinal plants. 2. Among Korean Primulaceae plants, Lysimachia was the most with 11 species. 3. Among medicinal plants, Lysimachia was the most with 5 species, followed by 1 species of Anagallis, 1 species of Primula, and 2 species of Androsace. 4. The domestic distribution of medicinal plants was 4 species in the north part, 7 species in the central part, 7 species in the south part, and 7 species in Jeju island. 5. Among the medicinal parts, the whole body was used the most with 9 species. Among the property flatness property was the most whith 10 species. And among the flavors, bitter taste was the most with 13 species. 6. Lung meridian channel was the most with 3 species. The effect of reducing swelling was the most with 10 species. 7. No toxic drugs have been reported yet. Conclusion : There were totaled to 8 genera and 30 species in Primulaceae in Korea and among them medicinal plants are 4 genera, 9 species, some 30% in total.

• 한국어병학회지
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• 제22권3호
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• pp.317-326
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• 2009

This study has shown the screening of anti-bacterial activity of three Indian medicinal plant choloroform : methanol (50:50) solvent leaf extracts (i.e. Azadirachta indica, Ocimum sanctum, and Curcuma longa) with different concentrations (10, 5, 2.5, 1.25, 0.625, 0.312, and 0.156 mg/ml) under in vitro conditions against fish pathogenic bacteria, Aeromonas hydrophila, Streptococcus iniae, Vibrio harveyi, V. anguillarum, and Edwardsiella tarda isolated from olive flounder farms, Jeju Island, South Korea. The anti-microbial activity of the A. indica and O. sanctum extracts yielded the zones of growth inhibition (ZI) was 3 and 1mm against A. hydrophila at concentration of 0.156 mg/ml when compared to that of tetracycline standard (3 mm). At highest concentration (10 mg/ml) of A. indica, O. sanctum, and C. longa, high inhibition was 9, 7, and 6 mm when compared to that of tetracycline (11 mm) against A. hydrophila. The minimum inhibitory concentration (MIC) of A. indica, O. sanctum, and C. longa at 0.156 mg/ml that yield 9, 10, and 13 CFU/ml for A. hydrophila, 16, 22, and 25 CFU/ml for S. iniae and 18, 22, and 23 CFU/ml for E. tarda compared to the tetracycline. At highest concentration (10 mg/ml) of the three extracts was better inhibiting the growth of A. hydrophila, S. iniae and E. tarda. A. indica, O. sanctum, and C. longa were determined to the potential antioxidant activityon the basis of their scavenging activity of the stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical. A. indica extract was 0.625 mg/ml which indicated that the strong anti-oxidant activity. However, O. sanctum and C. longa extracts showed weak anti-oxidant activity at this concentration. Hence, in vitro assay among the pathogens, A. hydropila is better inhibitory activity of the extracts. It is evident that the Indian medicinal plants extracts were subjected to its effectiveness against A. hydrophila, S. iniae, and E.tarda at low concentrations. The obtained results in the present study suggested that the Indian plant extracts is a prevention tools for Korean olive flounder aquaculture pathogens and its need further advance investigation.

• Journal of Applied Biological Chemistry
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• 제50권2호
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• pp.101-103
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• 2007

• 대한수의학회지
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• 제54권4호
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• pp.233-238
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• 2014

The present study was performed to evaluate the effect of medicinal plant extract on relieving hangovers in mice administered alcohol. The animals were divided into three groups. Each group was treated with fermented plant extract, non-fermented plant extract, or water 30 min after consuming ethanol (2 mL/kg). A locomotor activity test showed that all groups had decreased motor activity until 40 min after plant extract administration. The mice treated with water had lower motor activity until 100 min post-administration. However, the group treated with non-fermented plant extract showed increased motor activity 40 min post-administration, and the higher activity level was maintained until 120 min post-administration. The animals treated with fermented plant extract had a level of motor activity between those of the groups treated with water or non-fermented plant extract. Blood was collected from each mouse 120 min post-administration and aldehyde concentration was measured. The group treated with non-fermented plant extract had a significantly higher (p < 0.05) aldehyde concentration than the other groups. These results demonstrate that the non-fermented medicinal plant extract helped alleviate hangovers 40 min after administration by reducing aldehyde concentrations in the blood.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2011년도 춘계학술발표회
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• pp.88-89
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• 2011

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2010년도 심포지엄 및 추계학술발표회
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• pp.292-293
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• 2010