• Molecules and Cells
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• 제27권5호
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• pp.503-513
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• 2009

Proteoglycans located in basement membranes, the nanostructures underling epithelial and endothelial layers, are unique in several respects. They are usually large, elongated molecules with a collage of domains that share structural and functional homology with numerous extracellular matrix proteins, growth factors and surface receptors. They mainly carry heparan sulfate side chains and these contribute not only to storing and preserving the biological activity of various heparan sulfate-binding cytokines and growth factors, but also in presenting them in a more "active configuration" to their cognate receptors. Abnormal expression or deregulated function of these proteoglycans affect cancer and angiogenesis, and are critical for the evolution of the tumor microenvironment. This review will focus on the functional roles of the major heparan sulfate proteoglycans from basement membrane zones: perlecan, agrin and collagen XVIII, and on their roles in modulating cancer growth and angiogenesis.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1995년도 제34차 추계학술대회
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• pp.397-400
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• 1995

• 한국대기환경학회:학술대회논문집
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• 한국대기환경학회 2006년도 춘계학술대회 논문집
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• pp.140-141
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• 2006

• 대한핵의학회지
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• 제19권2호
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• pp.87-89
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• 1985

Unresolved major pulmonary embolism (UMPE) is an uncommon condition which causes pulmonary hypertension, cor pulmonale and death. An accurate and prompt diagnosis of UMPE is very important in the management of such patients with pulmonary embolectomy. Follow-up lung scans can lead to earlier diagnosis of UMPE especially on patients who have a history of acute pulmonary embolism in the past and. present with pulmonary hypertension, respiratory insufficiency and cor pulmonale. We report a case of UMPE strongly suggested by follow-up lung scans and subsequently confirmed by pulmonary angiography and postmortem examination.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1987년도 제26차 춘계학술대회
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• pp.118-119
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• 1987

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권1호
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• pp.61-65
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• 2022

Trigeminocardiac reflex (TCR) is a well-known brainstem reflex that manifests as hypotension, bradycardia, dysrhythmia, and asystole when stimulation is applied to a branch of the trigeminal nerve. Most commonly associated with ophthalmic, orbital, and neurologic surgeries, mandibular division and oral cavity variants occur far less frequently. Here, we describe a case of asystolic TCR elicited by lingual nerve stimulation. This case highlights the role of specific anesthetic medications in modulating this phenomenon and reinforces the need for early recognition and clear communication in case of its occurrence. Anesthesia providers must consider discontinuing or avoiding certain medications when clinically appropriate, even during low TCR-risk procedures.

• Archives of Plastic Surgery
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• 제47권5호
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• pp.460-466
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• 2020

Background Sternoclavicular joint (SCJ) osteomyelitis is a rare pathology requiring urgent intervention. Several operative approaches have been described with conflicting reports. Here, we present a multi-institutional study utilizing multiple surgical pathways for SCJ reconstruction. Methods A multi-institutional retrospective cohort study was conducted to identify patients who underwent surgical repair for sternoclavicular osteomyelitis between 2008 and 2019. Patients were stratified according to reconstruction approach: single-stage reconstruction with advancement flap and delayed-reconstruction with flap following initial debridement. Demographics, operative approach, type of reconstruction, and postoperative outcomes were analyzed. Results Thirty-two patients were identified. Mean patient age was 56.2±13.8 years and 68.8% were male. The average body mass index (BMI) was 30.0±8.8 kg/㎡. The most common infection etiologies were intravenous drug use and bacteremia (both 25%). Fourteen patients (43.8%) underwent one-stage reconstruction and 18 (56.2%) underwent delayed two-staged reconstruction. Both single and delayed-stage groups had comparable rates of reinfection (7.1% vs. 11.1%, respectively), surgical site complications (21.4% vs. 27.8%), readmissions (7.1% vs. 16.6%), and reoperations (7.1% vs. 5.6%; all P>0.05). The single-stage reconstruction group had a significantly lower BMI (26.2±5.7 kg/㎡ vs. 32.9±9.1 kg/㎡; P<0.05) and trended towards shorter hospital length of stay (11.3 days vs. 17.9 days; P=0.01). Conclusions Both single and delayed-stage approaches are appropriate methods with comparable outcomes for reconstruction for SCJ osteomyelitis. When clinically indicated, a single-stage reconstruction approach may be preferable in order to avoid a second operation as associated with the delayed phase, and possibly shortening total hospital length of stay.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1989년도 제28차 춘계학술대회
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• pp.136.2-137
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• 1989

• 한국간호교육학회지
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• 제24권3호
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• pp.259-268
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• 2018

Purpose: This study was to validate the Korean version of the Jefferson Scale of Empathy-Health Professions Students (K-JSE-HPS) in undergraduate nursing students. Methods: With a survey design, a total of 293 junior and senior nursing students were recruited and data were collected using a self-administered study questionnaire to measure their levels of empathy use the K-JSE-HPS. Using SPSS/WIN 22.0 and AMOS 22.0, data analysis was conducted with confirmatory factor analysis, criterion validity, and reliability. Results: For construct validity, confirmatory factor analysis showed an acceptable model fit (Goodness of Fit Index was 0.88) along with confirming convergent and discriminant validity (construct reliability was 0.70). For criterion validity, the scale was significantly related with the Interpersonal Reaction Index. For reliability, Cronbach's ${\alpha}$ coefficient for the scale was 0.87 and for the subscales were 0.84, 0.78, and 0.69, respectively. Conclusion: The findings show satisfactory construct and criterion validity and reliability of the Korean version of the JSE-HPS for measuring empathy in undergraduate nursing students.

• 대한간호학회지
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• 제46권2호
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• pp.207-214
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• 2016

Purpose: To validate the Korean Version of the Jefferson Empathy Scale for Health professionals (K-JSE-HP) in a sample of Korean nurses. Methods: Internal consistency reliability, construct and criterion validity were calculated using SPSS (22.0) and AMOS (22.0). Data were collected from 253 nurses (230 women, 23 men) working at one university hospital in Seoul, South Korea. Results: The Korean version of JSE-HP showed reliable internal consistency with Cronbach's alpha for the total scale of .89, and .74~.84 for subscales. The model of three subscales for the K-JSE-HP was validated by confirmatory factor analysis (${\chi}^2=864.60$, Q=6.55, p<.001, CFI=.94, NNFI=.92). Criterion validity compared to the Interpersonal Reaction Index (IRI) showed significant correlation. Conclusion: The findings of this study demonstrate that the Korean JSE-HP shows satisfactory construct and criterion validity and reliability. It is a useful tool to measure Korean nurses' empathy.